BACKGROUND The log odds of positive lymph nodes(LODDS)are correlated with survival outcomes in gastric cancer(GC)patients.However,the prognostic value across different tumor differentiation levels remains unclear.AIM ...BACKGROUND The log odds of positive lymph nodes(LODDS)are correlated with survival outcomes in gastric cancer(GC)patients.However,the prognostic value across different tumor differentiation levels remains unclear.AIM To evaluate the independent prognostic value of LODDS and the stratified predictive efficacy in GC patients with different histologic differentiations.METHODS We conducted a retrospective analysis of 2103 GC patients who underwent radical gastrectomy at Zhejiang Cancer Hospital.The prognostic value of LODDS was compared with that of other lymph node-based metrics,including the pathologic N stage,number of positive lymph nodes,number of total lymph nodes,and lymph node ratio,stratified by tumor differentiation.RESULTS LODDS was identified as an independent prognostic factor for overall survival in moderately to poorly differentiated GC patients.LODDS demonstrated superior predictive accuracy over other lymph node metrics.A nomogram incorporating LODDS,age,carbohydrate antigen(CA)125,carcinoembryonic antigen,and tumor differentiation showed good predictive accuracy(C-index=0.703).A higher LODDS was significantly associated with an increased risk of recurrence or metastasis,poorly differentiated tumors,advanced cancer,mucinous gastric adenocarcinoma,nerve invasion,and vascular tumor thrombus.Additionally,LODDS was positively correlated with the tumor markers CA19-9,CA72-4,CA125,and CA242(all P<0.05).CONCLUSION LODDS is an independent prognostic indicator for patients with moderately and poorly differentiated GC,and its predictive performance is superior to that of other models.展开更多
BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location rema...BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location remain unclear.AIM To investigate the tumor location of patients,we went on to study the influencing factors that lead to changes in the location of GC.METHODS A retrospective evaluation was carried out on 3287 patients who underwent gastrectomy for GC in Zhejiang Cancer Hospital.The patients were followed up post-diagnosis and post-gastrectomy.The clinicopathological variables and overall survival of the patients were recorded.By analyzing the location of GC,the tumor location was divided into four categories:“Upper”,“middle”,“lower”,and“total”.Statistical software was utilized to analyze the relationship of each variable with the location of GC.RESULTS A total of 3287 patients were included in this study.The clinicopathological indices of gender,age,serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA19-9)and CA72-4 levels,were significantly associated with tumor location in patients with GC.In addition,there was a strong correlation between GC location and the prognosis of postoperative patients.Specifically,patients with“lower”and“middle”GC demonstrated a better prognosis than those with tumors in other categories.CONCLUSION The five clinicopathological indices of gender,age,CEA,CA19-9 and CA72-4 levels exhibit varying degrees of influence on the tumor location.The tumor location correlates with patient prognosis following surgery.展开更多
In the past,arms used in the fields of industry and robotics have been designed not to vibrate by increasing their mass and stiffness.The weight of arms has tended to be reduced to improve speed of operation,and decre...In the past,arms used in the fields of industry and robotics have been designed not to vibrate by increasing their mass and stiffness.The weight of arms has tended to be reduced to improve speed of operation,and decrease the cost of their production.Since the weight saving makes the arms lose their stiffness and therefore vibrate more easily,the vibration suppression control is needed for realizing the above purpose.Incidentally,the use of various smart materials in actuators has grown.In particular,a shape memory alloy(SMA)is applied widely and has several advantages:light weight,large displacement by temperature change,and large force to mass ratio.However,the SMA actuators possess hysteresis nonlinearity between their own temperature and displacement obtained by the temperature.The hysteretic behavior of the SMA actuators affects their control performance.In previous research,an operator-based control system including a hysteresis compensator has been proposed.The vibration of a flexible arm is dealt with as the controlled object;one end of the arm is clamped and the other end is free.The effectiveness of the hysteresis compensator has been confirmed by simulations and experiments.Nevertheless,the feedback signal of the previous designed system has increased exponentially.It is difficult to use the system in the long-term because of the phenomenon.Additionally,the SMA actuator generates and radiates heat because electric current passing through the SMA actuator provides heat,and strain on the SMA actuator is generated.With long-time use of the SMA actuator,the environmental temperature around the SMA actuator varies through radiation of the heat.There exists a risk that the ambient temperature change dealt with as disturbance affects the temperature and strain of the SMA actuator.In this research,a design method of the operator-based control system is proposed considering the long-term use of the system.In the method,the hysteresis characteristics of the SMA actuator and the temperature change around the actuator are considered.The effectiveness of the proposed method is verified by simulations and experiments.展开更多
