Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing t...Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing the utilization of existing central processing unit(CPU)resources and reducing human and computational time costs via process automation.Accordingly,this paper proposes a scheme,called SSM,that combines“Srun job submission mode”,“Sbatch job submission mode”,and“Monitor function”.The SSM scheme includes three main modules:data management,command management,and resource management.Its core innovations are command splitting and parallel execution.The results show that this method effectively improves CPU utilization and reduces the time required for data processing.In terms of CPU utilization,the average value of this scheme is 89%.In contrast,the average CPU utilizations of“Srun job submission mode”and“Sbatch job submission mode”are significantly lower,at 43%and 52%,respectively.In terms of the data-processing time,SSM testing on the Five-hundred-meter Aperture Spherical radio Telescope(FAST)data requires only 5.5 h,compared with 8 h in the“Srun job submission mode”and 14 h in the“Sbatch job submission mode”.In addition,tests on the FAST and Parkes datasets demonstrate the universality of the SSM scheme,which can process data from different telescopes.The compatibility of the SSM scheme for pulsar searches is verified using 2 days of observational data from the globular cluster M2,with the scheme successfully discovering all published pulsars in M2.展开更多
To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen(HBsAg)clearance after pegylated interferonα(Peg-IFNα)treatment,...To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen(HBsAg)clearance after pegylated interferonα(Peg-IFNα)treatment,a retrospective analysis was conducted on 456 patients at Beijing Ditan Hospital from 2008 to 2023 who achieved HBsAg clearance and discontinued Peg-IFNαtreatment.The baseline was defined as the time of HBsAg clearance and treatment cessation.The endpoint was the first occurrence of liver adverse events(hepatocellular carcinoma or ascites)or last follow-up.Subsequently,we evaluated the incidence and risk factors of liver adverse events,along with changes in liver fibrosis,cirrhosis,and liver function indicators.During a median follow-up of 70 months,the incidence of liver adverse events was 2.30%,hepatocellular carcinoma 1.76%,and ascites 0.55%.Older age and cirrhosis were significant risk factors(HR 1.075 and 41.393,both P<0.01).The APRI score significantly improved at follow-up compared to baseline(0.53 vs.0.25,P<0.001),and cirrhosis prevalence decreased from 5.70%to 0.88%(P<0.001).In conclusion,patients who achieved HBsAg clearance and discontinued Peg-IFNαtreatment have a low risk of liver adverse events,while advanced age and cirrhosis remain major risk factors.展开更多
Porcine epidemic diarrhea virus(PEDV),an enteric coronavirus,is widely spread worldwide and causes huge economic losses.The effective measure to control the viral infection is to develop ideal vaccines.Here,the collag...Porcine epidemic diarrhea virus(PEDV),an enteric coronavirus,is widely spread worldwide and causes huge economic losses.The effective measure to control the viral infection is to develop ideal vaccines.Here,the collagenase equivalent domain(COE)of PEDV was displayed on the surface of nanoparticles(NPs)in order to develop a newer,safer and more effective subunit vaccine against PEDV.The monomeric COE was displayed on the mi3 protein,which self-assembles into nanoparticles composed of 60 subunits,using the SpyTag/SpyCatcher system.The size,zeta potential,microstructure of the COE-mi3 virus-like particles(VLPs)were investigated.The COE-mi3 VLPs that possessed good security,stability and better retention can be more efficiently taken up by antigen-presenting cells(APCs)and help promote dendritic cells(DCs)maturation.Moreover,COE-mi3 VLPs could prominently improve specifc antibody levels including neutralizing antibodies(NAbs),and serum IgG,mucosal IgA.Moreover,COE-mi3 VLPs elicited more activation of CD4^(+)and CD8^(+)T cells and production of IFN-γand IL-4 cytokines.In particular,COE-mi3 VLPs is an effectual antigen-delivery platform to enhance germinal center(GC)B cell responses.This structure-based self-assembly of NP gives great potential to be developed as a new subunit vaccines attractive platform,and may also provide new ideas for the development of other enteric coronavirus vaccines.展开更多
The permeability of rocks is of utmost importance in the exploitation of deep geological resources.Current characterizations of rock permeability typically consider the influence of either pores or fractures alone.How...The permeability of rocks is of utmost importance in the exploitation of deep geological resources.Current characterizations of rock permeability typically consider the influence of either pores or fractures alone.However,deep reservoir rock formations are subjected to complex environments with coupling of high temperature and stress.As a result,deep reservoir rocks possess a complex structure comprising of pores and fractures,making it challenging to understand their impact on permeability.Comprehending this relationship is vital for the secure and efficient exploitation of deep geological resources.This study presents a permeability calculation model that enables simultaneously quantify the impacts of pore and fracture with full feature size.The model independently considers large-scale fractures’fractal properties and tortuosity while also addressing the distribution and size of small-scale pores.A tortuosity expression that incorporates the effects of thermal damage has been developed using the pore geometric elasticity method.Considering the distinct contributions of pores and fractures to rock permeability,a comprehensive rock permeability calculation model is established.This model has two main strengths:it thoroughly characterizes the influence of pore structures on permeability at multiple scales and precisely details how fractal attributes of fractures affect permeability.To validate the applicability of the model,this study conducted seepage experiments and microscopic observations,capturing the variations in permeability under thermo-mechanical coupling,while quantifying the geometric characteristics and spatial distribution of pores and fractures within the rock.By comparing the measured permeability results,the theoretical values demonstrated a commendable fit.In comparison to previous models,this innovative approach more accurately captures various flow characteristics of the rock under the influence of thermo-mechanical coupling.展开更多
Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapie...Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapies in patients with CHB who were originally positive for hepatitis B envelope antigen(HBeAg).In this prospective study,HBeAg-positive CHB patients with confirmed HBsAg loss under interferon-based therapies were enrolled within 12 weeks from end of treatment and followed up for 48 weeks.Virological markers,biochemical indicators,and liver imaging examinations were observed every 3–6 months.Sustained functional cure was analysed as primary outcome.Factor associated with sustained HBsAg loss or reversion was also investigated.The rate of HBsAg loss sustainability was 91.8%(212/231).Patients receiving consolidation treatment for 12–24weeks or≥24 weeks had higher rates of sustained HBsAg negativity than those receiving consolidation treatment for<12 weeks(98.3%and 91.2%vs.86.7%,P=0.068),and the former groups had significantly higher anti-HBs levels than the later(P<0.05).The cumulative incidence of HBsAg reversion and HBV DNA reversion was 8.2%and 3.9%,respectively.Consolidation treatment of≥12 weeks[odd ratio(OR)3.318,95%confidence interval(CI)1.077–10.224,P=0.037)was a predictor of sustained functional cure,and HBeAg-positivity at cessation of treatment(OR 12.271,95%CI 1.076–139.919,P=0.043)was a predictor of HBsAg reversion.Interferon-alpha induced functional cure was durable and a consolidation treatment of≥12–24 weeks was needed after HBsAg loss in HBeAg-positive CHB patients.展开更多
This article concentrates on ground vision guided autonomous landing of a fixed-wing Unmanned Aerial Vehicle(UAV)within Global Navigation Satellite System(GNSS)denied environments.Cascaded deep learning models are dev...This article concentrates on ground vision guided autonomous landing of a fixed-wing Unmanned Aerial Vehicle(UAV)within Global Navigation Satellite System(GNSS)denied environments.Cascaded deep learning models are developed and employed into image detection and its accuracy promoting for UAV autolanding,respectively.Firstly,we design a target bounding box detection network Bbox Locate-Net to extract its image coordinate of the flying object.Secondly,the detected coordinate is fused into spatial localization with an extended Kalman filter estimator.Thirdly,a point regression network Point Refine-Net is developed for promoting detection accuracy once the flying vehicle’s motion continuity is checked unacceptable.The proposed approach definitely accomplishes the closed-loop mutual inspection of spatial positioning and image detection,and automatically improves the inaccurate coordinates within a certain range.Experimental results demonstrate and verify that our method outperforms the previous works in terms of accuracy,robustness and real-time criterions.Specifically,the newly developed Bbox Locate-Net attaches over 500 fps,almost five times the published state-of-the-art in this field,with comparable localization accuracy.展开更多
Blue-violet light can not only enhance the total content of biomass and glucoside but also enrich the taste of the fruit.Thus,it is meaningful to study the blue-violet luminescent materials for plant cultivation.In th...Blue-violet light can not only enhance the total content of biomass and glucoside but also enrich the taste of the fruit.Thus,it is meaningful to study the blue-violet luminescent materials for plant cultivation.In this study,titanium(IV)-activated CaYAlO4(CYAO) phosphors were synthesized by conventional hightemperature solid-state reaction.X-ray powder diffraction was employed to analyze the crystalstructure of CYAO.It is found that the doped Ti^4+ ions do not change obviously the crystal structure of phosphors.Upon 246 nm excitation,CaYAl1-xO4:xTi^4+phosphors exhibit broad blue-violet emission band peaking at 395 nm,which can be attributed to the charge transfer of Ti^4+-O^2-.Moreover,this phosphor exhibits strong thermal stability.The luminescence emission intensity at 150℃maintained about 91 mol% of its initial value at room temperature.Additionally,the electron transition process and concentration quenching mechanism of CaYAl1-xO4:xTi^4+are discussed in detail.The excellent luminescent properties indicate that CaYAl1-xO4:xTi^4+phosphor may have promising application in indoor plant cultivation.展开更多
Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applicat...Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs.展开更多
The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of rock.However,the idealization boundary condition for constant stres...The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of rock.However,the idealization boundary condition for constant stress in creep or constant strain in relaxation is not usually attained in natural geological systems.Therefore,generalized relaxation tests that explore the simultaneous changes of stress and strain with time under different stress levels with constant pore-water pressure are conducted in this study.The results show that in area Ⅰ,area Ⅱ,and area Ⅲ,the stress and strain both change synchronously with time and show similar evolutionary laws as the strain-time curve for creep or the stress-time curve for relaxation.When the applied stress level surpasses the δ_(ci) or δ_(cd) threshold,the variations in stress and strain and their respective rates of change exhibit a significant increase.The radial deformation and its rate of change exhibit greater sensitivity in response to stress levels.The apparent strain deforms homogeneously at the primary stage,and subsequently,gradually localizes due to the microcrack development at the secondary stage.Ultimately,interconnection of the microcracks causes the formation of a shear-localization zone at the tertiary stage.The strain-time responses inside and outside the localization zone are characterized by local strain accumulation and inelastic unloading during the secondary and tertiary stages,respectively.The width of the shear-localization zone is found to range from 4.43 mm to 7.08 mm and increased with a longer time-to-failure.Scanning electron microscopy(SEM)reveals a dominant coalescence of intergranular cracks on the fracture surface,and the degree of physiochemical deterioration caused by water-rock interaction is more severe under a longer lifetime.The brittle sandstone’s time-dependent deformation is essentially controlled by microcrack development during generalized relaxation,and its expectancy-life is determined by its initial microstructural state and the rheological path.展开更多
