BACKGROUND Periodontitis,when exacerbated by diabetes,is characterized by increased M1 macrophage polarization and decreased M2 polarization.O-linkedβ-N-acetylglucosamine(O-GlcNAcylation),catalyzed by O-GlcNAc transf...BACKGROUND Periodontitis,when exacerbated by diabetes,is characterized by increased M1 macrophage polarization and decreased M2 polarization.O-linkedβ-N-acetylglucosamine(O-GlcNAcylation),catalyzed by O-GlcNAc transferase(OGT),promotes inflammatory responses in diabetic periodontitis(DP).Additionally,p38 mitogen-activated protein kinase regulates macrophage polarization.However,the interplay between OGT,macrophage polarization,and p38 signaling in the progression of DP remains unexplored.AIM To investigate the effect of OGT on macrophage polarization in DP and its role in mediating O-GlcNAcylation of p38.METHODS For in vivo experiments,mice were divided into four groups:Control,DP model,model+short hairpin(sh)RNAnegative control,and model+sh-OGT.Diabetes was induced by streptozotocin,followed by ligation and lipopolysaccharide(LPS)administration to induce periodontitis.The impact of OGT was assessed by injecting sh-OGT lentivirus.Maxillary bone destruction was evaluated using micro-computed tomography analysis and tartrateresistant acid phosphatase staining,while macrophage polarization was determined through quantitative real-time polymerase chain reaction(qPCR)and immunohistochemistry.For in vitro experiments,RAW264.7 cells were treated with LPS and high glucose(HG)(25 mmol/L D-glucose)to establish a cell model of DP.OGT was inhibited by OGT inhibitor(OSMI4)treatment and knocked down by sh-OGT transfection.M1/M2 polarization was analyzed using qPCR,immunofluorescence,and flow cytometry.Levels of O-GlcNAcylation were measured using immunoprecipitation and western blotting.RESULTS Our results demonstrated that M1 macrophage polarization led to maxillary bone loss in DP mice,associated with elevated O-GlcNAcylation and OGT levels.Knockdown of OGT promoted the shift from M1 to M2 macrophage polarization in both mouse periodontal tissues and LPS+HG-induced RAW264.7 cells.Furthermore,LPS+HG enhanced the O-GlcNAcylation of p38 in RAW264.7 cells.OGT interacted with p38 to promote its O-GlcNAcylation at residues A28,T241,and T347,as well as its phosphorylation at residue Y221.CONCLUSION Inhibition of OGT-mediated p38 O-GlcNAcylation deactivates the p38 pathway by suppressing its self-phosphorylation,thereby promoting M1 to M2 macrophage polarization and mitigating DP.These findings suggested that modulating macrophage polarization through regulation of O-GlcNAcylation may represent a novel therapeutic strategy for treating DP.展开更多
Evolutionary algorithms have been extensively utilized in practical applications.However,manually designed population updating formulas are inherently prone to the subjective influence of the designer.Genetic programm...Evolutionary algorithms have been extensively utilized in practical applications.However,manually designed population updating formulas are inherently prone to the subjective influence of the designer.Genetic programming(GP),characterized by its tree-based solution structure,is a widely adopted technique for optimizing the structure of mathematical models tailored to real-world problems.This paper introduces a GP-based framework(GPEAs)for the autonomous generation of update formulas,aiming to reduce human intervention.Partial modifications to tree-based GP have been instigated,encompassing adjustments to its initialization process and fundamental update operations such as crossover and mutation within the algorithm.By designing suitable function sets and terminal sets tailored to the selected evolutionary algorithm,and ultimately derive an improved update formula.The Cat Swarm Optimization Algorithm(CSO)is chosen as a case study,and the GP-EAs is employed to regenerate the speed update formulas of the CSO.To validate the feasibility of the GP-EAs,the comprehensive performance of the enhanced algorithm(GP-CSO)was evaluated on the CEC2017 benchmark suite.Furthermore,GP-CSO is applied to deduce suitable embedding factors,thereby improving the robustness of the digital watermarking process.The experimental results indicate that the update formulas generated through training with GP-EAs possess excellent performance scalability and practical application proficiency.展开更多
