BACKGROUND Voltage-gated sodium channels(VGSCs,or Navs)are highly expressed in various tumors and play a critical role in tumor metastasis and invasion.AIM To identify Nav1.6-associated cancer genes through bioinforma...BACKGROUND Voltage-gated sodium channels(VGSCs,or Navs)are highly expressed in various tumors and play a critical role in tumor metastasis and invasion.AIM To identify Nav1.6-associated cancer genes through bioinformatics analysis and experimental validation,with the goal of determining the role of Nav1.6 in colorectal cancer(CRC)metastasis.METHODS The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)data were analyzed using weighted correlation network analysis(WGCNA)and Venn analysis to identify Nav1.6-associated genes in CRC.siRNA,real-time PCR,and western blotting were employed to validate the Nav1.6-associated cancer genes and signaling pathways identified in CRC.Cell counting kit-8 and Transwell migration assays were used to assess the proliferation and migration of CRC cells.RESULTS The analysis of TCGA and GEO datasets,along with WGCNA,identified 575 differentially expressed genes associated with SCN8A(Nav1.6)in CRC,which were particularly enriched in MAPK signaling pathways.Tissue microarray analysis of surgical samples revealed elevated Nav1.6 levels in CRC tissues,which were predominantly in the cytoplasm and nucleus rather than in the membrane.Cytoplasmic Nav1.6 expression increased with T stage increases,consistent with the TCGA findings.SCN8A knockdown in colon tumor cells significantly reduced cell proliferation and invasion and downregulated key proteins in the RAF-MAPK pathway.CONCLUSION These findings suggest that Nav1.6 promotes CRC cell proliferation and invasion which is related to the MAPK signaling pathway.展开更多
Diabetes mellitus,a global epidemic,represents a major public health threat.Stem cell therapy,with its regenerative capacity,has emerged as a promising approach for diabetes mellitus management.This paper reviews rece...Diabetes mellitus,a global epidemic,represents a major public health threat.Stem cell therapy,with its regenerative capacity,has emerged as a promising approach for diabetes mellitus management.This paper reviews recent advancements,prospects,and challenges in stem cell-based treatments for diabetes mellitus,focusing on the applications of induced pluripotent stem cells and mesenchymal stem cells,the development of pancreatic islet organoids,and the potential for personalized medicine.The review critically assesses the efficacy and safety of stem cell therapies in clinical trials and examines their applications in both type 1 and type 2 diabetes mellitus.Despite the promising potential,challenges such as safety concerns,transplantation efficiency,ethical considerations,and immune rejection remain prevalent.Lastly,the paper discusses future directions,including the integration of stem cell therapy with other treatments and the advancement of personalized therapeutic strategies,offering new perspectives and hope for dia-betes mellitus management.展开更多
Objective:This study aimed to evaluate the reliability and validity of the Chinese version of the Fear of Hypoglycemia scale with 15 items(FH-15).Methods:After obtaining the original author's authorization,the Eng...Objective:This study aimed to evaluate the reliability and validity of the Chinese version of the Fear of Hypoglycemia scale with 15 items(FH-15).Methods:After obtaining the original author's authorization,the English version of the FH-15 scale was translated,back translated,and culturally debugged to obtain the Chinese version of FH-15.A convenient sampling method was used to extract patients with type 2 diabetes from four tertiary hospitals in Tianjin.A total of 408 patients with type 2 diabetes were investigated in the hospital to test the reliability and validity of Chinese version FH-15 scale.Results:The content validity index of the scale was 0.92,and the content validity index of each item was 0.8-1.0.The exploratory factor analysis extracted three common factors(fear,avoidance,and interference),which contained 15 items,and the cumulative variance contribution rate was 71.245%.The confirmatory factor analysis results showed that the model fit was better at 1.981 x2/df,GFI=0.901,CGI=0.962,TLI=0.952,and RMSEA=0.070.The cut-off value for the total hypoglycemia fear scale was 30.5.The Cronbach'sαcoefficient of the three dimensions of the scale was 0.918,the Cronbach'sαcoefficient of each dimension is 0.876-0.916,the test-retest reliability was 0.903,and the test-retest reliability of each factor was 0.733-0.930.Conclusion:The Chinese version of the FH-15 scale can be considered reliable and valid.The item expression is concise,clear,and easy to understand.It is suitable for clinical practice as an initial screening tool to identify and evaluate the severity of fear of hypoglycemia in patients with type 2 diabetes.展开更多
Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMe...Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMed, EMBASE, Web of Science, Chinese biomedical literature database (CBM), Wan Fang database (Wan Fang), China National Knowledge Infrastructure (CNKI) and VIP Database for Chinese Technical Periodicals(VIP) were retrieved. The retrieval contents were randomized controlled trials on improving gastrointestinal complications of patients with enteral nutrition by heating infusion of nutrient solution. Data were collected by two reviewers according to the data extraction tables. Results: A total of 17 randomized controlled trials with 1683 subjects were chosen. The results of meta analysis showed that the rate of abdominal pain, abdominal distension and nausea in patients with enteral nutrition could be reduced by warm infusion of nutrient solution, but the effect of the infusion on vomiting, constipation, stomach retention and diarrhea was not superior. Conclusion: Heating infusion of nutrient solution can reduce the incidence of abdominal pain, abdominal distension and nausea in patients with enteral nutrition.展开更多
Objective:To select a common method of humanized mice and verify its feasibility with the aim to provide atheoretical basis for subsequent fecal bacteria transplantation research.Methods:1.Specific Pathogen Free(SPF)m...Objective:To select a common method of humanized mice and verify its feasibility with the aim to provide atheoretical basis for subsequent fecal bacteria transplantation research.Methods:1.Specific Pathogen Free(SPF)mice were fed with antibiotics mixed with sterilized drinking water for 3 weeks,during which the general situation of mice was recorded.After 3 weeks,the number of microbes in mice's feces was evaluated by Gram staining.2.After antibiotic treatment,mice were transplanted fecal bacteria by gavage for a week.Then,the contents of fecal bacteria in the donor and recipient feces was determined by RT-PCR,to evaluate the colonization effect of fecal bacteria.Results:(1)Antibiotic treatment had an effect on weight,feed and drinking water consumption of mice,and the fecal bacteria in mice decreased obviously.(2)After fecal bacteria transplantation,the Firmicutes,Bacteroidetes and Firmicutes/Bacteroidetes of the mice receiving Donor1 fecal bacteria accounted for 15.4%,112%and 13.7%of the mice receiving Donor2 fecal bacteria,respectively.The Firmicutes,Bacteroidetes and Firmicutes/Bacteroidetes of Donor1 fecal bacteria accounted for 33.7%,104%and 32%of Donor2,respectively.The recipient's gut microbes had the same trend as human donors.Conclusions:These results indicate that antibiotic treatment combined with fecal bacterial transplantation is feasible and safe for humanizing SPF mice.展开更多
Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TC...Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TCM in low birth weight premature infants were retrieved in electronic databases such as the Cochrane Library, PubMed, EMbase, Web of Science, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database) and Wanfang Database. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 11 articles were included, including 1282 preterm infants. The result showed that compared with the routine care model, TCM can effectively increase the weight when premature infants discharged one week [MD=225.57, 95%CI (171.78, 279.37), P<0.001], increase the weight after discharged one month [MD=0.89, 95%CI (0.72, 1.06), P<0.001], increase the weight after discharged three months [MD=670.44, 95%CI (527.65, 813.23), P<0.001], promote the height of newborns [MD=4.54, 95%CI (2.42, 6.65), P<0.001], reduce readmission rate [RR=0.38, 95%CI (0.25, 0.58), P<0.001], alleviate adverse skin reactions [RR=0.33, 95%CI (0.22, 0.50), P<0.001], increase nursing satisfaction of the families [RR=1.21, 95%CI (1.13, 1.31), P<0.001]. Conclusion: TCM can effectively promote the growth and development of the low birth weight premature infants, reduce the hospital readmission rate, alleviate adverse skin reactions of premature infants and improve the nursing satisfaction of the families. However, due to the limitation of the region and quality of the included studies, which the accuracy of the result still be treated with more caution. Further high-quality studies are needed to verify the conclusion.展开更多
Objective: The purpose of the present study is to review the existing literatures to understand the competency ofnursing students to prevent the pressure injury. Methods: Arksey and O'Malley’s scoping review fram...Objective: The purpose of the present study is to review the existing literatures to understand the competency ofnursing students to prevent the pressure injury. Methods: Arksey and O'Malley’s scoping review framework havebeen applied to understand the competency of nursing students on pressure injury prevention. A variety ofdatabases have been searched in this study, including PubMed, EMBASE, Web of Science, Cochrane Library,CNKI, Wanfang databases. Results: A total of 17 articles were selected and three main themes were summarized:“Knowledge and Attitude”, “Preparation” and “Educational situation and needs”. Conclusion: Although theattitudes towards pressure injuries were positive, the knowledge of nursing students on preventing pressure injurywas insufficient and their consciousness was weak. The controversy of the readiness of nursing students to preventpressure injuries has existed for a long time. Nursing students were severely lacking in pressure sore educationcourses and needed better education methods and more clinical practice opportunities.展开更多
