Tomato is one of the most essential vegetable crops worldwide,with the highest annual production rate of all agricultural staples(Kimura and Sinha,2008).Long-term domestication of tomatoes has led to the selection of ...Tomato is one of the most essential vegetable crops worldwide,with the highest annual production rate of all agricultural staples(Kimura and Sinha,2008).Long-term domestication of tomatoes has led to the selection of favorable agronomic traits that often come at the expense of stress resistance.To identify potential genetic targets for improved stress tolerance,whole-genome sequencing(WGS)has been applied to wild and cultivated accessions.展开更多
Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and ca...Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and caused widespread devastation to society and infrastructure.However,the drivers of this record-breaking flood remain unexplored.Here,we show that the record-breaking floods were contributed by both long-term climate warming and interannual variability,with multiple climatic drivers at play across the synoptic to seasonal timescales.First,the heavy snowmelt in March 2024 was associated with above-normal preceding winter snow accumulation.Second,extreme rainfall was at a record-high during March 2024,in line with its increasing trend under climate warming.Third,the snowmelt and extreme rainfall in March were compounded by record-high soil moisture conditions in the preceding winter,which was a result of interannual variability and related to excessive winter rainfall over Central Asia.As climate warming continues,the interplay between the increasing trend of extreme rainfall,interannual variations in soil moisture pre-conditions,as well as shifting timing and magnitudes of spring snowmelt,will further increase and complicate spring flooding risks.This is a growing and widespread challenge for the mid-to high-latitude regions.展开更多
Under global warming,Asian glaciers have experienced accelerated retreats and increased mass loss.Utilizing data from the World Glacier Monitoring Service(WGMS),this study selected 16 representative glaciers across As...Under global warming,Asian glaciers have experienced accelerated retreats and increased mass loss.Utilizing data from the World Glacier Monitoring Service(WGMS),this study selected 16 representative glaciers across Asia to analyse the temporal and spatial changes of glacial mass balance(GMB),equilibrium line altitude(ELA),and accumulation area ratio(AAR)in the past several decades.Based on structural equation modelling and correlation analysis,we evaluated the responses of glacier change to climate change.The results indicated that 14 glaciers experienced mass loss,with the Parlung No.94 Glacier exhibiting a severe loss and significant retreat.In contrast,the Abramov,Muztag Ata No.15,Chhota Shigri,and Yala glaciers showed an increase in GMB,consistent with the"Karakoram Glacier anomaly".Additionally,a latitudinal gradient was observed,with ELA decreasing,AAR rising,and the rate and magnitude of glacier mass loss decreasing as latitude increased.GMB was negatively correlated with ELA and positively correlated with AAR,with the Vodopaniy No.125 Glacier showing the highest sensitivity to GMB variations.GMB fluctuation is influenced by energy(surface net solar radiation,air temperature)and precipitation.The significant decline of the Parlung No.94 Glacier was ascribed to rising temperature.From west to east in the Himalayas,the negative effects of energy on GMB decreased,with positive precipitation having a particularly large impact on the Yala Glacier.The Chhota Shigri,Djankuat,and Hamaguri Yuki glaciers displayed different states of mass balance due to the influence of climatic factors.This study pro-vides valuable insights into the comprehensive understanding of glacier change in Asia and its responses to climate change.展开更多
The exchange of inorganic nutrients at the coastal sediment-water interface(SWI)plays a crucial role in regulating the nutrient budget in overlying water.The related studies mainly focus on the mid-to high-latitude re...The exchange of inorganic nutrients at the coastal sediment-water interface(SWI)plays a crucial role in regulating the nutrient budget in overlying water.The related studies mainly focus on the mid-to high-latitude regions,leaving a significant gap in the quantitative assessment of nutrient exchange and environmental controls at the SWI in lowlatitude coastal regions.We quantitatively assess the exchange of inorganic nutrients at the SWI in three tropical bays(Dongzhai Harbor,Xiaohai Lagoon,Qinglan Harbor).Sediments act as a source of ammonium,phosphate,and silicate,but for nitrate,sediments can be both a source and sink,although with substantial spatial and temporal variations in their fluxes.Labile organic matter is a critical regulator for the fluxes of inorganic nutrients at the SWI.The sedimentary nutrients input with high N/P molar ratio will alter the nutrient stoichiometry to mitigate the nitrogen limitation in coastal waters.However,the internal sediment release in these tropical bays plays a relative weak role in contributing to the nutrient addition in comparison with the other external nutrient sources including riverine input,submarine groundwater discharge,and atmospheric deposition.According to the global compilation on SWI nutrient fluxes,we propose that water column primary production and external inputs to interpret the variation in exchange and fluxes of nutrients at the SWI in different ecosystems.Such a conceptual understanding of these chain biogeochemical processes involving external nutrient input,primary production,particulate organic matter settling,and the accumulation and release of inorganic nutrients in sediments will be helpful for the scientific-based pollution prevent and control in coastal waters.展开更多
