AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC). METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by i...AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC). METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed. RESULTS: The percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P= 0.001<0.01), existence of vessel permeation (P= 0.027<0.05) and lymph node metastasis (P=0.027<0.05). CONCLUSION: The expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC.展开更多
AIM: To evaluate the role of preoperative angiography inthe diagnosis and treatment of colorectal cancer.METHODS: The authors performed selective arterialcannulation by Seldinger's method in 47 patients to locatet...AIM: To evaluate the role of preoperative angiography inthe diagnosis and treatment of colorectal cancer.METHODS: The authors performed selective arterialcannulation by Seldinger's method in 47 patients to locatethe primary cancer and to diagnose metastasis to the liver.Each patient was then given intra-arterial regionalchemotherapy, and received 5-fluorouracil (5-Fu, 1 000 mg),mitomycin C (MMC, 20 mg), and cisplatinum (CDDP, 80 mg).RESULTS: The location and shape of each tumor wereobserved, including metastatic tumors in the liver, in 42 ofthe 47 (89.4 %) patients. The site of the primary tumor wasdifficult to identify in 5 cases because the patients had arecurrence of cancer. Arterial chemotherapy was performedsuccessfully in all patients. The authors recorded no partialor significant morbidity resulted from angiography. The onlyincident was bleeding from the artery puncture site in onepatient, which was successfully stopped by generalmedication.CONCLUSION: Preoperative selective arterial angiographycan help the diagnosis and locate primary tumors and todetect liver metastasis. At the same time, regional arterialchemotherapy can be an important form of preoperativetherapy.展开更多
The failure of a fluid catalysis and cracking unit (FCCU) in a Chinese refinery was investigated by using nondestructive detection methods, fracture surface examination, hardness measurement, chemical composition and...The failure of a fluid catalysis and cracking unit (FCCU) in a Chinese refinery was investigated by using nondestructive detection methods, fracture surface examination, hardness measurement, chemical composition and corrosion products analysis. The results showed that the failure was caused by the dew point nitrate stress corrosion cracking. For a long operation period, the wall temperature of the regenerator in the FCCU was below the fume dew point. As a result, an acid fume NOx-SOx-H2O medium present- ed on the surface, resulting in stress corrosion cracking of the component with high residual stress. In order to confirm the relative conclusion, simulated testing was conducted in laboratory, and the results showed similar cracking characteristics. Finally, some sug- gestions have been made to prevent the stress corrosion cracking of an FCCU from re-occurring in the future.展开更多
Purpose: To investigate the clinical characteristics of juvenile macular hole without trauma and hypermyopia, and research the mechanism of macular hole.Methods: Sixty-seven patients less than 40 years of age were stu...Purpose: To investigate the clinical characteristics of juvenile macular hole without trauma and hypermyopia, and research the mechanism of macular hole.Methods: Sixty-seven patients less than 40 years of age were studied retrospectively from June 1998 to March 2003. Five cases (7 eyes) aged from 22 to 38 years were reported and the clinical characteristics that had macular hole without trauma or hypermyopia were summed up.Results: There was 1 male and 4 females with visual acuity from 0.08 to 0.8. The images of optical coherence tomography (OCT) showed full thickness macular hole in 5 patients (7 eyes), and the diameters were from 87 to 1043 μm. Among them, 2 cases were combined with retina pigmentosa; 1 case with binocular Coat's disease; 1 case had bilateral macular hole combined with Eagles' disease; 1 case was combined with 2-2.5PD old retinochoroidal lesion under middle-peripheral fundus, and 1.5 PD retinal pigment epithelium (RPE) defect on the optical disk.Conclusion: The juvenile macular hole without trauma and hypermyopia combined the different retina vascular damages and the RPE defects.展开更多
This note settles the complexity of the single genotype resolution problemshowing it is NP-complete. This solves an open problem raised by P. Bonizzoni, G.D. Vedova, R.Dondi, and J. Li. The same proof also gives an al...This note settles the complexity of the single genotype resolution problemshowing it is NP-complete. This solves an open problem raised by P. Bonizzoni, G.D. Vedova, R.Dondi, and J. Li. The same proof also gives an alternative and simpler reduction of the NP-hardnessof Maximum Resolution problem.展开更多
基金Supported by the Research Fund of Beijing Municipal ScienceTechnology Commission, No. H020920030390
文摘AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC). METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed. RESULTS: The percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P= 0.001<0.01), existence of vessel permeation (P= 0.027<0.05) and lymph node metastasis (P=0.027<0.05). CONCLUSION: The expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC.
