BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral...BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup technique.AIM To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup technique.METHODS We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January 2017.All acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 mo.RESULTS The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last follow-up.The mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm post-operatively.Greater trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 mo.There was no evidence of component migration at the last follow-up.CONCLUSION The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.展开更多
Furfurylated wood exhibits excellent dimensional stability and corrosion resistance,making it a promising material for constructing buildings,but it is highly flammable.Herein,flame-retardant furfurylated poplar wood ...Furfurylated wood exhibits excellent dimensional stability and corrosion resistance,making it a promising material for constructing buildings,but it is highly flammable.Herein,flame-retardant furfurylated poplar wood was produced via a two-step process utilizing boric acid(BA)and ammonium dihydrogen phosphate(ADP)as flame-retardant components,and biomass-derived furfuryl alcohol(FA)as a modifier.The acidity of BA and ADP allowed them to catalyze the polymerization of FA,which formed a cross-linked network that immobilized BA and ADP inside the wood.The addition of BA/ADP substantially delayed the time to ignition from 10 to 385 s and reduced the total heat release and total smoke release by 58.75%and 77.31%,respectively.Analysis of the pyrolysis process showed that the decomposition products of BA and ADP protected the underlying furfurylated wood and diluted combustible gases.This method significantly improved the fire retardancy and smokeless properties of furfurylated wood,providing promising prospects for its application as an engineering material.展开更多
In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and control.Here,we demonstrate two calibration methods using a two-qubit system as...In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and control.Here,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control line.Both methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit types.The two methods differ in correction accuracy and complexity.The first,coarse predistortion(CPD)method,partially mitigates distortion.The second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation uniformity.Both methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic pulse.We believe these methods will enhance qubit characterization accuracy and operation quality in future applications.展开更多
短串联重复序列(short tandem repeat,STR)已广泛用于法医学亲子鉴定和个体识别中,但STR的突变可能会影响其结果的解释。在大多数类似研究中,由于忽略“隐性”突变现象,STR的突变率被低估。鉴于此,为获得更加准确的STR实际突变率,本研...短串联重复序列(short tandem repeat,STR)已广泛用于法医学亲子鉴定和个体识别中,但STR的突变可能会影响其结果的解释。在大多数类似研究中,由于忽略“隐性”突变现象,STR的突变率被低估。鉴于此,为获得更加准确的STR实际突变率,本研究使用Slooten与Ricciardi提出的有限突变模型和大规模数据,对28,313例(78,739个体)中国北京汉族已确认亲生关系的亲子鉴定案的20个常染色体STR基因座(D3S1358、D1S1656、D13S317、Penta E、D16S539、D18S51、D2S1338、CSF1PO、Penta D、TH01、vWA、D21S11、D6S1043、D7S820、D5S818、TPOX、D8S1179、D12S391、D19S433和FGA;由于有限突变模型中未包含D6S1043的矫正参数,因此本文实际计算其余19个STR基因座的突变率)进行了调查。结果发现,所有基因座均存在突变现象,总计发生1665个突变事件,包括1614个一步突变,34个两步突变,8个三步突变和9个非整步突变。基因座特异性的平均实际突变率在三联体中为0.00007700(TPOX)~0.00459050(FGA),在二联体中为0.00000000(TPOX)~0.00344850(FGA)。此外,本研究还分析了表面和实际突变率、三联体和二联体突变率、父源和母源的突变率之间的关系。研究表明,实际突变率多大于表面突变率,而且μ1^(*)/μ2^(*)(表面突变率)的比值通常也大于μ1/μ2(实际突变率)(μ1^(*),μ1;μ2^(*),μ2分别是一步和两步的突变率),即更多的“隐性”突变被释放出来。而且父源和母源的三联体和二联体的突变率也有存在差异。随后,将这些突变率数据与已发表的中国其他汉族人口的相关研究进行比较,展现出了STR突变率的时间与区域差异。由于样本量大,本研究中还报告了一些少见的突变事件,例如同卵双胞胎突变和“假四步突变”等。综上所述,本研究通过大量数据获得了接近真实的STR突变率的估计值,不仅可为中国法医DNA数据库和群体遗传学数据库提供重要的基础数据,也对开展法医学个体识别、亲权鉴定和遗传学研究具有重要的意义。展开更多
Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-ye...Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-year-old woman who presented with low-grade fever and weight loss of three months.On CT scanning,a mass was identified which appeared to be a hypoattenuating lesion,on ultrasonographic imaging,the mass was hypoechoic,therefore,liver abscess or hepatic metastasis from a gastrointestinal primary was initially suspected.Tumor markers such as alpha-fetoprotein,carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits.PET/CT demonstrated a large abnormal ring-like hypermetabolic focus in the right liver lobe.The lesion was resected and the histo-pathological findings were consistent with lymphoma.The patient was discharged two weeks after surgery and did not receive any further treatment.After 25 mo follow-up,she is in good health.18F-fluorodeoxyglucose PET/CT is useful in confirming the diagnosis of primary hepatic lymphoma by demonstrating no other foci with high uptake in other parts of the body.展开更多