Carbon dioxide hydrogenation to gasoline can effectively alleviate the energy crisis and benefit the global environment.Owing to its orthogonally connected nanosheet configuration,large pore volume,and appropriate thi...Carbon dioxide hydrogenation to gasoline can effectively alleviate the energy crisis and benefit the global environment.Owing to its orthogonally connected nanosheet configuration,large pore volume,and appropriate thickness of single nanosheet,self-pillared pentasil(SPP)nanosheet zeolite is integrated with In_(2)O_(3)-ZrO_(2)as a tandem catalyst for CO_(2)hydrogenation to C_(5+)hydrocarbons.By substituting Al in the SPP framework with Ga,the acid strength of SPP is reduced,and acid density is increased,which favors the generation of C_(5+)hydrocarbons and enhances the cracking resistance of long-chain hydrocarbons.A maximum C_(5+)hydrocarbon selectivity of 82%was obtained on In_(2)O_(3)-ZrO_(2)/Ga-SPP(Si/Ga=100),which shows no deactivation after 200 h reaction time.Furthermore,introducing Pd into the In_(2)O_(3)-ZrO_(2)not only boosts CO_(2)conversion to 11%but also suppresses methane selectivity to below 1%.This study offers valuable insights into the design of highly active CO_(2)-to-gasoline catalysts by leveraging the distinctive structure and acidity of zeolites within the tandem catalyst systems.展开更多
Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau （QTP） in China. However, it is lacking of studies on the effects of warming and...Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau （QTP） in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010-2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in Octo- ber 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments： control （CK）, warming （W）, clipping （C） and warming＋clipping combination （WC）. The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0-30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0-60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0-30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40-100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30-50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the down- ward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen However, long-term data collection is needed to further explain this interesting phenomenon.展开更多
The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is design...The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic.展开更多
L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide meta...L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.展开更多
BACKGROUND Bronchogenic cysts are cystic masses caused by congenital abnormal development of the respiratory system,and usually occur in the pulmonary parenchyma or mediastinum.CASE SUMMARY A rare case of a bronchogen...BACKGROUND Bronchogenic cysts are cystic masses caused by congenital abnormal development of the respiratory system,and usually occur in the pulmonary parenchyma or mediastinum.CASE SUMMARY A rare case of a bronchogenic cyst discovered in the abdominal cavity of a 35-year-old man is reported.Physical examination found a space-occupying lesion in the patient’s abdomen for 4 d.Laparoscopic exploration found the cyst tightly adhered to the stomach and its peripheral blood vessels;therefore,intraoperative laparotomy was performed.The cystic mass was resected en bloc with an Endo-GIA stapler.The final postoperative pathological diagnosis confirmed an abdominal bronchogenic cyst.CONCLUSION This is a rare case of a bronchogenic cyst that was discovered within the abdominal cavity of a male patient.The cyst is easily confused with or misdiagnosed as other lesions.Therefore,it is necessary to distinguish abdominal bronchogenic cyst from gastrointestinal stromal tumor,Meckel’s diverticulum,enteric duplication cyst,or lymphangioma.Although computer tomography and magnetic resonance imaging were the primary diagnostic approaches,endoscopic ultrasound-guided fine-needle aspiration could assist with clarification of the cytological or histopathological diagnosis before surgery.展开更多
