Objective This study aimed to systematically evaluate the application of the Cavitron Ultrasonic Surgical Aspirator(CUSA)system in epilepsy surgery and summarize associated surgical experiences.Methods In this retrosp...Objective This study aimed to systematically evaluate the application of the Cavitron Ultrasonic Surgical Aspirator(CUSA)system in epilepsy surgery and summarize associated surgical experiences.Methods In this retrospective analysis,70 patients with refractory epilepsy underwent CUSA-assisted resection,while 20 controls underwent conventional surgical resection.Patients were categorized according to surgical scenarios for CUSA application,including lesion-related epilepsy resections,mesial temporal lobe procedures,neocortical resections within eloquent areas,and cases requiring preservation of critical vascular structures.Detailed operative metrics were analyzed for each category.Comparative assessments between the CUSA and conventional groups included surgical efficiency,complication rates,and postoperative seizure outcomes on the basis of the modified Engel classification.Results CUSA was used for the following procedures:resection of epileptic lesions(n=26),mesial temporal structures(n=32),the epileptogenic neocortex(n=28),and the rolandic cortex(n=17).Additionally,it was utilized in 6 cases requiring vascular protection during insular resection and in 18 cases involving preservation of cortical dangerous veins.Although the overall surgical efficiency was comparable between the CUSA and conventional groups(68.0±18.2 vs.61.1±14.7 min,P=0.180),the CUSA group demonstrated superior efficiency in resecting low-grade tumors(58.6±14.9 vs.68.1±11.2 min,P=0.034).Furthermore,the CUSA group presented significantly fewer permanent complications(5.7%vs.10%,P<0.0001)and a higher rate of Engel Class I outcomes(82.9%vs.70.0%,P=0.278).Conclusions The CUSA system represents a suitable and promising surgical tool for resective epilepsy surgery,potentially serving as a valuable option for epilepsy surgeons.Further studies are warranted to validate these findings.展开更多
Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-in...Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.展开更多
Osteosarcoma is the most prevalent primarymalignant bone tumor,primarily affecting adolescents aged 15–25 years.It is characterized by a high recurrence rate,poor prognosis,and lack of important biomarkers.Significan...Osteosarcoma is the most prevalent primarymalignant bone tumor,primarily affecting adolescents aged 15–25 years.It is characterized by a high recurrence rate,poor prognosis,and lack of important biomarkers.Significant mitochondrial dysfunction in osteosarcoma cells has been widely reported by recent studies.Dysfunctional mitochondria occupy an important position in cellularmetabolic reprogramming,immune microenvironment regulation,and programmed cell death.Therefore,targeting mitochondrial dysfunction may represent a new mechanism to overcome therapeutic barriers in the treatment of osteosarcoma and provides crucial target molecules for further development of targeted therapies and immunotherapies.The present article summarizes the recent reports of mitochondrial dysfunction in osteosarcoma and links it to various programmed cell death mechanisms,aiming to provide the basis for further clinical practice.展开更多
基金supported by the Featured Clinical Technique of Guangzhou(2023P-TS09).
文摘Objective This study aimed to systematically evaluate the application of the Cavitron Ultrasonic Surgical Aspirator(CUSA)system in epilepsy surgery and summarize associated surgical experiences.Methods In this retrospective analysis,70 patients with refractory epilepsy underwent CUSA-assisted resection,while 20 controls underwent conventional surgical resection.Patients were categorized according to surgical scenarios for CUSA application,including lesion-related epilepsy resections,mesial temporal lobe procedures,neocortical resections within eloquent areas,and cases requiring preservation of critical vascular structures.Detailed operative metrics were analyzed for each category.Comparative assessments between the CUSA and conventional groups included surgical efficiency,complication rates,and postoperative seizure outcomes on the basis of the modified Engel classification.Results CUSA was used for the following procedures:resection of epileptic lesions(n=26),mesial temporal structures(n=32),the epileptogenic neocortex(n=28),and the rolandic cortex(n=17).Additionally,it was utilized in 6 cases requiring vascular protection during insular resection and in 18 cases involving preservation of cortical dangerous veins.Although the overall surgical efficiency was comparable between the CUSA and conventional groups(68.0±18.2 vs.61.1±14.7 min,P=0.180),the CUSA group demonstrated superior efficiency in resecting low-grade tumors(58.6±14.9 vs.68.1±11.2 min,P=0.034).Furthermore,the CUSA group presented significantly fewer permanent complications(5.7%vs.10%,P<0.0001)and a higher rate of Engel Class I outcomes(82.9%vs.70.0%,P=0.278).Conclusions The CUSA system represents a suitable and promising surgical tool for resective epilepsy surgery,potentially serving as a valuable option for epilepsy surgeons.Further studies are warranted to validate these findings.
基金financially supported by the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(Nos.2025GXNSFAA069283 and 2023GXNSFAA026264)Guangxi Science and Technology Base and Talent Special Project(No.GuikeAD21220008)+3 种基金the National Natural Science Foundation of China(No.82060195)Guangxi Medical and Health Suitable Technology Development and Popularization Applications Project(No.S2023093)the Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening,the Education Department of Guangxi Zhuang Autonomous Region(No.GXYWSX202404)the Major Talent Project of Guangxi Autonomous Region
文摘Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.
基金supported by the Guangxi Natural Science Foundation(No.2023JJA140880).
文摘Osteosarcoma is the most prevalent primarymalignant bone tumor,primarily affecting adolescents aged 15–25 years.It is characterized by a high recurrence rate,poor prognosis,and lack of important biomarkers.Significant mitochondrial dysfunction in osteosarcoma cells has been widely reported by recent studies.Dysfunctional mitochondria occupy an important position in cellularmetabolic reprogramming,immune microenvironment regulation,and programmed cell death.Therefore,targeting mitochondrial dysfunction may represent a new mechanism to overcome therapeutic barriers in the treatment of osteosarcoma and provides crucial target molecules for further development of targeted therapies and immunotherapies.The present article summarizes the recent reports of mitochondrial dysfunction in osteosarcoma and links it to various programmed cell death mechanisms,aiming to provide the basis for further clinical practice.