Background:In Asia,facial overfilled syndrome(FOS)can arise from iatrogenic causes involving the excessive use of filling materials,as well as physiological causes such as adipose tissue hypertrophy type,age-related t...Background:In Asia,facial overfilled syndrome(FOS)can arise from iatrogenic causes involving the excessive use of filling materials,as well as physiological causes such as adipose tissue hypertrophy type,age-related type,and lacuna type.This study aimed to demonstrate the safety and effectiveness of plasma radiofrequency-assisted microsuction(PRFAMS)for improving the appearance of FOS induced by various causes.Methods:PRFAMS was performed on 84 anatomical regions of 37 female patients(including 12 with physiological causes,6 with hyaluronic acid causes,and 19 with fat causes),aged between 20 and 50 years(mean,35.9 years),who had FOS.Demographic and surgical data were collected retrospectively.Preoperative and postoperative photographs were taken,and satisfaction interviews were conducted at least six months after surgery.Results:All the patients underwent successful surgery under local or intravenous anesthesia.Only four anatomic regions showed noticeable asymmetry postoperatively,requiring a secondary operation.Postoperative skin numbness,muscle paralysis,bruising,and minor contouring irregularities improved significantly within 2–3 weeks of recovery.Additionally,five patients with longer edema periods demonstrated substantial improvement after more than five weeks.No cases of skin necrosis,thermal injury,or other serious complications related to the device or procedure were reported.Ultimately,all patients expressed satisfaction with their outcomes.Conclusion:The PRFAMS technique is a safe and effective method for treating FOS induced by various causes,while minimizing complications and ensuring high patient satisfaction.展开更多
For lack of deep research on model, system structure and top-level design, the integrated system concept of energy, information and transportation networks fails to provide effective guidance for transferring the theo...For lack of deep research on model, system structure and top-level design, the integrated system concept of energy, information and transportation networks fails to provide effective guidance for transferring the theory to practice. In this paper, with dispatching of energy flow and information flow as a focus, clean energy of wind power and solar power as carrier, battery charging & swapping station as medium and all kinds of transportation flows as entity, a five-in-one threenetwork integrated system model is built by full use of technologies of Internet of Vehicles(IOV) and Internet of things(IOT) to promote the innovative concept of three-network integration into practice, and provide a reference for future researches.展开更多
BACKGROUND A recurrent valgus deformity was a common complication after total knee arthroplasty(TKA)in patients with valgus deformity.However,re-revision surgery for re-recurrent valgus deformity after revision TKA in...BACKGROUND A recurrent valgus deformity was a common complication after total knee arthroplasty(TKA)in patients with valgus deformity.However,re-revision surgery for re-recurrent valgus deformity after revision TKA in patients with valgus deformity before primary TKA was uncommon.CASE SUMMARY We reported a 72-year-old female patient with two recurrent valgus deformities after TKA for a valgus knee deformity who underwent two revision surgeries to rectify the deformity.In the re-revision surgery,bone defects were successfully reconstructed by the augments and cement in combination with screws and a sleeve.An appropriate neutral alignment of the lower limb was restored by the perfect femoral entry point and the long diaphyseal cementless stem.Adequate fixation of the metaphysis and diaphysis of the femur was obtained by the sleeve and long diaphyseal cementless stem.The patient was pain-free and deformityfree for 2.5 years.CONCLUSION The management of bone defects,the choice of the stem and the femoral entry point were of vital importance in the revision or re-revision TKA for a recurrent valgus deformity.展开更多
