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喹诺酮和喹啉类化合物的抗单纯疱疹病毒活性 被引量:1
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作者 张姝 李红 +3 位作者 梅敏 冯连顺 刘明亮 郭慧元 《国外医药(抗生素分册)》 CAS 2019年第3期229-235,共7页
单纯疱疹病毒(HSV)感染人群极为普遍,超过70%的成人曾感染过HSV。目前,对HSV感染的控制尚无特异性有效措施,因此亟需研发抗HSV药物。喹诺酮和喹啉类化合物具有包括抗病毒在内的多种生物活性,其中的某些化合物如6显示出良好的体内外抗HS... 单纯疱疹病毒(HSV)感染人群极为普遍,超过70%的成人曾感染过HSV。目前,对HSV感染的控制尚无特异性有效措施,因此亟需研发抗HSV药物。喹诺酮和喹啉类化合物具有包括抗病毒在内的多种生物活性,其中的某些化合物如6显示出良好的体内外抗HSV活性,极具进一步开发前景。本文将着重介绍近年来喹诺酮和喹啉类化合物在抗HSV领域的最新研究进展,并归纳此类化合物的构-效关系,以启迪科学家设计活性更高的候选物。 展开更多
关键词 喹诺酮 喹啉 单纯疱疹病毒 构-效关系
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Tailoring grain morphology in Ti-6Al-3Mo through heterogeneous nucleation in directed energy deposition 被引量:2
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作者 Fengying Zhang Panpan Gao +5 位作者 Hua Tan Yao Li Yongnan Chen min mei Adam T.Clare Lai-Chang Zhang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第29期132-142,共11页
A common challenge in direct energy deposition(DED)is eliminating the anisotropy in mechanical performance associated with microstructure and the formation of coarse columnar grains.In this work,a heterogeneous nuclea... A common challenge in direct energy deposition(DED)is eliminating the anisotropy in mechanical performance associated with microstructure and the formation of coarse columnar grains.In this work,a heterogeneous nucleation mechanism was introduced into the melt pool,and,from this mechanism,an almost fully equiaxed grain morphology was obtained in the DED of Ti-6 Al-3 Mo.Three types of grain morphologies in DED Ti-6 Al-3 Mo,including full columnar grains,near-equiaxed grains and almost fully equiaxed grains were obtained from premixed and satellite powder blends from Ti,6 wt.%Al and 3 wt.%Mo,respectively.Combined with the analysis of the interactions between powder particles and the melt pool in DED,the formation mechanism of the equiaxed grains caused by the incomplete melting of high melting point Mo particles was revealed.As the prior-βgrains transformed from coarse columnar grains to fine-equiaxed grains,the strong<100>fiber texture along the deposition direction was weakened,while the size of theα-laths in the prior-βgrains slightly decreased,and the selection ofα-variants was weakened.Due to the transformation of the prior-βgrains from coarse columnar grains to fine-equiaxed grains,the tensile strength of the deposited samples increased from 982 MPa to 1082 MPa,while the yield strength increased from 840 MPa to 922 MPa,and the elongation of the as-deposited alloy also increased from 9.0%to 9.8%,which confirmed that the presence of fine-equiaxed grains is beneficial to the strength and plasticity of the DED alloy.This work further demonstrates the role that satelliting powders can play in terms of enhancing the columnar to equiaxed transition(CET)behavior associated with DED. 展开更多
关键词 Direct energy deposition Titanium alloy Grain morphology MICROSTRUCTURE Mechanical properties
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中国学生泰语“三组辅音”的辅助教学方式之创建与研究
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作者 Somprasong Saeng-in 闵梅 《普洱学院学报》 2019年第4期70-73,共4页
泰语属壮侗语系(台-卡岱语系),汉语属汉藏语系,两种语言有很多相似之处.基于此,依据母语迁移的理论和Krashen的二语习得理论,创建辅助中国学生学习泰语"三组辅音"的教学方式,获得四句辅助记忆泰语"三组辅音"的中文... 泰语属壮侗语系(台-卡岱语系),汉语属汉藏语系,两种语言有很多相似之处.基于此,依据母语迁移的理论和Krashen的二语习得理论,创建辅助中国学生学习泰语"三组辅音"的教学方式,获得四句辅助记忆泰语"三组辅音"的中文句子,并将其运用于教学实践,取得一定教学效果. 展开更多
关键词 泰语 教学 助记符 三组辅音
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泰语商业信函特征剖析
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作者 闵梅 《科教文汇》 2016年第25期177-178,共2页
商业信函在对外贸易中起着不容忽视的作用,一封礼貌得体的商业信函,将为公司带来正面效应。鉴于泰语商业信函具有自己独特的风格,本文将结合实例,从词汇、篇章层面分析其特征,旨为泰语商业信函写作交流提供指导。
关键词 泰语 商业信函 特征
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