Two types of layers were prepared by means of laser surface alloying process using High-power Transverse Flow CO2 laser beam with different additions,which were pure Cr powder and Co alloy powder on the 32Cr3Mo1V subs...Two types of layers were prepared by means of laser surface alloying process using High-power Transverse Flow CO2 laser beam with different additions,which were pure Cr powder and Co alloy powder on the 32Cr3Mo1V substrate.The unique characters of laser treatments,such as microstructure,distribution of elements,and micro-hardness were studies in thorough;furthermore,the abilities anti-molten aluminum's corroding of the layers were tested in 700 centigrade molten aluminum.The results indicate that both laser treated layers can enforce the ability anti-corroding of the molten aluminum on 32Cr3Mo1V substrate,while the laser alloying layer with Cr powder shows the most advantage of anti-aluminum corrosion character,i.e.the layer does not be corroded at all in the corrosion experiment.And the diffused thickness of aluminum in the layers by laser alloying process with Co powder is half below that of in the 32Cr3Mo1V substrate.展开更多
During the life cycle of a plant,seed germination is crucial.Upon ingestion of water,the dry seeds resumed energy metabolism and cellular repair.To dissect the complex mechanisms at the very beginning of seed germinat...During the life cycle of a plant,seed germination is crucial.Upon ingestion of water,the dry seeds resumed energy metabolism and cellular repair.To dissect the complex mechanisms at the very beginning of seed germination,two approaches including transcriptome and small RNA sequencing were conducted during the water imbibition process of mung bean seeds compared with dry seed.The transcriptome sequencing analysis identified 10,108 differentially expressed genes(DEGs)between dry and imbibed mung bean seeds.KEGG enrichment analyses demonstrated numerous DEGs involved in hormone signaling pathways,carbohydrate,and energy metabolism.Out of the total DEGs,129 genes were investigated to involve in abscisic acid,gibberellin,and ethylene pathways,with 56 genes involved in glycolysis and TCA cycle.Through the analysis of small RNA sequencing among different samples,there were 284 miRNAs found in the imbibed and dried seeds of mung bean containing 213 known and 71 novel miRNAs.From comparison between the two types of seeds,51 miRNAs were differentially expressed.The integrated analyses of transcriptome and miRNAome data showed that 23 DEGs are the putative target genes of 8 miRNAs including miR156,miR171b-3p,miR166e-3p,miR169-1,etc.QRT-PCR was used to validate several DEGs and miRNAs.The data suggested that the seed imbibition process is regulated by a variety of DEGs and microRNAs.Meanwhile,we hope to gain a deeper insight into how mung bean seeds germinate in order to optimize seed growth.展开更多
Planning for water quality management is important for facilitating sustainable socio-economic development;however, the planning is also complicated by a variety of uncertainties and nonlinearities. In this study, an ...Planning for water quality management is important for facilitating sustainable socio-economic development;however, the planning is also complicated by a variety of uncertainties and nonlinearities. In this study, an interval-parameter fuzzy robust nonlinear programming (IFRNP) model was developed for water quality management to deal with such difficulties. The developed model incorporated interval nonlinear programming (INP) and fuzzy robust programming (FRP) methods within a general optimization framework. The developed IFRNP model not only could explicitly deal with uncertainties represented as discrete interval numbers and fuzzy membership functions, but also was able to deal with nonlinearities in the objective function.展开更多
Objective:As a traditional herbal formula,Mahuang Xixin Fuzi decoction(MXFD)has been used to treat allergic rhinitis(AR).It regulates the transcription factor GATA3 in T cells,blocks Th2 skewing and rebalances the Th1...Objective:As a traditional herbal formula,Mahuang Xixin Fuzi decoction(MXFD)has been used to treat allergic rhinitis(AR).It regulates the transcription factor GATA3 in T cells,blocks Th2 skewing and rebalances the Th1/Th2 immunity.Type 2 innate lymphoid cells(ILC2s)are closely associated with GATA3.However,it remains unknown whether ILC2s could be one mechanism through which MXFD acts.We sought to elucidate the efficacy and mechanism of action of this decoction in AR treatment.Methods:Forty C57BL/6J female mice were equally divided into control,model,loratadine-and MXFDtreated groups in random.AR was induced by ovalbumin(OVA),and then treatment with loratadine