Iterative coupled methods are widely used in multi-fidelity simulation of rotating components due to the simple implementation,which iteratively eliminates the errors between the computational fluid dynamics models an...Iterative coupled methods are widely used in multi-fidelity simulation of rotating components due to the simple implementation,which iteratively eliminates the errors between the computational fluid dynamics models and approximate characteristic maps.However,the convergence and accuracy of the iterative coupled method are trapped in characteristic maps.In particular,iterative steps increase sharply as the operation point moves away from the design point.To address these problems,this paper developed an auxiliary iterative coupled method that introduces the static-pressure-auxiliary characteristic maps and modification factor of mass flow into the component-level model.The developed auxiliary method realized the direct transfer of static pressure between the high-fidelity models and the component-level model.Multi-fidelity simulations of the throttle characteristics were carried out using both the auxiliary and traditional iterative coupled methods,and the simulation results were verified using the experimental data.Additionally,the consistency between the auxiliary and traditional iterative coupled methods was confirmed.Subsequently,multi-fidelity simulations of the speed and altitude characteristics were also conducted.The auxiliary and traditional iterative coupled methods were evaluated in terms of convergence speed and accuracy.The evaluation indicated that the auxiliary iterative coupled method significantly reduces iterative steps by approximately 50%at the near-choked state.In general,the auxiliary iterative coupled method is preferred as a development of the traditional iterative coupled method in the near-choked state,and the combined auxiliary-traditional iterative coupled method provides support for successful multi-fidelity simulation in far-off-design conditions.展开更多
OBJECTIVE To investigate the effects of LW-AFC,a new formula derived fromLiuwei Dihuang decoction,on gut microbiota and the behavior of learning and memory of SAMP8 mice,a mouse model of Alzheimer Disease(AD),and iden...OBJECTIVE To investigate the effects of LW-AFC,a new formula derived fromLiuwei Dihuang decoction,on gut microbiota and the behavior of learning and memory of SAMP8 mice,a mouse model of Alzheimer Disease(AD),and identify the specific intestinal microbiota correlating with cognitive ability.METHODS Morris-water maze test,novel object recognition test and shuttle-box test were conducted to observe the ability of learning and memory.16S rRNA amplicon sequencing(Illumina,San Diego,CA,USA)was employed to investigate gut microbiota.RESULTS The treatment of LW-AFC improved cognitive impairments of SAMP8 mice,including spatial learning and memory ability,active avoidance response,and object recognition memory capability.Our data indicated that there were significantly 8 increased and 12 decreased operational taxonomic units(OTUs)in the gut microbiota of SAMP8 mice compared with senescence accelerated mouse resistant 1(SAMR1) strains,the control of SAMP8 mice.The treatment of LW-AFC altered 22(16 increased and 6 decreased)OTUs in SAMP8 mice and among them,15 OTUs could be reversed by LW-AFC treatment resulting in a microbial composition similar to that of SAMR1 mice.We further showed that there were7(3 negative and 4 positive correlation)OTUs significantly correlated with all the three types of cognitive abilities,at the order level,including Bacteroidales,Clostridiales,Desulfovibrionales,CW040,and two unclassified orders.LW-AFC had influences on bacterial taxa correlated with the abilities of learning and memory in SAMP8 mice and restored them to SAMR1 mice.CONCLUSION The effects of LW-AFC on improving cognitive impairments of SAMP8 mice might be via modulating intestinal microbiome and LW-AFC could be used as a potential anti-AD agent.展开更多
The effect of self absorption on the ratio of excimer to monochromophore emission intensities, I-e/I-m, has been explored by experimentally changing the solution layer thickness of the emission light path traversed in...The effect of self absorption on the ratio of excimer to monochromophore emission intensities, I-e/I-m, has been explored by experimentally changing the solution layer thickness of the emission light path traversed in the solution in the right-angle geometry. The result shows that data obtained by front-face geometry are better than those obtained by right-angle geometry even after correction to zero solution thickness. The correction formula based on geometric optics given by Tsai and Torkelson is not adequate.展开更多
Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With prote...Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum computing.Here, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.展开更多
