急性胰腺炎(AP)是消化系统常见的急腹症,可累及全身器官和系统而形成危急重症,而急性胃肠损伤(AGI)是炎症反应和多脏器功能衰竭的启动因素,与AP的发生、发展密切相关。现代研究证实,中医治疗包括中医内治法如中药复方、中成药制剂,中医...急性胰腺炎(AP)是消化系统常见的急腹症,可累及全身器官和系统而形成危急重症,而急性胃肠损伤(AGI)是炎症反应和多脏器功能衰竭的启动因素,与AP的发生、发展密切相关。现代研究证实,中医治疗包括中医内治法如中药复方、中成药制剂,中医外治法如中药灌肠、中药外敷、穴位刺激等,均能起到抑制炎症反应、改善胃肠损伤的作用。本文通过搜索中国知网全文数据库(CNKI)、万方数据库、百度学术、PubMed、Web of Science近五年相关文献,总结归纳中医治疗AP并发AGI的作用机制及疗效,以期未来在更深入的临床及基础研究下,中医可在防治AP并发AGI中发挥更多优势。展开更多
Implant-related infections and tissue inflammation are the main factors for peri-implantitis.Lack of antibacterial activity and poor soft tissue sealing property increase the occurrence probability of peri-implantitis...Implant-related infections and tissue inflammation are the main factors for peri-implantitis.Lack of antibacterial activity and poor soft tissue sealing property increase the occurrence probability of peri-implantitis.To prevent and treat peri-implantitis,cerium-doped defective titanium oxide coatings are prepared on medical titanium surfaces by plasma electrolytic oxidation and thermal reduction treatment.In the darkness,Ce-doped defective titanium oxide coatings with micro-porous structure surface can inhibit the bacteria adhesion to some extent with antibacterial rates of 38.0%against S.aureus and 65.0%against E.coli.Under near infrared(NIR)irradiation,Ce-doped defective titanium oxide coatings show good photothermal antibacterial activity with antibacterial rates of 99.9%against S.aureus and 99.9%against E.coli.Moreover,with the increasing content of Ce-doping,the coatings exhibit higher capacity to scavenge hydrogen peroxide(H2O2)and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)radical cation(ABTS^(·+)).The coatings with enhanced antioxidant effect can protect human gingival fibroblasts from oxidative stress damage by eliminating reactive oxygen species and promoting initial cell adhesion.Besides,Ce-doped coatings can regulate the immune microenvironment by up-regulating the expression of anti-inflammatory genes and down-regulating the pro-inflammatory genes.In vivo animal experiments further confirm the good antibacterial activity of Ce-doped defective titanium oxide coatings under NIR irradiation and good biosafety.This work provides a novel surface modification strategy for implant abutment,which shows good application prospects for preventing and treating peri-implantitis.展开更多
文摘急性胰腺炎(AP)是消化系统常见的急腹症,可累及全身器官和系统而形成危急重症,而急性胃肠损伤(AGI)是炎症反应和多脏器功能衰竭的启动因素,与AP的发生、发展密切相关。现代研究证实,中医治疗包括中医内治法如中药复方、中成药制剂,中医外治法如中药灌肠、中药外敷、穴位刺激等,均能起到抑制炎症反应、改善胃肠损伤的作用。本文通过搜索中国知网全文数据库(CNKI)、万方数据库、百度学术、PubMed、Web of Science近五年相关文献,总结归纳中医治疗AP并发AGI的作用机制及疗效,以期未来在更深入的临床及基础研究下,中医可在防治AP并发AGI中发挥更多优势。
基金supported by the National Natural Science Foundation of China(No.52272283)the Science and Technology Commission of Shanghai Municipality(Nos.22S31902900 and 22ZR1457600)+3 种基金Youth Innovation Promotion Association CAS(No.2023263)Young Elite Scientists Sponsorship Program by CAST(No.2022-2024QNRC001)General Research Fund of the Research Grants Council(No.17207719)the Health and Medical Research Fund(No.20190244).
文摘Implant-related infections and tissue inflammation are the main factors for peri-implantitis.Lack of antibacterial activity and poor soft tissue sealing property increase the occurrence probability of peri-implantitis.To prevent and treat peri-implantitis,cerium-doped defective titanium oxide coatings are prepared on medical titanium surfaces by plasma electrolytic oxidation and thermal reduction treatment.In the darkness,Ce-doped defective titanium oxide coatings with micro-porous structure surface can inhibit the bacteria adhesion to some extent with antibacterial rates of 38.0%against S.aureus and 65.0%against E.coli.Under near infrared(NIR)irradiation,Ce-doped defective titanium oxide coatings show good photothermal antibacterial activity with antibacterial rates of 99.9%against S.aureus and 99.9%against E.coli.Moreover,with the increasing content of Ce-doping,the coatings exhibit higher capacity to scavenge hydrogen peroxide(H2O2)and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)radical cation(ABTS^(·+)).The coatings with enhanced antioxidant effect can protect human gingival fibroblasts from oxidative stress damage by eliminating reactive oxygen species and promoting initial cell adhesion.Besides,Ce-doped coatings can regulate the immune microenvironment by up-regulating the expression of anti-inflammatory genes and down-regulating the pro-inflammatory genes.In vivo animal experiments further confirm the good antibacterial activity of Ce-doped defective titanium oxide coatings under NIR irradiation and good biosafety.This work provides a novel surface modification strategy for implant abutment,which shows good application prospects for preventing and treating peri-implantitis.
