To the Editor:Cervical cancer is the fourth most common malignancy in women globally,with 84%of cases occurring in developing countries.[1]In China,it has the highest incidence among female reproductive system cancers...To the Editor:Cervical cancer is the fourth most common malignancy in women globally,with 84%of cases occurring in developing countries.[1]In China,it has the highest incidence among female reproductive system cancers.Cervical squamous intraepithelial lesion(SIL)is closely associated with cervical cancer.In 2014,the World Health Organization classified SIL into low-grade SIL(LSIL)and high-grade SIL(HSIL),with HSIL having cancerous potential.Most LSIL cases are self-limiting;however,HSIL can become cancerous,representing a precancerous lesion.[2]Therefore,the early detection and treatment of HSIL are crucial for the prevention of cervical cancer.HSIL treatment involves cervical conization(CC),and total hysterectomy(TH)may be necessary later depending on postoperative pathology and other factors such as the patient’s age,fertility requirements,and comorbidities.This study analyzed perioperative data of HSIL patients who underwent TH after loop electrosurgical excision procedure(LEEP)at the Affiliated Cancer Hospital of University of Electronic Science and Technology of China over the past 8 years,comparing the effects of performing TH within 3 days and within 4 weeks after surgery.Early TH addresses residual disease and prevents recurrence,whereas in TH performed after 4 weeks,patients are better recovered and the assessment of surgical margins and recurrence risks is clearer.展开更多
Plant viruses cause substantial agricultural devastation and economic losses worldwide.Plant nucleotide-binding domain leucine-rich repeat receptors(NLRs)play a pivotal role in detecting viral infection and activating...Plant viruses cause substantial agricultural devastation and economic losses worldwide.Plant nucleotide-binding domain leucine-rich repeat receptors(NLRs)play a pivotal role in detecting viral infection and activating robust immune responses.Recent advances,including the elucidation of the interaction mechanisms between NLRs and pathogen effectors,the discovery of helper NLRs,and the resolution of the ZAR1 resistosome structure,have significantly deepened our understanding of NLR-mediated immune responses,marking a new era in NLR research.In this scenario,significant progress has been made in the study of NLRmediated antiviral immunity.This review comprehensively summarizes the progress made in plant antiviral NLR research over the past decades,with a focus on NLR recognition of viral pathogen effectors,NLR activation and regulation,downstream immune signaling,and the engineering of NLRs.展开更多
基金supported by Sichuan Medical Research Projects(No.S21090).
文摘To the Editor:Cervical cancer is the fourth most common malignancy in women globally,with 84%of cases occurring in developing countries.[1]In China,it has the highest incidence among female reproductive system cancers.Cervical squamous intraepithelial lesion(SIL)is closely associated with cervical cancer.In 2014,the World Health Organization classified SIL into low-grade SIL(LSIL)and high-grade SIL(HSIL),with HSIL having cancerous potential.Most LSIL cases are self-limiting;however,HSIL can become cancerous,representing a precancerous lesion.[2]Therefore,the early detection and treatment of HSIL are crucial for the prevention of cervical cancer.HSIL treatment involves cervical conization(CC),and total hysterectomy(TH)may be necessary later depending on postoperative pathology and other factors such as the patient’s age,fertility requirements,and comorbidities.This study analyzed perioperative data of HSIL patients who underwent TH after loop electrosurgical excision procedure(LEEP)at the Affiliated Cancer Hospital of University of Electronic Science and Technology of China over the past 8 years,comparing the effects of performing TH within 3 days and within 4 weeks after surgery.Early TH addresses residual disease and prevents recurrence,whereas in TH performed after 4 weeks,patients are better recovered and the assessment of surgical margins and recurrence risks is clearer.
基金supported by the Funds from the National Key Research and Development Program of China(Grant Nos.2022YFF1001500,2022YFD1401200)the National Natural Science Foundation of China(Grant Nos.32272488,31630062,32220103008,32430088,and 32102169)+1 种基金Jiangsu Provincial Key Research and Development Plan(Grant No.BE2022369)the Jiangsu Key Technology R&D Program and International Science and Technology Cooperation Project(Grant Nos.BZ2023030)。
文摘Plant viruses cause substantial agricultural devastation and economic losses worldwide.Plant nucleotide-binding domain leucine-rich repeat receptors(NLRs)play a pivotal role in detecting viral infection and activating robust immune responses.Recent advances,including the elucidation of the interaction mechanisms between NLRs and pathogen effectors,the discovery of helper NLRs,and the resolution of the ZAR1 resistosome structure,have significantly deepened our understanding of NLR-mediated immune responses,marking a new era in NLR research.In this scenario,significant progress has been made in the study of NLRmediated antiviral immunity.This review comprehensively summarizes the progress made in plant antiviral NLR research over the past decades,with a focus on NLR recognition of viral pathogen effectors,NLR activation and regulation,downstream immune signaling,and the engineering of NLRs.