文摘AIM: To evaluate the role of preoperative angiography inthe diagnosis and treatment of colorectal cancer.METHODS: The authors performed selective arterialcannulation by Seldinger's method in 47 patients to locatethe primary cancer and to diagnose metastasis to the liver.Each patient was then given intra-arterial regionalchemotherapy, and received 5-fluorouracil (5-Fu, 1 000 mg),mitomycin C (MMC, 20 mg), and cisplatinum (CDDP, 80 mg).RESULTS: The location and shape of each tumor wereobserved, including metastatic tumors in the liver, in 42 ofthe 47 (89.4 %) patients. The site of the primary tumor wasdifficult to identify in 5 cases because the patients had arecurrence of cancer. Arterial chemotherapy was performedsuccessfully in all patients. The authors recorded no partialor significant morbidity resulted from angiography. The onlyincident was bleeding from the artery puncture site in onepatient, which was successfully stopped by generalmedication.CONCLUSION: Preoperative selective arterial angiographycan help the diagnosis and locate primary tumors and todetect liver metastasis. At the same time, regional arterialchemotherapy can be an important form of preoperativetherapy.
基金This work was financially supported by the Major State Basic Research Development Program of China (973 ProgramNo.19990970) and Petrochemical Company of China.
文摘The failure of a fluid catalysis and cracking unit (FCCU) in a Chinese refinery was investigated by using nondestructive detection methods, fracture surface examination, hardness measurement, chemical composition and corrosion products analysis. The results showed that the failure was caused by the dew point nitrate stress corrosion cracking. For a long operation period, the wall temperature of the regenerator in the FCCU was below the fume dew point. As a result, an acid fume NOx-SOx-H2O medium present- ed on the surface, resulting in stress corrosion cracking of the component with high residual stress. In order to confirm the relative conclusion, simulated testing was conducted in laboratory, and the results showed similar cracking characteristics. Finally, some sug- gestions have been made to prevent the stress corrosion cracking of an FCCU from re-occurring in the future.
文摘Purpose: To investigate the clinical characteristics of juvenile macular hole without trauma and hypermyopia, and research the mechanism of macular hole.Methods: Sixty-seven patients less than 40 years of age were studied retrospectively from June 1998 to March 2003. Five cases (7 eyes) aged from 22 to 38 years were reported and the clinical characteristics that had macular hole without trauma or hypermyopia were summed up.Results: There was 1 male and 4 females with visual acuity from 0.08 to 0.8. The images of optical coherence tomography (OCT) showed full thickness macular hole in 5 patients (7 eyes), and the diameters were from 87 to 1043 μm. Among them, 2 cases were combined with retina pigmentosa; 1 case with binocular Coat's disease; 1 case had bilateral macular hole combined with Eagles' disease; 1 case was combined with 2-2.5PD old retinochoroidal lesion under middle-peripheral fundus, and 1.5 PD retinal pigment epithelium (RPE) defect on the optical disk.Conclusion: The juvenile macular hole without trauma and hypermyopia combined the different retina vascular damages and the RPE defects.
文摘This note settles the complexity of the single genotype resolution problemshowing it is NP-complete. This solves an open problem raised by P. Bonizzoni, G.D. Vedova, R.Dondi, and J. Li. The same proof also gives an alternative and simpler reduction of the NP-hardnessof Maximum Resolution problem.