or MXFD was administered.AR scores were evaluated and compared before and after treatment.Pathological changes in the nasal mucosa and lung were observed using hematoxylin-eosin staining of tissue samples.Activation of ILC2 in nasal mucosa was assessed by immunofluorescence and quantitative polymerase chain reaction analysis.ILC2 cell count in lungs was measured by flow cytometry and levels of interleukin-(IL)4,IL-5 and IL-13 in serum were detected by ELISA.Results:The decoction alleviated the symptoms of AR in mice,improved vascular congestion and expansion,glandular hyperplasia and inflammatory cell infiltration in mouse nasal mucosa and slowly improved the interstitial pneumonia and lesions.Meanwhile,MXFD reduced the number and percentage of ILC2s in the nasal mucosa and lungs,downregulated the expression of GATA3 mRNA and RORa mRNA,and reduced the related inflammatory cytokine levels,including IL-4,IL-5 and IL-13.Conclusion:These data suggest that inhibition of ILC2s by MXFD may be an important means by which to treat AR.展开更多
目的:探究血清氯离子浓度对危重症和临床病情稳定的肝硬化失代偿期患者的预后价值。方法:回顾性纳入2017年1月至2022年1月于兰州大学第一医院重症医学科(intensive care unit,ICU)和消化科就诊的肝硬化失代偿期患者。分为ICU组和消化科...目的:探究血清氯离子浓度对危重症和临床病情稳定的肝硬化失代偿期患者的预后价值。方法:回顾性纳入2017年1月至2022年1月于兰州大学第一医院重症医学科(intensive care unit,ICU)和消化科就诊的肝硬化失代偿期患者。分为ICU组和消化科组;ICU组终点事件是院内死亡,logistic回归分析血清氯化物水平与ICU死亡率之间的关系,采用受试者工作特征曲线,并计算曲线下面积(area under the curve,AUC)评估血氯水平对ICU死亡率的预测价值。对纳入的消化科患者随访,终点事件是患者全因死亡率,运用Cox回归分析和Kaplan-Meier分析,探讨血氯水平对于患者死亡率的预测价值。结果:ICU组中:血清氯离子与ICU院内死亡率明显相关(OR=0.934,95%CI=0.871~0.993,P=0.035),血氯预测ICU院内死亡率AUC值为0.687;消化科组:在Child-Pugh评分<10的亚组中,血清氯离子浓度与患者死亡率明显相关(HR=0.906,95%CI=0.822~0.997,P=0.043),低氯血症与更低的生存率相关。结论:低氯血症与肝硬化失代偿期患者的死亡率增加相关。展开更多
To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy...To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy storage systems based on measurement feedback is proposed.First,considering the high charge/discharge losses of hydrogen storage and the low energy density of battery storage,an operational optimization objective is established to enable adaptive energy adjustment in the Battery-hydrogen hybrid energy storage system.Next,an online optimization model minimizing the operational cost of the hybrid system is constructed to suppress grid-injected power deviations with satisfying the operational constraints of hydrogen storage and batteries.Finally,utilizing the online measurement of the energy states of hydrogen storage and batteries,an online optimization strategy based on measurement feedback is designed.Case study results show:before and after smoothing the fluctuations in wind power,the time when the power exceeded the upper and lower limits of the grid-injected power accounted for 24.1%and 1.45%of the total time,respectively,the proposed strategy can effectively keep the grid-injected power deviations of wind farms within the allowable range.Hydrogen storage and batteries respectively undertake long-term and short-term charge/discharge tasks,effectively reducing charge/discharge losses of the Battery-hydrogen hybrid energy storage systems and improving its operational efficiency.展开更多
A flexure hinge is a major component in designing compliant mechanisms that o ers unique possibilities in a wide range of application fields in which high positioning accuracy is required. Although various flexure hin...A flexure hinge is a major component in designing compliant mechanisms that o ers unique possibilities in a wide range of application fields in which high positioning accuracy is required. Although various flexure hinges with di erent configurations have been successively proposed, they are often designed based on designers' experiences and inspirations. This study presents a systematic method for topological optimization of flexure hinges by using the level set method. Optimization formulations are developed by considering the functional requirements and geometrical constraints of flexure hinges. The functional requirements are first constructed by maximizing the compliance in the desired direction while minimizing the compliances in the other directions. The weighting sum method is used to construct an objective function in which a self-adjust method is used to set the weighting factors. A constraint on the symmetry of the obtained configuration is developed. Several numerical examples are presented to demonstrate the validity of the proposed method. The obtained results reveal that the design of a flexure hinge starting from the topology level can yield more choices for compliant mechanism design and obtain better designs that achieve higher performance.展开更多
