The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-roll...The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-rolled alloys are significantly enhanced compared to those of the as-cast alloy.When subjected to three rolling passes at 450℃ and 490℃,grain refinement occurs due to dynamic recrystallization.A mixed-grain structure is formed after a single pass rolling with a substantial reduction(65%)at 490℃.The dynamic recrystallization(DRX)mechanism of the alloy during the HPR includes continuous dynamic recrystallization(CDRX),discontinuous dynamic recrystallization(DDRX),and twin-induced recrystallization(TDRX).The WE54 alloy exhibits the highest strength after three passes of HPR at 450℃,with tensile strength and yield strength of 374 and 323 MPa,respectively.The significant improvement in the mechanical properties of the alloy is primarily attributed to fine-grain strengthening,solid solution strengthening,and dislocation strengthening.展开更多
为探究不同热处理条件对驼乳、牛乳和山羊乳中氨基酸组成的影响,该研究以新鲜驼乳、牛乳和山羊乳为原料,基于HPLC技术,检测低温长时巴氏杀菌(low temperature long time,LTLT)、高温短时杀菌(high temperature short time,HTST)和超高...为探究不同热处理条件对驼乳、牛乳和山羊乳中氨基酸组成的影响,该研究以新鲜驼乳、牛乳和山羊乳为原料,基于HPLC技术,检测低温长时巴氏杀菌(low temperature long time,LTLT)、高温短时杀菌(high temperature short time,HTST)和超高温瞬时灭菌(ultra high temperature,UHT)对3种畜乳中氨基酸组成和含量的影响。结果表明,通过HPLC可以很好地检测到3种乳中的17种氨基酸,且色谱峰形尖锐、无杂峰干扰。未处理组的聚类和主成分分析结果显示,相比牛乳,驼乳和山羊乳在氨基酸组成上更相近。对氨基酸组成的分析发现,未经处理和加热处理的驼乳、牛乳和山羊乳中氨基酸含量差异显著;未经处理的3种乳中必需氨基酸总量(essential amino acid,EAA)/氨基酸总量(total amino acid,TAA)和EAA/非必需氨基酸总量(non essential amino acid,NEAA)均达到了联合国粮农组织(Food and Agriculture Organization of the United Nations,FAO)/世界卫生组织(World Health Organization,WHO)理想蛋白相应指标,而加热处理对不同乳中EAA/TAA和EAA/NEAA具有不同的影响。UHT处理的牛乳和山羊乳中氨基酸的组成差异较大;而相比牛乳和山羊乳,3种热处理条件对驼乳中氨基酸含量的影响较低。同时,热处理会不同程度地增加3种乳中的Glu、Asp、Met和Cys的含量,进而增加乳香味、提高产品的风味。展开更多
The travel-time corrections for the primary seismic phases of 72 stations in the Guangdong seismic network,relative to the 1D South China travel-time model,were determined using joint hypocentral determination(JHD)and...The travel-time corrections for the primary seismic phases of 72 stations in the Guangdong seismic network,relative to the 1D South China travel-time model,were determined using joint hypocentral determination(JHD)and statistical analysis methods.The travel-time corrections for the Pg phase of 72 stations range between-0.25 s and 0.14 s,while the corrections for the Sg phase range between 0.27 s and 0.35 s,and those for the Pn phase are between-0.86 s and 0.07 s.The spatial distribution of travel-time corrections for Pg,Sg,and Pn phases of 72 stations correlates well with the geological structure in this region.This indicates that the travel-time corrections for Pg and Sg phases are mainly caused by the discrepancy between the actual crustal velocity structure beneath the stations and the 1D South China travel-time model.These corrections empirically compensate for systematic travel-time errors arising from such discrepancies.The primary factor contributing to the travel-time corrections for the Pn phase is the Moho undulations or tilt.These corrections are intended to compensate for systematic errors in travel time caused by variations in the actual Moho.By integrating the obtained travel-time corrections into the HYPO-SAT location algorithm,test results showed an obvious improvement in location accuracy and origin time precision for explosion events.The variation of horizontal distance between repeating earthquake pairs has also improved,with 86%of the repeating earthquake pair spacing being more accurately estimated after correction.This suggests the crucial significance of travel-time correction in earthquake location,and the consideration of travel-time correction exerts a notable impact on enhancing earthquake location accuracy.展开更多
Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to all...Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota.In this study,we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat diet(HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress.Furthermore,B.adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria,and thereby decreased the production of lipopolysaccharide(LPS)and the occurrence of LPS related diseases.A high fiber intake increased the abundance of Lactobacillus and the concentrations of short chain fatty acids in obese mice,but these changes were reversed by B.adolescentis CCFM8630 treatment.In addition,targeted metabolomic analysis and microbiota relationship analysis revealed that B.adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan(Trp)to xanthurenic acid,kynurenic acid,tryptamine,indole-3-acetic acid,and indole-3-carboxaldehyde;facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon;and upregulated the expression of tight junction proteins,thereby strengthening intestinal barriers.In summary,our findings suggest that the intake of B.adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.展开更多
Objective:Grifola frondosa,a medicinal mushroom,is widely used to enhance immunity and treat cancer.Polysaccharides are its primary active components.We aimed to investigate the effects of the alkaloid G.frondosa poly...Objective:Grifola frondosa,a medicinal mushroom,is widely used to enhance immunity and treat cancer.Polysaccharides are its primary active components.We aimed to investigate the effects of the alkaloid G.frondosa polysaccharide(GFP)extract on immunity and gut microbiota.Methods:Alkaloid GFP was extracted using an alkaline extraction method,followed by hollow-fiber microfiltration.The molecular weight of alkaloid GFP was determined by high-performance gel permeation chromatography(HPGPC).Monosaccharide composition was analyzed by pre-column derivatization combined with high-performance liquid chromatography(HPLC).Methylation analysis was performed to characterize glycosidic linkages in alkaloid GFP.The immune function of alkaloid GFP was assessed in a cyclophosphamide(CTX)-induced immunosuppressive mouse model.Splenic lymphocyte proliferation,macrophage phagocytic capacity,and natural killer(NK)cell cytotoxicity were evaluated.The effect of alkaloid GFP on gut microbiota was assessed by 16S rRNA sequencing.Results:The molecular weight distribution of alkaloid GFP ranged from 17 to 18 kDa.The alkaloid GFP contained aβ-(1→6)-glucan backbone branched at O-3 byβ-1,3-D-Glcp.Oral administration of alkaloid GFP mitigated the effects of CTX on spleen index,splenic lymphocyte proliferation,and peritoneal macrophage phagocytosis.Additionally,alkaloid GFP improved the gut microbiota composition of immunosuppressed mice,increasing the relative abundances of Ligilactobacillus and Lactobacillus.Conclusions:Alkaloid GFP demonstrated immune-enhancing effects and gut microbiota regulatory activity,providing a basis for developing related health food ingredients.展开更多
基金financially supported by the Natural Science Basic Research Program of Shaanxi Province,China(No.2023-JC-QN-0581)Advanced Power Specialty,China(No.YK22C-9)。
文摘The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-rolled alloys are significantly enhanced compared to those of the as-cast alloy.When subjected to three rolling passes at 450℃ and 490℃,grain refinement occurs due to dynamic recrystallization.A mixed-grain structure is formed after a single pass rolling with a substantial reduction(65%)at 490℃.The dynamic recrystallization(DRX)mechanism of the alloy during the HPR includes continuous dynamic recrystallization(CDRX),discontinuous dynamic recrystallization(DDRX),and twin-induced recrystallization(TDRX).The WE54 alloy exhibits the highest strength after three passes of HPR at 450℃,with tensile strength and yield strength of 374 and 323 MPa,respectively.The significant improvement in the mechanical properties of the alloy is primarily attributed to fine-grain strengthening,solid solution strengthening,and dislocation strengthening.
