Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived f...Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived from individual strongly convex functions of each agent,considering both input disturbances and network communication constraints.A novel predefined-time optimal formation control(PTOFC)algorithm is presented,ensuring agent state convergence to optimal formation positions within an adjustable settling time.Through the integration of an integral sliding mode technique,disturbances are effectively countered.A representative numerical example highlights the effectiveness and robustness of the developed approach.展开更多
In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtained using structure-guided optimization method and further screened for their insecticidal activiti...In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtained using structure-guided optimization method and further screened for their insecticidal activities, in the basis of the core structures of the two active compounds N-（3-methoxyphenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6e） and N-（4-（tert-butyl）phenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6i）, previously presented by us. The chemical structures of the title compounds were identified by spectral analyses. The preliminary bioassay results indicated that one among the synthesized pyrazole derivatives, compound 34, endowed with good activity against Mythimna Separata at 10 mg/L, which was equal to that displayed by the positive control tebufenozide. In addition, examples of molecular docking and molecular dynamics studies demonstrated that 34 may be the potential inhibitor to Ec R and its docking conformation was similar to that of tebufenozide. In addition, increasing the hydrophobic effect and considering the suitable bulk effect on pyrazole ring are beneficial to the inhibiting activity to Ec R and activity in vivo.展开更多
The utility of artificial microRNAs（amiRNAs） to induce loss of gene function has been reported for many plant species,but expression efficiency of the different amiRNA constructs in different transgenic plants was l...The utility of artificial microRNAs（amiRNAs） to induce loss of gene function has been reported for many plant species,but expression efficiency of the different amiRNA constructs in different transgenic plants was less predictable,In this study,expressions of amiRNAs through the gene backbone of Arabidopsis miR168a were examined by both Agrobacterium-mediated transient expression and stable plant genetic transformation.A corresponding trend in expression of amiRNAs by the same amiRNA constructs between the transient and the stable expression systems was observed in the experiments.Plant genetic transformation of the constructs that were highly expressible in amiRNAs in the transient agro-infiltration assays resulted in generation of transgenic lines with high level of amiRNAs.This provides a simple method for rapid and effective selection of amiRNA constructs used for a time-consuming genetic transformation in plants.展开更多
In recent year, a multipole graphical model, which is constructed by using individual MCG measurements based on the equivalent current dipole (ECD) or equivalent magnetic dipole (EMD) source model, has been developed ...In recent year, a multipole graphical model, which is constructed by using individual MCG measurements based on the equivalent current dipole (ECD) or equivalent magnetic dipole (EMD) source model, has been developed with the aim of instead of the volume conductor model in the inverse solution of cardiac source estimation. In this paper, two graphical models known as the double magnetic dipole source model (DMD) and the dual current dipole source model (DCD) are introduced. The simulation results and the comparison of two evaluation criteria, i.e. average GOF (Goodness of Fit) and average RMSE (Root Mean Square Error), indicated that both multipole graphical models can provide a good representation of dynamic magnetic field from the noninvasively detected MCG- recordings, even when the heart is of the dilation. The time-averaged sources localization error and the RMSE for both models are demonstrated, and the characteristic of two multipole models is discussed.展开更多
Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments.The physical signals of structural anisotropy o...Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments.The physical signals of structural anisotropy offer significant potential for orchestrating multicellular regulation through physical contact and cellular mechano-sensing pathways,irrespective of cell type.In this study,we developed a highly oriented anisotropic nanofiber hydrogel designed to provide directional guidance for cellular extension and cytoskeletal organization,thereby achieving pronounced multicellular modulation,including shape-induced polarization of macrophages,morphogenetic maturation of Schwann cells,oriented extracellular matrix(ECM)deposition by fibroblasts,and enhanced vascularization by endothelial cells.Additionally,we incorporated a VEGF-mimicking peptide to further reinforce angiogenesis,a pivotal phase that interlocks with immune regulation,neurogenesis,and tissue regeneration,ultimately contributing to optimized inter-microenvironmental crosstalk.In vivo studies validated that the anisotropic bioactive nanofiber hydrogel effectively accelerated diabetic wound healing by harnessing the triadic synergy of the immune-angiogenic-neurogenic microenvironments.Our findings highlight the promising potential of combining physical and bioactive signals for the modulation of various cell types and the refinement of the multidimensional microenvironment,offering a novel strategy for diabetic wound healing.展开更多
文摘为研究承载型60°斜十字全熔透焊接接头(oblique cruciform full-penetration welded joints,OCFWJs)局部应力分布及疲劳性能,设计3个试验模型完成3种名义应力幅水平下的疲劳试验,得到试件疲劳破坏时的循环次数.利用ABAQUS软件建立60°OCFWJs有限元模型,计算得到焊趾处热点正应力、热点剪应力及等效热点应力.基于规范中的名义应力S-N曲线和热点应力S-N曲线,分别采用名义主应力法、等效热点应力法和相互作用方程方法对拉—剪联合作用下60°OCFWJs疲劳寿命进行了评估.结果表明,采用名义应力幅、名义拉应力幅或名义剪应力幅均无法对60°OCFWJs疲劳寿命进行可靠评估.依据国际焊接学会(International Institute of Welding,IIW)规范无论采用热点拉应力幅或热点剪应力幅也无法对60°OCFWJs疲劳寿命进行可靠评估.按欧洲钢结构设计规范Eurocode3相互作用方程方法预测的疲劳寿命远低于试验值,按等效热点应力方法预测的疲劳寿命与试验值符合良好.