In this paper, operator-based nonlinear water temperature control for a group of three connected microreactors actuated by Peltier devices is proposed. To control the water temperature of tube in the microreactor, the...In this paper, operator-based nonlinear water temperature control for a group of three connected microreactors actuated by Peltier devices is proposed. To control the water temperature of tube in the microreactor, the temperature change of aluminum effects is considered. Therefore, the temperature change of aluminum becomes the part of an input of the tube. First, nonlinear thermal models of aluminum plates and tubes that structure the microreactor are obtained. Then, an operator based nonlinear water temperature control system for the microreactor is designed. Finally, the effectiveness of the proposed models and methods is confirmed by simulation and experimental results.展开更多
In this paper,robust stability of nonlinear plants represented by non-symmetric Prandtl-Ishlinskii(PI)hysteresis model is studied.In general,PI hysteresis model is the weighted superposition of play or stop hysteresis...In this paper,robust stability of nonlinear plants represented by non-symmetric Prandtl-Ishlinskii(PI)hysteresis model is studied.In general,PI hysteresis model is the weighted superposition of play or stop hysteresis operators,and the slopes of the operators are considered to be the same.In order to make a hysteresis model,a modified form of non-symmetric play hysteresis operator with unknown slopes is given.The hysteresis model is described by a generalized Lipschitz operator term and a bounded parasitic term.Since the generalized Lipschitz operator is unknown,a new condition using robust right coprime factorization is proposed to guarantee robust stability of the controlled plant with the hysteresis nonlinearity.As a result,based on the proposed robust condition,a stabilized plant is obtained.A numerical example is presented to validate the effectiveness of the proposed method.展开更多
基金Supported by the National Natural Science Foundation of China,No.82473195 and No.32370797the Natural Science Foundation of Zhejiang Province,No.LTGY23H160018+3 种基金the Zhejiang Medical and Health Science and Technology Program,No.2024KY789 and No.2023KY615the National Research Center for Translational Medicine at Shanghai Program,No.NRCTM(SH)-2025-07the Beijing Science and Technology Innovation Medical Development Foundation,No.KC2023-JX-0270-07the Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,No.2022E10021.
文摘BACKGROUND The log odds of positive lymph nodes(LODDS)are correlated with survival outcomes in gastric cancer(GC)patients.However,the prognostic value across different tumor differentiation levels remains unclear.AIM To evaluate the independent prognostic value of LODDS and the stratified predictive efficacy in GC patients with different histologic differentiations.METHODS We conducted a retrospective analysis of 2103 GC patients who underwent radical gastrectomy at Zhejiang Cancer Hospital.The prognostic value of LODDS was compared with that of other lymph node-based metrics,including the pathologic N stage,number of positive lymph nodes,number of total lymph nodes,and lymph node ratio,stratified by tumor differentiation.RESULTS LODDS was identified as an independent prognostic factor for overall survival in moderately to poorly differentiated GC patients.LODDS demonstrated superior predictive accuracy over other lymph node metrics.A nomogram incorporating LODDS,age,carbohydrate antigen(CA)125,carcinoembryonic antigen,and tumor differentiation showed good predictive accuracy(C-index=0.703).A higher LODDS was significantly associated with an increased risk of recurrence or metastasis,poorly differentiated tumors,advanced cancer,mucinous gastric adenocarcinoma,nerve invasion,and vascular tumor thrombus.Additionally,LODDS was positively correlated with the tumor markers CA19-9,CA72-4,CA125,and CA242(all P<0.05).CONCLUSION LODDS is an independent prognostic indicator for patients with moderately and poorly differentiated GC,and its predictive performance is superior to that of other models.
基金Supported by the National Natural Science Foundation of China,No.82473195Natural Science Foundation of Zhejiang Province,No.LTGY23H160018+2 种基金Zhejiang Medical and Health Science and Technology Program,No.2024KY789Beijing Science and Technology Innovation Medical Development Foundation,No.KC2023-JX-0270-07National Natural Science Foundation of China,No.32370797.
