<strong>Background:</strong> Intrauterine Adhesions (IUAs) or Asherman’s Syndrome (AS) usually contains symptoms such as decreased menstrual flow or even amenorrhea, chronic pelvic pain, recurrent abortio...<strong>Background:</strong> Intrauterine Adhesions (IUAs) or Asherman’s Syndrome (AS) usually contains symptoms such as decreased menstrual flow or even amenorrhea, chronic pelvic pain, recurrent abortion and infertility. The current treatment of IUAs includes hysteroscopic adhesiolysis, oral hormone and biological barriers, but each of them has limitation. Stem cell therapy may be an expanding field seeking for therapy in IUAs. <strong>Objective: </strong>We will discuss current advances in stem cell therapy as a treatment for endometrial pathophysiology. <strong>Materials and Methods:</strong> We search on PubMed, Embase and Cochrane library and select several keywords on researches, then review the cell biology theories and animal experiments, finally do meta-analysis in human clinical trials. <strong>Results: </strong>77 articles on PubMed, 71 articles on Embase and 17 articles on Cochrane Library, as a result, 37 articles are included under the criteria, which are intrauterine adhesions (IUAs), Asherman’s Syndrome (AS), cell therapy, stem cells, bone marrow stem cells, clinical trials, recent 10 years and human or animal experiments. The included criteria: original articles, cohort study, case control study, animal experiments, human clinical trials, high quality, 10 years recent. The excluded articles are case reports, meeting reports, low quality or more than 10 years ago. <strong>Conclusion:</strong> Stem cell may be a new therapeutic schedule for IUAs in the future clinical treatment, but it is necessary to compare it with traditional therapy such as oral hormone, also the development of random clinical tests should proceed. For clinical treatment on IUAs, stem cells could be a new choice.展开更多
Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain...Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of <5 kD a and hydrophilic fractions, which are widely viewed as the most difficult to remove by coagulation.This study provides insight into the interactions between Al species and IOM, and advances the optimization of coagulation for the removal of IOM in eutrophic water.展开更多
tract in external use on expression of proto-onco- genes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model. To explore the mechanisms of Rupifang Extract in external use for preve...tract in external use on expression of proto-onco- genes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model. To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia. METHODS Thirty virginal female Wistar rats were randomized into 5 groups, 6 in each, A： blank con- trol group; B： model group; C： the low dose group of Rupifang; D： the middle dose group of Rupifang; and E： The high dose group of Rupifang. The mam- mary hyperplasia rat models were produced by in- jecting estradiol benzoate and progesterone and ir- ritating by tail nipping. Drug intervention was also launched during the model formation. After 30 days, the expression of her2 and p16 in breast tis- sues of rats in each group were detected by the SP immunohistochemical method. RESULTS： Compared with Blank control group, the expression of her2 in breast tissues in Model group was higher, and the expression of p16 was lower （P〈O.05 or P〈O.01）. After intervention with Rupi- fang Extract, compared with Model group, the ex- pression of her2 in breast tissues in Rupifang groups was lower, and the expression of p16 higher （P〈O.05 or P〈O.01）. CONCLUSION： The mechanisms of Rupifang Ex- tract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and in- creasing the expression of tumor suppression genes p16.展开更多
In this study, AZ31 Mg alloy was processed by a new severe plasticity deformation methodology with multi-pass lowered temperature, and the deformation behavior and microstructure evolution were investigated by finite ...In this study, AZ31 Mg alloy was processed by a new severe plasticity deformation methodology with multi-pass lowered temperature, and the deformation behavior and microstructure evolution were investigated by finite element method and electron back-scattered diffraction technique and hardness. The results show that with the increase of deformation pass, the strain gradually springs, and its interval distribution tends to homogenize. Meanwhile, the effective strain increases dramatically with the shear force sudden upgrade in the deformation process. Moreover, the new deformation technique can refine grain size remarkably. With the passes on, {10-12} tensile twins behavior and the pyramidal < c + a > slip are triggered more frequently, leading to the completeness of dynamic recrystallization (DRX) gradually, which weaken and disperse the basal texture obviously. Besides, the standard deviation of hardness is getting smaller, and the maximum can reach 78.40 HV on average, which can be attributed to the even large strain distribution, complete DRX, and the high geometrically necessary dislocation.展开更多