Family care plays an important role in the health maintenance of children with epilepsy.In this paper,the relevant literatures of family nursing intervention were collected and summarized.There are two main methods of...Family care plays an important role in the health maintenance of children with epilepsy.In this paper,the relevant literatures of family nursing intervention were collected and summarized.There are two main methods of family care intervention for children with epilepsy:Family-managed care interventions and family-centered care interventions.It is not only spread the knowledge of epilepsy,but more importantly,improve the ability of family caregivers to manage the disease,and improve family function and reduce the behavior of children with epilepsy effectively.展开更多
Objective： To evaluate the correlation between time management disposition and ability confidence of Nursing Students in China through the Pearson correlation coefficient. Methods： Electronic databases including the...Objective： To evaluate the correlation between time management disposition and ability confidence of Nursing Students in China through the Pearson correlation coefficient. Methods： Electronic databases including the Cochrane library, PubMed, EMBASE, the Web of Science, CBM, Wanfang, VIP and CNKI were searched from inception to October 2017 to collect literature on the correlation between time manage-ment disposition and ability confidence of Chinese nursing students. The studies were examined according to the inclusion and exclusion criteria. After extracting data and evaluating the quality of the included studies. Meta-analysis was carried out using Stata 12.0 software. Results： A total of 7 articles with 1632 nursing students were included, and the quality of the literature was at medium level. Meta-analysis shown the total score of time management disposition of Chinese nursing students and its three dimensions were related to ability confidence. The summary correlation coefficient between time management disposition and ability confidence was 0.52 （0.43 to 0.59） ; There is a weak correlation between time value and ability confidence （r, 0.33; 95% CI, 0.25 to 0.39）; There was a moderate level of correlation between time control and ability confidence （r, 0.49; 95% CI, 0.43 to 0.54）; There was a moderate level of correlation between time efficacy and ability confidence （0.47, 0.41, 0.53）.And the relevance of nursing time management disposition and behavioral confidence varies with the nursing student＇s area, nursing student＇s diploma, measurement tools and sample size. Conclusion： The time man- agement disposition of Chinese nursing students is moderately related to ability confidence. When there are different in nursing students in the area, nursing diploma, measurement tools and sample size, the relevance is very different. The time management disposition of Chinese nursing students and their ability confidence are mutually reinforcing, and the time management disposition and their ability confidence should be further strengthened in the future.展开更多
Objective:To analyze the current situation and shortcomings of the research on nurses'empathy ability in China by using the method of bibliometrics,in order to provide some reference for the related scholars in th...Objective:To analyze the current situation and shortcomings of the research on nurses'empathy ability in China by using the method of bibliometrics,in order to provide some reference for the related scholars in this field.Methods:All articles on nurses'empathy ability in China was retrieved from CNKI,Wanfang database,VIP database and CBM until June 30,2018.Results:A total of 108 articles were included and distributed in 23 provinces,municipali ties and autonomous regions.Among them,Hunan and Hebei province had the largest number of documents;The proportion of literature had fund supports was 16.67%;the literature was included in 48 periodicals,and 18 articles(16.67%)were published in Chinese Nursing Research;the research institutions were mainly hospitals,79(73.15%).A total of 69 articles(63.89%)were non-experimental study,but the qualitative research papers was 0.Conclusion:The research on empathy of nurses in China is still in its infancy,and there are still some problems such as uneven regional distribution,lack of fund support,single type of research and the depth of research content need to be further improved.Therefore,in the future research,we should pay attention to strengthen cooperation and exchanges between regions and encourage relevant scholars to be brave in innovation,so as to promote the further development of research on the empathy ability of nurses in China.展开更多
基金Supported by Science and Technology Project of Quzhou of China,No.2021Y011Beijing Science and Technology Innovation Medical Development Foundation,No.KC2021-JX-0186-81.