AIM: To investigate the effect of albuminuria on diabetic macular edema(DME) and the possible association between baseline urinary albumin excretion(UAE) and intravitreal conbercept(IVC) treatment frequency in DME pat...AIM: To investigate the effect of albuminuria on diabetic macular edema(DME) and the possible association between baseline urinary albumin excretion(UAE) and intravitreal conbercept(IVC) treatment frequency in DME patients. METHODS: In this hospital-based retrospective study, a total of 350 in-patients with type 2 diabetes mellitus were recruited and their clinical records were reviewed. Thereafter, 52 patients identified with severe non-proliferative diabetic retinopathy(NPDR) combined with albuminuria were divided into the microalbuminuria(UAE 30-300 mg/24 h) and macroalbuminuria(UAE>300 mg/24 h) groups, which were compared and analyzed by both independent sample t-test and Chi-square test. Correlations between the systemic variables and the central foveal thickness(CFT) were evaluated using Spearman’s correlation and linear regression analyses. Of the 52 patients with centerinvolved DME, 43 received an initial combined injection of conbercept(0.5 mg/0.05 mL) and triamcinolone acetonide(1 mg/0.05 mL), followed by an IVC injection, as needed. The relationship between baseline UAE and number of IVCinjections during the first year of treatment was analyzed using Spearman’s partial correlation.RESULTS: Of 350 patients, a higher incidence of DME was observed in severe non-proliferative retinopathy(NPDR) patients than that observed in other groups. By dividing the 52 patients with severe NPDR into the micro-and macro-albuminuria subgroups, significant differences in CFT, systolic blood pressure, total cholesterol and serum creatinine levels, and UAE were revealed. Furthermore, a positive liner correlation between the UAE and CFT was found. Finally, the partial correlation coefficient adjusted for either the CFT or UAE indicated that both parameters directly correlated with the number of IVC injections administered during the 12 mo of follow-up. CONCLUSION: Generally, macular edema occurred in patients with severe NPDR, for whom the UAE is an independent risk predictor of DME. The baseline UAE and CFT predicted the treatment frequency of IVC injections administered in the first year for eyes with DME.展开更多
Two new highly oxygenated limonoids,flexuosoids A(1)and B(2),and three new arylnaphthalene lignan glycosides,phyllanthusmins D–F(3–5),were isolated from the roots of Phyllanthus flexuosus,in addition to three known ...Two new highly oxygenated limonoids,flexuosoids A(1)and B(2),and three new arylnaphthalene lignan glycosides,phyllanthusmins D–F(3–5),were isolated from the roots of Phyllanthus flexuosus,in addition to three known lignans,phyllanthusmin C,arabelline,and(?)-diasyringaresinol.Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods.Compounds 1 and 2,two new decaoxygenated limonoids with a C-19/29 lactol bridge and heptaoxygenated substituents at C-1,C-2,C-3,C-7,C-11,C-17,and C-30,represent the second example of limonoids in the Euphorbiaceae family.Most of the isolates were tested for their antifeedant,anti-herpes simplex virus 1,and cytotoxic activities.The new limonoids 1 and 2 showed promising antifeedant activity against the beet army worm(Spodoptera exigua)with EC50 values of 25.1 and 17.3 lg/cm2,respectively.In addition,both of them displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line,along with the known lignan glycoside,phyllanthusmin C,with the IC50 values of 11.5(1),8.5(2),and 7.8(phyllanthusmin C)lM,respectively.展开更多
BACKGROUND Inflammatory myofibroblastic tumor(IMT)is a distinct tumor with a low incidence rate,which can be diagnosed at any age with a predilection for children and adolescents.Although IMT is visible in any tissues...BACKGROUND Inflammatory myofibroblastic tumor(IMT)is a distinct tumor with a low incidence rate,which can be diagnosed at any age with a predilection for children and adolescents.Although IMT is visible in any tissues and organs,it is more commonly found in the lungs.The clinical and radiological manifestations of IMT lack specificity,hence resulting in frequent misdiagnosis.Surgical resection is currently the main therapeutic approach for IMT.Only scarce cases of IMT treated with metformin have been reported.Here we report the case of an IMT patient with partial penile resection treated with metformin.CASE SUMMARY A 1-year-old boy was born with a shorter penis,and his foreskin could not be completely turned over.When he was 6 month old,a well-circumscribed mass on the glans was found,while it did not attract the attention of his parents.The mass gradually increased in size over time before he was admitted to the hospital,where physical examination was performed.It was revealed that the glans hidden behind the foreskin had a mass with a diameter of about 4 cm surrounding the penis.The mass appeared to be hard with a smooth surface and poor mobility.The two testicles examined at the bottom of the scrotum were revealed to have a normal size.Magnetic resonance imaging showed a tumor with rich blood supply encircling the cavernosum with a size of 3.5 cm×2.1 cm×2.0 cm.A thick urinary line was found without urine dripping,urgency,and urodynia.Surgical treatment was performed.During the operation,it was observed that the mass had surrounded and invaded the cavernosum without obvious boundaries,and that the tumor occupied about one-half of the penis cross-section as well as infiltrated more than one-half of the glans.In addition,the tumor had caused urethral invasion and anterior urethrostenosis.With the intention of keeping the glans and cavernosum,the tumor at the anterior urethra was partially removed,leaving about 30%of the tumor mass.Pathology analysis demonstrated that the tumor was rich in spindle cells with infiltration of inflammatory cells.Immunohistochemistry analysis indicated that the cells were positive for CD4,CD99,Ki67,BCL2,and CD68,and negative for ALK,MyoG,S100,SOX10,PR,and EMA.Hence,the tumor was diagnosed as IMT.Metformin was prescribed for the patient after the operation,following which an oral dose of 7 mg/kg was given three times a day after meals.Three months later,it was observed that the remaining tumor had completely disappeared and that the urination process from the urethra opening had resumed normal.In addition,there were no side effects observed.There was also no tumor recurrence.The growth and development of the boy were unaffected as a result of the treatment.CONCLUSION The tumor was observed to have completely disappeared after treatment with metformin.Our finding is of great significance to facilitate future clinical treatment with IMT.展开更多