The single-shot readout data process is essential for the realization of high-fidelity qubits and fault-tolerant quantum algorithms in semiconductor quantum dots. However, the fidelity and visibility of the readout pr...The single-shot readout data process is essential for the realization of high-fidelity qubits and fault-tolerant quantum algorithms in semiconductor quantum dots. However, the fidelity and visibility of the readout process are sensitive to the choice of the thresholds and limited by the experimental hardware. By demonstrating the linear dependence between the measured spin state probabilities and readout visibilities along with dark counts, we describe an alternative threshold-independent method for the single-shot readout of spin qubits in semiconductor quantum dots. We can obtain the extrapolated spin state probabilities of the prepared probabilities of the excited spin state through the threshold-independent method. We then analyze the corresponding errors of the method, finding that errors of the extrapolated probabilities cannot be neglected with no constraints on the readout time and threshold voltage. Therefore, by limiting the readout time and threshold voltage, we ensure the accuracy of the extrapolated probability. We then prove that the efficiency and robustness of this method are 60 times larger than those of the most commonly used method. Moreover, we discuss the influence of the electron temperature on the effective area with a fixed external magnetic field and provide a preliminary demonstration for a single-shot readout of up to 0.7K/1.5T in the future.展开更多
To the Editor:SARS-CoV-2,the pathogen responsible for the pandemic of coronavirus disease 2019(COVID-19),has had profound impacts on human health,and its antagonist Paxlovid is a commonly used treatment option[1].Howe...To the Editor:SARS-CoV-2,the pathogen responsible for the pandemic of coronavirus disease 2019(COVID-19),has had profound impacts on human health,and its antagonist Paxlovid is a commonly used treatment option[1].However,treatment selection for immunosuppressed patients,such as liver recipients,remains uncertain due to potential drug interactions and the risk of immunosuppressant dosage adjustment,which can cause liver injury[2].展开更多
Dear Editor,RNA virus features the high per-generation mutation rate,resulting in highly diversified population, which determines viral phenotypes and fitness (Domingo et al. 2012).The development of deep sequencing a...Dear Editor,RNA virus features the high per-generation mutation rate,resulting in highly diversified population, which determines viral phenotypes and fitness (Domingo et al. 2012).The development of deep sequencing and bioinformatic techniques paves the way to study viral population genetics at an intrahost level, and has provided new insights into viral evolution.展开更多
The locking plate and percutaneous crossing metallic screws and crossing absorbable screws have been used clinically to treat intra-articular calcaneal fractures, but little is known about the biomechanical difference...The locking plate and percutaneous crossing metallic screws and crossing absorbable screws have been used clinically to treat intra-articular calcaneal fractures, but little is known about the biomechanical differences between them. This study compared the biomechanical stability of calcaneal fractures fixed using a locking plate and crossing screws. Three-dimensional finite-element models of intact and fractured calcanei were developed based on the CT images of a cadaveric sample. Surgeries were simulated on models of Sanders type III calcaneal fractures to produce accurate postoperative models fixed by the three implants. A vertical force was applied to the superior surface of the subtalar joint to simulate the stance phase of a walking gait. This model was validated by an in vitro experiment using the same calcaneal sample. The intact calcaneus showed greater stiffness than the fixation models. Of the three fixations, the locking plate produced the greatest stiffness and the highest von Mises stress peak. The micromotion of the fracture fixated with the locking plate was similar to that of the fracture fixated with the metallic screws but smaller than that fixated with the absorbable screws. Fixation with both plate and crossing screws can be used to treat intra-articular calcaneal fractures. In general, fixation with crossing metallic screws is preferable because it provides sufficient stability with less stress shielding.展开更多
基金National Key Research and Development Program of China,No.2017YFB1104104.