文摘BACKGROUND Voltage-gated sodium channels(VGSCs,or Navs)are highly expressed in various tumors and play a critical role in tumor metastasis and invasion.AIM To identify Nav1.6-associated cancer genes through bioinformatics analysis and experimental validation,with the goal of determining the role of Nav1.6 in colorectal cancer(CRC)metastasis.METHODS The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)data were analyzed using weighted correlation network analysis(WGCNA)and Venn analysis to identify Nav1.6-associated genes in CRC.siRNA,real-time PCR,and western blotting were employed to validate the Nav1.6-associated cancer genes and signaling pathways identified in CRC.Cell counting kit-8 and Transwell migration assays were used to assess the proliferation and migration of CRC cells.RESULTS The analysis of TCGA and GEO datasets,along with WGCNA,identified 575 differentially expressed genes associated with SCN8A(Nav1.6)in CRC,which were particularly enriched in MAPK signaling pathways.Tissue microarray analysis of surgical samples revealed elevated Nav1.6 levels in CRC tissues,which were predominantly in the cytoplasm and nucleus rather than in the membrane.Cytoplasmic Nav1.6 expression increased with T stage increases,consistent with the TCGA findings.SCN8A knockdown in colon tumor cells significantly reduced cell proliferation and invasion and downregulated key proteins in the RAF-MAPK pathway.CONCLUSION These findings suggest that Nav1.6 promotes CRC cell proliferation and invasion which is related to the MAPK signaling pathway.
基金Supported by the Faculty Development Grants of Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine,No.XYY2025D05,No.2024QDJZR037 and No.2024QDJZR015.
文摘Diabetes mellitus,a global epidemic,represents a major public health threat.Stem cell therapy,with its regenerative capacity,has emerged as a promising approach for diabetes mellitus management.This paper reviews recent advancements,prospects,and challenges in stem cell-based treatments for diabetes mellitus,focusing on the applications of induced pluripotent stem cells and mesenchymal stem cells,the development of pancreatic islet organoids,and the potential for personalized medicine.The review critically assesses the efficacy and safety of stem cell therapies in clinical trials and examines their applications in both type 1 and type 2 diabetes mellitus.Despite the promising potential,challenges such as safety concerns,transplantation efficiency,ethical considerations,and immune rejection remain prevalent.Lastly,the paper discusses future directions,including the integration of stem cell therapy with other treatments and the advancement of personalized therapeutic strategies,offering new perspectives and hope for dia-betes mellitus management.
文摘Objective:This study aimed to evaluate the reliability and validity of the Chinese version of the Fear of Hypoglycemia scale with 15 items(FH-15).Methods:After obtaining the original author's authorization,the English version of the FH-15 scale was translated,back translated,and culturally debugged to obtain the Chinese version of FH-15.A convenient sampling method was used to extract patients with type 2 diabetes from four tertiary hospitals in Tianjin.A total of 408 patients with type 2 diabetes were investigated in the hospital to test the reliability and validity of Chinese version FH-15 scale.Results:The content validity index of the scale was 0.92,and the content validity index of each item was 0.8-1.0.The exploratory factor analysis extracted three common factors(fear,avoidance,and interference),which contained 15 items,and the cumulative variance contribution rate was 71.245%.The confirmatory factor analysis results showed that the model fit was better at 1.981 x2/df,GFI=0.901,CGI=0.962,TLI=0.952,and RMSEA=0.070.The cut-off value for the total hypoglycemia fear scale was 30.5.The Cronbach'sαcoefficient of the three dimensions of the scale was 0.918,the Cronbach'sαcoefficient of each dimension is 0.876-0.916,the test-retest reliability was 0.903,and the test-retest reliability of each factor was 0.733-0.930.Conclusion:The Chinese version of the FH-15 scale can be considered reliable and valid.The item expression is concise,clear,and easy to understand.It is suitable for clinical practice as an initial screening tool to identify and evaluate the severity of fear of hypoglycemia in patients with type 2 diabetes.