Objective:To study the effect of adjuvant Shuxuening injection therapy on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.Methods:Patients with acute exacerbation of COPD who rec...Objective:To study the effect of adjuvant Shuxuening injection therapy on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.Methods:Patients with acute exacerbation of COPD who received Shuxuening injection combined with conventional western medicine treatment in our hospital between May 2014 and December 2015 were selected for study, and before treatment as well as 1 week, 2 weeks, 3 weeks and 4 weeks after treatment, peripheral blood mononuclear cells were collected to determine TLRs expression, and serum was collected to determine the levels of inflammatory cytokines and airway remodeling molecules.Results:1 week, 2 weeks, 3 weeks and 4 weeks after treatment, TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells as well as TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels in serum of patients with COPD were significantly lower than those before treatment, and TLR3, TLR7, TLR8 and TLR9 mRNA expression were not significantly different from those before treatment;TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells were positively correlated with serum TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels. Conclusion:Adjuvant Shuxuening injection therapy has significant inhibitory effect on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.展开更多
The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.
Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines stil...Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.展开更多
Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and ta...Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.展开更多
The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exace...The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exacerbated this issue by increasing selective pressure within bacterial populations.This study aimed to investigate the association between carbapenem consumption and resistance rates in four priority Gram-negative bacteria:Escherichia coli(EC),Klebsiella pneumoniae(KP),Acinetobacter baumannii(AB),and Pseudomonas aeruginosa(PA).Retrospective data were collected from the First Affiliated Hospital of Zhengzhou University,covering the period from January 2010 to December 2022.Trends in carbapenem consumption and resistance were analyzed using the Mann-Kendall test to assess statistical significance and the Sen’s slope(SS)estimator to determine the magnitude of change.Correlations between carbapenem use and bacterial resistance rates were evaluated via Spearman correlation analysis.Over the study period,the consumption of meropenem,imipenem,biapenem,and total carbapenems exhibited a significant upward trend(|Z|>1.96,SS>0).Correspondingly,the resistance rates of EC and KP to meropenem and imipenem also increased significantly(|Z|>1.96,SS>0).A strong positive correlation was observed between the resistance rate of EC to meropenem and the defined daily doses(DDDs)of meropenem(r=0.732,P<0.05)and between EC resistance to imipenem and its DDDs(r=0.49,P<0.05).Similar significant correlations were identified for KP.However,no significant associations were found between carbapenem resistance in AB or PA and carbapenem consumption.These findings underscored the strong correlation between carbapenem use and the resistance rates of EC and KP,highlighting the urgent need for stringent control and stewardship of carbapenem use in clinical settings to mitigate or delay the development of bacterial drug resistance.展开更多
This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each...This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.展开更多
The vectorial evolution of light polarization can reveal the microstructure and anisotropy of a medium beyond what can be obtained from measuring light intensity alone.However,polarization imaging in reflection geomet...The vectorial evolution of light polarization can reveal the microstructure and anisotropy of a medium beyond what can be obtained from measuring light intensity alone.However,polarization imaging in reflection geometry,which is ubiquitous and often preferred in diverse applications,has often suffered from poor and even incorrect characterization of anisotropic media.We present reciprocal polarization imaging of complex media in reflection geometry with the reciprocal polar decomposition of backscattering Mueller matrices enforcing reciprocity.We demonstrate that reciprocal polarization imaging of complex chiral and anisotropic media ac-curately quantifies their anisotropic properties in reflection geometry,whereas traditional approaches encounter difficulties and produce inferior and often erroneous results from the violation of reciprocity.In particular,reciprocal polarization imaging provides a consistent characterization of complex media of different thicknesses,accurately measures the optical activity and glucose concentration of turbid media in reflection,and discriminates between cancerous and normal tissue with even stronger contrast than forward measurement.Reciprocal polarization imaging promises broad applications of polarization optics ranging from remote sensing to bio-medicine in reflection geometries,especially in in vivo biomedical imaging,where reflection is the only feasible geometry.展开更多
