Extracellular adenosine 5'-triphosphate (ATP) has been established as a neurotransmitter or neuromodulator in both the periphe- ral and central nervous systems,in addition to diverse intracellular roles of it.P2 p...Extracellular adenosine 5'-triphosphate (ATP) has been established as a neurotransmitter or neuromodulator in both the periphe- ral and central nervous systems,in addition to diverse intracellular roles of it.P2 purinergic receptors,the receptors of ATP,are classified into two subfamilites,ionotropic P2X and metabotropic P2Y receptors.Recent studies suggest that ATP play a significant role in facilitating perpheral and spinal nociceptive transmission via P2X receptors.However,we demonstrated that at the supraspinal level P2X receptor agonists produce an antinociception.On the other hand,the activation of some subtypes of P2Y receptors in the spinal cord caused inhibitory effects on nociceptive transmission.Thus,P2X and P2Y receptors are suggested to be related to diverse roles in nociceptive functions at peripheral,spinal and supraspinal levels.We would like to take an overview about the significance of P2X and P2Y receptors in nociception and antinociception.展开更多
文摘Extracellular adenosine 5'-triphosphate (ATP) has been established as a neurotransmitter or neuromodulator in both the periphe- ral and central nervous systems,in addition to diverse intracellular roles of it.P2 purinergic receptors,the receptors of ATP,are classified into two subfamilites,ionotropic P2X and metabotropic P2Y receptors.Recent studies suggest that ATP play a significant role in facilitating perpheral and spinal nociceptive transmission via P2X receptors.However,we demonstrated that at the supraspinal level P2X receptor agonists produce an antinociception.On the other hand,the activation of some subtypes of P2Y receptors in the spinal cord caused inhibitory effects on nociceptive transmission.Thus,P2X and P2Y receptors are suggested to be related to diverse roles in nociceptive functions at peripheral,spinal and supraspinal levels.We would like to take an overview about the significance of P2X and P2Y receptors in nociception and antinociception.