文摘BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup technique.AIM To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup technique.METHODS We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January 2017.All acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 mo.RESULTS The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last follow-up.The mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm post-operatively.Greater trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 mo.There was no evidence of component migration at the last follow-up.CONCLUSION The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.
基金financially supported by the Key Research and Development Program of Hunan Province,China(2023NK2038)National Natural Science Foundation of China(32201485)+2 种基金Natural Science Foundation of Hunan Province,China(2022JJ40863,2023JJ60161)Scientific Research Project of Hunan Provincial Education Department,China(21B0238,22A0177)Hunan Provincial Technical Innovation Platform and Talent Program in Science and Technology,China(2023RC3159).
文摘Furfurylated wood exhibits excellent dimensional stability and corrosion resistance,making it a promising material for constructing buildings,but it is highly flammable.Herein,flame-retardant furfurylated poplar wood was produced via a two-step process utilizing boric acid(BA)and ammonium dihydrogen phosphate(ADP)as flame-retardant components,and biomass-derived furfuryl alcohol(FA)as a modifier.The acidity of BA and ADP allowed them to catalyze the polymerization of FA,which formed a cross-linked network that immobilized BA and ADP inside the wood.The addition of BA/ADP substantially delayed the time to ignition from 10 to 385 s and reduced the total heat release and total smoke release by 58.75%and 77.31%,respectively.Analysis of the pyrolysis process showed that the decomposition products of BA and ADP protected the underlying furfurylated wood and diluted combustible gases.This method significantly improved the fire retardancy and smokeless properties of furfurylated wood,providing promising prospects for its application as an engineering material.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12074368,92165207,12474490,12034018,and 92265113)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302300)+1 种基金the USTC Tang Scholarshippartially carried out at the USTC Center for Micro and Nanoscale Research and Fabrication。
文摘In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and control.Here,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control line.Both methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit types.The two methods differ in correction accuracy and complexity.The first,coarse predistortion(CPD)method,partially mitigates distortion.The second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation uniformity.Both methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic pulse.We believe these methods will enhance qubit characterization accuracy and operation quality in future applications.
文摘短串联重复序列(short tandem repeat,STR)已广泛用于法医学亲子鉴定和个体识别中,但STR的突变可能会影响其结果的解释。在大多数类似研究中,由于忽略“隐性”突变现象,STR的突变率被低估。鉴于此,为获得更加准确的STR实际突变率,本研究使用Slooten与Ricciardi提出的有限突变模型和大规模数据,对28,313例(78,739个体)中国北京汉族已确认亲生关系的亲子鉴定案的20个常染色体STR基因座(D3S1358、D1S1656、D13S317、Penta E、D16S539、D18S51、D2S1338、CSF1PO、Penta D、TH01、vWA、D21S11、D6S1043、D7S820、D5S818、TPOX、D8S1179、D12S391、D19S433和FGA;由于有限突变模型中未包含D6S1043的矫正参数,因此本文实际计算其余19个STR基因座的突变率)进行了调查。结果发现,所有基因座均存在突变现象,总计发生1665个突变事件,包括1614个一步突变,34个两步突变,8个三步突变和9个非整步突变。基因座特异性的平均实际突变率在三联体中为0.00007700(TPOX)~0.00459050(FGA),在二联体中为0.00000000(TPOX)~0.00344850(FGA)。此外,本研究还分析了表面和实际突变率、三联体和二联体突变率、父源和母源的突变率之间的关系。研究表明,实际突变率多大于表面突变率,而且μ1^(*)/μ2^(*)(表面突变率)的比值通常也大于μ1/μ2(实际突变率)(μ1^(*),μ1;μ2^(*),μ2分别是一步和两步的突变率),即更多的“隐性”突变被释放出来。而且父源和母源的三联体和二联体的突变率也有存在差异。随后,将这些突变率数据与已发表的中国其他汉族人口的相关研究进行比较,展现出了STR突变率的时间与区域差异。由于样本量大,本研究中还报告了一些少见的突变事件,例如同卵双胞胎突变和“假四步突变”等。综上所述,本研究通过大量数据获得了接近真实的STR突变率的估计值,不仅可为中国法医DNA数据库和群体遗传学数据库提供重要的基础数据,也对开展法医学个体识别、亲权鉴定和遗传学研究具有重要的意义。