文摘Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMed, EMBASE, Web of Science, Chinese biomedical literature database (CBM), Wan Fang database (Wan Fang), China National Knowledge Infrastructure (CNKI) and VIP Database for Chinese Technical Periodicals(VIP) were retrieved. The retrieval contents were randomized controlled trials on improving gastrointestinal complications of patients with enteral nutrition by heating infusion of nutrient solution. Data were collected by two reviewers according to the data extraction tables. Results: A total of 17 randomized controlled trials with 1683 subjects were chosen. The results of meta analysis showed that the rate of abdominal pain, abdominal distension and nausea in patients with enteral nutrition could be reduced by warm infusion of nutrient solution, but the effect of the infusion on vomiting, constipation, stomach retention and diarrhea was not superior. Conclusion: Heating infusion of nutrient solution can reduce the incidence of abdominal pain, abdominal distension and nausea in patients with enteral nutrition.
基金National Natural Science Foundation of China(No.81703496)Hubei Medical College Fund Project(No.FDFR201615)Postgraduate Science and Technology Innovation Program of Hubei University of Medicine(No.YC2020027)。
文摘Objective:To select a common method of humanized mice and verify its feasibility with the aim to provide atheoretical basis for subsequent fecal bacteria transplantation research.Methods:1.Specific Pathogen Free(SPF)mice were fed with antibiotics mixed with sterilized drinking water for 3 weeks,during which the general situation of mice was recorded.After 3 weeks,the number of microbes in mice's feces was evaluated by Gram staining.2.After antibiotic treatment,mice were transplanted fecal bacteria by gavage for a week.Then,the contents of fecal bacteria in the donor and recipient feces was determined by RT-PCR,to evaluate the colonization effect of fecal bacteria.Results:(1)Antibiotic treatment had an effect on weight,feed and drinking water consumption of mice,and the fecal bacteria in mice decreased obviously.(2)After fecal bacteria transplantation,the Firmicutes,Bacteroidetes and Firmicutes/Bacteroidetes of the mice receiving Donor1 fecal bacteria accounted for 15.4%,112%and 13.7%of the mice receiving Donor2 fecal bacteria,respectively.The Firmicutes,Bacteroidetes and Firmicutes/Bacteroidetes of Donor1 fecal bacteria accounted for 33.7%,104%and 32%of Donor2,respectively.The recipient's gut microbes had the same trend as human donors.Conclusions:These results indicate that antibiotic treatment combined with fecal bacterial transplantation is feasible and safe for humanizing SPF mice.
文摘Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TCM in low birth weight premature infants were retrieved in electronic databases such as the Cochrane Library, PubMed, EMbase, Web of Science, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database) and Wanfang Database. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 11 articles were included, including 1282 preterm infants. The result showed that compared with the routine care model, TCM can effectively increase the weight when premature infants discharged one week [MD=225.57, 95%CI (171.78, 279.37), P<0.001], increase the weight after discharged one month [MD=0.89, 95%CI (0.72, 1.06), P<0.001], increase the weight after discharged three months [MD=670.44, 95%CI (527.65, 813.23), P<0.001], promote the height of newborns [MD=4.54, 95%CI (2.42, 6.65), P<0.001], reduce readmission rate [RR=0.38, 95%CI (0.25, 0.58), P<0.001], alleviate adverse skin reactions [RR=0.33, 95%CI (0.22, 0.50), P<0.001], increase nursing satisfaction of the families [RR=1.21, 95%CI (1.13, 1.31), P<0.001]. Conclusion: TCM can effectively promote the growth and development of the low birth weight premature infants, reduce the hospital readmission rate, alleviate adverse skin reactions of premature infants and improve the nursing satisfaction of the families. However, due to the limitation of the region and quality of the included studies, which the accuracy of the result still be treated with more caution. Further high-quality studies are needed to verify the conclusion.