The genus Neoseiulus Hughes,1948 is one of the largest genera in Phytoseiidae and contains more than 364 valid species in the world.In this paper,a new species N.setarius Ma,Meng&Fan,sp.nov.is described based on b...The genus Neoseiulus Hughes,1948 is one of the largest genera in Phytoseiidae and contains more than 364 valid species in the world.In this paper,a new species N.setarius Ma,Meng&Fan,sp.nov.is described based on both adult female and male specimens collected from Setaria viridis(L.)Beauv.(Gramineae),in Inner Mongolia of China.The adult females of the new species are characterized by having a fully reticulated dorsal shield,barbed Z5,bellshaped spermathecal calyx with a short basal stalk.Furthermore,seta R1 is off dorsal idiosomal shield in adult males.展开更多
Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology ...Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.展开更多
Background:To predict the effective targets of Kang’ai injection and analyze the pharmacological mechanism for the treatment of breast cancer based on the method of network pharmacology.Methods:The Traditional Chines...Background:To predict the effective targets of Kang’ai injection and analyze the pharmacological mechanism for the treatment of breast cancer based on the method of network pharmacology.Methods:The Traditional Chinese Medicine Systems Pharmacology database was used to predict the effective components of the Chinese patent medicine Kang’ai injection,and GeneCards database,Online Mendelian Inheritance in Man database and the Therapeutic Target Database were used to predict the therapeutic targets of breast cancer.Cytoscape 3.7.2 was used to construct active ingredient-disease-target network.String database and Cytoscape 3.7.2 software were used to draw the protein-protein interaction network and obtain the core target.Bioconductor and R language were used to analyze the effective action target for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.Results:There were 42 effective active ingredients in the Chinese patent medicine Kang’ai injection,which acted on 105 targets,and it had 32 components that acted on 96 targets associated with breast cancer.The target regulates various biological processes such as inflammation,angiogenesis,apoptosis and cell proliferation,and regulates pathways such as PI3K-Akt signaling pathway,MAPK signaling pathway,AGE-RAGE signaling pathway in diabetic complications and thyroid hormone signaling pathway through gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis.Conclusion:The treatment of breast cancer with the Chinese patent medicine Kang’ai injection is a complex mechanism process with multiple targets,multiple pathways,and multiple choices,which provides a theoretical basis for the further extraction of effective components in the treatment of breast cancer.展开更多
Herein,vacancy engineering is utilized reasonably to explore molybdenum tungsten oxide nanowires(W_(4)MoO_(3)NWs)rich in O-vacancies as an advanced electrochemical nitrogen reduction reaction(eNRR)electrocatalyst,real...Herein,vacancy engineering is utilized reasonably to explore molybdenum tungsten oxide nanowires(W_(4)MoO_(3)NWs)rich in O-vacancies as an advanced electrochemical nitrogen reduction reaction(eNRR)electrocatalyst,realizing further enhancement of NRR performance.In 0.1 mol/L Na_(2)SO_(4),W_(4)MoO_(3)NWs rich in O vacancies(CTAB-D-W_(4)MoO_(3))achieve a large NH3yield of 60.77μg h^(-1)mg^(-1)cat.at-0.70 V vs.RHE and a high faradaic efficiency of 56.42%at-0.60 V,much superior to the W_(4)MoO_(3)NWs deficient in oxygen vacancies(20.26μg h^(-1)mg^(-1)cat.and 17.1%at-0.70 V vs.RHE).Meanwhile,W_(4)MoO_(3)NWs rich in O-vacancies also show high electrochemical stability.Density functional theory(DFT)calculations present that O vacancies in CTAB-D-W_(4)MoO_(3)reduce the energy barrier formed by the intermediate of^(*)N-NH,facilitate the activation and further hydrogenation of^(*)N-N,promote the NRR process,and improve NRR activity.展开更多
For the efficient harnessing of solar energy and mitigation of environmental pollution,the develop-ment and application of semiconductor photocatalysis technology is paramount.Herein,a novel SubPc-Br/CdS supramolecula...For the efficient harnessing of solar energy and mitigation of environmental pollution,the develop-ment and application of semiconductor photocatalysis technology is paramount.Herein,a novel SubPc-Br/CdS supramolecular array with an S-scheme heterojunction was synthesized through the intermolecu-larπ-stacked self-assembly of subphthalocyanine(SubPc-Br)and nanometer cadmium sulfide(CdS).This self-assembly system features a highly structured architecture and excellent stability.Experiments and ground-state differential charge calculations demonstrate that SubPc-Br and CdS form a built-in electric field during the self-assembly process,a critical factor in promoting the dissociation of electrons and holes.Additionally,this study utilized time-dependent density functional theory(TDDFT)to simulate the dynamic adsorption behavior of excited oxygen molecules on the SubPc-Br/CdS interface for the first time.The analysis of molecular charge differential density under different excited states proved that the addi-tion of SubPc-Br molecules not only improves the photocorrosion resistance of CdS in an O2 adsorption environment but also enhances the production of advanced reactive oxygen species under the synergistic action of h+and·O2-.When subjected to visible light,the degradation efficiency of minocycline(MC)achieved 96.8%within 60 min and maintained 80.3%after 5 cycles.In summary,this study highlights the feasibility of creating advanced S-scheme heterojunction photocatalysts through the strategic incor-poration of organic supramolecules with semiconductor catalysts.展开更多