基金supported by the National Natural Science Foundation of China(62373162,U24A20268,624B2055)the Shenzhen Science and Technology Program(JCYJ 20240813114007010)the Knowledge Innovation Program of Wuhan-Basic Research(2023010201010100).
文摘Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived from individual strongly convex functions of each agent,considering both input disturbances and network communication constraints.A novel predefined-time optimal formation control(PTOFC)algorithm is presented,ensuring agent state convergence to optimal formation positions within an adjustable settling time.Through the integration of an integral sliding mode technique,disturbances are effectively countered.A representative numerical example highlights the effectiveness and robustness of the developed approach.
基金supported by the National Natural Science Foundation of China (No. 21272265)the National High Technology Research and Development Program of China (No.2011AA10A204)
文摘In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtained using structure-guided optimization method and further screened for their insecticidal activities, in the basis of the core structures of the two active compounds N-（3-methoxyphenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6e） and N-（4-（tert-butyl）phenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6i）, previously presented by us. The chemical structures of the title compounds were identified by spectral analyses. The preliminary bioassay results indicated that one among the synthesized pyrazole derivatives, compound 34, endowed with good activity against Mythimna Separata at 10 mg/L, which was equal to that displayed by the positive control tebufenozide. In addition, examples of molecular docking and molecular dynamics studies demonstrated that 34 may be the potential inhibitor to Ec R and its docking conformation was similar to that of tebufenozide. In addition, increasing the hydrophobic effect and considering the suitable bulk effect on pyrazole ring are beneficial to the inhibiting activity to Ec R and activity in vivo.
基金supported by the Ministry of Education of China and Agriculture and Agri-Food Canada(MOE-AAFC) PhD student research program
文摘The utility of artificial microRNAs（amiRNAs） to induce loss of gene function has been reported for many plant species,but expression efficiency of the different amiRNA constructs in different transgenic plants was less predictable,In this study,expressions of amiRNAs through the gene backbone of Arabidopsis miR168a were examined by both Agrobacterium-mediated transient expression and stable plant genetic transformation.A corresponding trend in expression of amiRNAs by the same amiRNA constructs between the transient and the stable expression systems was observed in the experiments.Plant genetic transformation of the constructs that were highly expressible in amiRNAs in the transient agro-infiltration assays resulted in generation of transgenic lines with high level of amiRNAs.This provides a simple method for rapid and effective selection of amiRNA constructs used for a time-consuming genetic transformation in plants.
文摘In recent year, a multipole graphical model, which is constructed by using individual MCG measurements based on the equivalent current dipole (ECD) or equivalent magnetic dipole (EMD) source model, has been developed with the aim of instead of the volume conductor model in the inverse solution of cardiac source estimation. In this paper, two graphical models known as the double magnetic dipole source model (DMD) and the dual current dipole source model (DCD) are introduced. The simulation results and the comparison of two evaluation criteria, i.e. average GOF (Goodness of Fit) and average RMSE (Root Mean Square Error), indicated that both multipole graphical models can provide a good representation of dynamic magnetic field from the noninvasively detected MCG- recordings, even when the heart is of the dilation. The time-averaged sources localization error and the RMSE for both models are demonstrated, and the characteristic of two multipole models is discussed.
基金financial support from the Beijing Natural Science Foundation of China(Grant No.QY23102,2254091,and L234075)the National Natural Science Foundation of China(Grant No.32271414,32401140,and 82301560).
文摘Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments.The physical signals of structural anisotropy offer significant potential for orchestrating multicellular regulation through physical contact and cellular mechano-sensing pathways,irrespective of cell type.In this study,we developed a highly oriented anisotropic nanofiber hydrogel designed to provide directional guidance for cellular extension and cytoskeletal organization,thereby achieving pronounced multicellular modulation,including shape-induced polarization of macrophages,morphogenetic maturation of Schwann cells,oriented extracellular matrix(ECM)deposition by fibroblasts,and enhanced vascularization by endothelial cells.Additionally,we incorporated a VEGF-mimicking peptide to further reinforce angiogenesis,a pivotal phase that interlocks with immune regulation,neurogenesis,and tissue regeneration,ultimately contributing to optimized inter-microenvironmental crosstalk.In vivo studies validated that the anisotropic bioactive nanofiber hydrogel effectively accelerated diabetic wound healing by harnessing the triadic synergy of the immune-angiogenic-neurogenic microenvironments.Our findings highlight the promising potential of combining physical and bioactive signals for the modulation of various cell types and the refinement of the multidimensional microenvironment,offering a novel strategy for diabetic wound healing.