基金Supported by the National Natural Science Foundation of China,No.81973684Natural Science Foundation of Sichuan Province,No.2023NSFSC1760Youth Talent Fund of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital,No.2021QN09。
文摘BACKGROUND Periodontitis,when exacerbated by diabetes,is characterized by increased M1 macrophage polarization and decreased M2 polarization.O-linkedβ-N-acetylglucosamine(O-GlcNAcylation),catalyzed by O-GlcNAc transferase(OGT),promotes inflammatory responses in diabetic periodontitis(DP).Additionally,p38 mitogen-activated protein kinase regulates macrophage polarization.However,the interplay between OGT,macrophage polarization,and p38 signaling in the progression of DP remains unexplored.AIM To investigate the effect of OGT on macrophage polarization in DP and its role in mediating O-GlcNAcylation of p38.METHODS For in vivo experiments,mice were divided into four groups:Control,DP model,model+short hairpin(sh)RNAnegative control,and model+sh-OGT.Diabetes was induced by streptozotocin,followed by ligation and lipopolysaccharide(LPS)administration to induce periodontitis.The impact of OGT was assessed by injecting sh-OGT lentivirus.Maxillary bone destruction was evaluated using micro-computed tomography analysis and tartrateresistant acid phosphatase staining,while macrophage polarization was determined through quantitative real-time polymerase chain reaction(qPCR)and immunohistochemistry.For in vitro experiments,RAW264.7 cells were treated with LPS and high glucose(HG)(25 mmol/L D-glucose)to establish a cell model of DP.OGT was inhibited by OGT inhibitor(OSMI4)treatment and knocked down by sh-OGT transfection.M1/M2 polarization was analyzed using qPCR,immunofluorescence,and flow cytometry.Levels of O-GlcNAcylation were measured using immunoprecipitation and western blotting.RESULTS Our results demonstrated that M1 macrophage polarization led to maxillary bone loss in DP mice,associated with elevated O-GlcNAcylation and OGT levels.Knockdown of OGT promoted the shift from M1 to M2 macrophage polarization in both mouse periodontal tissues and LPS+HG-induced RAW264.7 cells.Furthermore,LPS+HG enhanced the O-GlcNAcylation of p38 in RAW264.7 cells.OGT interacted with p38 to promote its O-GlcNAcylation at residues A28,T241,and T347,as well as its phosphorylation at residue Y221.CONCLUSION Inhibition of OGT-mediated p38 O-GlcNAcylation deactivates the p38 pathway by suppressing its self-phosphorylation,thereby promoting M1 to M2 macrophage polarization and mitigating DP.These findings suggested that modulating macrophage polarization through regulation of O-GlcNAcylation may represent a novel therapeutic strategy for treating DP.
文摘Evolutionary algorithms have been extensively utilized in practical applications.However,manually designed population updating formulas are inherently prone to the subjective influence of the designer.Genetic programming(GP),characterized by its tree-based solution structure,is a widely adopted technique for optimizing the structure of mathematical models tailored to real-world problems.This paper introduces a GP-based framework(GPEAs)for the autonomous generation of update formulas,aiming to reduce human intervention.Partial modifications to tree-based GP have been instigated,encompassing adjustments to its initialization process and fundamental update operations such as crossover and mutation within the algorithm.By designing suitable function sets and terminal sets tailored to the selected evolutionary algorithm,and ultimately derive an improved update formula.The Cat Swarm Optimization Algorithm(CSO)is chosen as a case study,and the GP-EAs is employed to regenerate the speed update formulas of the CSO.To validate the feasibility of the GP-EAs,the comprehensive performance of the enhanced algorithm(GP-CSO)was evaluated on the CEC2017 benchmark suite.Furthermore,GP-CSO is applied to deduce suitable embedding factors,thereby improving the robustness of the digital watermarking process.The experimental results indicate that the update formulas generated through training with GP-EAs possess excellent performance scalability and practical application proficiency.