Objectives:Keratin 6A(KRT6A)has been implicated in the progression of multiple malignancies;however,its expression pattern and biological role in cervical cancer(CC)have not been elucidated.This study aims to investig...Objectives:Keratin 6A(KRT6A)has been implicated in the progression of multiple malignancies;however,its expression pattern and biological role in cervical cancer(CC)have not been elucidated.This study aims to investigate KRT6A expression in CC tissues and evaluate its effects on cellular proliferation,migration,and invasion,thereby assessing its potential as a biomarker and therapeutic target.Methods:Differentially expressed genes were screened from the Gene Expression Omnibus(GEO)dataset(GSE9750)using the thresholds∣log2FC∣>2 and false discovery rate(FDR)<0.05.Immunohistochemistry was performed to evaluate KRT6A protein expression in tumor tissues.Stable KRT6A knockdown was established in CC cell lines to assess proliferation,colony formation,migration,and invasion in vitro.A nude-mouse xenograft model was used to evaluate tumor growth in vivo.Results:KRT6A expression was significantly increased in CC tissues relative to adjacent non-tumor tissues(p=0.019).Patients with KRT6A-positive tumors had a significantly lower 3-year progression-free survival(PFS)rate than those with KRT6Anegative tumors(45.16%vs.78.57%;p=0.009).KRT6A was identified as an independent prognostic indicator for CC(p=0.044).In vitro,KRT6A silencing significantly reduced colony formation,proliferation,migration,and invasion in SiHa and HeLa cells in comparison to controls(p<0.05).In vivo,tumors in the KRT6A knockdown group were significantly smaller,with reduced expression of both KRT6A and Ki-67 in tumor tissues(p<0.05).Conclusion:KRT6A is overexpressed in CC and associates with adverse clinicopathological features and poor PFS.Knockdown of KRT6A suppresses cell proliferation,migration,and invasion,indicating that KRT6A may represent a promising prognostic biomarker and potential target for treating CC.展开更多
In this study, microstructure and texture evolution of TB8 titanium alloys during hot deformation were investigated by using electron back-scattered diffraction(EBSD) analysis. The results showed that dynamic recrysta...In this study, microstructure and texture evolution of TB8 titanium alloys during hot deformation were investigated by using electron back-scattered diffraction(EBSD) analysis. The results showed that dynamic recrystallization(DRX) behavior of TB8 titanium alloys was drastically sensitive to the strain. As the true strain raised from 0.2 to 0.8, the degree of DRX gradually increased. The nucleation mechanism of recrystallization was observed, including discontinuous dynamic recrystallization(DDRX) resulting from the bulging of original boundaries. Furthermore, continuous dynamic recrystallization(CDRX) occurred because of the transformation of low-angle grain boundaries(LAGBs) to high-angle grain boundaries(HAGBs) in the interior of the original deformed grains. The texture evolution of TB8 titanium alloy during hot deformation process was analyzed in detail, and five texture components were observed,including{001}h100 i,{011}h100 i,{112}h110 i,{111}h110 i, and {111}h112 i. As the true strain increased,deformation textures were gradually weakened due to an increase in the volume fraction of DRX grains. When the true strain was 0.8, the main texture components consisted of the recrystallization texture components of the{001}h100 i and {011}h100 i textures.展开更多
A novel and effective method to co-extrude metallic alloys is described which named Direct Extrusion and Bending-Shear Deformation.The compound extrusion plates have cracked at 290℃ and 3 mm/s.According to this pheno...A novel and effective method to co-extrude metallic alloys is described which named Direct Extrusion and Bending-Shear Deformation.The compound extrusion plates have cracked at 290℃ and 3 mm/s.According to this phenomenon,a model was built to investigate the crack generation and development between the 6061 Al and AZ31 Mg alloy during the compound extrusion process by DEFORM-3D.The cracking behavior of the Mg/Al composite rod with a soft Mg AZ31 core and a hard Al 6061 sleeve were systematically studied to disclose the influence of microstructure on crack in the different regions.The simulation results show that the distribution of strain and velocity has significant differences due to the influence of dies structure and material properties at different locations in the same region.The experimental results show that in the same conditions,there are differences in recrystallization and texture weakening of AZ31 Mg alloys and 6061 Al alloy,which are important factors for the formation of crack.Both the Mg layer and the Al layer have a homogeneous microstructure in the region d.展开更多