In order to realize the combination of chemotherapy and immunotherapy,a reduction-responsive paclitaxel(PTX)prodrug PEG-SS-PTX was synthesized and used as a carrier to encapsulate IDO inhibitor CY-1-4 for preparing PE...In order to realize the combination of chemotherapy and immunotherapy,a reduction-responsive paclitaxel(PTX)prodrug PEG-SS-PTX was synthesized and used as a carrier to encapsulate IDO inhibitor CY-1-4 for preparing PEG-SS-PTX/CY-1-4 NPs.PEG-SS-PTX/CY-1-4 NPs were evaluated by cytotoxicity,immunogenic cell death(ICD)induction ability and anti-tumor efficacy.Dynamic light scattering(DLS)results showed that the size of PEG-SS-PTX/CY-1-4 NPs was about 149 nm.In vitro experiments indicated that its cytotoxicity was in a concentration-dependent manner,and it induced the ICD of B16-F10 cells.In vivo studies in melanoma mouse model indicated that PEG-SS-PTX/CY-1-4 NPs significantly inhibited the tumor growth and reduced the expression of IDO in tumor tissues.Moreover,it increased the rate of CD8+T cells in the spleen.In summary,PEG-SS-PTX/CY-1-4 NPs achieved good anti-tumor effects and reduced the dose of chemotherapy drugs,which was a safe and effective combined delivery system.展开更多
Photothermal(PTT) and photodynamic(PDT) combined therapy has been hindered to clinical translation, due to the lack of available biomaterials, difficult designs of functions,and complex chemical synthetic or preparati...Photothermal(PTT) and photodynamic(PDT) combined therapy has been hindered to clinical translation, due to the lack of available biomaterials, difficult designs of functions,and complex chemical synthetic or preparation procedures. To actualize a high-efficiency combination therapy for cancer via a feasible approach, three readily available materials are simply associated together in one-pot, namely the single-walled carbon nanohorns(SWCNH), zinc phthalocyanine(ZnPc), and surfactant TPGS. The established nanodispersion is recorded as PCT. The association of SWCNH/ZnPc/TPGS was confirmed by energy dispersive spectrum, Raman spectrum and thermogravimetric analysis. Under lighting, PCT induced a temperature rising up to about 60 ℃ due to the presence of SWCNH, production a 7-folds of singlet oxygen level elevation because of ZnPc, which destroyed almost all4T1 tumor cells in vitro. The photothermal effect of PCT depended on both laser intensity and nanodispersion concentration in a linear and nonlinear manner, respectively. After a single peritumoral injection in mice and laser treatment, PCT exhibited the highest tumor temperature rise(to 65 ℃) among all test groups, completely destroyed primary tumor without obvious toxicity, and inhibited distant site tumor. Generally, this study demonstrated the high potential of PCT nanodispersion in tumor combined therapy.展开更多
Dear Editor, Histone methylation is a dynamic process that plays important roles in gene transcription regulation, and a number of enzymes have been shown to catalyze the removal of methyl marks [1]. Shi et al. （200...Dear Editor, Histone methylation is a dynamic process that plays important roles in gene transcription regulation, and a number of enzymes have been shown to catalyze the removal of methyl marks [1]. Shi et al. （2004） identified one of the amino oxidases, lysine-specific demethylase 1 （LSD1）, as the first specific demethylase for both mono（me） and dimethylation （me2） of H3K4 and H3K9 in humans [2].展开更多
Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week g...Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week greenhouse pot experiment was conducted to obtain several actinomycete strains helping AM symbiosis in suppressing the Phytophthora blight of pepper(Capsicum annuum L.),using a soil inoculated with Phytophthora capsici after sterilization.Five Streptomyces strains,including S.pseudogriseolus,S.albogriseolus,S.griseoaurantiacus,S.tricolor,and S.tendae,as well as the AM fungus(Funneliformis caledonium)were tested.The Phytophthora blight severity reached 66%at full productive stage in the uninoculated control,and inoculation of F.caledonium,S.griseoaurantiacus,and S.tricolor alone significantly decreased(P<0.05)it to 47%,40%,and 35%,respectively.Compared to F.caledonium alone,additional inoculation of S.tricolor or S.tendae,which were isolated from the rhizosphere of a healthy individual in an infected field,significantly elevated(P<0.05)root mycorrhizal colonization,root biomass,fruit yield,and total K acquisitions of pepper and further significantly decreased(P<0.05)blight severity.According to the feature of enhancing disease-suppression by AM symbiosis,both S.tricolor and S.tendae were confirmed as MHB strains here.Specifically,S.tendae had a stronger performance in directly accelerating mycorrhization,while S.tricolor was also an antagonist to the pathogenic P.capsici.Furthermore,S.griseoaurantiacus with the independent disease-suppression function was not an MHB strain here.The redundancy analyses demonstrated that when AM fungus was present,root mycorrhizal colonization replaced soil pH becoming the main factor affecting pepper Phytophthora blight.Thus,S.tricolor and S.tendae seemed to have the value of preparation and application in the future to help AM symbiosis against pepper Phytophthora blight.展开更多
This study reviews the historical development,current applications,and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients.As a method for coping with life’s pr...This study reviews the historical development,current applications,and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients.As a method for coping with life’s pressures through religious beliefs or activities,religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life(QOL).Research indicates that religious faith can alleviate the physical symptoms of cancer patients,extend survival time,reduce the fear of death,assist in coping with treatment side effects,and improve self-efficacy and overall quality of life.Additionally,this study explores factors influencing religious psychological coping,including demographic and sociological characteristics,the faith status of caregivers,types of religion,the relationship between the course of the disease and the duration of belief,and psychological factors.Considering the cultural differences between China and other countries,this study calls for further research into the real experiences of cancer patients with religious beliefs and provides theoretical guidance for clinical nursing practices to achieve holistic care for the body,mind,and spirit of cancer patients.展开更多
