Silicate bioceramics have demonstrated great potential in hydrog el dressings for wound healing due to their special origins of promoting endothelial cell angiogenesis and inhibiting apoptosis of cardiomyocyte.However...Silicate bioceramics have demonstrated great potential in hydrog el dressings for wound healing due to their special origins of promoting endothelial cell angiogenesis and inhibiting apoptosis of cardiomyocyte.However,there are still some deficiencies,such as insufficient biological activity,instability of silicate ion release,and lower wet adhesion on wounds with tissue exudate,limiting their further clinical applications.Herein,inspired by mussels,a multifunctional double-network hydrogel(FS/PAM-Gel-PDA) wound dressing composited gelatin with silicate ceramic powder with satisfactory wet adhesion,stable release of bioactive ions,hemostasis,and the ability of promoting vascular regeneration was engineered through specifically grafting dopamine to gelatin and introducing ferrous silicate ceramic powder into the hydrogel.The comprehensive experimental results substantiate that the FS/PAM-Gel-PDA has wet-adhesion strength of up to 21.78 kPa,and remains stably adherent to porcine myocardial tissues intuitively after bending,twisting,soaking in water,and stretching.The test results of ion release behavior in vitro show that the oxidation and agglomeration of ferrous silicate ceramic powder can be effectively inhibited by using dopamine to form an antioxidant layer on the surface of ceramic powder,and thus,the stable release of Fe^(2+)and SiO_(4)^(4-)effective ions can be realized.The animal experiment exhibits that FS/PAM-Gel-PDA can achieve rapid hemostasis in the lethal liver defect model.Meanwhile,the FS/PAM-Gel-PDA reveals the remarkable ability to promote wound healing in a full-thickness skin injury model,which can obviously accelerate skin re-epithelialization.To sum up,the FS/PAM-Gel-PDA has excellent wet adhesion and stable release of active ions to accelerate angiogenesis,which shows great potential in promoting wound healing.展开更多
In the information-explosion era,developing novel algorithms and memristive devices has become a promising concept for next-generation capacity enlargement technology.Organic small molecule-based devices displaying su...In the information-explosion era,developing novel algorithms and memristive devices has become a promising concept for next-generation capacity enlargement technology.Organic small molecule-based devices displaying superior learning-memory performance have attracted much attention,except for the existence of poor heat-resilience and mediocre conductivity.In this paper,a strategy of transforming an organic-type data-storage material to metal complex is proposed to resolve these intrinsic issues.A pristine NDI-derivative(NIPy)and its corresponding Co(II)complex(CoNIPy)are synthesized for the purpose of electrical property investigation.CoNIPy complex-based memristive device exhibits superior ternary WORM memory performance compared with the binary behavior of NIPy,including>104 s of reading,lower threshold voltage(V_(th)),1:10^(2):10^(5)of OFF/ON1/ON2 current ratio,and long-term stability in heating environment.The variable learning-memory behavior can be attributed to the enhanced ligand-to-metal charge transfer(LMCT)and improved redox activity after the introduction of central metal atom and coordination bond.These studies on material innovation and optimal performance are of great importance not only for environmentally-robust memristive devices but also for practical application of a host of organic electronic devices.展开更多
基金funding and generous support of National Natural Science Foundation of China(22278259 and 22278257)The Key R&D Program of Shaanxi Province(2022GY-272)+2 种基金The Scientific Research Program Funded by Shaanxi Provincial Education Department(22JY013)The Chinese Postdoctoral Science Foundation(2021M692000)Wenzhou Science and Technology Major Project(ZY2022028).
文摘Silicate bioceramics have demonstrated great potential in hydrog el dressings for wound healing due to their special origins of promoting endothelial cell angiogenesis and inhibiting apoptosis of cardiomyocyte.However,there are still some deficiencies,such as insufficient biological activity,instability of silicate ion release,and lower wet adhesion on wounds with tissue exudate,limiting their further clinical applications.Herein,inspired by mussels,a multifunctional double-network hydrogel(FS/PAM-Gel-PDA) wound dressing composited gelatin with silicate ceramic powder with satisfactory wet adhesion,stable release of bioactive ions,hemostasis,and the ability of promoting vascular regeneration was engineered through specifically grafting dopamine to gelatin and introducing ferrous silicate ceramic powder into the hydrogel.The comprehensive experimental results substantiate that the FS/PAM-Gel-PDA has wet-adhesion strength of up to 21.78 kPa,and remains stably adherent to porcine myocardial tissues intuitively after bending,twisting,soaking in water,and stretching.The test results of ion release behavior in vitro show that the oxidation and agglomeration of ferrous silicate ceramic powder can be effectively inhibited by using dopamine to form an antioxidant layer on the surface of ceramic powder,and thus,the stable release of Fe^(2+)and SiO_(4)^(4-)effective ions can be realized.The animal experiment exhibits that FS/PAM-Gel-PDA can achieve rapid hemostasis in the lethal liver defect model.Meanwhile,the FS/PAM-Gel-PDA reveals the remarkable ability to promote wound healing in a full-thickness skin injury model,which can obviously accelerate skin re-epithelialization.To sum up,the FS/PAM-Gel-PDA has excellent wet adhesion and stable release of active ions to accelerate angiogenesis,which shows great potential in promoting wound healing.
基金Y.L.thanks financial support from the National Natural Science Foundation of China(Grants No.22008164)the Natural Science Foundation of Jiangsu Province(Grants No.BK20190939)+4 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grants No.19KJB150018)This work is also supported by Six Talent Peaks Project of Jiangsu Province,China(XCL-078)Jiangsu Key Disciplines of the Fourteenth Five-Year Plan(2021135)the Suzhou Key Laboratory for Low Dimensional Optoelectronic Materials and Devices(SzS201611)Q.Z.thanks thefunding support from City University of Hong Kong(9380117,7005620 and 7020040)and Hong Kong Institute for Advanced Study,City University of Hong Kong,Hong Kong,P.R.China.
文摘In the information-explosion era,developing novel algorithms and memristive devices has become a promising concept for next-generation capacity enlargement technology.Organic small molecule-based devices displaying superior learning-memory performance have attracted much attention,except for the existence of poor heat-resilience and mediocre conductivity.In this paper,a strategy of transforming an organic-type data-storage material to metal complex is proposed to resolve these intrinsic issues.A pristine NDI-derivative(NIPy)and its corresponding Co(II)complex(CoNIPy)are synthesized for the purpose of electrical property investigation.CoNIPy complex-based memristive device exhibits superior ternary WORM memory performance compared with the binary behavior of NIPy,including>104 s of reading,lower threshold voltage(V_(th)),1:10^(2):10^(5)of OFF/ON1/ON2 current ratio,and long-term stability in heating environment.The variable learning-memory behavior can be attributed to the enhanced ligand-to-metal charge transfer(LMCT)and improved redox activity after the introduction of central metal atom and coordination bond.These studies on material innovation and optimal performance are of great importance not only for environmentally-robust memristive devices but also for practical application of a host of organic electronic devices.