Gossypium raimondii(2n=2x=26,D_(5)),an untapped wild species,is the putative progenitor of the D-subgenome of G.hirsutum(2n=4x=52,AD_(1)),an extensively cultivated species.Here,we developed a G.hirsutum(recipient)–G....Gossypium raimondii(2n=2x=26,D_(5)),an untapped wild species,is the putative progenitor of the D-subgenome of G.hirsutum(2n=4x=52,AD_(1)),an extensively cultivated species.Here,we developed a G.hirsutum(recipient)–G.raimondii(donor)introgression population to exploit the favorable QTLs/genes and mapped potential quantitative trait loci(QTLs)from wild cotton species.The introgression population consisted of 256 lines with an introgression rate of 52.33%for the G.raimondii genome.The introgression segment length range was 0.03–19.12 Mb,with an average of 1.22 Mb.The coverage of total introgression fragments from G.raimondii was 386.98 Mb.Further genome-wide association analysis(Q+K+MLM)and QTL mapping(RSTEP-LRT)identified 59 common QTLs,including 14 stable QTLs and six common QTL(co-QTL)clusters,and one hotspot of micronaire(MIC).The common QTLs for seed index all showed positive additive effects,while the common QTLs for boll weight all had negative additive effects,indicating that the linkage between seed index and boll weight could be broken.QTLs for lint percentage showed positive effects and could be beneficial for improving cotton yield.Most QTLs for fiber quality had negative additive effects,implying these QTLs were domesticated/improved in G.hirsutum.A few fiber quality QTLs showed positive additive effects,so they could be used to improve cotton fiber quality.The introgression lines developed could be useful for molecular marker-assisted breeding and mapping QTLs precisely for mining desirable genes from the wild species G.raimondii.Such genes can improve cultivated cotton in the future through a designbreeding approach.展开更多
Most of acridine based thermally activated delayed fluorescence(TADF)emitters are characterized by advantageous reverse intersystem crossing(RISC)rate(kRISCs)due to the perpendicular orientation of the acridine donor ...Most of acridine based thermally activated delayed fluorescence(TADF)emitters are characterized by advantageous reverse intersystem crossing(RISC)rate(kRISCs)due to the perpendicular orientation of the acridine donor to the acceptor moiety,but suffer from a poor radiation rate(kr)typically in the order of 10^(6) s^(−1).Herein,two sky blue TADF emitters 3,6-DMAC-AD-Py and 3,6-SFAC-AD-Py were developed by linking acridine(DMAC)and spiro-fluorene-acridine(SFAC)donors to 10-(pyridin-2-yl)acridin-9(10H)-one(AD-Py)acceptor.Larger SFAC and electron-deficient pyridyl groups are deliberately incorporated in 3,6-SFACAD-Py since the unique through-space interaction between them is designed to drive the rotation of inner acridine ring in SFAC for enhancing frontier molecular orbitals overlap while keeping a decent TADF behavior.Thus,the kr of 3,6-SFACAD-Py is increased to 1.5×10^(7) s^(−1).Simultaneously,SFAC donors improve spin orbital coupling strength and reduce the energy gaps,generating kRISC of 1.8×10^(6) s^(−1).This is the first acridine donor based TADF emitter realizing kr of 10^(7) s^(−1) and kRISC of 10^(6) s^(−1) by a through-space interaction strategy.3,6-SFACAD-Py enables a highly efficient sky-blue organic light-emitting diode with a maximum external quantum efficiency(EQE)of 34.7%and Commission International de I'Eclairage coordinates of(0.19,0.37).More importantly,the EQE still remained 27.6%and 16.9%at high brightness of 1000 and 10,000 cd m^(−2).展开更多
Snowmelt runoffis an important component of water resources in the Northwest China(NWC).With global cli-mate warming and the increasing frequency of extreme events,snowmelt floods have caused significant damage.Howeve...Snowmelt runoffis an important component of water resources in the Northwest China(NWC).With global cli-mate warming and the increasing frequency of extreme events,snowmelt floods have caused significant damage.However,current studies lack comprehensive research and systematic risk assessments of snowmelt floods across the NWC.Based on the snowmelt runoffsimulated by GLDAS-NOAH model(1948-2022),the multiple indicators of snowmelt floods were retrieved by Peaks Over Threshold(POT)model in the NWC,and comprehensive risk assessment was conducted by integrating socio-economic data.The results indicated that the snowmelt runoffin the NWC shows a significant increasing trend and exhibits a spatial pattern of being more abundant in the northwest and southwest edges while less in the central and eastern regions.In Northern Xinjiang,snowmelt floods occurred relatively infrequently but with large magnitudes,while around the Qilian Mountains,snowmelt floods were more frequent but of smaller magnitudes.The longest duration of snowmelt floods was observed in the Kashgar and Yarkant River.Basins near mountainous areas are prone to snowmelt floods,especially the Tongtian and Lancang River basins,as well as the Ebinur Lake,Ili River basin,and the rivers south of the Altai Mountains,which face the highest risk of snowmelt floods.Based on comprehensive assessment of hazard,expo-sure,vulnerability and adaptability,high and very high-risk areas account for 15.5%of the NWC.It is urgent to enhance monitoring,early warning systems,and implement corresponding disaster prevention and mitigation measures in large mountainous basins.展开更多
基金supported by grants from the Shanghai Agriculture Applied Technology Development Program(2021-02-08-00-12-F00792)Projects of International Cooperation and Exchanges NSFC(3201101910).
文摘Tomato is one of the most essential vegetable crops worldwide,with the highest annual production rate of all agricultural staples(Kimura and Sinha,2008).Long-term domestication of tomatoes has led to the selection of favorable agronomic traits that often come at the expense of stress resistance.To identify potential genetic targets for improved stress tolerance,whole-genome sequencing(WGS)has been applied to wild and cultivated accessions.