Understanding the anisotropic fracture behavior and the characteristics of the fracture process zone(FPZ)under size effects in laminated rocks,as well as its role in rock fracturing,is crucial for various engineering ...Understanding the anisotropic fracture behavior and the characteristics of the fracture process zone(FPZ)under size effects in laminated rocks,as well as its role in rock fracturing,is crucial for various engineering applications.In this study,three-point bending tests were conducted on shale specimens with varying bedding angles and sizes.The anisotropic characteristics and size effects of fracture parameters were revealed.A comparative analysis was performed on the evolutions of FPZs computed using size effect theory,digital image correlation(DIC),and linear elastic fracture mechanics.The results divulged that:(i)With increasing bedding angles,there is a noticeable decrease in apparent fracture toughness(KICA),apparent fracture energy(GICA),and nominal strength(σ_(Nu)).When the bedding angle of shale is less than 45°,the crack propagation and fracture parameters are mainly influenced by the matrix.Contrary,shale with bedding angles greater than 60°,the crack propagation and fracture parameters are mainly controlled by the bedding.When the bedding angle is between 45°and 60°,the fracture propagation evolves from permeating the matrix to extending along the bedding;(ii)The fracture parameters exhibit significant size dependent behavior,as KICA and GICA rise with increasing specimen size,butσNu falls with increasing specimen sizes.The fracture parameters align with the theoretical predictions of Bažant size effect law;and(iii)The lengths of DIC-based FPZ,effective FPZ,and inelastic zone follow W-shape variations with bedding angle.The dimensionless sizes of FPZ and inelastic zone decrease with specimen size,indicating a size effect.Furthermore,there is a negative relation between KICA and the dimensionless size of the FPZ,whileσNu is positively correlated to the dimensionless size of the FPZ.This highlights the essential role of the FPZ in the size effect of rock fracture.The bedding angle exerts an influence on the FPZ,subsequently affecting the anisotropic fracture and size-dependent behavior of shale.展开更多
In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_...In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.展开更多
Objective To investigate chronic hepatitis C virus(HCV)infection's effect on gestational liver function,pregnancy and delivery complications,and neonatal development.Methods A total of 157 HCV antibody-positive(an...Objective To investigate chronic hepatitis C virus(HCV)infection's effect on gestational liver function,pregnancy and delivery complications,and neonatal development.Methods A total of 157 HCV antibody-positive(anti-HCV[+])and HCV RNA(+)patients(Group C)and121 anti-HCV(+)and HCV RNA(-)patients(Group B)were included as study participants,while 142 antiHCV(-)and HCV RNA(-)patients(Group A)were the control group.Data on biochemical indices during pregnancy,pregnancy complications,delivery-related information,and neonatal complications were also collected.Results Elevated alanine aminotransferase(ALT)rates in Group C during early,middle,and late pregnancy were 59.87%,43.95%,and 42.04%,respectively—significantly higher than Groups B(26.45%,15.70%,10.74%)and A(23.94%,19.01%,6.34%)(P<0.05).Median ALT levels in Group C were significantly higher than in Groups A and B at all pregnancy stages(P<0.05).No significant differences were found in neonatal malformation rates across groups(P>0.05).However,neonatal jaundice incidence was significantly greater in Group C(75.16%)compared to Groups A(42.25%)and B(57.02%)(χ^(2)=33.552,P<0.001).HCV RNA positivity during pregnancy was an independent risk factor for neonatal jaundice(OR=2.111,95%CI 1.242–3.588,P=0.006).Conclusions Chronic HCV infection can affect the liver function of pregnant women,but does not increase the pregnancy or delivery complication risks.HCV RNA(+)is an independent risk factor for neonatal jaundice.展开更多
Objective Hepatocellular carcinoma(HCC)is sensitive to ferroptosis,a new form of programmed cell death that occurs in most tumor types.However,the mechanism through which ferroptosis modulates HCC remains unclear.This...Objective Hepatocellular carcinoma(HCC)is sensitive to ferroptosis,a new form of programmed cell death that occurs in most tumor types.However,the mechanism through which ferroptosis modulates HCC remains unclear.This study aimed to investigate the oncogenic role and prognostic value of FANCD2 and provide novel insights into the prognostic assessment and prediction of immunotherapy.Methods Using clinicopathological parameters and bioinformatic techniques,we comprehensively examined the expression of FANCD2 macroscopically and microcosmically.We conducted univariate and multivariate Cox regression analyses to identify the prognostic value of FANCD2 in HCC and elucidated the detailed molecular mechanisms underlying the involvement of FANCD2 in oncogenesis by promoting iron-related death.Results FANCD2 was significantly upregulated in digestive system cancers with abundant immune infiltration.As an independent risk factor for HCC,a high FANCD2 expression level was associated with poor clinical outcomes and response to immune checkpoint blockade.Gene set enrichment analysis revealed that FANCD2 was mainly involved in the cell cycle and CYP450 metabolism.Conclusion To the best of our knowledge,this is the first study to comprehensively elucidate the oncogenic role of FANCD2.FANCD2 has a tumor-promoting aspect in the digestive system and acts as an independent risk factor in HCC;hence,it has recognized value for predicting tumor aggressiveness and prognosis and may be a potential biomarker for poor responsiveness to immunotherapy.展开更多
基金supported by the National Nature Science Foundation of China(12363010)supported by the Guizhou Provincial Basic Research Program(Natural Science)(ZK[2023]039)the Key Technology R&D Program([2023]352).
文摘Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing the utilization of existing central processing unit(CPU)resources and reducing human and computational time costs via process automation.Accordingly,this paper proposes a scheme,called SSM,that combines“Srun job submission mode”,“Sbatch job submission mode”,and“Monitor function”.The SSM scheme includes three main modules:data management,command management,and resource management.Its core innovations are command splitting and parallel execution.The results show that this method effectively improves CPU utilization and reduces the time required for data processing.In terms of CPU utilization,the average value of this scheme is 89%.In contrast,the average CPU utilizations of“Srun job submission mode”and“Sbatch job submission mode”are significantly lower,at 43%and 52%,respectively.In terms of the data-processing time,SSM testing on the Five-hundred-meter Aperture Spherical radio Telescope(FAST)data requires only 5.5 h,compared with 8 h in the“Srun job submission mode”and 14 h in the“Sbatch job submission mode”.In addition,tests on the FAST and Parkes datasets demonstrate the universality of the SSM scheme,which can process data from different telescopes.The compatibility of the SSM scheme for pulsar searches is verified using 2 days of observational data from the globular cluster M2,with the scheme successfully discovering all published pulsars in M2.