文摘Objective: The purpose of the present study is to review the existing literatures to understand the competency ofnursing students to prevent the pressure injury. Methods: Arksey and O'Malley’s scoping review framework havebeen applied to understand the competency of nursing students on pressure injury prevention. A variety ofdatabases have been searched in this study, including PubMed, EMBASE, Web of Science, Cochrane Library,CNKI, Wanfang databases. Results: A total of 17 articles were selected and three main themes were summarized:“Knowledge and Attitude”, “Preparation” and “Educational situation and needs”. Conclusion: Although theattitudes towards pressure injuries were positive, the knowledge of nursing students on preventing pressure injurywas insufficient and their consciousness was weak. The controversy of the readiness of nursing students to preventpressure injuries has existed for a long time. Nursing students were severely lacking in pressure sore educationcourses and needed better education methods and more clinical practice opportunities.
文摘Family care plays an important role in the health maintenance of children with epilepsy.In this paper,the relevant literatures of family nursing intervention were collected and summarized.There are two main methods of family care intervention for children with epilepsy:Family-managed care interventions and family-centered care interventions.It is not only spread the knowledge of epilepsy,but more importantly,improve the ability of family caregivers to manage the disease,and improve family function and reduce the behavior of children with epilepsy effectively.
文摘Objective： To evaluate the correlation between time management disposition and ability confidence of Nursing Students in China through the Pearson correlation coefficient. Methods： Electronic databases including the Cochrane library, PubMed, EMBASE, the Web of Science, CBM, Wanfang, VIP and CNKI were searched from inception to October 2017 to collect literature on the correlation between time manage-ment disposition and ability confidence of Chinese nursing students. The studies were examined according to the inclusion and exclusion criteria. After extracting data and evaluating the quality of the included studies. Meta-analysis was carried out using Stata 12.0 software. Results： A total of 7 articles with 1632 nursing students were included, and the quality of the literature was at medium level. Meta-analysis shown the total score of time management disposition of Chinese nursing students and its three dimensions were related to ability confidence. The summary correlation coefficient between time management disposition and ability confidence was 0.52 （0.43 to 0.59） ; There is a weak correlation between time value and ability confidence （r, 0.33; 95% CI, 0.25 to 0.39）; There was a moderate level of correlation between time control and ability confidence （r, 0.49; 95% CI, 0.43 to 0.54）; There was a moderate level of correlation between time efficacy and ability confidence （0.47, 0.41, 0.53）.And the relevance of nursing time management disposition and behavioral confidence varies with the nursing student＇s area, nursing student＇s diploma, measurement tools and sample size. Conclusion： The time man- agement disposition of Chinese nursing students is moderately related to ability confidence. When there are different in nursing students in the area, nursing diploma, measurement tools and sample size, the relevance is very different. The time management disposition of Chinese nursing students and their ability confidence are mutually reinforcing, and the time management disposition and their ability confidence should be further strengthened in the future.
文摘Objective:To analyze the current situation and shortcomings of the research on nurses'empathy ability in China by using the method of bibliometrics,in order to provide some reference for the related scholars in this field.Methods:All articles on nurses'empathy ability in China was retrieved from CNKI,Wanfang database,VIP database and CBM until June 30,2018.Results:A total of 108 articles were included and distributed in 23 provinces,municipali ties and autonomous regions.Among them,Hunan and Hebei province had the largest number of documents;The proportion of literature had fund supports was 16.67%;the literature was included in 48 periodicals,and 18 articles(16.67%)were published in Chinese Nursing Research;the research institutions were mainly hospitals,79(73.15%).A total of 69 articles(63.89%)were non-experimental study,but the qualitative research papers was 0.Conclusion:The research on empathy of nurses in China is still in its infancy,and there are still some problems such as uneven regional distribution,lack of fund support,single type of research and the depth of research content need to be further improved.Therefore,in the future research,we should pay attention to strengthen cooperation and exchanges between regions and encourage relevant scholars to be brave in innovation,so as to promote the further development of research on the empathy ability of nurses in China.
