Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary a...Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective properties.The purpose of this study is to assess the impact of BBR on DCM.Methods:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart sections.Microstructural and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin staining.Immunofluorescence and western blot were used to determine protein expression.Results:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane components.BBR exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling pathways.In addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its efficacy.Conclusion:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3βsignaling.Further studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.展开更多
Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ability.However,there are abundant persistent free radicals(PFRs)in biochar,so the d...Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ability.However,there are abundant persistent free radicals(PFRs)in biochar,so the direct and indirect PFRs-mediated removal of organic and inorganic contaminants by biochar was widely reported.In order to comprehend deeply the formation of PFRs in biochar and their interactions with contaminants,this paper reviews the formation mechanisms of PFRs in biochar and the PFRs-mediated environmental applications of biochar in recent years.Finally,future challenges in this field are also proposed.This review provides a more comprehensive understanding on the emerging applications of biochar from the viewpoint of the catalytic role of PFRs.展开更多
Objective: Lung-toxin Dispelling Formula No. 1, referred to as Respiratory Detox Shot(RDS), was developed based on a classical prescription of traditional Chinese medicine(TCM) and the theoretical understanding of her...Objective: Lung-toxin Dispelling Formula No. 1, referred to as Respiratory Detox Shot(RDS), was developed based on a classical prescription of traditional Chinese medicine(TCM) and the theoretical understanding of herbal properties within TCM. Therapeutic benefits of using RDS for both disease control and prevention, in the effort to contain the coronavirus disease 2019(COVID-19), have been shown. However,the biochemically active constituents of RDS and their mechanisms of action are still unclear. The goal of the present study is to clarify the material foundation and action mechanism of RDS.Methods: To conduct an analysis of RDS, an integrative analytical platform was constructed, including target prediction, protein–protein interaction(PPI) network, and cluster analysis;further, the hub genes involved in the disease-related pathways were identified, and the their corresponding compounds were used for in vitro validation of molecular docking predictions. The presence of these validated compounds was also measured in samples of the RDS formula to quantify the abundance of the biochemically active constituents. In our network pharmacological study, a total of 26 bioinformatic programs and databases were used, and six networks, covering the entire Zang-fu viscera, were constructed to comprehensively analyze the intricate connections among the compounds-targets-disease pathways-meridians of RDS.Results: For all 1071 known chemical constituents of the nine ingredients in RDS, identified from established TCM databases, 157 passed drug-likeness screening and led to 339 predicted targets in the constituent–target network. Forty-two hub genes with core regulatory effects were extracted from the PPI network, and 134 compounds and 29 crucial disease pathways were implicated in the target–constitu ent–disease network. Twelve disease pathways attributed to the Lung–Large Intestine meridians, with six and five attributed to the Kidney–Urinary Bladder and Stomach–Spleen meridians, respectively. Onehundred and eighteen candidate constituents showed a high binding affinity with SARS-coronavirus-23-chymotrypsin-like protease(3 CLpro), as indicated by molecular docking using computational pattern recognition. The in vitro activity of 22 chemical constituents of RDS was validated using the 3 CLproinhibition assay. Finally, using liquid chromatography mass spectrometry in data-independent analysis mode,the presence of seven out of these 22 constituents was confirmed and validated in an aqueous decoction of RDS, using reference standards in both non-targeted and targeted approaches.Conclusion: RDS acts primarily in the Lung–Large Intestine, Kidney–Urinary Bladder and Stomach–Spleen meridians, with other Zang-fu viscera strategically covered by all nine ingredients. In the context of TCM meridian theory, the multiple components and targets of RDS contribute to RDS’s dual effects of healthstrengthening and pathogen-eliminating. This results in general therapeutic effects for early COVID-19 control and prevention.展开更多
