Bocaviruses are associated with many human infectious diseases, such as respiratory tract infections, gastroenteritis, and hepatitis. Rats are known to be reservoirs of bocaviruses, including rodent bocavirus and rat ...Bocaviruses are associated with many human infectious diseases, such as respiratory tract infections, gastroenteritis, and hepatitis. Rats are known to be reservoirs of bocaviruses, including rodent bocavirus and rat bocavirus.Recently, ungulate bocaparvovirus 4, a known porcine bocavirus, has also been found in rats. Thus, investigating bocaviruses in rats is important for determining the origin of the viruses and preventing and controlling their transmission. To the best of our knowledge, no study to date has investigated bocaviruses in the livers of rats. In this report, a total of 624 rats were trapped in southern China between 2014 and 2017. Liver and serum samples from rats were tested for the prevalence of bocaviruses using PCR. Sequences related to ungulate bocaparvovirus 4and rodent bocavirus were detected in both liver and serum samples. Interestingly, the prevalence of ungulate bocaparvovirus 4(reference strain: KJ622366.1) was higher than that of rodent bocavirus(reference strain:KY927868.1) in both liver(2.24% and 0.64%, respectively) and serum samples(2.19% and 0.44%, respectively).The NS1 regions of ungulate bocaparvovirus 4 and rodent bocavirus related sequences displayed over 84% and88% identity at the nucleic acid and amino acid levels, respectively. Furthermore, these sequences had similar genomic structure, genomic features, and codon usage bias, and shared a common ancestor. These viruses also displayed greater adaptability to rats than pigs. Our results suggested that ungulate bocaparvovirus 4 and rodent bocavirus may originate from rats and may be different genotypes of the same bocavirus species.展开更多
Background As of July 22,2025,the chikungunya virus transmission has been documented across 119 countries and territories of the world.In 2025,an outbreak of chikungunya fever(CF)occurred in Foshan,Guangdong Province,...Background As of July 22,2025,the chikungunya virus transmission has been documented across 119 countries and territories of the world.In 2025,an outbreak of chikungunya fever(CF)occurred in Foshan,Guangdong Province,China.We aimed to analyze the epidemiological characteristics and transmission dynamics during the early stage of this outbreak.Methods We collected the data of CF cases in Foshan from July 8 to July 26,2025.Case data were extracted from the National Notifiable Infectious Disease Reporting System.Demographics and tempo-spatial distributions of cases,incidence rates and the onset-to-report interval times were analyzed.Global spatial autocorrelation(Moran’s I)to assess township-level clustering;Kruskal-Wallis tests with Dunn's post-hoc comparisons(Bonferroni-corrected)to analyze onset-to-report intervals across four epidemic phases.The basic reproduction number(R0)was calculated using a maximum likelihood method,which was also compared with the R0 from the CF outbreak in Dongguan City of Guangdong Province in 2010.Results A total of 4,754 local cases were reported during the study period.Persons aged 65 years or above had the highest incidence(116.57 per 100,000 population).Most cases were business/service workers,homemakers,and retirees.The median onset-to-report interval decreased from 4 days to 1 day after outbreak control measures were implemented.The outbreak,initially detected in Shunde District,spread rapidly to other districts of Foshan,forming a significant spatial cluster(Moran's I=0.152,P=0.029).The estimated R0 was 16.3(95%confidence interval:15.0 to 17.5),substantially higher than the estimated R0 of 5.5 for the Dongguan outbreak in 2010.Conclusions This outbreak was characterized by high transmissibility,with older persons being a primary high-risk group.The rapid reduction in case reporting delay highlights the effectiveness of response interventions.Sustained,integrated and prompt response has been essential to control the outbreak.展开更多
基金supported by the Key-Area Research and Development Program of Guangdong Province (no. 2018B020241002)the National Natural Science Foundation of China (no. 81373051)。
文摘Bocaviruses are associated with many human infectious diseases, such as respiratory tract infections, gastroenteritis, and hepatitis. Rats are known to be reservoirs of bocaviruses, including rodent bocavirus and rat bocavirus.Recently, ungulate bocaparvovirus 4, a known porcine bocavirus, has also been found in rats. Thus, investigating bocaviruses in rats is important for determining the origin of the viruses and preventing and controlling their transmission. To the best of our knowledge, no study to date has investigated bocaviruses in the livers of rats. In this report, a total of 624 rats were trapped in southern China between 2014 and 2017. Liver and serum samples from rats were tested for the prevalence of bocaviruses using PCR. Sequences related to ungulate bocaparvovirus 4and rodent bocavirus were detected in both liver and serum samples. Interestingly, the prevalence of ungulate bocaparvovirus 4(reference strain: KJ622366.1) was higher than that of rodent bocavirus(reference strain:KY927868.1) in both liver(2.24% and 0.64%, respectively) and serum samples(2.19% and 0.44%, respectively).The NS1 regions of ungulate bocaparvovirus 4 and rodent bocavirus related sequences displayed over 84% and88% identity at the nucleic acid and amino acid levels, respectively. Furthermore, these sequences had similar genomic structure, genomic features, and codon usage bias, and shared a common ancestor. These viruses also displayed greater adaptability to rats than pigs. Our results suggested that ungulate bocaparvovirus 4 and rodent bocavirus may originate from rats and may be different genotypes of the same bocavirus species.
基金supported by the Key Area Research and Development Program of Guangdong Province(2025B1111050002,2022B1111020006)National Natural Science Foundation of China(82373636)Guangdong Natural Science and Technology Project(2023A1515011921).
文摘Background As of July 22,2025,the chikungunya virus transmission has been documented across 119 countries and territories of the world.In 2025,an outbreak of chikungunya fever(CF)occurred in Foshan,Guangdong Province,China.We aimed to analyze the epidemiological characteristics and transmission dynamics during the early stage of this outbreak.Methods We collected the data of CF cases in Foshan from July 8 to July 26,2025.Case data were extracted from the National Notifiable Infectious Disease Reporting System.Demographics and tempo-spatial distributions of cases,incidence rates and the onset-to-report interval times were analyzed.Global spatial autocorrelation(Moran’s I)to assess township-level clustering;Kruskal-Wallis tests with Dunn's post-hoc comparisons(Bonferroni-corrected)to analyze onset-to-report intervals across four epidemic phases.The basic reproduction number(R0)was calculated using a maximum likelihood method,which was also compared with the R0 from the CF outbreak in Dongguan City of Guangdong Province in 2010.Results A total of 4,754 local cases were reported during the study period.Persons aged 65 years or above had the highest incidence(116.57 per 100,000 population).Most cases were business/service workers,homemakers,and retirees.The median onset-to-report interval decreased from 4 days to 1 day after outbreak control measures were implemented.The outbreak,initially detected in Shunde District,spread rapidly to other districts of Foshan,forming a significant spatial cluster(Moran's I=0.152,P=0.029).The estimated R0 was 16.3(95%confidence interval:15.0 to 17.5),substantially higher than the estimated R0 of 5.5 for the Dongguan outbreak in 2010.Conclusions This outbreak was characterized by high transmissibility,with older persons being a primary high-risk group.The rapid reduction in case reporting delay highlights the effectiveness of response interventions.Sustained,integrated and prompt response has been essential to control the outbreak.