基金financially supported by the National Key Research and Development Program of China(2024YFB4105401)the National Natural Science Foundation of China(22472017)+1 种基金the Liaoning Binhai Laboratory(LBLG-2024-06)the Fundamental Research Funds for the Central Universities(DUT22LAB602and DUT24RC(3)071)。
文摘Carbon dioxide hydrogenation to gasoline can effectively alleviate the energy crisis and benefit the global environment.Owing to its orthogonally connected nanosheet configuration,large pore volume,and appropriate thickness of single nanosheet,self-pillared pentasil(SPP)nanosheet zeolite is integrated with In_(2)O_(3)-ZrO_(2)as a tandem catalyst for CO_(2)hydrogenation to C_(5+)hydrocarbons.By substituting Al in the SPP framework with Ga,the acid strength of SPP is reduced,and acid density is increased,which favors the generation of C_(5+)hydrocarbons and enhances the cracking resistance of long-chain hydrocarbons.A maximum C_(5+)hydrocarbon selectivity of 82%was obtained on In_(2)O_(3)-ZrO_(2)/Ga-SPP(Si/Ga=100),which shows no deactivation after 200 h reaction time.Furthermore,introducing Pd into the In_(2)O_(3)-ZrO_(2)not only boosts CO_(2)conversion to 11%but also suppresses methane selectivity to below 1%.This study offers valuable insights into the design of highly active CO_(2)-to-gasoline catalysts by leveraging the distinctive structure and acidity of zeolites within the tandem catalyst systems.
基金financially supported by the Hundred Talent Program of Chinese Academy of Sciences and the National Natural Science Foundation of China (41301211, 41201195)
文摘Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau （QTP） in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010-2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in Octo- ber 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments： control （CK）, warming （W）, clipping （C） and warming＋clipping combination （WC）. The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0-30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0-60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0-30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40-100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30-50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the down- ward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen However, long-term data collection is needed to further explain this interesting phenomenon.
基金supported by the National Natural Science Foundation of China (51962008)。
文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic.
基金Project supported by the National Natural Science Foundation of China(51962008)Jiangxi Provincial Natural Science Foundation(20202BABL203018)。
文摘L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.
文摘BACKGROUND Bronchogenic cysts are cystic masses caused by congenital abnormal development of the respiratory system,and usually occur in the pulmonary parenchyma or mediastinum.CASE SUMMARY A rare case of a bronchogenic cyst discovered in the abdominal cavity of a 35-year-old man is reported.Physical examination found a space-occupying lesion in the patient’s abdomen for 4 d.Laparoscopic exploration found the cyst tightly adhered to the stomach and its peripheral blood vessels;therefore,intraoperative laparotomy was performed.The cystic mass was resected en bloc with an Endo-GIA stapler.The final postoperative pathological diagnosis confirmed an abdominal bronchogenic cyst.CONCLUSION This is a rare case of a bronchogenic cyst that was discovered within the abdominal cavity of a male patient.The cyst is easily confused with or misdiagnosed as other lesions.Therefore,it is necessary to distinguish abdominal bronchogenic cyst from gastrointestinal stromal tumor,Meckel’s diverticulum,enteric duplication cyst,or lymphangioma.Although computer tomography and magnetic resonance imaging were the primary diagnostic approaches,endoscopic ultrasound-guided fine-needle aspiration could assist with clarification of the cytological or histopathological diagnosis before surgery.
