Straight-chain aliphatic tert-amine N-oxides were found to be useful oxidizing agent for epoxidation of tri- and tetra-substituted perfluoroalkenes under mild conditions in high yields. The process for epoxidation by ...Straight-chain aliphatic tert-amine N-oxides were found to be useful oxidizing agent for epoxidation of tri- and tetra-substituted perfluoroalkenes under mild conditions in high yields. The process for epoxidation by employing tri-n-butylamine N-oxide gave the best result in the reagent survey.展开更多
Superhydrophobicity endows various substrates with astonishing multifunctional properties and has received widespread praise in industrial production.However,the fragile connection between the coating and the substrat...Superhydrophobicity endows various substrates with astonishing multifunctional properties and has received widespread praise in industrial production.However,the fragile connection between the coating and the substrate not only limits the service life of superhydrophobic coatings,but also poses limitations.To address this issue,this study used 3-(perfluorooctyl)propanol and organic polysilazane(OPSZ)with universal anchoring properties as starting materials to obtain fluorine modified OPSZ through a one-step synthesis method,and then doped SiO_(2)micro nano particles to produce superhydrophobic coatings that can be widely applied to various substrates.Investigating the relationship between the hydrophobic properties of the coatings and the amounts of SiO_(2)microparticles and nanoparticles used to create the microscopic rough structure of the superhydrophobic coatings,it was discovered that the hydrophobic properties of the coatings tended to increase as the number of nanoparticles increased.The water contact angle of prepared coatings was still over 157°after 48 h of UV exposure or 180 days of exposure to air.The heat resistance of the created superhydrophobic coatings was tested in a muffle furnace at 400℃ for 2 h.The results revealed that the coatings maintained their water contact angle of 155.1°±3.01°and water sliding angle of 6.4°±1.98°,demonstrating their excellent heat resistance and suitability for use in a variety of high-temperatu re environme nts.The work provided a practical way for creating superhydrophobic composite coatings with excellent mechanical stability,acid and alkali corrosion resistance,and heat resistance,and had potential application in antifouling and anti-corrosion.展开更多
Perfluorooctanoic acid(PFOA) or perfluorooctane sulphonate(PFOS) was one of the most prominent fluorosurfactants and applied widely in firefighting and daily chemical, etc. However, these surfactants have recently bee...Perfluorooctanoic acid(PFOA) or perfluorooctane sulphonate(PFOS) was one of the most prominent fluorosurfactants and applied widely in firefighting and daily chemical, etc. However, these surfactants have recently been identified as toxic and undegradability in the environment. Developing an efficient approach to environment-friendly fluorosurfactants is essential. A fluorocarbon branched chain strategy was adopted to develop/PFOS substitutes. A series of intermediates of novel branched fluorinated surfactants with CF_3 CF_2CF_2C(CF3)_2 group were synthesized from perfluoro-2-methyl-2-pentene. All the steps were mild, easy-handled and cheap. It is expected to be a very significant direction for the development of non-bioaccumulable alternatives of PFOA or PFOS.展开更多
This minireview describes the strategies for synthesis of fluorinated surfactants potentially non- bioaccumulable. Various strategies have been focused on （Ⅰ） reducing the length of the perfluorocarbon chain, （Ⅱ...This minireview describes the strategies for synthesis of fluorinated surfactants potentially non- bioaccumulable. Various strategies have been focused on （Ⅰ） reducing the length of the perfluorocarbon chain, （Ⅱ） introducing hereto atoms into the fluorocarbon chain, （Ⅲ） introducing branch （herein and after branch means the fluoro-carbon chain section is not straight）. In most cases, the surface tensions versus the surfactant concentrations have been assessed. These above strategies led to various highly fluorinated （perfluorinated or not perfluorinated） surfactants whose chemical changes enabled to obtain novel alternatives to perfluorooctanoic acid （PFOA） and perfluorooctane sulphonate （PFOS）.展开更多
BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain ambiguous.In the present study,the complementary...BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain ambiguous.In the present study,the complementary sites between lncRNA SRA1,miRNA-363-5p,and phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC progression.AIM To investigate the molecular events of SRA1 in the malignant behavior in ESCC.METHODS Thirty-eight ESCC tissues and paired adjacent normal tissues were acquired.SRA1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain reaction.Cell counting Kit-8 assay,transwell invasion assay,glycolysis assay,and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of SRA1.The t-test and theχ2 test were used for comparison between groups.Survival curve analysis was performed using the Kaplan-Meier method.RESULTS SRA1 downregulation was identified in ESCC.ESCC patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 expression.The introduction of SRA1 inhibited cell proliferation,glucose uptake,and lactate production in ESCC.In vivo,the growth of ESCC was hindered by SRA1 overexpression.Then,SRA1 overexpresses the LHPP by inhibiting miRNA-363-5p.Lastly,the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by SRA1.CONCLUSION SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP axis.The SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.展开更多
Based on the substitutability of economic activities,by comparing the profit margin of farmers' planting of food crops and non-food crops,grain growing and breeding,as well as the daily return of grain growing and...Based on the substitutability of economic activities,by comparing the profit margin of farmers' planting of food crops and non-food crops,grain growing and breeding,as well as the daily return of grain growing and working outside during 2001-2013,this paper points out that the comparative income from farmers' behavior of growing grain is not absolutely low,and the income from growing grain is higher than from breeding pigs. It also studies the effect of food subsidies on farmers' behavior of growing grain. Farmers' behavior of growing grain is a helpless choice under many constraints,including not only economic returns,but also moral sentiments,political and social factors. From yield,quality and price,government should rely on science and technology to give full play to the functions of government guidance and supervision,and enhance the enthusiasm of farmers for growing grain,to increase food production and ensure food security.展开更多
A novel branched fluorinated anion surfactant 4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis-trifluoromethyl-pentyl)-benzene lithium phosphonate was successfully synthesized via a four-step route using perfluoro-2-methyl-2-pent...A novel branched fluorinated anion surfactant 4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis-trifluoromethyl-pentyl)-benzene lithium phosphonate was successfully synthesized via a four-step route using perfluoro-2-methyl-2-pentene as starting material.The surface activity was investigated.The result showed that the cmc value of the surfactant in water is about 1.5×10^(−2) mol/L at 298 K and the surface tension of the aqueous solution is 19.2 mN/m at the cmc.展开更多
文摘Straight-chain aliphatic tert-amine N-oxides were found to be useful oxidizing agent for epoxidation of tri- and tetra-substituted perfluoroalkenes under mild conditions in high yields. The process for epoxidation by employing tri-n-butylamine N-oxide gave the best result in the reagent survey.
基金supported by the National Key Research and Development Program of China(2022YFC3004901-3)the National Natural Science Foundation of China(21908109)+2 种基金the Open Project of Key Laboratory of Fire Emergency Rescue Equipment of Ministry of Emergency Management of People's Republic of China(2020XFZB05)the Fundamental Research Funds for the Central Universities(30919011272)the Natural Science Foundation of Jiangsu Province(BK20180816)。
文摘Superhydrophobicity endows various substrates with astonishing multifunctional properties and has received widespread praise in industrial production.However,the fragile connection between the coating and the substrate not only limits the service life of superhydrophobic coatings,but also poses limitations.To address this issue,this study used 3-(perfluorooctyl)propanol and organic polysilazane(OPSZ)with universal anchoring properties as starting materials to obtain fluorine modified OPSZ through a one-step synthesis method,and then doped SiO_(2)micro nano particles to produce superhydrophobic coatings that can be widely applied to various substrates.Investigating the relationship between the hydrophobic properties of the coatings and the amounts of SiO_(2)microparticles and nanoparticles used to create the microscopic rough structure of the superhydrophobic coatings,it was discovered that the hydrophobic properties of the coatings tended to increase as the number of nanoparticles increased.The water contact angle of prepared coatings was still over 157°after 48 h of UV exposure or 180 days of exposure to air.The heat resistance of the created superhydrophobic coatings was tested in a muffle furnace at 400℃ for 2 h.The results revealed that the coatings maintained their water contact angle of 155.1°±3.01°and water sliding angle of 6.4°±1.98°,demonstrating their excellent heat resistance and suitability for use in a variety of high-temperatu re environme nts.The work provided a practical way for creating superhydrophobic composite coatings with excellent mechanical stability,acid and alkali corrosion resistance,and heat resistance,and had potential application in antifouling and anti-corrosion.
