Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this w...Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this work,a novel electrochemical sensor for detecting PA was successfully fabricated based on iron single atoms distributed on multiwall carbon nanotubes (Fe/MWCNTs)that were prepared through the Lewis acid doping strategy.MWCNTs wrapped by polyaniline-derived N-doped carbon not only provide the anchoring sites for Fe,but also endow the catalyst with high conductivity and mass transfer ability.Theoretical calculation results reveal that atomically dispersed Fe sites hold good catalytic activity toward PA oxidation reaction,because of easier OH absorption at the first step and more facile occurrence of the key transformation from OH*+PA into H2O*+PA_H,during which electrons transferred from PA to catalysts,thereby facilitating the dissociation of N-H bond and the oxidation of PA.The Fe/MWCNTs sensor showed excellent PA detecting performance,delivering a low detection limit of 0.14μM in wide ranges of 0.5-100μM and 100-500μM.Without any pretreatments,the built sensor can directly and accurately detect PA in several complex commercial pharmaceutical formulations and spiked human urine samples with satisfactory recoveries from 96.98% to 107.59%,thereby fully demonstrating its practical application prospects.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.22375005 and 22474003)the Provincial University Research and Innovation Team(No.2022AH010023)+4 种基金the Natural Science Foundation of Anhui Province(No.2408085JX004)the Natural Science Research Project of Anhui Province Education Department(No.2022AH050323)the Postdoctoral Start-up Funding of Anhui University of Technology(No.DT2300001444)the Doctoral Start-up Funding of Anhui University of Technology(No.DT2300000981)Anhui Medical University Research Fund Project(No.2022xkj130)
文摘Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this work,a novel electrochemical sensor for detecting PA was successfully fabricated based on iron single atoms distributed on multiwall carbon nanotubes (Fe/MWCNTs)that were prepared through the Lewis acid doping strategy.MWCNTs wrapped by polyaniline-derived N-doped carbon not only provide the anchoring sites for Fe,but also endow the catalyst with high conductivity and mass transfer ability.Theoretical calculation results reveal that atomically dispersed Fe sites hold good catalytic activity toward PA oxidation reaction,because of easier OH absorption at the first step and more facile occurrence of the key transformation from OH*+PA into H2O*+PA_H,during which electrons transferred from PA to catalysts,thereby facilitating the dissociation of N-H bond and the oxidation of PA.The Fe/MWCNTs sensor showed excellent PA detecting performance,delivering a low detection limit of 0.14μM in wide ranges of 0.5-100μM and 100-500μM.Without any pretreatments,the built sensor can directly and accurately detect PA in several complex commercial pharmaceutical formulations and spiked human urine samples with satisfactory recoveries from 96.98% to 107.59%,thereby fully demonstrating its practical application prospects.