The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically inve...The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically investigated. The results show that the grain size monotonically increases from 6.4 to 12.6 lm and the texture intensity increases from 6.7 to 9.6with the increase in the extrusion temperature. The combining effect of the pre-twinning and the frustum shearing deformation is found to contribute to the development of the weak basal texture in Mg alloys. The Mg alloy sheet produced at the extrusion temperature of 563 K exhibits excellent mechanical properties. The yield strength, ultimate tensile strength and elongation for the extruded alloys are 189.6 MPa, 288.4 MPa and 24.9%, respectively. Such improved mechanical properties are comparable or even superior to those of the alloys subjected to other deformation techniques, rendering the pre-compression and frustum shearing extrusion a promising way for further tailoring properties of Mg alloys.展开更多
Microstructure and texture evolution in commercial-purity Zr 702 during cold rolling and annealing was investigated by optical microscopy, transmission electron microscopy, and X-ray diffraction. The results showed th...Microstructure and texture evolution in commercial-purity Zr 702 during cold rolling and annealing was investigated by optical microscopy, transmission electron microscopy, and X-ray diffraction. The results showed that crystallographic slip was the predominant deformation mechanism in the early stage of deformation. Deformation twins started to form when the rolling reduction was larger than 38.9%; both the dislocation density and the number of twins increased with increasing rolling reduction. The initial texture of the Zr 702 plate consisted of the basal fiber component. During cold rolling the strength of the basal fiber first decreased and then increased with increasing rolling reduction. The cold-rolled sheets were fully recrystallized after being annealed at 550℃. The recrystallization temperature and the size of recrystallized grains decreased with increasing rolling reduction. A larger rolling reduction resulted in a higher grain growth rate when the annealing temperature increased from 550℃ to 700℃. The recrystallization texture was characterized by a major basal fiber and a minor {0113}〈2110〉 component. The strength of the recrystallization texture increased with increasing rolling reduction.展开更多
Hydrophobic treatment of the catalyst surfaces can suppress the competitive hydrogen evolution reaction(HER) during the nitrogen reduction reaction(NRR).In this work,the surface of Ti_(3)C_(2)Ti_(x) MXene is modified ...Hydrophobic treatment of the catalyst surfaces can suppress the competitive hydrogen evolution reaction(HER) during the nitrogen reduction reaction(NRR).In this work,the surface of Ti_(3)C_(2)Ti_(x) MXene is modified by cetyltrimethylammonium bromide(CTAB) and trimethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-trideca fluorooctyl) silane(FOTS) to increase the hydrophobicity of MXenes.The ammonia(NH_(3)) production rate and faradaic efficiency(FE) are improved from 37.62 to 54.01 μg h^(-1)mg_(cat)^(-1).and 5.5% to 18.1% at-0.7 V vs.RHE,respectively after surface modification.^(15)N isotopic labeling experiment confirms that nitrogen in produced ammonia originates from N_(2) in the electrolyte.The excellent NRR activity of surface hydrophobic MXenes is mainly due to surfactant molecules,which inhibit the entry of water molecules and the competitive HER,which have been verified by in situ FT-IR,DFT and molecular dynamics calculations.This strategy provides an ingenious method to design more active NRR electrocatalysts.展开更多
文摘<strong>Background:</strong> Intrauterine Adhesions (IUAs) or Asherman’s Syndrome (AS) usually contains symptoms such as decreased menstrual flow or even amenorrhea, chronic pelvic pain, recurrent abortion and infertility. The current treatment of IUAs includes hysteroscopic adhesiolysis, oral hormone and biological barriers, but each of them has limitation. Stem cell therapy may be an expanding field seeking for therapy in IUAs. <strong>Objective: </strong>We will discuss current advances in stem cell therapy as a treatment for endometrial pathophysiology. <strong>Materials and Methods:</strong> We search on PubMed, Embase and Cochrane library and select several keywords on researches, then review the cell biology theories and animal experiments, finally do meta-analysis in human clinical trials. <strong>Results: </strong>77 articles on PubMed, 71 articles on Embase and 17 articles on Cochrane Library, as a result, 37 articles are included under the criteria, which are intrauterine adhesions (IUAs), Asherman’s Syndrome (AS), cell therapy, stem cells, bone marrow stem cells, clinical trials, recent 10 years and human or animal experiments. The included criteria: original articles, cohort study, case control study, animal experiments, human clinical trials, high quality, 10 years recent. The excluded articles are case reports, meeting reports, low quality or more than 10 years ago. <strong>Conclusion:</strong> Stem cell may be a new therapeutic schedule for IUAs in the future clinical treatment, but it is necessary to compare it with traditional therapy such as oral hormone, also the development of random clinical tests should proceed. For clinical treatment on IUAs, stem cells could be a new choice.