The biosorption potential of dried activated sludge as a biosorbent for zinc（Ⅱ） removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dos...The biosorption potential of dried activated sludge as a biosorbent for zinc（Ⅱ） removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosage on the biosorption processes were determined,and the equilibrium data were modeled by the Langmuir and Freundlich isotherms.The Langmuir isotherm model （R 2=0.999） was proved to fit the equilibrium data much better than the Freundlich isotherm model （R 2=0.918）.The monolayer adsorption capacity of dried activated sludge for zinc（Ⅱ） was found to be 17.86 mg/g at pH of 5 and 25°C.The kinetic data were tested using pseudo firstand second-order models.The results suggested that the pseudo second-order model （R 2 〉 0.999） was better for the description of the adsorption behavior of zinc（Ⅱ） onto the dried activated sludge.Fourier transform infrared spectral analysis showed that the dominant mechanism of zinc（Ⅱ） biosorption onto the dried activated sludge was the binding between amide groups and zinc ions.展开更多
Based on the data of measured formation pressure, drilling fluid density of key exploration wells and calculated pressure by well logging, combined with the analysis of natural gas geological conditions, the character...Based on the data of measured formation pressure, drilling fluid density of key exploration wells and calculated pressure by well logging, combined with the analysis of natural gas geological conditions, the characteristics and formation mechanisms of formation fluid overpressure systems in different foreland basins and the relationship between overpressure systems and large-scale gas accumulation are discussed.(1) The formation mechanisms of formation overpressure in different foreland basins are different. The formation mechanism of overpressure in the Kuqa foreland basin is mainly the overpressure sealing of plastic salt gypsum layer and hydrocarbon generation pressurization in deep–ultra-deep layers, that in the southern Junggar foreland basin is mainly hydrocarbon generation pressurization and under-compaction sealing, and that in the western Sichuan foreland basin is mainly hydrocarbon generation pressurization and paleo-fluid overpressure residual.(2) There are three common characteristics in foreland basins, i.e. superimposed development of multi-type overpressure and multi-layer overpressure, strong–extremely strong overpressure developed in a closed foreland thrust belt, and strong–extremely strong overpressure developed in a deep foreland uplift area.(3) There are four regional overpressure sealing and storage mechanisms, which play an important role in controlling large gas fields, such as the overpressure of plastic salt gypsum layer, the overpressure formed by hydrocarbon generation pressurization, the residual overpressure after Himalayan uplift and denudation, and the under-compaction overpressure.(4) Regional overpressure is an important guarantee for forming large gas fields, the sufficient gas source, large-scale reservoir and trap development in overpressure system are the basic conditions for forming large gas fields, and the overpressure system is conducive to forming deep to ultra-deep large gas fields.展开更多
AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospit...AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University from June 2000 to December 2007.Data regarding demographic,clinical characteristics and immunosuppressants usage were analyzed. RESULTS:A total of 227 eligible patients were evaluated in this study,including 104 patients with Crohn’s disease and 123 with ulcerative colitis.Among the patients,61 had indications for immunosuppressive agents use.However,only 21 (34.4%)received immunosuppressive agents.Among the 21 patients,6(37.5%)received a subtherapeutic dose of azathioprine with no attempt to increase the dosage.Of the 20 patients that received immunosuppressive agent treatment longer than 6 mo,15 patients went into remission,four patients were not affected and one relapsed.Among these 20 patients,four patients suffered from myelotoxicity and one suffered from hepatotoxicity.CONCLUSION:Immunosuppressive agents are used less frequently to treat IBD patients from East China compared with Western countries.Monitoring immunosuppressive agent use is recommended to optimize dispensation of drugs for IBD in China.展开更多
In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protectio...In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protection of the IoV has become the focus of the society.This paper analyzes the advantages and disadvantages of the existing location privacy protection system structure and algorithms,proposes a privacy protection system structure based on untrusted data collection server,and designs a vehicle location acquisition algorithm based on a local differential privacy and game model.The algorithm first meshes the road network space.Then,the dynamic game model is introduced into the game user location privacy protection model and the attacker location semantic inference model,thereby minimizing the possibility of exposing the regional semantic privacy of the k-location set while maximizing the availability of the service.On this basis,a statistical method is designed,which satisfies the local differential privacy of k-location sets and obtains unbiased estimation of traffic density in different regions.Finally,this paper verifies the algorithm based on the data set of mobile vehicles in Shanghai.The experimental results show that the algorithm can guarantee the user’s location privacy and location semantic privacy while satisfying the service quality requirements,and provide better privacy protection and service for the users of the IoV.展开更多
Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity ...Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity of blockchain has caused widespread concern.In this paper,we put forward AABN,an Anonymity Assessment model based on Bayesian Network.Firstly,we investigate and analyze the anonymity assessment techniques,and focus on typical anonymity assessment schemes.Then the related concepts involved in the assessment model are introduced and the model construction process is described in detail.Finally,the anonymity in the MIX anonymous network is quantitatively evaluated using the methods of accurate reasoning and approximate reasoning respectively,and the anonymity assessment experiments under different output strategies of the MIX anonymous network are analyzed.展开更多
Porous Ti with low modulus,excellent bio-corrosion resistance,biocompatibility,and antibacterial activity is highly pursued as advanced implant materials.In this work,a new approach to prepare micron porous structures...Porous Ti with low modulus,excellent bio-corrosion resistance,biocompatibility,and antibacterial activity is highly pursued as advanced implant materials.In this work,a new approach to prepare micron porous structures on the surface layer of a grade 2 commercially-pure Ti(TA2)was proposed,which utilized a simple vacuum wetting process of pure Ag on the surface of TA2.The microstructure,corrosion resistance,biocompatibility,mechanical properties,antibacterial ability,and formation mechanism of the asfabricated porous Ti were studied.The results show that the pores(with average pore sizes of 0.5-5μm)are distributed on the surface layer of the TA2 with a depth of~10μm.In particular,a large number of silver nanoparticles(Ag NPs)form which are dispersed on the porous structures.The formation mechanisms of the porous structures and Ag NPs were elucidated,suggesting that the volatilization/sublimation of Ag in TA2 is crucial.The porous Ti possesses excellent bio-corrosion resistance,surface wettability,biocompatibility,antibacterial activity,and a relatively low elastic modulus of 40-55 GPa,which may have a promising future in the field of orthopedic implants.This work also provides a novel idea for the development of advanced porous Ti materials for orthopedic-related basic research and biomedical applications.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82270892)Natural Science Foundation of Hubei Province(Grant No.2022CFB287)+2 种基金Xianning City Science and Technology Plan Project(Grant No.2022ZRKX052)School projects of Hubei University of Science and Technology(Grant No.2022T01,2021WG05,2021TNB01)Hubei University of Science and Technology School-level Fund(Grant No.BK202122).
文摘Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective properties.The purpose of this study is to assess the impact of BBR on DCM.Methods:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart sections.Microstructural and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin staining.Immunofluorescence and western blot were used to determine protein expression.Results:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane components.BBR exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling pathways.In addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its efficacy.Conclusion:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3βsignaling.Further studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.
基金supported by the National Natural Science Foundation of China(No.52000013)the Scientific Research Foundation of Hunan Provincial Education Department,China(No.18B415,18B406 and 18A378)+1 种基金the Natural Science Foundation of Hunan Province,China(No.2020JJ4643)the training program for Excellent Yong Innovators of Changsha(No.kq1802022)。
文摘Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ability.However,there are abundant persistent free radicals(PFRs)in biochar,so the direct and indirect PFRs-mediated removal of organic and inorganic contaminants by biochar was widely reported.In order to comprehend deeply the formation of PFRs in biochar and their interactions with contaminants,this paper reviews the formation mechanisms of PFRs in biochar and the PFRs-mediated environmental applications of biochar in recent years.Finally,future challenges in this field are also proposed.This review provides a more comprehensive understanding on the emerging applications of biochar from the viewpoint of the catalytic role of PFRs.
基金the financial support from National Key Research and Development Program of China (No.2018YFC1707900).
