Contrast-enhanced inner ear magnetic resonance imaging(MRI)provides clinicians with powerful structural and pathological information for the diagnosis of inner ear diseases.However,currently used gadolinium(Gd)chelate...Contrast-enhanced inner ear magnetic resonance imaging(MRI)provides clinicians with powerful structural and pathological information for the diagnosis of inner ear diseases.However,currently used gadolinium(Gd)chelate-mediated contrast-enhanced MRI conveys insufficient inner ear specificity,and Gd-based contrast agents have a short body retention time and cause severe ototoxicity.Herein,we present the rational design of a sensitive inner ear-specific nanoprobe(I-PUSPIO)for inner ear MRI that is composed of an ultrasmall iron oxide core,the IETP2 peptide,and polyethylene glycol.Such a welldefined nanostructure endows it with blood-labyrinth barrier crossing capacity,leading to a high accumulation rate in the inner ear and prolonged body retention.In vivo I-PUSPIO can enhance high-resolution MRI of cochlear tissue and shows no evidence of toxicity.This study demonstrates the potential of I-PUSPIO as a sensitive contrast agent for inner ear MRI in clinical settings.展开更多
基金supported by the National Natural Science Foundation of China(22475210,22105197)the Science and Technology Development Project of Jilin Province(20230101040JC)+1 种基金the Jilin Province Youth Scientific and Technological Talent Support Project(QT202403)the Sponsored by Beijing Nova Program(20230484315,20250484903).
文摘Contrast-enhanced inner ear magnetic resonance imaging(MRI)provides clinicians with powerful structural and pathological information for the diagnosis of inner ear diseases.However,currently used gadolinium(Gd)chelate-mediated contrast-enhanced MRI conveys insufficient inner ear specificity,and Gd-based contrast agents have a short body retention time and cause severe ototoxicity.Herein,we present the rational design of a sensitive inner ear-specific nanoprobe(I-PUSPIO)for inner ear MRI that is composed of an ultrasmall iron oxide core,the IETP2 peptide,and polyethylene glycol.Such a welldefined nanostructure endows it with blood-labyrinth barrier crossing capacity,leading to a high accumulation rate in the inner ear and prolonged body retention.In vivo I-PUSPIO can enhance high-resolution MRI of cochlear tissue and shows no evidence of toxicity.This study demonstrates the potential of I-PUSPIO as a sensitive contrast agent for inner ear MRI in clinical settings.