基金funded by the Beijing Research Ward Ecxellence Program,BRWEP(BRWEP2024W102170101)the capital health research and development of special public health project(2022-1-2172)+3 种基金the National Key Research and Development Program(2022YFC2603500,2022YFC2603505,2023YFC2306901,2023YFC2308105,2023YFC2308105)the Beijing Municipal Health Commission high-level public health technical personnel construction project,discipline leader-03-26Beijing Hospitals Authority"peak"talent training program(DFL20241803)the Beijing Hospitals Authority Clinical medicine Development of special funding support(ZLRK202301).
文摘To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen(HBsAg)clearance after pegylated interferonα(Peg-IFNα)treatment,a retrospective analysis was conducted on 456 patients at Beijing Ditan Hospital from 2008 to 2023 who achieved HBsAg clearance and discontinued Peg-IFNαtreatment.The baseline was defined as the time of HBsAg clearance and treatment cessation.The endpoint was the first occurrence of liver adverse events(hepatocellular carcinoma or ascites)or last follow-up.Subsequently,we evaluated the incidence and risk factors of liver adverse events,along with changes in liver fibrosis,cirrhosis,and liver function indicators.During a median follow-up of 70 months,the incidence of liver adverse events was 2.30%,hepatocellular carcinoma 1.76%,and ascites 0.55%.Older age and cirrhosis were significant risk factors(HR 1.075 and 41.393,both P<0.01).The APRI score significantly improved at follow-up compared to baseline(0.53 vs.0.25,P<0.001),and cirrhosis prevalence decreased from 5.70%to 0.88%(P<0.001).In conclusion,patients who achieved HBsAg clearance and discontinued Peg-IFNαtreatment have a low risk of liver adverse events,while advanced age and cirrhosis remain major risk factors.
基金supported by the Major Scientific and Technological Project of the Henan Province,China(221100110600)the Beijing Life Science Academy,China(2024500CA0010)+1 种基金the Major Program of National Natural Science Foundation of China(32192452)the Chinese Postdoctoral Science Foundation(2023M743209)。
文摘Porcine epidemic diarrhea virus(PEDV),an enteric coronavirus,is widely spread worldwide and causes huge economic losses.The effective measure to control the viral infection is to develop ideal vaccines.Here,the collagenase equivalent domain(COE)of PEDV was displayed on the surface of nanoparticles(NPs)in order to develop a newer,safer and more effective subunit vaccine against PEDV.The monomeric COE was displayed on the mi3 protein,which self-assembles into nanoparticles composed of 60 subunits,using the SpyTag/SpyCatcher system.The size,zeta potential,microstructure of the COE-mi3 virus-like particles(VLPs)were investigated.The COE-mi3 VLPs that possessed good security,stability and better retention can be more efficiently taken up by antigen-presenting cells(APCs)and help promote dendritic cells(DCs)maturation.Moreover,COE-mi3 VLPs could prominently improve specifc antibody levels including neutralizing antibodies(NAbs),and serum IgG,mucosal IgA.Moreover,COE-mi3 VLPs elicited more activation of CD4^(+)and CD8^(+)T cells and production of IFN-γand IL-4 cytokines.In particular,COE-mi3 VLPs is an effectual antigen-delivery platform to enhance germinal center(GC)B cell responses.This structure-based self-assembly of NP gives great potential to be developed as a new subunit vaccines attractive platform,and may also provide new ideas for the development of other enteric coronavirus vaccines.
基金supported by the National Natural Science Foundation of China(Nos.52192625,52174082,and U22A20166)Guangdong Basic and Applied Basic Research Foundation(No.2025B1515020039)+3 种基金National Key Research and Development Program(No.2023YFF0723200)Shenzhen Science and Technology Program(No.RCYX20221008092903013)the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(No.2019ZT08G315)the Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-MSX1593).
文摘The permeability of rocks is of utmost importance in the exploitation of deep geological resources.Current characterizations of rock permeability typically consider the influence of either pores or fractures alone.However,deep reservoir rock formations are subjected to complex environments with coupling of high temperature and stress.As a result,deep reservoir rocks possess a complex structure comprising of pores and fractures,making it challenging to understand their impact on permeability.Comprehending this relationship is vital for the secure and efficient exploitation of deep geological resources.This study presents a permeability calculation model that enables simultaneously quantify the impacts of pore and fracture with full feature size.The model independently considers large-scale fractures’fractal properties and tortuosity while also addressing the distribution and size of small-scale pores.A tortuosity expression that incorporates the effects of thermal damage has been developed using the pore geometric elasticity method.Considering the distinct contributions of pores and fractures to rock permeability,a comprehensive rock permeability calculation model is established.This model has two main strengths:it thoroughly characterizes the influence of pore structures on permeability at multiple scales and precisely details how fractal attributes of fractures affect permeability.To validate the applicability of the model,this study conducted seepage experiments and microscopic observations,capturing the variations in permeability under thermo-mechanical coupling,while quantifying the geometric characteristics and spatial distribution of pores and fractures within the rock.By comparing the measured permeability results,the theoretical values demonstrated a commendable fit.In comparison to previous models,this innovative approach more accurately captures various flow characteristics of the rock under the influence of thermo-mechanical coupling.