文摘Objective: Lung-toxin Dispelling Formula No. 1, referred to as Respiratory Detox Shot(RDS), was developed based on a classical prescription of traditional Chinese medicine(TCM) and the theoretical understanding of herbal properties within TCM. Therapeutic benefits of using RDS for both disease control and prevention, in the effort to contain the coronavirus disease 2019(COVID-19), have been shown. However,the biochemically active constituents of RDS and their mechanisms of action are still unclear. The goal of the present study is to clarify the material foundation and action mechanism of RDS.Methods: To conduct an analysis of RDS, an integrative analytical platform was constructed, including target prediction, protein–protein interaction(PPI) network, and cluster analysis;further, the hub genes involved in the disease-related pathways were identified, and the their corresponding compounds were used for in vitro validation of molecular docking predictions. The presence of these validated compounds was also measured in samples of the RDS formula to quantify the abundance of the biochemically active constituents. In our network pharmacological study, a total of 26 bioinformatic programs and databases were used, and six networks, covering the entire Zang-fu viscera, were constructed to comprehensively analyze the intricate connections among the compounds-targets-disease pathways-meridians of RDS.Results: For all 1071 known chemical constituents of the nine ingredients in RDS, identified from established TCM databases, 157 passed drug-likeness screening and led to 339 predicted targets in the constituent–target network. Forty-two hub genes with core regulatory effects were extracted from the PPI network, and 134 compounds and 29 crucial disease pathways were implicated in the target–constitu ent–disease network. Twelve disease pathways attributed to the Lung–Large Intestine meridians, with six and five attributed to the Kidney–Urinary Bladder and Stomach–Spleen meridians, respectively. Onehundred and eighteen candidate constituents showed a high binding affinity with SARS-coronavirus-23-chymotrypsin-like protease(3 CLpro), as indicated by molecular docking using computational pattern recognition. The in vitro activity of 22 chemical constituents of RDS was validated using the 3 CLproinhibition assay. Finally, using liquid chromatography mass spectrometry in data-independent analysis mode,the presence of seven out of these 22 constituents was confirmed and validated in an aqueous decoction of RDS, using reference standards in both non-targeted and targeted approaches.Conclusion: RDS acts primarily in the Lung–Large Intestine, Kidney–Urinary Bladder and Stomach–Spleen meridians, with other Zang-fu viscera strategically covered by all nine ingredients. In the context of TCM meridian theory, the multiple components and targets of RDS contribute to RDS’s dual effects of healthstrengthening and pathogen-eliminating. This results in general therapeutic effects for early COVID-19 control and prevention.
基金supported by the National Natural Science Foundation of China (No. 50778066)the National Science and Technology Support Program of China(No. 2006BAJ04A13)+1 种基金the Program for New Century Excellent Talents in University from the Ministry of Education of China (No. NCET-08-0181)the China Postdoctoral Science Foundation (No. 200801338)
文摘The biosorption potential of dried activated sludge as a biosorbent for zinc（Ⅱ） removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosage on the biosorption processes were determined,and the equilibrium data were modeled by the Langmuir and Freundlich isotherms.The Langmuir isotherm model （R 2=0.999） was proved to fit the equilibrium data much better than the Freundlich isotherm model （R 2=0.918）.The monolayer adsorption capacity of dried activated sludge for zinc（Ⅱ） was found to be 17.86 mg/g at pH of 5 and 25°C.The kinetic data were tested using pseudo firstand second-order models.The results suggested that the pseudo second-order model （R 2 〉 0.999） was better for the description of the adsorption behavior of zinc（Ⅱ） onto the dried activated sludge.Fourier transform infrared spectral analysis showed that the dominant mechanism of zinc（Ⅱ） biosorption onto the dried activated sludge was the binding between amide groups and zinc ions.
基金Supported by the Petrochina Science and Technology Major Project(2016B-05)。
文摘Based on the data of measured formation pressure, drilling fluid density of key exploration wells and calculated pressure by well logging, combined with the analysis of natural gas geological conditions, the characteristics and formation mechanisms of formation fluid overpressure systems in different foreland basins and the relationship between overpressure systems and large-scale gas accumulation are discussed.(1) The formation mechanisms of formation overpressure in different foreland basins are different. The formation mechanism of overpressure in the Kuqa foreland basin is mainly the overpressure sealing of plastic salt gypsum layer and hydrocarbon generation pressurization in deep–ultra-deep layers, that in the southern Junggar foreland basin is mainly hydrocarbon generation pressurization and under-compaction sealing, and that in the western Sichuan foreland basin is mainly hydrocarbon generation pressurization and paleo-fluid overpressure residual.(2) There are three common characteristics in foreland basins, i.e. superimposed development of multi-type overpressure and multi-layer overpressure, strong–extremely strong overpressure developed in a closed foreland thrust belt, and strong–extremely strong overpressure developed in a deep foreland uplift area.(3) There are four regional overpressure sealing and storage mechanisms, which play an important role in controlling large gas fields, such as the overpressure of plastic salt gypsum layer, the overpressure formed by hydrocarbon generation pressurization, the residual overpressure after Himalayan uplift and denudation, and the under-compaction overpressure.(4) Regional overpressure is an important guarantee for forming large gas fields, the sufficient gas source, large-scale reservoir and trap development in overpressure system are the basic conditions for forming large gas fields, and the overpressure system is conducive to forming deep to ultra-deep large gas fields.