基金jointly supported by the National Natural Science Foundation of China(Grant Nos.42422502,42275038)the China Meteorological Administration Climate Change Special Program(Grant No.QBZ202306)。
文摘Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and caused widespread devastation to society and infrastructure.However,the drivers of this record-breaking flood remain unexplored.Here,we show that the record-breaking floods were contributed by both long-term climate warming and interannual variability,with multiple climatic drivers at play across the synoptic to seasonal timescales.First,the heavy snowmelt in March 2024 was associated with above-normal preceding winter snow accumulation.Second,extreme rainfall was at a record-high during March 2024,in line with its increasing trend under climate warming.Third,the snowmelt and extreme rainfall in March were compounded by record-high soil moisture conditions in the preceding winter,which was a result of interannual variability and related to excessive winter rainfall over Central Asia.As climate warming continues,the interplay between the increasing trend of extreme rainfall,interannual variations in soil moisture pre-conditions,as well as shifting timing and magnitudes of spring snowmelt,will further increase and complicate spring flooding risks.This is a growing and widespread challenge for the mid-to high-latitude regions.
基金supported by the National Key Research and Devel-opment Program of China(2023YFC3206300)the National Natural Science Foundation of China(42477529)the Gansu Provincial Science and Technology Program(22ZD6FA005).
文摘Under global warming,Asian glaciers have experienced accelerated retreats and increased mass loss.Utilizing data from the World Glacier Monitoring Service(WGMS),this study selected 16 representative glaciers across Asia to analyse the temporal and spatial changes of glacial mass balance(GMB),equilibrium line altitude(ELA),and accumulation area ratio(AAR)in the past several decades.Based on structural equation modelling and correlation analysis,we evaluated the responses of glacier change to climate change.The results indicated that 14 glaciers experienced mass loss,with the Parlung No.94 Glacier exhibiting a severe loss and significant retreat.In contrast,the Abramov,Muztag Ata No.15,Chhota Shigri,and Yala glaciers showed an increase in GMB,consistent with the"Karakoram Glacier anomaly".Additionally,a latitudinal gradient was observed,with ELA decreasing,AAR rising,and the rate and magnitude of glacier mass loss decreasing as latitude increased.GMB was negatively correlated with ELA and positively correlated with AAR,with the Vodopaniy No.125 Glacier showing the highest sensitivity to GMB variations.GMB fluctuation is influenced by energy(surface net solar radiation,air temperature)and precipitation.The significant decline of the Parlung No.94 Glacier was ascribed to rising temperature.From west to east in the Himalayas,the negative effects of energy on GMB decreased,with positive precipitation having a particularly large impact on the Yala Glacier.The Chhota Shigri,Djankuat,and Hamaguri Yuki glaciers displayed different states of mass balance due to the influence of climatic factors.This study pro-vides valuable insights into the comprehensive understanding of glacier change in Asia and its responses to climate change.
基金The Major Science and Technology Plan of Hainan Province under contract No.ZDKJ2021008the Hainan Provincial Natural Science Foundation of China under contract No.623RC456+1 种基金the Hainan Province Science and Technology Special Fund under contract Nos ZDYF2021SHFZ064 and ZDYF2022SHFZ056the Collaborative Innovation Center of Marine Science and Technology in Hainan University under contract No.XTCX2022HYC19.
文摘The exchange of inorganic nutrients at the coastal sediment-water interface(SWI)plays a crucial role in regulating the nutrient budget in overlying water.The related studies mainly focus on the mid-to high-latitude regions,leaving a significant gap in the quantitative assessment of nutrient exchange and environmental controls at the SWI in lowlatitude coastal regions.We quantitatively assess the exchange of inorganic nutrients at the SWI in three tropical bays(Dongzhai Harbor,Xiaohai Lagoon,Qinglan Harbor).Sediments act as a source of ammonium,phosphate,and silicate,but for nitrate,sediments can be both a source and sink,although with substantial spatial and temporal variations in their fluxes.Labile organic matter is a critical regulator for the fluxes of inorganic nutrients at the SWI.The sedimentary nutrients input with high N/P molar ratio will alter the nutrient stoichiometry to mitigate the nitrogen limitation in coastal waters.However,the internal sediment release in these tropical bays plays a relative weak role in contributing to the nutrient addition in comparison with the other external nutrient sources including riverine input,submarine groundwater discharge,and atmospheric deposition.According to the global compilation on SWI nutrient fluxes,we propose that water column primary production and external inputs to interpret the variation in exchange and fluxes of nutrients at the SWI in different ecosystems.Such a conceptual understanding of these chain biogeochemical processes involving external nutrient input,primary production,particulate organic matter settling,and the accumulation and release of inorganic nutrients in sediments will be helpful for the scientific-based pollution prevent and control in coastal waters.