基金supported by the National Natural Science Foundation of China(No. 2167020782)
文摘Perfluorooctanoic acid(PFOA) or perfluorooctane sulphonate(PFOS) was one of the most prominent fluorosurfactants and applied widely in firefighting and daily chemical, etc. However, these surfactants have recently been identified as toxic and undegradability in the environment. Developing an efficient approach to environment-friendly fluorosurfactants is essential. A fluorocarbon branched chain strategy was adopted to develop/PFOS substitutes. A series of intermediates of novel branched fluorinated surfactants with CF_3 CF_2CF_2C(CF3)_2 group were synthesized from perfluoro-2-methyl-2-pentene. All the steps were mild, easy-handled and cheap. It is expected to be a very significant direction for the development of non-bioaccumulable alternatives of PFOA or PFOS.
基金supported by the National Natural Science Foundation of China(No.21102167)the Science and Technology Commission of Shanghai Municipality(No.12DZ1930902)Shanghai Green Chemical Engineering Technology Research Center and the Knowledge Innovation Program of the Chinese Academy of Sciences
文摘This minireview describes the strategies for synthesis of fluorinated surfactants potentially non- bioaccumulable. Various strategies have been focused on （Ⅰ） reducing the length of the perfluorocarbon chain, （Ⅱ） introducing hereto atoms into the fluorocarbon chain, （Ⅲ） introducing branch （herein and after branch means the fluoro-carbon chain section is not straight）. In most cases, the surface tensions versus the surfactant concentrations have been assessed. These above strategies led to various highly fluorinated （perfluorinated or not perfluorinated） surfactants whose chemical changes enabled to obtain novel alternatives to perfluorooctanoic acid （PFOA） and perfluorooctane sulphonate （PFOS）.
基金Supported by Innovative Team of Jiangsu Province,No.CXTDA2017042Jiangsu Provincial Medical Youth Talent,No.QNRC2016508In-Hospital Project of Taizhou People's Hospital,No.ZL201930.
文摘BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain ambiguous.In the present study,the complementary sites between lncRNA SRA1,miRNA-363-5p,and phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC progression.AIM To investigate the molecular events of SRA1 in the malignant behavior in ESCC.METHODS Thirty-eight ESCC tissues and paired adjacent normal tissues were acquired.SRA1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain reaction.Cell counting Kit-8 assay,transwell invasion assay,glycolysis assay,and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of SRA1.The t-test and theχ2 test were used for comparison between groups.Survival curve analysis was performed using the Kaplan-Meier method.RESULTS SRA1 downregulation was identified in ESCC.ESCC patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 expression.The introduction of SRA1 inhibited cell proliferation,glucose uptake,and lactate production in ESCC.In vivo,the growth of ESCC was hindered by SRA1 overexpression.Then,SRA1 overexpresses the LHPP by inhibiting miRNA-363-5p.Lastly,the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by SRA1.CONCLUSION SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP axis.The SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.
基金Supported by Fundamental Research Funds for Central Universities in 2015(2012QT025)
文摘Based on the substitutability of economic activities,by comparing the profit margin of farmers' planting of food crops and non-food crops,grain growing and breeding,as well as the daily return of grain growing and working outside during 2001-2013,this paper points out that the comparative income from farmers' behavior of growing grain is not absolutely low,and the income from growing grain is higher than from breeding pigs. It also studies the effect of food subsidies on farmers' behavior of growing grain. Farmers' behavior of growing grain is a helpless choice under many constraints,including not only economic returns,but also moral sentiments,political and social factors. From yield,quality and price,government should rely on science and technology to give full play to the functions of government guidance and supervision,and enhance the enthusiasm of farmers for growing grain,to increase food production and ensure food security.
基金the National Basic Research Program of China(973-2010CB833200 and 973-2010CB833300)the National Natural Science Foundation of China(21102167)+1 种基金the Science and Technology Commission of Shanghai Municipality(12DZ1930902)Shanghai Green Chemical Engineering Technology Research Center and the Knowledge Innovation Program of the Chinese Academy of Sciences.
文摘A novel branched fluorinated anion surfactant 4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis-trifluoromethyl-pentyl)-benzene lithium phosphonate was successfully synthesized via a four-step route using perfluoro-2-methyl-2-pentene as starting material.The surface activity was investigated.The result showed that the cmc value of the surfactant in water is about 1.5×10^(−2) mol/L at 298 K and the surface tension of the aqueous solution is 19.2 mN/m at the cmc.