文摘Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-year-old woman who presented with low-grade fever and weight loss of three months.On CT scanning,a mass was identified which appeared to be a hypoattenuating lesion,on ultrasonographic imaging,the mass was hypoechoic,therefore,liver abscess or hepatic metastasis from a gastrointestinal primary was initially suspected.Tumor markers such as alpha-fetoprotein,carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits.PET/CT demonstrated a large abnormal ring-like hypermetabolic focus in the right liver lobe.The lesion was resected and the histo-pathological findings were consistent with lymphoma.The patient was discharged two weeks after surgery and did not receive any further treatment.After 25 mo follow-up,she is in good health.18F-fluorodeoxyglucose PET/CT is useful in confirming the diagnosis of primary hepatic lymphoma by demonstrating no other foci with high uptake in other parts of the body.
文摘Background:In Asia,facial overfilled syndrome(FOS)can arise from iatrogenic causes involving the excessive use of filling materials,as well as physiological causes such as adipose tissue hypertrophy type,age-related type,and lacuna type.This study aimed to demonstrate the safety and effectiveness of plasma radiofrequency-assisted microsuction(PRFAMS)for improving the appearance of FOS induced by various causes.Methods:PRFAMS was performed on 84 anatomical regions of 37 female patients(including 12 with physiological causes,6 with hyaluronic acid causes,and 19 with fat causes),aged between 20 and 50 years(mean,35.9 years),who had FOS.Demographic and surgical data were collected retrospectively.Preoperative and postoperative photographs were taken,and satisfaction interviews were conducted at least six months after surgery.Results:All the patients underwent successful surgery under local or intravenous anesthesia.Only four anatomic regions showed noticeable asymmetry postoperatively,requiring a secondary operation.Postoperative skin numbness,muscle paralysis,bruising,and minor contouring irregularities improved significantly within 2–3 weeks of recovery.Additionally,five patients with longer edema periods demonstrated substantial improvement after more than five weeks.No cases of skin necrosis,thermal injury,or other serious complications related to the device or procedure were reported.Ultimately,all patients expressed satisfaction with their outcomes.Conclusion:The PRFAMS technique is a safe and effective method for treating FOS induced by various causes,while minimizing complications and ensuring high patient satisfaction.
基金supported by National Key Research and Development Program of China(2017YFB0903000)
文摘For lack of deep research on model, system structure and top-level design, the integrated system concept of energy, information and transportation networks fails to provide effective guidance for transferring the theory to practice. In this paper, with dispatching of energy flow and information flow as a focus, clean energy of wind power and solar power as carrier, battery charging & swapping station as medium and all kinds of transportation flows as entity, a five-in-one threenetwork integrated system model is built by full use of technologies of Internet of Vehicles(IOV) and Internet of things(IOT) to promote the innovative concept of three-network integration into practice, and provide a reference for future researches.
基金Supported by National Key Research and Development Program of China,No.2017YFB1104104
文摘BACKGROUND A recurrent valgus deformity was a common complication after total knee arthroplasty(TKA)in patients with valgus deformity.However,re-revision surgery for re-recurrent valgus deformity after revision TKA in patients with valgus deformity before primary TKA was uncommon.CASE SUMMARY We reported a 72-year-old female patient with two recurrent valgus deformities after TKA for a valgus knee deformity who underwent two revision surgeries to rectify the deformity.In the re-revision surgery,bone defects were successfully reconstructed by the augments and cement in combination with screws and a sleeve.An appropriate neutral alignment of the lower limb was restored by the perfect femoral entry point and the long diaphyseal cementless stem.Adequate fixation of the metaphysis and diaphysis of the femur was obtained by the sleeve and long diaphyseal cementless stem.The patient was pain-free and deformityfree for 2.5 years.CONCLUSION The management of bone defects,the choice of the stem and the femoral entry point were of vital importance in the revision or re-revision TKA for a recurrent valgus deformity.