文摘Two types of layers were prepared by means of laser surface alloying process using High-power Transverse Flow CO2 laser beam with different additions,which were pure Cr powder and Co alloy powder on the 32Cr3Mo1V substrate.The unique characters of laser treatments,such as microstructure,distribution of elements,and micro-hardness were studies in thorough;furthermore,the abilities anti-molten aluminum's corroding of the layers were tested in 700 centigrade molten aluminum.The results indicate that both laser treated layers can enforce the ability anti-corroding of the molten aluminum on 32Cr3Mo1V substrate,while the laser alloying layer with Cr powder shows the most advantage of anti-aluminum corrosion character,i.e.the layer does not be corroded at all in the corrosion experiment.And the diffused thickness of aluminum in the layers by laser alloying process with Co powder is half below that of in the 32Cr3Mo1V substrate.
基金This study was funded by the Agricultural Variety Improvement Project of Shandong Province(Grant Nos.2019LZGC017 and 2021LZGC025)Modern Agricultural Industrial Technology System of Shandong Province(Grant No.SDAIT-15-01).
文摘During the life cycle of a plant,seed germination is crucial.Upon ingestion of water,the dry seeds resumed energy metabolism and cellular repair.To dissect the complex mechanisms at the very beginning of seed germination,two approaches including transcriptome and small RNA sequencing were conducted during the water imbibition process of mung bean seeds compared with dry seed.The transcriptome sequencing analysis identified 10,108 differentially expressed genes(DEGs)between dry and imbibed mung bean seeds.KEGG enrichment analyses demonstrated numerous DEGs involved in hormone signaling pathways,carbohydrate,and energy metabolism.Out of the total DEGs,129 genes were investigated to involve in abscisic acid,gibberellin,and ethylene pathways,with 56 genes involved in glycolysis and TCA cycle.Through the analysis of small RNA sequencing among different samples,there were 284 miRNAs found in the imbibed and dried seeds of mung bean containing 213 known and 71 novel miRNAs.From comparison between the two types of seeds,51 miRNAs were differentially expressed.The integrated analyses of transcriptome and miRNAome data showed that 23 DEGs are the putative target genes of 8 miRNAs including miR156,miR171b-3p,miR166e-3p,miR169-1,etc.QRT-PCR was used to validate several DEGs and miRNAs.The data suggested that the seed imbibition process is regulated by a variety of DEGs and microRNAs.Meanwhile,we hope to gain a deeper insight into how mung bean seeds germinate in order to optimize seed growth.
文摘Planning for water quality management is important for facilitating sustainable socio-economic development;however, the planning is also complicated by a variety of uncertainties and nonlinearities. In this study, an interval-parameter fuzzy robust nonlinear programming (IFRNP) model was developed for water quality management to deal with such difficulties. The developed model incorporated interval nonlinear programming (INP) and fuzzy robust programming (FRP) methods within a general optimization framework. The developed IFRNP model not only could explicitly deal with uncertainties represented as discrete interval numbers and fuzzy membership functions, but also was able to deal with nonlinearities in the objective function.
基金the National Natural Science Foundation of China(81774375)the Fundamental Research Funds for the Central Universities(2018-JYB-ZDSYS002).
文摘Objective:As a traditional herbal formula,Mahuang Xixin Fuzi decoction(MXFD)has been used to treat allergic rhinitis(AR).It regulates the transcription factor GATA3 in T cells,blocks Th2 skewing and rebalances the Th1/Th2 immunity.Type 2 innate lymphoid cells(ILC2s)are closely associated with GATA3.However,it remains unknown whether ILC2s could be one mechanism through which MXFD acts.We sought to elucidate the efficacy and mechanism of action of this decoction in AR treatment.Methods:Forty C57BL/6J female mice were equally divided into control,model,loratadine-and MXFDtreated groups in random.AR was induced by ovalbumin(OVA),and then treatment with loratadine or MXFD was administered.AR scores were evaluated and compared before and after treatment.Pathological changes in the nasal mucosa and lung were observed using hematoxylin-eosin staining of tissue samples.Activation of ILC2 in nasal mucosa was assessed by immunofluorescence and quantitative polymerase chain reaction analysis.ILC2 cell count in lungs was measured by flow cytometry and levels of interleukin-(IL)4,IL-5 and IL-13 in serum were detected by ELISA.Results:The decoction alleviated the symptoms of AR in mice,improved vascular congestion and expansion,glandular hyperplasia and inflammatory cell infiltration in mouse nasal mucosa and slowly improved the interstitial pneumonia and lesions.Meanwhile,MXFD reduced the number and percentage of ILC2s in the nasal mucosa and lungs,downregulated the expression of GATA3 mRNA and RORa mRNA,and reduced the related inflammatory cytokine levels,including IL-4,IL-5 and IL-13.Conclusion:These data suggest that inhibition of ILC2s by MXFD may be an important means by which to treat AR.