基金funded in part by the Beijing Municipal Science and Technology Commission(No.Z151100004015122)Beijing Municipal Administration of Hospitals’Clinical Medicine Development of special funding support(No.XMLX 201706 and XMLX202127)+3 种基金National Science and Technology Major Project of China(2017ZX10203202-003,2017ZX10201201-001-006,and 2017ZX10201201-002-006)Beijing Science and Technology Commission(No.D161100002716002)Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals(No.XXZ0302 and XXT28)Special public health project of Capital health development(2021-1G-4061 and 2022-1-2172)。
文摘Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapies in patients with CHB who were originally positive for hepatitis B envelope antigen(HBeAg).In this prospective study,HBeAg-positive CHB patients with confirmed HBsAg loss under interferon-based therapies were enrolled within 12 weeks from end of treatment and followed up for 48 weeks.Virological markers,biochemical indicators,and liver imaging examinations were observed every 3–6 months.Sustained functional cure was analysed as primary outcome.Factor associated with sustained HBsAg loss or reversion was also investigated.The rate of HBsAg loss sustainability was 91.8%(212/231).Patients receiving consolidation treatment for 12–24weeks or≥24 weeks had higher rates of sustained HBsAg negativity than those receiving consolidation treatment for<12 weeks(98.3%and 91.2%vs.86.7%,P=0.068),and the former groups had significantly higher anti-HBs levels than the later(P<0.05).The cumulative incidence of HBsAg reversion and HBV DNA reversion was 8.2%and 3.9%,respectively.Consolidation treatment of≥12 weeks[odd ratio(OR)3.318,95%confidence interval(CI)1.077–10.224,P=0.037)was a predictor of sustained functional cure,and HBeAg-positivity at cessation of treatment(OR 12.271,95%CI 1.076–139.919,P=0.043)was a predictor of HBsAg reversion.Interferon-alpha induced functional cure was durable and a consolidation treatment of≥12–24 weeks was needed after HBsAg loss in HBeAg-positive CHB patients.
基金supported by the National Natural Science Foundation of China(No.61973327)。
文摘This article concentrates on ground vision guided autonomous landing of a fixed-wing Unmanned Aerial Vehicle(UAV)within Global Navigation Satellite System(GNSS)denied environments.Cascaded deep learning models are developed and employed into image detection and its accuracy promoting for UAV autolanding,respectively.Firstly,we design a target bounding box detection network Bbox Locate-Net to extract its image coordinate of the flying object.Secondly,the detected coordinate is fused into spatial localization with an extended Kalman filter estimator.Thirdly,a point regression network Point Refine-Net is developed for promoting detection accuracy once the flying vehicle’s motion continuity is checked unacceptable.The proposed approach definitely accomplishes the closed-loop mutual inspection of spatial positioning and image detection,and automatically improves the inaccurate coordinates within a certain range.Experimental results demonstrate and verify that our method outperforms the previous works in terms of accuracy,robustness and real-time criterions.Specifically,the newly developed Bbox Locate-Net attaches over 500 fps,almost five times the published state-of-the-art in this field,with comparable localization accuracy.
基金supported by the National Natural Science Foundation of China(21706060,51703061)Natural Science Foundation of Hunan Province(2017JJ3103)+1 种基金Youth Project of Hunan Education Department(17B1118)Hunan Provincial Engineering Technology Research Center for Optical Agriculture(2018TP2003).
文摘Blue-violet light can not only enhance the total content of biomass and glucoside but also enrich the taste of the fruit.Thus,it is meaningful to study the blue-violet luminescent materials for plant cultivation.In this study,titanium(IV)-activated CaYAlO4(CYAO) phosphors were synthesized by conventional hightemperature solid-state reaction.X-ray powder diffraction was employed to analyze the crystalstructure of CYAO.It is found that the doped Ti^4+ ions do not change obviously the crystal structure of phosphors.Upon 246 nm excitation,CaYAl1-xO4:xTi^4+phosphors exhibit broad blue-violet emission band peaking at 395 nm,which can be attributed to the charge transfer of Ti^4+-O^2-.Moreover,this phosphor exhibits strong thermal stability.The luminescence emission intensity at 150℃maintained about 91 mol% of its initial value at room temperature.Additionally,the electron transition process and concentration quenching mechanism of CaYAl1-xO4:xTi^4+are discussed in detail.The excellent luminescent properties indicate that CaYAl1-xO4:xTi^4+phosphor may have promising application in indoor plant cultivation.
基金supported by National Key Research and Development Program of China (No.2021YFF0500600)NSFC (22279120)Key R&D projects in Henan Province (221111240100)。
文摘Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52304099,52172625)Shenzhen Science and Technology Program(Grant No.RCYX20221008092903013).
文摘The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of rock.However,the idealization boundary condition for constant stress in creep or constant strain in relaxation is not usually attained in natural geological systems.Therefore,generalized relaxation tests that explore the simultaneous changes of stress and strain with time under different stress levels with constant pore-water pressure are conducted in this study.The results show that in area Ⅰ,area Ⅱ,and area Ⅲ,the stress and strain both change synchronously with time and show similar evolutionary laws as the strain-time curve for creep or the stress-time curve for relaxation.When the applied stress level surpasses the δ_(ci) or δ_(cd) threshold,the variations in stress and strain and their respective rates of change exhibit a significant increase.The radial deformation and its rate of change exhibit greater sensitivity in response to stress levels.The apparent strain deforms homogeneously at the primary stage,and subsequently,gradually localizes due to the microcrack development at the secondary stage.Ultimately,interconnection of the microcracks causes the formation of a shear-localization zone at the tertiary stage.The strain-time responses inside and outside the localization zone are characterized by local strain accumulation and inelastic unloading during the secondary and tertiary stages,respectively.The width of the shear-localization zone is found to range from 4.43 mm to 7.08 mm and increased with a longer time-to-failure.Scanning electron microscopy(SEM)reveals a dominant coalescence of intergranular cracks on the fracture surface,and the degree of physiochemical deterioration caused by water-rock interaction is more severe under a longer lifetime.The brittle sandstone’s time-dependent deformation is essentially controlled by microcrack development during generalized relaxation,and its expectancy-life is determined by its initial microstructural state and the rheological path.