文摘为探究不同热处理条件对驼乳、牛乳和山羊乳中氨基酸组成的影响,该研究以新鲜驼乳、牛乳和山羊乳为原料,基于HPLC技术,检测低温长时巴氏杀菌(low temperature long time,LTLT)、高温短时杀菌(high temperature short time,HTST)和超高温瞬时灭菌(ultra high temperature,UHT)对3种畜乳中氨基酸组成和含量的影响。结果表明,通过HPLC可以很好地检测到3种乳中的17种氨基酸,且色谱峰形尖锐、无杂峰干扰。未处理组的聚类和主成分分析结果显示,相比牛乳,驼乳和山羊乳在氨基酸组成上更相近。对氨基酸组成的分析发现,未经处理和加热处理的驼乳、牛乳和山羊乳中氨基酸含量差异显著;未经处理的3种乳中必需氨基酸总量(essential amino acid,EAA)/氨基酸总量(total amino acid,TAA)和EAA/非必需氨基酸总量(non essential amino acid,NEAA)均达到了联合国粮农组织(Food and Agriculture Organization of the United Nations,FAO)/世界卫生组织(World Health Organization,WHO)理想蛋白相应指标,而加热处理对不同乳中EAA/TAA和EAA/NEAA具有不同的影响。UHT处理的牛乳和山羊乳中氨基酸的组成差异较大;而相比牛乳和山羊乳,3种热处理条件对驼乳中氨基酸含量的影响较低。同时,热处理会不同程度地增加3种乳中的Glu、Asp、Met和Cys的含量,进而增加乳香味、提高产品的风味。
基金supported by the National Key Research and Development Program of China(2023YFC3008605)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(311021002)the Seismological Research Foundation for Youths of Guangdong Earthquake Agency(Open Funding Project of Key Laboratory of Earthquake Monitoring and Disaster Mitigation Technology,China Earthquake Administration)(GDDZY202309)。
文摘The travel-time corrections for the primary seismic phases of 72 stations in the Guangdong seismic network,relative to the 1D South China travel-time model,were determined using joint hypocentral determination(JHD)and statistical analysis methods.The travel-time corrections for the Pg phase of 72 stations range between-0.25 s and 0.14 s,while the corrections for the Sg phase range between 0.27 s and 0.35 s,and those for the Pn phase are between-0.86 s and 0.07 s.The spatial distribution of travel-time corrections for Pg,Sg,and Pn phases of 72 stations correlates well with the geological structure in this region.This indicates that the travel-time corrections for Pg and Sg phases are mainly caused by the discrepancy between the actual crustal velocity structure beneath the stations and the 1D South China travel-time model.These corrections empirically compensate for systematic travel-time errors arising from such discrepancies.The primary factor contributing to the travel-time corrections for the Pn phase is the Moho undulations or tilt.These corrections are intended to compensate for systematic errors in travel time caused by variations in the actual Moho.By integrating the obtained travel-time corrections into the HYPO-SAT location algorithm,test results showed an obvious improvement in location accuracy and origin time precision for explosion events.The variation of horizontal distance between repeating earthquake pairs has also improved,with 86%of the repeating earthquake pair spacing being more accurately estimated after correction.This suggests the crucial significance of travel-time correction in earthquake location,and the consideration of travel-time correction exerts a notable impact on enhancing earthquake location accuracy.
基金supported by the National Natural Science Foundation of China(32272332,32021005,31820103010)the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP22006,JUSRP51501)the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province.
文摘Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota.In this study,we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat diet(HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress.Furthermore,B.adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria,and thereby decreased the production of lipopolysaccharide(LPS)and the occurrence of LPS related diseases.A high fiber intake increased the abundance of Lactobacillus and the concentrations of short chain fatty acids in obese mice,but these changes were reversed by B.adolescentis CCFM8630 treatment.In addition,targeted metabolomic analysis and microbiota relationship analysis revealed that B.adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan(Trp)to xanthurenic acid,kynurenic acid,tryptamine,indole-3-acetic acid,and indole-3-carboxaldehyde;facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon;and upregulated the expression of tight junction proteins,thereby strengthening intestinal barriers.In summary,our findings suggest that the intake of B.adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.
基金supported by Infinitus Co.,Ltd(2019009)the Scientific and Technologic Foundation of Jilin Province(No.20230202050NC).
文摘Objective:Grifola frondosa,a medicinal mushroom,is widely used to enhance immunity and treat cancer.Polysaccharides are its primary active components.We aimed to investigate the effects of the alkaloid G.frondosa polysaccharide(GFP)extract on immunity and gut microbiota.Methods:Alkaloid GFP was extracted using an alkaline extraction method,followed by hollow-fiber microfiltration.The molecular weight of alkaloid GFP was determined by high-performance gel permeation chromatography(HPGPC).Monosaccharide composition was analyzed by pre-column derivatization combined with high-performance liquid chromatography(HPLC).Methylation analysis was performed to characterize glycosidic linkages in alkaloid GFP.The immune function of alkaloid GFP was assessed in a cyclophosphamide(CTX)-induced immunosuppressive mouse model.Splenic lymphocyte proliferation,macrophage phagocytic capacity,and natural killer(NK)cell cytotoxicity were evaluated.The effect of alkaloid GFP on gut microbiota was assessed by 16S rRNA sequencing.Results:The molecular weight distribution of alkaloid GFP ranged from 17 to 18 kDa.The alkaloid GFP contained aβ-(1→6)-glucan backbone branched at O-3 byβ-1,3-D-Glcp.Oral administration of alkaloid GFP mitigated the effects of CTX on spleen index,splenic lymphocyte proliferation,and peritoneal macrophage phagocytosis.Additionally,alkaloid GFP improved the gut microbiota composition of immunosuppressed mice,increasing the relative abundances of Ligilactobacillus and Lactobacillus.Conclusions:Alkaloid GFP demonstrated immune-enhancing effects and gut microbiota regulatory activity,providing a basis for developing related health food ingredients.