基金funded by the Science and Technology Innovation Committee Foundation of Shenzhen,China(Nos.JCYJ20200109141403840 and ZDSYS20220527171405012)the National Natural Science Foundation of China(No.52106045)the Pearl River Talent Recruitment Program,China(No.2019CX01Z084)。
文摘Iterative coupled methods are widely used in multi-fidelity simulation of rotating components due to the simple implementation,which iteratively eliminates the errors between the computational fluid dynamics models and approximate characteristic maps.However,the convergence and accuracy of the iterative coupled method are trapped in characteristic maps.In particular,iterative steps increase sharply as the operation point moves away from the design point.To address these problems,this paper developed an auxiliary iterative coupled method that introduces the static-pressure-auxiliary characteristic maps and modification factor of mass flow into the component-level model.The developed auxiliary method realized the direct transfer of static pressure between the high-fidelity models and the component-level model.Multi-fidelity simulations of the throttle characteristics were carried out using both the auxiliary and traditional iterative coupled methods,and the simulation results were verified using the experimental data.Additionally,the consistency between the auxiliary and traditional iterative coupled methods was confirmed.Subsequently,multi-fidelity simulations of the speed and altitude characteristics were also conducted.The auxiliary and traditional iterative coupled methods were evaluated in terms of convergence speed and accuracy.The evaluation indicated that the auxiliary iterative coupled method significantly reduces iterative steps by approximately 50%at the near-choked state.In general,the auxiliary iterative coupled method is preferred as a development of the traditional iterative coupled method in the near-choked state,and the combined auxiliary-traditional iterative coupled method provides support for successful multi-fidelity simulation in far-off-design conditions.
基金supported by National Science and Technology Major Project(2013ZX09508104,2012ZX09301003-002-001)
文摘OBJECTIVE To investigate the effects of LW-AFC,a new formula derived fromLiuwei Dihuang decoction,on gut microbiota and the behavior of learning and memory of SAMP8 mice,a mouse model of Alzheimer Disease(AD),and identify the specific intestinal microbiota correlating with cognitive ability.METHODS Morris-water maze test,novel object recognition test and shuttle-box test were conducted to observe the ability of learning and memory.16S rRNA amplicon sequencing(Illumina,San Diego,CA,USA)was employed to investigate gut microbiota.RESULTS The treatment of LW-AFC improved cognitive impairments of SAMP8 mice,including spatial learning and memory ability,active avoidance response,and object recognition memory capability.Our data indicated that there were significantly 8 increased and 12 decreased operational taxonomic units(OTUs)in the gut microbiota of SAMP8 mice compared with senescence accelerated mouse resistant 1(SAMR1) strains,the control of SAMP8 mice.The treatment of LW-AFC altered 22(16 increased and 6 decreased)OTUs in SAMP8 mice and among them,15 OTUs could be reversed by LW-AFC treatment resulting in a microbial composition similar to that of SAMR1 mice.We further showed that there were7(3 negative and 4 positive correlation)OTUs significantly correlated with all the three types of cognitive abilities,at the order level,including Bacteroidales,Clostridiales,Desulfovibrionales,CW040,and two unclassified orders.LW-AFC had influences on bacterial taxa correlated with the abilities of learning and memory in SAMP8 mice and restored them to SAMR1 mice.CONCLUSION The effects of LW-AFC on improving cognitive impairments of SAMP8 mice might be via modulating intestinal microbiome and LW-AFC could be used as a potential anti-AD agent.
基金This work was supported by the National Key Projects for Fundamental Research, "Macromolecular Condensed State", of Ministry of Science and Technology, China.