基金The National Natural Science Foundation of China(Grants No.31671017,81872809)the National Key Research and Development Program of China(Grants No.2017YFA0205600)Beijing Natural Science Foundation(Grants No.7162108)。
文摘In order to realize the combination of chemotherapy and immunotherapy,a reduction-responsive paclitaxel(PTX)prodrug PEG-SS-PTX was synthesized and used as a carrier to encapsulate IDO inhibitor CY-1-4 for preparing PEG-SS-PTX/CY-1-4 NPs.PEG-SS-PTX/CY-1-4 NPs were evaluated by cytotoxicity,immunogenic cell death(ICD)induction ability and anti-tumor efficacy.Dynamic light scattering(DLS)results showed that the size of PEG-SS-PTX/CY-1-4 NPs was about 149 nm.In vitro experiments indicated that its cytotoxicity was in a concentration-dependent manner,and it induced the ICD of B16-F10 cells.In vivo studies in melanoma mouse model indicated that PEG-SS-PTX/CY-1-4 NPs significantly inhibited the tumor growth and reduced the expression of IDO in tumor tissues.Moreover,it increased the rate of CD8+T cells in the spleen.In summary,PEG-SS-PTX/CY-1-4 NPs achieved good anti-tumor effects and reduced the dose of chemotherapy drugs,which was a safe and effective combined delivery system.
基金supported by the National Natural Science Foundation of China (81690264)the National Basic Research Program of China (2015CB932100)the Innovation Team of the Ministry of Education (BMU20110263)。
文摘Photothermal(PTT) and photodynamic(PDT) combined therapy has been hindered to clinical translation, due to the lack of available biomaterials, difficult designs of functions,and complex chemical synthetic or preparation procedures. To actualize a high-efficiency combination therapy for cancer via a feasible approach, three readily available materials are simply associated together in one-pot, namely the single-walled carbon nanohorns(SWCNH), zinc phthalocyanine(ZnPc), and surfactant TPGS. The established nanodispersion is recorded as PCT. The association of SWCNH/ZnPc/TPGS was confirmed by energy dispersive spectrum, Raman spectrum and thermogravimetric analysis. Under lighting, PCT induced a temperature rising up to about 60 ℃ due to the presence of SWCNH, production a 7-folds of singlet oxygen level elevation because of ZnPc, which destroyed almost all4T1 tumor cells in vitro. The photothermal effect of PCT depended on both laser intensity and nanodispersion concentration in a linear and nonlinear manner, respectively. After a single peritumoral injection in mice and laser treatment, PCT exhibited the highest tumor temperature rise(to 65 ℃) among all test groups, completely destroyed primary tumor without obvious toxicity, and inhibited distant site tumor. Generally, this study demonstrated the high potential of PCT nanodispersion in tumor combined therapy.
文摘Dear Editor, Histone methylation is a dynamic process that plays important roles in gene transcription regulation, and a number of enzymes have been shown to catalyze the removal of methyl marks [1]. Shi et al. （2004） identified one of the amino oxidases, lysine-specific demethylase 1 （LSD1）, as the first specific demethylase for both mono（me） and dimethylation （me2） of H3K4 and H3K9 in humans [2].
基金funded by the National Natural Science Foundation of China(No.42177304)the National Key R&D Program of China(No.2022YFD1500202)supported by the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2016285)。
文摘Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week greenhouse pot experiment was conducted to obtain several actinomycete strains helping AM symbiosis in suppressing the Phytophthora blight of pepper(Capsicum annuum L.),using a soil inoculated with Phytophthora capsici after sterilization.Five Streptomyces strains,including S.pseudogriseolus,S.albogriseolus,S.griseoaurantiacus,S.tricolor,and S.tendae,as well as the AM fungus(Funneliformis caledonium)were tested.The Phytophthora blight severity reached 66%at full productive stage in the uninoculated control,and inoculation of F.caledonium,S.griseoaurantiacus,and S.tricolor alone significantly decreased(P<0.05)it to 47%,40%,and 35%,respectively.Compared to F.caledonium alone,additional inoculation of S.tricolor or S.tendae,which were isolated from the rhizosphere of a healthy individual in an infected field,significantly elevated(P<0.05)root mycorrhizal colonization,root biomass,fruit yield,and total K acquisitions of pepper and further significantly decreased(P<0.05)blight severity.According to the feature of enhancing disease-suppression by AM symbiosis,both S.tricolor and S.tendae were confirmed as MHB strains here.Specifically,S.tendae had a stronger performance in directly accelerating mycorrhization,while S.tricolor was also an antagonist to the pathogenic P.capsici.Furthermore,S.griseoaurantiacus with the independent disease-suppression function was not an MHB strain here.The redundancy analyses demonstrated that when AM fungus was present,root mycorrhizal colonization replaced soil pH becoming the main factor affecting pepper Phytophthora blight.Thus,S.tricolor and S.tendae seemed to have the value of preparation and application in the future to help AM symbiosis against pepper Phytophthora blight.
文摘This study reviews the historical development,current applications,and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients.As a method for coping with life’s pressures through religious beliefs or activities,religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life(QOL).Research indicates that religious faith can alleviate the physical symptoms of cancer patients,extend survival time,reduce the fear of death,assist in coping with treatment side effects,and improve self-efficacy and overall quality of life.Additionally,this study explores factors influencing religious psychological coping,including demographic and sociological characteristics,the faith status of caregivers,types of religion,the relationship between the course of the disease and the duration of belief,and psychological factors.Considering the cultural differences between China and other countries,this study calls for further research into the real experiences of cancer patients with religious beliefs and provides theoretical guidance for clinical nursing practices to achieve holistic care for the body,mind,and spirit of cancer patients.
基金funded by the National Natural Science Foundation of China(Grant Nos.12172230,U22A20166)the Department of Science and Technology of Guangdong Province(Grant No.2019ZT08G315).