文摘BACKGROUND Gastric cancer(GC)is a highly prevalent gastrointestinal tract tumor.Several trials have demonstrated that the location of GC can affect patient prognosis.However,the factors determining tumor location remain unclear.AIM To investigate the tumor location of patients,we went on to study the influencing factors that lead to changes in the location of GC.METHODS A retrospective evaluation was carried out on 3287 patients who underwent gastrectomy for GC in Zhejiang Cancer Hospital.The patients were followed up post-diagnosis and post-gastrectomy.The clinicopathological variables and overall survival of the patients were recorded.By analyzing the location of GC,the tumor location was divided into four categories:“Upper”,“middle”,“lower”,and“total”.Statistical software was utilized to analyze the relationship of each variable with the location of GC.RESULTS A total of 3287 patients were included in this study.The clinicopathological indices of gender,age,serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA19-9)and CA72-4 levels,were significantly associated with tumor location in patients with GC.In addition,there was a strong correlation between GC location and the prognosis of postoperative patients.Specifically,patients with“lower”and“middle”GC demonstrated a better prognosis than those with tumors in other categories.CONCLUSION The five clinicopathological indices of gender,age,CEA,CA19-9 and CA72-4 levels exhibit varying degrees of influence on the tumor location.The tumor location correlates with patient prognosis following surgery.
文摘In the past,arms used in the fields of industry and robotics have been designed not to vibrate by increasing their mass and stiffness.The weight of arms has tended to be reduced to improve speed of operation,and decrease the cost of their production.Since the weight saving makes the arms lose their stiffness and therefore vibrate more easily,the vibration suppression control is needed for realizing the above purpose.Incidentally,the use of various smart materials in actuators has grown.In particular,a shape memory alloy(SMA)is applied widely and has several advantages:light weight,large displacement by temperature change,and large force to mass ratio.However,the SMA actuators possess hysteresis nonlinearity between their own temperature and displacement obtained by the temperature.The hysteretic behavior of the SMA actuators affects their control performance.In previous research,an operator-based control system including a hysteresis compensator has been proposed.The vibration of a flexible arm is dealt with as the controlled object;one end of the arm is clamped and the other end is free.The effectiveness of the hysteresis compensator has been confirmed by simulations and experiments.Nevertheless,the feedback signal of the previous designed system has increased exponentially.It is difficult to use the system in the long-term because of the phenomenon.Additionally,the SMA actuator generates and radiates heat because electric current passing through the SMA actuator provides heat,and strain on the SMA actuator is generated.With long-time use of the SMA actuator,the environmental temperature around the SMA actuator varies through radiation of the heat.There exists a risk that the ambient temperature change dealt with as disturbance affects the temperature and strain of the SMA actuator.In this research,a design method of the operator-based control system is proposed considering the long-term use of the system.In the method,the hysteresis characteristics of the SMA actuator and the temperature change around the actuator are considered.The effectiveness of the proposed method is verified by simulations and experiments.
文摘In this paper, operator-based nonlinear water temperature control for a group of three connected microreactors actuated by Peltier devices is proposed. To control the water temperature of tube in the microreactor, the temperature change of aluminum effects is considered. Therefore, the temperature change of aluminum becomes the part of an input of the tube. First, nonlinear thermal models of aluminum plates and tubes that structure the microreactor are obtained. Then, an operator based nonlinear water temperature control system for the microreactor is designed. Finally, the effectiveness of the proposed models and methods is confirmed by simulation and experimental results.
文摘In this paper,robust stability of nonlinear plants represented by non-symmetric Prandtl-Ishlinskii(PI)hysteresis model is studied.In general,PI hysteresis model is the weighted superposition of play or stop hysteresis operators,and the slopes of the operators are considered to be the same.In order to make a hysteresis model,a modified form of non-symmetric play hysteresis operator with unknown slopes is given.The hysteresis model is described by a generalized Lipschitz operator term and a bounded parasitic term.Since the generalized Lipschitz operator is unknown,a new condition using robust right coprime factorization is proposed to guarantee robust stability of the controlled plant with the hysteresis nonlinearity.As a result,based on the proposed robust condition,a stabilized plant is obtained.A numerical example is presented to validate the effectiveness of the proposed method.