基金supported by the Natural Key R&D Program of China (No.2016YFC0400802)the Natural Science Foundation of China (No.51225805)
文摘Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of <5 kD a and hydrophilic fractions, which are widely viewed as the most difficult to remove by coagulation.This study provides insight into the interactions between Al species and IOM, and advances the optimization of coagulation for the removal of IOM in eutrophic water.
基金Supported by China National Foundation of Natural Science(Project No.81173265)Foundation of Natural Science of Guangdong Province(Project No.10151063201000065)+11 种基金Science and Technology Plan Projects of Guangdong Province(No:2009B0308012382012B031800155)The Fundamental Research Funds for the Central Universities (No.21612422216113119)Guangzhou Municipal Planned Science and Technology Project(No.2009Z1-E091)Guangdong Provincial Administration of Traditional Chinese Medicine(No.201111752008092)Guangdong University Students' Innovation Experimental Program(No.1055910014)Jinan University's the National Collegiate Innovation Experimental Program,2010(No.101055916)Jinan University's Cultivation Project of Scientific Research Creation for Outstanding Undergraduates Recommended for Post-graduate StudyJinan University's the National Collegiate Innovation and Startups Training Program(No.1210559029)Jinan University's 211 Engineering Construction Program
文摘tract in external use on expression of proto-onco- genes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model. To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia. METHODS Thirty virginal female Wistar rats were randomized into 5 groups, 6 in each, A： blank con- trol group; B： model group; C： the low dose group of Rupifang; D： the middle dose group of Rupifang; and E： The high dose group of Rupifang. The mam- mary hyperplasia rat models were produced by in- jecting estradiol benzoate and progesterone and ir- ritating by tail nipping. Drug intervention was also launched during the model formation. After 30 days, the expression of her2 and p16 in breast tis- sues of rats in each group were detected by the SP immunohistochemical method. RESULTS： Compared with Blank control group, the expression of her2 in breast tissues in Model group was higher, and the expression of p16 was lower （P〈O.05 or P〈O.01）. After intervention with Rupi- fang Extract, compared with Model group, the ex- pression of her2 in breast tissues in Rupifang groups was lower, and the expression of p16 higher （P〈O.05 or P〈O.01）. CONCLUSION： The mechanisms of Rupifang Ex- tract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and in- creasing the expression of tumor suppression genes p16.
基金supported by the National Natural Science Foundation of China(Grant Nos.52174362 and 51975207)the Xiangtan Special Project for Building a National Innovative City(Grant No.CG-YB20221043)the Yancheng“Talent Plan of Yellow Sea Pearl"for Leading Talent Project。
文摘In this study, AZ31 Mg alloy was processed by a new severe plasticity deformation methodology with multi-pass lowered temperature, and the deformation behavior and microstructure evolution were investigated by finite element method and electron back-scattered diffraction technique and hardness. The results show that with the increase of deformation pass, the strain gradually springs, and its interval distribution tends to homogenize. Meanwhile, the effective strain increases dramatically with the shear force sudden upgrade in the deformation process. Moreover, the new deformation technique can refine grain size remarkably. With the passes on, {10-12} tensile twins behavior and the pyramidal < c + a > slip are triggered more frequently, leading to the completeness of dynamic recrystallization (DRX) gradually, which weaken and disperse the basal texture obviously. Besides, the standard deviation of hardness is getting smaller, and the maximum can reach 78.40 HV on average, which can be attributed to the even large strain distribution, complete DRX, and the high geometrically necessary dislocation.
基金supported by Science and Technology Planning Project of Inner Mongolia(2020GG0065)the National Natural Science Foundation of China(32060636)+1 种基金Natural Science Foundation of Inner Mongolia(2019MS03018)Shanxi Scholarship Council of China(HGKY2019044)。
文摘The genus Neoseiulus Hughes,1948 is one of the largest genera in Phytoseiidae and contains more than 364 valid species in the world.In this paper,a new species N.setarius Ma,Meng&Fan,sp.nov.is described based on both adult female and male specimens collected from Setaria viridis(L.)Beauv.(Gramineae),in Inner Mongolia of China.The adult females of the new species are characterized by having a fully reticulated dorsal shield,barbed Z5,bellshaped spermathecal calyx with a short basal stalk.Furthermore,seta R1 is off dorsal idiosomal shield in adult males.