基金Supported by Nature Science Foundation of Shaanxi Province of China (No.2017JM8074)
文摘AIM: To investigate the effect of albuminuria on diabetic macular edema(DME) and the possible association between baseline urinary albumin excretion(UAE) and intravitreal conbercept(IVC) treatment frequency in DME patients. METHODS: In this hospital-based retrospective study, a total of 350 in-patients with type 2 diabetes mellitus were recruited and their clinical records were reviewed. Thereafter, 52 patients identified with severe non-proliferative diabetic retinopathy(NPDR) combined with albuminuria were divided into the microalbuminuria(UAE 30-300 mg/24 h) and macroalbuminuria(UAE>300 mg/24 h) groups, which were compared and analyzed by both independent sample t-test and Chi-square test. Correlations between the systemic variables and the central foveal thickness(CFT) were evaluated using Spearman’s correlation and linear regression analyses. Of the 52 patients with centerinvolved DME, 43 received an initial combined injection of conbercept(0.5 mg/0.05 mL) and triamcinolone acetonide(1 mg/0.05 mL), followed by an IVC injection, as needed. The relationship between baseline UAE and number of IVCinjections during the first year of treatment was analyzed using Spearman’s partial correlation.RESULTS: Of 350 patients, a higher incidence of DME was observed in severe non-proliferative retinopathy(NPDR) patients than that observed in other groups. By dividing the 52 patients with severe NPDR into the micro-and macro-albuminuria subgroups, significant differences in CFT, systolic blood pressure, total cholesterol and serum creatinine levels, and UAE were revealed. Furthermore, a positive liner correlation between the UAE and CFT was found. Finally, the partial correlation coefficient adjusted for either the CFT or UAE indicated that both parameters directly correlated with the number of IVC injections administered during the 12 mo of follow-up. CONCLUSION: Generally, macular edema occurred in patients with severe NPDR, for whom the UAE is an independent risk predictor of DME. The baseline UAE and CFT predicted the treatment frequency of IVC injections administered in the first year for eyes with DME.
基金the NSFC 21002105,the 973 Program of Science and Technology of P.R.China(2011CB915503)the Fourteenth Batch Candidates of the Young Academic Leaders of Yunnan Province(Min XU,2011CI044)。
文摘Two new highly oxygenated limonoids,flexuosoids A(1)and B(2),and three new arylnaphthalene lignan glycosides,phyllanthusmins D–F(3–5),were isolated from the roots of Phyllanthus flexuosus,in addition to three known lignans,phyllanthusmin C,arabelline,and(?)-diasyringaresinol.Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods.Compounds 1 and 2,two new decaoxygenated limonoids with a C-19/29 lactol bridge and heptaoxygenated substituents at C-1,C-2,C-3,C-7,C-11,C-17,and C-30,represent the second example of limonoids in the Euphorbiaceae family.Most of the isolates were tested for their antifeedant,anti-herpes simplex virus 1,and cytotoxic activities.The new limonoids 1 and 2 showed promising antifeedant activity against the beet army worm(Spodoptera exigua)with EC50 values of 25.1 and 17.3 lg/cm2,respectively.In addition,both of them displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line,along with the known lignan glycoside,phyllanthusmin C,with the IC50 values of 11.5(1),8.5(2),and 7.8(phyllanthusmin C)lM,respectively.
基金Shanghai Science and Technology Committee,No.17441903200 and No.17411950400.
文摘BACKGROUND Inflammatory myofibroblastic tumor(IMT)is a distinct tumor with a low incidence rate,which can be diagnosed at any age with a predilection for children and adolescents.Although IMT is visible in any tissues and organs,it is more commonly found in the lungs.The clinical and radiological manifestations of IMT lack specificity,hence resulting in frequent misdiagnosis.Surgical resection is currently the main therapeutic approach for IMT.Only scarce cases of IMT treated with metformin have been reported.Here we report the case of an IMT patient with partial penile resection treated with metformin.CASE SUMMARY A 1-year-old boy was born with a shorter penis,and his foreskin could not be completely turned over.When he was 6 month old,a well-circumscribed mass on the glans was found,while it did not attract the attention of his parents.The mass gradually increased in size over time before he was admitted to the hospital,where physical examination was performed.It was revealed that the glans hidden behind the foreskin had a mass with a diameter of about 4 cm surrounding the penis.The mass appeared to be hard with a smooth surface and poor mobility.The two testicles examined at the bottom of the scrotum were revealed to have a normal size.Magnetic resonance imaging showed a tumor with rich blood supply encircling the cavernosum with a size of 3.5 cm×2.1 cm×2.0 cm.A thick urinary line was found without urine dripping,urgency,and urodynia.Surgical treatment was performed.During the operation,it was observed that the mass had surrounded and invaded the cavernosum without obvious boundaries,and that the tumor occupied about one-half of the penis cross-section as well as infiltrated more than one-half of the glans.In addition,the tumor had caused urethral invasion and anterior urethrostenosis.With the intention of keeping the glans and cavernosum,the tumor at the anterior urethra was partially removed,leaving about 30%of the tumor mass.Pathology analysis demonstrated that the tumor was rich in spindle cells with infiltration of inflammatory cells.Immunohistochemistry analysis indicated that the cells were positive for CD4,CD99,Ki67,BCL2,and CD68,and negative for ALK,MyoG,S100,SOX10,PR,and EMA.Hence,the tumor was diagnosed as IMT.Metformin was prescribed for the patient after the operation,following which an oral dose of 7 mg/kg was given three times a day after meals.Three months later,it was observed that the remaining tumor had completely disappeared and that the urination process from the urethra opening had resumed normal.In addition,there were no side effects observed.There was also no tumor recurrence.The growth and development of the boy were unaffected as a result of the treatment.CONCLUSION The tumor was observed to have completely disappeared after treatment with metformin.Our finding is of great significance to facilitate future clinical treatment with IMT.