文摘The effect of self absorption on the ratio of excimer to monochromophore emission intensities, I-e/I-m, has been explored by experimentally changing the solution layer thickness of the emission light path traversed in the solution in the right-angle geometry. The result shows that data obtained by front-face geometry are better than those obtained by right-angle geometry even after correction to zero solution thickness. The correction formula based on geometric optics given by Tsai and Torkelson is not adequate.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 12074368, 92165207, 12034018, and 92265113)the Innovation Program for Quantum Science and Technology (Grant No. 2021ZD0302300)+1 种基金the Anhui Province Natural Science Foundation (Grant No. 2108085J03)the USTC Tang Scholarship。
文摘Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum computing.Here, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12074368,92165207,12034018,and 62004185)the Anhui Province Natural Science Foundation (Grant No.2108085J03)the USTC Tang Scholarship。
文摘The single-shot readout data process is essential for the realization of high-fidelity qubits and fault-tolerant quantum algorithms in semiconductor quantum dots. However, the fidelity and visibility of the readout process are sensitive to the choice of the thresholds and limited by the experimental hardware. By demonstrating the linear dependence between the measured spin state probabilities and readout visibilities along with dark counts, we describe an alternative threshold-independent method for the single-shot readout of spin qubits in semiconductor quantum dots. We can obtain the extrapolated spin state probabilities of the prepared probabilities of the excited spin state through the threshold-independent method. We then analyze the corresponding errors of the method, finding that errors of the extrapolated probabilities cannot be neglected with no constraints on the readout time and threshold voltage. Therefore, by limiting the readout time and threshold voltage, we ensure the accuracy of the extrapolated probability. We then prove that the efficiency and robustness of this method are 60 times larger than those of the most commonly used method. Moreover, we discuss the influence of the electron temperature on the effective area with a fixed external magnetic field and provide a preliminary demonstration for a single-shot readout of up to 0.7K/1.5T in the future.
基金The study was supported by grants from the National Natural Science Foundation of China(81871259,81971495,82070675,81530048,82200731 and 81570562)the Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘To the Editor:SARS-CoV-2,the pathogen responsible for the pandemic of coronavirus disease 2019(COVID-19),has had profound impacts on human health,and its antagonist Paxlovid is a commonly used treatment option[1].However,treatment selection for immunosuppressed patients,such as liver recipients,remains uncertain due to potential drug interactions and the risk of immunosuppressant dosage adjustment,which can cause liver injury[2].
基金supported in part by grants from the National Natural Science Foundation of China (91631110, 81571956 and U1435222)supported by the Beijing Nova Program (Z181100006218114)
文摘Dear Editor,RNA virus features the high per-generation mutation rate,resulting in highly diversified population, which determines viral phenotypes and fitness (Domingo et al. 2012).The development of deep sequencing and bioinformatic techniques paves the way to study viral population genetics at an intrahost level, and has provided new insights into viral evolution.
基金supported by the Shanghai Municipal Commission of Health and Family Planning(20144Y0250,20134Y207)the National Natural Science Foundation of China(11302154,11272273)The Hong Kong Research Grant Council GRF(PolyU152216/14E,PolyU5326/11E)
文摘The locking plate and percutaneous crossing metallic screws and crossing absorbable screws have been used clinically to treat intra-articular calcaneal fractures, but little is known about the biomechanical differences between them. This study compared the biomechanical stability of calcaneal fractures fixed using a locking plate and crossing screws. Three-dimensional finite-element models of intact and fractured calcanei were developed based on the CT images of a cadaveric sample. Surgeries were simulated on models of Sanders type III calcaneal fractures to produce accurate postoperative models fixed by the three implants. A vertical force was applied to the superior surface of the subtalar joint to simulate the stance phase of a walking gait. This model was validated by an in vitro experiment using the same calcaneal sample. The intact calcaneus showed greater stiffness than the fixation models. Of the three fixations, the locking plate produced the greatest stiffness and the highest von Mises stress peak. The micromotion of the fracture fixated with the locking plate was similar to that of the fracture fixated with the metallic screws but smaller than that fixated with the absorbable screws. Fixation with both plate and crossing screws can be used to treat intra-articular calcaneal fractures. In general, fixation with crossing metallic screws is preferable because it provides sufficient stability with less stress shielding.