基金Supported by Zhejiang Province Natural Science Foundationof China,R2080029 Caoqian Research Group
文摘AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University from June 2000 to December 2007.Data regarding demographic,clinical characteristics and immunosuppressants usage were analyzed. RESULTS:A total of 227 eligible patients were evaluated in this study,including 104 patients with Crohn’s disease and 123 with ulcerative colitis.Among the patients,61 had indications for immunosuppressive agents use.However,only 21 (34.4%)received immunosuppressive agents.Among the 21 patients,6(37.5%)received a subtherapeutic dose of azathioprine with no attempt to increase the dosage.Of the 20 patients that received immunosuppressive agent treatment longer than 6 mo,15 patients went into remission,four patients were not affected and one relapsed.Among these 20 patients,four patients suffered from myelotoxicity and one suffered from hepatotoxicity.CONCLUSION:Immunosuppressive agents are used less frequently to treat IBD patients from East China compared with Western countries.Monitoring immunosuppressive agent use is recommended to optimize dispensation of drugs for IBD in China.
基金This work is supported by Major Scientific and Technological Special Project of Guizhou Province(20183001)Research on the education mode for complicate skill students in new media with cross specialty integration(22150117092)+2 种基金Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ014)Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ019)Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ022).
文摘In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protection of the IoV has become the focus of the society.This paper analyzes the advantages and disadvantages of the existing location privacy protection system structure and algorithms,proposes a privacy protection system structure based on untrusted data collection server,and designs a vehicle location acquisition algorithm based on a local differential privacy and game model.The algorithm first meshes the road network space.Then,the dynamic game model is introduced into the game user location privacy protection model and the attacker location semantic inference model,thereby minimizing the possibility of exposing the regional semantic privacy of the k-location set while maximizing the availability of the service.On this basis,a statistical method is designed,which satisfies the local differential privacy of k-location sets and obtains unbiased estimation of traffic density in different regions.Finally,this paper verifies the algorithm based on the data set of mobile vehicles in Shanghai.The experimental results show that the algorithm can guarantee the user’s location privacy and location semantic privacy while satisfying the service quality requirements,and provide better privacy protection and service for the users of the IoV.
基金supported by the following grants:the National Natural Science Foundation of China under Grant No.61170273the China Scholarship Council under Grant No.[2013]3050+1 种基金CCF-Tencent Open Fund WeBank Special Fuding(CCF-WebankRAGR20180104)the Beijing Natural Science Foundation(4194086)
文摘Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity of blockchain has caused widespread concern.In this paper,we put forward AABN,an Anonymity Assessment model based on Bayesian Network.Firstly,we investigate and analyze the anonymity assessment techniques,and focus on typical anonymity assessment schemes.Then the related concepts involved in the assessment model are introduced and the model construction process is described in detail.Finally,the anonymity in the MIX anonymous network is quantitatively evaluated using the methods of accurate reasoning and approximate reasoning respectively,and the anonymity assessment experiments under different output strategies of the MIX anonymous network are analyzed.
基金sponsored by the National Natural Science Foundation of China(Nos.52171036,52065043,and 51971108)the Central Guidance on Local:Construction of regional innovation system-Cross Regional R&D cooperation projects(No.20221ZDH04054)the Interdisciplinary Innovation Fund of Natural Science,Nanchang Universit
文摘Porous Ti with low modulus,excellent bio-corrosion resistance,biocompatibility,and antibacterial activity is highly pursued as advanced implant materials.In this work,a new approach to prepare micron porous structures on the surface layer of a grade 2 commercially-pure Ti(TA2)was proposed,which utilized a simple vacuum wetting process of pure Ag on the surface of TA2.The microstructure,corrosion resistance,biocompatibility,mechanical properties,antibacterial ability,and formation mechanism of the asfabricated porous Ti were studied.The results show that the pores(with average pore sizes of 0.5-5μm)are distributed on the surface layer of the TA2 with a depth of~10μm.In particular,a large number of silver nanoparticles(Ag NPs)form which are dispersed on the porous structures.The formation mechanisms of the porous structures and Ag NPs were elucidated,suggesting that the volatilization/sublimation of Ag in TA2 is crucial.The porous Ti possesses excellent bio-corrosion resistance,surface wettability,biocompatibility,antibacterial activity,and a relatively low elastic modulus of 40-55 GPa,which may have a promising future in the field of orthopedic implants.This work also provides a novel idea for the development of advanced porous Ti materials for orthopedic-related basic research and biomedical applications.