文摘Objective:To study the effect of adjuvant Shuxuening injection therapy on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.Methods:Patients with acute exacerbation of COPD who received Shuxuening injection combined with conventional western medicine treatment in our hospital between May 2014 and December 2015 were selected for study, and before treatment as well as 1 week, 2 weeks, 3 weeks and 4 weeks after treatment, peripheral blood mononuclear cells were collected to determine TLRs expression, and serum was collected to determine the levels of inflammatory cytokines and airway remodeling molecules.Results:1 week, 2 weeks, 3 weeks and 4 weeks after treatment, TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells as well as TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels in serum of patients with COPD were significantly lower than those before treatment, and TLR3, TLR7, TLR8 and TLR9 mRNA expression were not significantly different from those before treatment;TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells were positively correlated with serum TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels. Conclusion:Adjuvant Shuxuening injection therapy has significant inhibitory effect on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.
文摘The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.
文摘Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.
基金Science and Technology strategic cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University (2019LZXNYD-P01DUAN)National Key R&D Program of China (2024YFC3505400)Regional Key R&D Program of Ningxia Hui Autonomous Region (2024BEG01003)。
文摘Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.
基金The Henan Key Research and Development and Promotion Project(Grant No.232102310245)the Joint Construction Project of Medical Science and Technology of Henan Province(Grant No.LHGJ20220426).
文摘The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exacerbated this issue by increasing selective pressure within bacterial populations.This study aimed to investigate the association between carbapenem consumption and resistance rates in four priority Gram-negative bacteria:Escherichia coli(EC),Klebsiella pneumoniae(KP),Acinetobacter baumannii(AB),and Pseudomonas aeruginosa(PA).Retrospective data were collected from the First Affiliated Hospital of Zhengzhou University,covering the period from January 2010 to December 2022.Trends in carbapenem consumption and resistance were analyzed using the Mann-Kendall test to assess statistical significance and the Sen’s slope(SS)estimator to determine the magnitude of change.Correlations between carbapenem use and bacterial resistance rates were evaluated via Spearman correlation analysis.Over the study period,the consumption of meropenem,imipenem,biapenem,and total carbapenems exhibited a significant upward trend(|Z|>1.96,SS>0).Correspondingly,the resistance rates of EC and KP to meropenem and imipenem also increased significantly(|Z|>1.96,SS>0).A strong positive correlation was observed between the resistance rate of EC to meropenem and the defined daily doses(DDDs)of meropenem(r=0.732,P<0.05)and between EC resistance to imipenem and its DDDs(r=0.49,P<0.05).Similar significant correlations were identified for KP.However,no significant associations were found between carbapenem resistance in AB or PA and carbapenem consumption.These findings underscored the strong correlation between carbapenem use and the resistance rates of EC and KP,highlighting the urgent need for stringent control and stewardship of carbapenem use in clinical settings to mitigate or delay the development of bacterial drug resistance.
基金support of these experiments.This work was supported by the National Natural Science Foundation of China(12405268,12175227,11875255,12375226,and 11975231)the National Magnetic Confinement Fusion Science Program of China(2022YFE03060003,2022YFE03100004)+1 种基金the Fundamental Research Funds for the Central Universities(WK2140000016)the China Postdoctoral Science Foundation(2022M723066).
文摘This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.
基金upported by the Natural Science Foundation of Zhejiang Province(Grant No.LZ16H180002)the National Natural Science Foundation of China(Grant No.61905181)+1 种基金the Wenzhou Municipal Science and Technology Bureau(Grant No.ZS2017022)the National Science Foundation of the U.S.(Grant No.1607664).
文摘The vectorial evolution of light polarization can reveal the microstructure and anisotropy of a medium beyond what can be obtained from measuring light intensity alone.However,polarization imaging in reflection geometry,which is ubiquitous and often preferred in diverse applications,has often suffered from poor and even incorrect characterization of anisotropic media.We present reciprocal polarization imaging of complex media in reflection geometry with the reciprocal polar decomposition of backscattering Mueller matrices enforcing reciprocity.We demonstrate that reciprocal polarization imaging of complex chiral and anisotropic media ac-curately quantifies their anisotropic properties in reflection geometry,whereas traditional approaches encounter difficulties and produce inferior and often erroneous results from the violation of reciprocity.In particular,reciprocal polarization imaging provides a consistent characterization of complex media of different thicknesses,accurately measures the optical activity and glucose concentration of turbid media in reflection,and discriminates between cancerous and normal tissue with even stronger contrast than forward measurement.Reciprocal polarization imaging promises broad applications of polarization optics ranging from remote sensing to bio-medicine in reflection geometries,especially in in vivo biomedical imaging,where reflection is the only feasible geometry.