基金National Natural Science Foundation of China(Nos.81803979,81741130,81673979 and 81473688)Natural Science Foundation of Guangdong Province(Nos.2018A030313393,2016A030313114)+3 种基金Science and Technology Program of Guangzhou(Nos.201803010051,201707010245,201704020117)Science and Technology Program of Guangdong(No.2014A020212672)the Fourth Batch of TCM Clinical Outstanding Talent Program of China(No.444258)Scientific Research and Innovation Fund of Jinan University/the Fundamental Research Funds for the Central Universities,China(Nos.21617467,21615412).
文摘Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.
基金This research was funded by Science and Technology Program of Guangzhou(Nos.201803010051).
文摘Background:To predict the effective targets of Kang’ai injection and analyze the pharmacological mechanism for the treatment of breast cancer based on the method of network pharmacology.Methods:The Traditional Chinese Medicine Systems Pharmacology database was used to predict the effective components of the Chinese patent medicine Kang’ai injection,and GeneCards database,Online Mendelian Inheritance in Man database and the Therapeutic Target Database were used to predict the therapeutic targets of breast cancer.Cytoscape 3.7.2 was used to construct active ingredient-disease-target network.String database and Cytoscape 3.7.2 software were used to draw the protein-protein interaction network and obtain the core target.Bioconductor and R language were used to analyze the effective action target for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.Results:There were 42 effective active ingredients in the Chinese patent medicine Kang’ai injection,which acted on 105 targets,and it had 32 components that acted on 96 targets associated with breast cancer.The target regulates various biological processes such as inflammation,angiogenesis,apoptosis and cell proliferation,and regulates pathways such as PI3K-Akt signaling pathway,MAPK signaling pathway,AGE-RAGE signaling pathway in diabetic complications and thyroid hormone signaling pathway through gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis.Conclusion:The treatment of breast cancer with the Chinese patent medicine Kang’ai injection is a complex mechanism process with multiple targets,multiple pathways,and multiple choices,which provides a theoretical basis for the further extraction of effective components in the treatment of breast cancer.
基金supported by the National Natural Science Foundation of China(No.51872173)Natural Science Foundation of Shandong Province(No.ZR2022JQ21)。
文摘Herein,vacancy engineering is utilized reasonably to explore molybdenum tungsten oxide nanowires(W_(4)MoO_(3)NWs)rich in O-vacancies as an advanced electrochemical nitrogen reduction reaction(eNRR)electrocatalyst,realizing further enhancement of NRR performance.In 0.1 mol/L Na_(2)SO_(4),W_(4)MoO_(3)NWs rich in O vacancies(CTAB-D-W_(4)MoO_(3))achieve a large NH3yield of 60.77μg h^(-1)mg^(-1)cat.at-0.70 V vs.RHE and a high faradaic efficiency of 56.42%at-0.60 V,much superior to the W_(4)MoO_(3)NWs deficient in oxygen vacancies(20.26μg h^(-1)mg^(-1)cat.and 17.1%at-0.70 V vs.RHE).Meanwhile,W_(4)MoO_(3)NWs rich in O-vacancies also show high electrochemical stability.Density functional theory(DFT)calculations present that O vacancies in CTAB-D-W_(4)MoO_(3)reduce the energy barrier formed by the intermediate of^(*)N-NH,facilitate the activation and further hydrogenation of^(*)N-N,promote the NRR process,and improve NRR activity.
基金the National Natural Science Foun-dation of China(No.22278334)。
文摘For the efficient harnessing of solar energy and mitigation of environmental pollution,the develop-ment and application of semiconductor photocatalysis technology is paramount.Herein,a novel SubPc-Br/CdS supramolecular array with an S-scheme heterojunction was synthesized through the intermolecu-larπ-stacked self-assembly of subphthalocyanine(SubPc-Br)and nanometer cadmium sulfide(CdS).This self-assembly system features a highly structured architecture and excellent stability.Experiments and ground-state differential charge calculations demonstrate that SubPc-Br and CdS form a built-in electric field during the self-assembly process,a critical factor in promoting the dissociation of electrons and holes.Additionally,this study utilized time-dependent density functional theory(TDDFT)to simulate the dynamic adsorption behavior of excited oxygen molecules on the SubPc-Br/CdS interface for the first time.The analysis of molecular charge differential density under different excited states proved that the addi-tion of SubPc-Br molecules not only improves the photocorrosion resistance of CdS in an O2 adsorption environment but also enhances the production of advanced reactive oxygen species under the synergistic action of h+and·O2-.When subjected to visible light,the degradation efficiency of minocycline(MC)achieved 96.8%within 60 min and maintained 80.3%after 5 cycles.In summary,this study highlights the feasibility of creating advanced S-scheme heterojunction photocatalysts through the strategic incor-poration of organic supramolecules with semiconductor catalysts.