文摘Understanding the anisotropic fracture behavior and the characteristics of the fracture process zone(FPZ)under size effects in laminated rocks,as well as its role in rock fracturing,is crucial for various engineering applications.In this study,three-point bending tests were conducted on shale specimens with varying bedding angles and sizes.The anisotropic characteristics and size effects of fracture parameters were revealed.A comparative analysis was performed on the evolutions of FPZs computed using size effect theory,digital image correlation(DIC),and linear elastic fracture mechanics.The results divulged that:(i)With increasing bedding angles,there is a noticeable decrease in apparent fracture toughness(KICA),apparent fracture energy(GICA),and nominal strength(σ_(Nu)).When the bedding angle of shale is less than 45°,the crack propagation and fracture parameters are mainly influenced by the matrix.Contrary,shale with bedding angles greater than 60°,the crack propagation and fracture parameters are mainly controlled by the bedding.When the bedding angle is between 45°and 60°,the fracture propagation evolves from permeating the matrix to extending along the bedding;(ii)The fracture parameters exhibit significant size dependent behavior,as KICA and GICA rise with increasing specimen size,butσNu falls with increasing specimen sizes.The fracture parameters align with the theoretical predictions of Bažant size effect law;and(iii)The lengths of DIC-based FPZ,effective FPZ,and inelastic zone follow W-shape variations with bedding angle.The dimensionless sizes of FPZ and inelastic zone decrease with specimen size,indicating a size effect.Furthermore,there is a negative relation between KICA and the dimensionless size of the FPZ,whileσNu is positively correlated to the dimensionless size of the FPZ.This highlights the essential role of the FPZ in the size effect of rock fracture.The bedding angle exerts an influence on the FPZ,subsequently affecting the anisotropic fracture and size-dependent behavior of shale.
基金supported by the National Natural Science Foundation of China(NSFC)(No.21978137).
文摘In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.
基金The National Key Research and Development Program(2022YFC2603500,2022YFC2603505,2023YFC2306901,2023YFC2308105)The capital health research and development of special public health project(2022-1-2172)+3 种基金Beijing Municipal Health Commission high-level public health technical personnel construction project,discipline leader-03-26Beijing Hospitals Authority“peak”talent training program(DFL20241803)Beijing Hospitals Authority Clinical medicine Development of special funding support(ZLRK202301)Beijing Research Ward Excellence Program(BRWEP2024W102170101)。
文摘Objective To investigate chronic hepatitis C virus(HCV)infection's effect on gestational liver function,pregnancy and delivery complications,and neonatal development.Methods A total of 157 HCV antibody-positive(anti-HCV[+])and HCV RNA(+)patients(Group C)and121 anti-HCV(+)and HCV RNA(-)patients(Group B)were included as study participants,while 142 antiHCV(-)and HCV RNA(-)patients(Group A)were the control group.Data on biochemical indices during pregnancy,pregnancy complications,delivery-related information,and neonatal complications were also collected.Results Elevated alanine aminotransferase(ALT)rates in Group C during early,middle,and late pregnancy were 59.87%,43.95%,and 42.04%,respectively—significantly higher than Groups B(26.45%,15.70%,10.74%)and A(23.94%,19.01%,6.34%)(P<0.05).Median ALT levels in Group C were significantly higher than in Groups A and B at all pregnancy stages(P<0.05).No significant differences were found in neonatal malformation rates across groups(P>0.05).However,neonatal jaundice incidence was significantly greater in Group C(75.16%)compared to Groups A(42.25%)and B(57.02%)(χ^(2)=33.552,P<0.001).HCV RNA positivity during pregnancy was an independent risk factor for neonatal jaundice(OR=2.111,95%CI 1.242–3.588,P=0.006).Conclusions Chronic HCV infection can affect the liver function of pregnant women,but does not increase the pregnancy or delivery complication risks.HCV RNA(+)is an independent risk factor for neonatal jaundice.
基金supported by Beijing Science and Technology Commission(grant number Z211100002921059)National Science and Technology Major Projects of China(2017ZX10201201-001-006,2017ZX10201201-002-006,and 2018ZX10715-005-003-005)+5 种基金Digestive Medical Coordinated Development Center of Beijing Hospital Authority(XXZ0302 and XXT28)National Key R&D Program China(2022YFC2603505)Beijing Hospital Authority Clinical Medicine Development with Special Funding Support(XMLX 202127)High-Level Public Health Technical Personnel Training Program of Beijing the Municipal Health Commission(2022-3-050)Capital Health Research and Development of Special(2022-1-2172)HBV infection,Clinical Cure and Immunology Joint Laboratory for Clinical Medicine Capital Medical University.
文摘Objective Hepatocellular carcinoma(HCC)is sensitive to ferroptosis,a new form of programmed cell death that occurs in most tumor types.However,the mechanism through which ferroptosis modulates HCC remains unclear.This study aimed to investigate the oncogenic role and prognostic value of FANCD2 and provide novel insights into the prognostic assessment and prediction of immunotherapy.Methods Using clinicopathological parameters and bioinformatic techniques,we comprehensively examined the expression of FANCD2 macroscopically and microcosmically.We conducted univariate and multivariate Cox regression analyses to identify the prognostic value of FANCD2 in HCC and elucidated the detailed molecular mechanisms underlying the involvement of FANCD2 in oncogenesis by promoting iron-related death.Results FANCD2 was significantly upregulated in digestive system cancers with abundant immune infiltration.As an independent risk factor for HCC,a high FANCD2 expression level was associated with poor clinical outcomes and response to immune checkpoint blockade.Gene set enrichment analysis revealed that FANCD2 was mainly involved in the cell cycle and CYP450 metabolism.Conclusion To the best of our knowledge,this is the first study to comprehensively elucidate the oncogenic role of FANCD2.FANCD2 has a tumor-promoting aspect in the digestive system and acts as an independent risk factor in HCC;hence,it has recognized value for predicting tumor aggressiveness and prognosis and may be a potential biomarker for poor responsiveness to immunotherapy.