文摘目的:探究血清氯离子浓度对危重症和临床病情稳定的肝硬化失代偿期患者的预后价值。方法:回顾性纳入2017年1月至2022年1月于兰州大学第一医院重症医学科(intensive care unit,ICU)和消化科就诊的肝硬化失代偿期患者。分为ICU组和消化科组;ICU组终点事件是院内死亡,logistic回归分析血清氯化物水平与ICU死亡率之间的关系,采用受试者工作特征曲线,并计算曲线下面积(area under the curve,AUC)评估血氯水平对ICU死亡率的预测价值。对纳入的消化科患者随访,终点事件是患者全因死亡率,运用Cox回归分析和Kaplan-Meier分析,探讨血氯水平对于患者死亡率的预测价值。结果:ICU组中:血清氯离子与ICU院内死亡率明显相关(OR=0.934,95%CI=0.871~0.993,P=0.035),血氯预测ICU院内死亡率AUC值为0.687;消化科组:在Child-Pugh评分<10的亚组中,血清氯离子浓度与患者死亡率明显相关(HR=0.906,95%CI=0.822~0.997,P=0.043),低氯血症与更低的生存率相关。结论:低氯血症与肝硬化失代偿期患者的死亡率增加相关。
基金Supported by State Grid Zhejiang Electric Power Co.,Ltd.Science and Technology Project Funding(No.B311DS230005).
文摘To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy storage systems based on measurement feedback is proposed.First,considering the high charge/discharge losses of hydrogen storage and the low energy density of battery storage,an operational optimization objective is established to enable adaptive energy adjustment in the Battery-hydrogen hybrid energy storage system.Next,an online optimization model minimizing the operational cost of the hybrid system is constructed to suppress grid-injected power deviations with satisfying the operational constraints of hydrogen storage and batteries.Finally,utilizing the online measurement of the energy states of hydrogen storage and batteries,an online optimization strategy based on measurement feedback is designed.Case study results show:before and after smoothing the fluctuations in wind power,the time when the power exceeded the upper and lower limits of the grid-injected power accounted for 24.1%and 1.45%of the total time,respectively,the proposed strategy can effectively keep the grid-injected power deviations of wind farms within the allowable range.Hydrogen storage and batteries respectively undertake long-term and short-term charge/discharge tasks,effectively reducing charge/discharge losses of the Battery-hydrogen hybrid energy storage systems and improving its operational efficiency.
基金Supported by National Natural Science Foundation of China(Grant Nos.51605166,51820105007)Fundamental Research Funds for the Central Universities of China
文摘A flexure hinge is a major component in designing compliant mechanisms that o ers unique possibilities in a wide range of application fields in which high positioning accuracy is required. Although various flexure hinges with di erent configurations have been successively proposed, they are often designed based on designers' experiences and inspirations. This study presents a systematic method for topological optimization of flexure hinges by using the level set method. Optimization formulations are developed by considering the functional requirements and geometrical constraints of flexure hinges. The functional requirements are first constructed by maximizing the compliance in the desired direction while minimizing the compliances in the other directions. The weighting sum method is used to construct an objective function in which a self-adjust method is used to set the weighting factors. A constraint on the symmetry of the obtained configuration is developed. Several numerical examples are presented to demonstrate the validity of the proposed method. The obtained results reveal that the design of a flexure hinge starting from the topology level can yield more choices for compliant mechanism design and obtain better designs that achieve higher performance.
