The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissu...The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing.Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction.For example,impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers,venous ulcers and bedsores.This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds.Furthermore,we review wound lymphangiogenesis processes and remodelling,especially the influence of the inflammatory phase.Finally,we outline how to control lymphangiogenesis to promote wound healing,assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.展开更多
基金supported by grants from the Collaborative Innovation Center of the Chinese Ministry of Education(Grant No.2020-39)Talents Science Cooperation Platform of Guizhou(No.2020-5012)+2 种基金Talents Science Platform of Zunyi city(Grant No.2021-3)Science and Technology Program of Guizhou Province([2020]1Y331)Scientific Research and Talent Training Funds of Kweichow Moutai Hospital(Grant No.2022-13).
文摘The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing.Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction.For example,impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers,venous ulcers and bedsores.This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds.Furthermore,we review wound lymphangiogenesis processes and remodelling,especially the influence of the inflammatory phase.Finally,we outline how to control lymphangiogenesis to promote wound healing,assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.