基金funded by the National Key Research and Development Program of China(2016YFD0100203 and 2016YFD0102000)the Key Scientific and Technological Projects of the Eighth Division of the Xinjiang Production and Construction Corps(XPCC),China(2024NY01,2023 NY09,2023 NY10)+2 种基金the Key Scientific and Technological Project of XPCC,China(2021AB010)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(KYCX22_0748)supported by the High-performance Computing Platform of the Bioinformatics Center,Nanjing Agricultural University,China。
文摘Gossypium raimondii(2n=2x=26,D_(5)),an untapped wild species,is the putative progenitor of the D-subgenome of G.hirsutum(2n=4x=52,AD_(1)),an extensively cultivated species.Here,we developed a G.hirsutum(recipient)–G.raimondii(donor)introgression population to exploit the favorable QTLs/genes and mapped potential quantitative trait loci(QTLs)from wild cotton species.The introgression population consisted of 256 lines with an introgression rate of 52.33%for the G.raimondii genome.The introgression segment length range was 0.03–19.12 Mb,with an average of 1.22 Mb.The coverage of total introgression fragments from G.raimondii was 386.98 Mb.Further genome-wide association analysis(Q+K+MLM)and QTL mapping(RSTEP-LRT)identified 59 common QTLs,including 14 stable QTLs and six common QTL(co-QTL)clusters,and one hotspot of micronaire(MIC).The common QTLs for seed index all showed positive additive effects,while the common QTLs for boll weight all had negative additive effects,indicating that the linkage between seed index and boll weight could be broken.QTLs for lint percentage showed positive effects and could be beneficial for improving cotton yield.Most QTLs for fiber quality had negative additive effects,implying these QTLs were domesticated/improved in G.hirsutum.A few fiber quality QTLs showed positive additive effects,so they could be used to improve cotton fiber quality.The introgression lines developed could be useful for molecular marker-assisted breeding and mapping QTLs precisely for mining desirable genes from the wild species G.raimondii.Such genes can improve cultivated cotton in the future through a designbreeding approach.
基金the National Natural Science Foundation of China(22078051,22478063,22408035)the Fundamental Research Funds for the Central Universities(DUT22-LAB610)the Open Fund of the Key Laboratory of Advanced Display and System Applications,Ministry of Education,Shanghai University(OF202401)for financial support of this work.
文摘Most of acridine based thermally activated delayed fluorescence(TADF)emitters are characterized by advantageous reverse intersystem crossing(RISC)rate(kRISCs)due to the perpendicular orientation of the acridine donor to the acceptor moiety,but suffer from a poor radiation rate(kr)typically in the order of 10^(6) s^(−1).Herein,two sky blue TADF emitters 3,6-DMAC-AD-Py and 3,6-SFAC-AD-Py were developed by linking acridine(DMAC)and spiro-fluorene-acridine(SFAC)donors to 10-(pyridin-2-yl)acridin-9(10H)-one(AD-Py)acceptor.Larger SFAC and electron-deficient pyridyl groups are deliberately incorporated in 3,6-SFACAD-Py since the unique through-space interaction between them is designed to drive the rotation of inner acridine ring in SFAC for enhancing frontier molecular orbitals overlap while keeping a decent TADF behavior.Thus,the kr of 3,6-SFACAD-Py is increased to 1.5×10^(7) s^(−1).Simultaneously,SFAC donors improve spin orbital coupling strength and reduce the energy gaps,generating kRISC of 1.8×10^(6) s^(−1).This is the first acridine donor based TADF emitter realizing kr of 10^(7) s^(−1) and kRISC of 10^(6) s^(−1) by a through-space interaction strategy.3,6-SFACAD-Py enables a highly efficient sky-blue organic light-emitting diode with a maximum external quantum efficiency(EQE)of 34.7%and Commission International de I'Eclairage coordinates of(0.19,0.37).More importantly,the EQE still remained 27.6%and 16.9%at high brightness of 1000 and 10,000 cd m^(−2).
基金supported by China-Pakistan joint program of the Chi-nese Academy of Sciences(Grant No.046GJHZ2023069MI)National Natural Science Foundation of China(Grant No.42371145)the program of the Key Laboratory of Cryospheric Science and Frozen Soil Engineering,CAS(Grant No.CSFSE-ZZ-2402).
文摘Snowmelt runoffis an important component of water resources in the Northwest China(NWC).With global cli-mate warming and the increasing frequency of extreme events,snowmelt floods have caused significant damage.However,current studies lack comprehensive research and systematic risk assessments of snowmelt floods across the NWC.Based on the snowmelt runoffsimulated by GLDAS-NOAH model(1948-2022),the multiple indicators of snowmelt floods were retrieved by Peaks Over Threshold(POT)model in the NWC,and comprehensive risk assessment was conducted by integrating socio-economic data.The results indicated that the snowmelt runoffin the NWC shows a significant increasing trend and exhibits a spatial pattern of being more abundant in the northwest and southwest edges while less in the central and eastern regions.In Northern Xinjiang,snowmelt floods occurred relatively infrequently but with large magnitudes,while around the Qilian Mountains,snowmelt floods were more frequent but of smaller magnitudes.The longest duration of snowmelt floods was observed in the Kashgar and Yarkant River.Basins near mountainous areas are prone to snowmelt floods,especially the Tongtian and Lancang River basins,as well as the Ebinur Lake,Ili River basin,and the rivers south of the Altai Mountains,which face the highest risk of snowmelt floods.Based on comprehensive assessment of hazard,expo-sure,vulnerability and adaptability,high and very high-risk areas account for 15.5%of the NWC.It is urgent to enhance monitoring,early warning systems,and implement corresponding disaster prevention and mitigation measures in large mountainous basins.