基金supported by Yixing Taodu Light Science and Technology Research Plan,Grant Number:2024SF14.
文摘Objectives:Keratin 6A(KRT6A)has been implicated in the progression of multiple malignancies;however,its expression pattern and biological role in cervical cancer(CC)have not been elucidated.This study aims to investigate KRT6A expression in CC tissues and evaluate its effects on cellular proliferation,migration,and invasion,thereby assessing its potential as a biomarker and therapeutic target.Methods:Differentially expressed genes were screened from the Gene Expression Omnibus(GEO)dataset(GSE9750)using the thresholds∣log2FC∣>2 and false discovery rate(FDR)<0.05.Immunohistochemistry was performed to evaluate KRT6A protein expression in tumor tissues.Stable KRT6A knockdown was established in CC cell lines to assess proliferation,colony formation,migration,and invasion in vitro.A nude-mouse xenograft model was used to evaluate tumor growth in vivo.Results:KRT6A expression was significantly increased in CC tissues relative to adjacent non-tumor tissues(p=0.019).Patients with KRT6A-positive tumors had a significantly lower 3-year progression-free survival(PFS)rate than those with KRT6Anegative tumors(45.16%vs.78.57%;p=0.009).KRT6A was identified as an independent prognostic indicator for CC(p=0.044).In vitro,KRT6A silencing significantly reduced colony formation,proliferation,migration,and invasion in SiHa and HeLa cells in comparison to controls(p<0.05).In vivo,tumors in the KRT6A knockdown group were significantly smaller,with reduced expression of both KRT6A and Ki-67 in tumor tissues(p<0.05).Conclusion:KRT6A is overexpressed in CC and associates with adverse clinicopathological features and poor PFS.Knockdown of KRT6A suppresses cell proliferation,migration,and invasion,indicating that KRT6A may represent a promising prognostic biomarker and potential target for treating CC.
基金The National Natural Science Foundation of Chinathe Civil Aviation Administration of China(U1733119)Civil Aviation Science and Technology Project Funding(20150220)
基金partly supported by the National Natural Science Foundation of China (Nos. 52174362, 51975207)the Xiangtan Special Project for Building a National Innovative City,China (No. CG-YB20221043)the Yancheng “Talent Plan of Yellow Sea Pearl” for Leading Talent Project,China。
基金This study was financially supported by the National Natural Science Foundation of China(No.51804087)the Science and Technology Cooperative Foundation of Guizhou province(Nos.[2017]7240 and[2017]5788)+1 种基金the Basic Research Program of Guizhou Province(No.[2019]1091)the Youth Science and Technology Talent Growth Project of Guizhou Education Bureau(No.[2018]107)。
文摘In this study, microstructure and texture evolution of TB8 titanium alloys during hot deformation were investigated by using electron back-scattered diffraction(EBSD) analysis. The results showed that dynamic recrystallization(DRX) behavior of TB8 titanium alloys was drastically sensitive to the strain. As the true strain raised from 0.2 to 0.8, the degree of DRX gradually increased. The nucleation mechanism of recrystallization was observed, including discontinuous dynamic recrystallization(DDRX) resulting from the bulging of original boundaries. Furthermore, continuous dynamic recrystallization(CDRX) occurred because of the transformation of low-angle grain boundaries(LAGBs) to high-angle grain boundaries(HAGBs) in the interior of the original deformed grains. The texture evolution of TB8 titanium alloy during hot deformation process was analyzed in detail, and five texture components were observed,including{001}h100 i,{011}h100 i,{112}h110 i,{111}h110 i, and {111}h112 i. As the true strain increased,deformation textures were gradually weakened due to an increase in the volume fraction of DRX grains. When the true strain was 0.8, the main texture components consisted of the recrystallization texture components of the{001}h100 i and {011}h100 i textures.
基金This work was partly supported by National Natural Science Foundation of China(Grant nos.51975207&51728202)Hunan Provincial Natural Science Foundation for Excellent Young Scholars of China(Grant no.2019JJ30010)+1 种基金the Scientific Research Fund of Hunan Provincial Education Department(Grant No.17B089)the Hunan Provincial Research and Innovation Project for postgraduate(Grant No.CX2018B696).
文摘A novel and effective method to co-extrude metallic alloys is described which named Direct Extrusion and Bending-Shear Deformation.The compound extrusion plates have cracked at 290℃ and 3 mm/s.According to this phenomenon,a model was built to investigate the crack generation and development between the 6061 Al and AZ31 Mg alloy during the compound extrusion process by DEFORM-3D.The cracking behavior of the Mg/Al composite rod with a soft Mg AZ31 core and a hard Al 6061 sleeve were systematically studied to disclose the influence of microstructure on crack in the different regions.The simulation results show that the distribution of strain and velocity has significant differences due to the influence of dies structure and material properties at different locations in the same region.The experimental results show that in the same conditions,there are differences in recrystallization and texture weakening of AZ31 Mg alloys and 6061 Al alloy,which are important factors for the formation of crack.Both the Mg layer and the Al layer have a homogeneous microstructure in the region d.
基金partly supported by the National Natural Science Foundation of China(Grant Nos.51505143 and51704112)the Scientific Research Fund of Hunan Provincial Education Department(Grant No.17B089)the financial supports from the China Postdoctoral Science Foundation(Grant No.2016T90759)
文摘The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically investigated. The results show that the grain size monotonically increases from 6.4 to 12.6 lm and the texture intensity increases from 6.7 to 9.6with the increase in the extrusion temperature. The combining effect of the pre-twinning and the frustum shearing deformation is found to contribute to the development of the weak basal texture in Mg alloys. The Mg alloy sheet produced at the extrusion temperature of 563 K exhibits excellent mechanical properties. The yield strength, ultimate tensile strength and elongation for the extruded alloys are 189.6 MPa, 288.4 MPa and 24.9%, respectively. Such improved mechanical properties are comparable or even superior to those of the alloys subjected to other deformation techniques, rendering the pre-compression and frustum shearing extrusion a promising way for further tailoring properties of Mg alloys.
基金financially supported by the National Basic Research and Development Program of China (No. 2010CB731606)
文摘Microstructure and texture evolution in commercial-purity Zr 702 during cold rolling and annealing was investigated by optical microscopy, transmission electron microscopy, and X-ray diffraction. The results showed that crystallographic slip was the predominant deformation mechanism in the early stage of deformation. Deformation twins started to form when the rolling reduction was larger than 38.9%; both the dislocation density and the number of twins increased with increasing rolling reduction. The initial texture of the Zr 702 plate consisted of the basal fiber component. During cold rolling the strength of the basal fiber first decreased and then increased with increasing rolling reduction. The cold-rolled sheets were fully recrystallized after being annealed at 550℃. The recrystallization temperature and the size of recrystallized grains decreased with increasing rolling reduction. A larger rolling reduction resulted in a higher grain growth rate when the annealing temperature increased from 550℃ to 700℃. The recrystallization texture was characterized by a major basal fiber and a minor {0113}〈2110〉 component. The strength of the recrystallization texture increased with increasing rolling reduction.
基金supported by the Joint funding project of the National Natural Science Foundation of Chinathe China Civil Aviation Administration (No.U1733119)civil aviation science and Technology project (No.20150220)
基金supported by the National Natural Science Foundation of China(Nos.52174362,51975207)Natural Science Foundation of Hunan Province,China(No.2023JJ10020)+1 种基金Xiangtan Special Project for Building a National Innovative City,China(No.CG-YB20221043)Yancheng“Talent Plan of Yellow Sea Pearl”for Leading Talent Project,China。
基金fundings from the National Natural Science Foundation of China (No. 51872173)Taishan Scholar Foundation of Shandong Province (No. tsqn201812068)+3 种基金Natural Science Foundation of Shandong Province (No. ZR2022JQ21)Higher School Youth Innovation Team of Shandong Province (No. 2019KJA013)Hong Kong Scholars Program (No. XJ2019042)Innovation and Technology Commission of the Hong Kong Special Administrative Region (No. ITC-CNERC14EG03)。
文摘Hydrophobic treatment of the catalyst surfaces can suppress the competitive hydrogen evolution reaction(HER) during the nitrogen reduction reaction(NRR).In this work,the surface of Ti_(3)C_(2)Ti_(x) MXene is modified by cetyltrimethylammonium bromide(CTAB) and trimethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-trideca fluorooctyl) silane(FOTS) to increase the hydrophobicity of MXenes.The ammonia(NH_(3)) production rate and faradaic efficiency(FE) are improved from 37.62 to 54.01 μg h^(-1)mg_(cat)^(-1).and 5.5% to 18.1% at-0.7 V vs.RHE,respectively after surface modification.^(15)N isotopic labeling experiment confirms that nitrogen in produced ammonia originates from N_(2) in the electrolyte.The excellent NRR activity of surface hydrophobic MXenes is mainly due to surfactant molecules,which inhibit the entry of water molecules and the competitive HER,which have been verified by in situ FT-IR,DFT and molecular dynamics calculations.This strategy provides an ingenious method to design more active NRR electrocatalysts.
