Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four f...Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four flavonoids containing one glucose unit with similar molecular weight isolated from the Tibetan medicinal herb Pyrethrum tatsienense,namely.apigenin-7-O-β-D-glucoside（1）,luteolin-7-O-β-D-glucoside（2）.quercetin-7-O-β-D-glucoside（3）.quercetin-3-O-β-D-glycoside（4）.and human serum albumin（HSA）,were investigated by fluorescence.UV-vis absorbance,circular dichroism,and molecular modeling.The effects of biological metal ions Mg2＋,Zn2＋,and Cu2＋ on the binding affinity between flavonoids and HSA were further examined.Structure-activity relationships of four flavonoids binding to HSA were discussed in depth and some meaningful conclusions have been drawn by the experiment data and theoretical simulation.In addition,an interesting phenomenon was observed that the microenvironment of the binding site I in HSA has hardly changed in the presence of 4 differentiating from the other three flavonoids on the basis of conformation investigations.展开更多
Enamel demineralization,the formation of white spot lesions,is a common issue in clinical orthodontic treatment.The appearance of white spot lesions not only affects the texture and health of dental hard tissues but a...Enamel demineralization,the formation of white spot lesions,is a common issue in clinical orthodontic treatment.The appearance of white spot lesions not only affects the texture and health of dental hard tissues but also impacts the health and aesthetics of teeth after orthodontic treatment.The prevention,diagnosis,and treatment of white spot lesions that occur throughout the orthodontic treatment process involve multiple dental specialties.This expert consensus will focus on providing guiding opinions on the management and prevention of white spot lesions during orthodontic treatment,advocating for proactive prevention,early detection,timely treatment,scientific follow-up,and multidisciplinary management of white spot lesions throughout the orthodontic process,thereby maintaining the dental health of patients during orthodontic treatment.展开更多
Endoscopic polypectomy(EP)is the preferred method for the treatment of rectal polyps because of its micro-trauma and rapid recovery.However,the incidence of postoperative abdominal distension can reach 15–30%.This co...Endoscopic polypectomy(EP)is the preferred method for the treatment of rectal polyps because of its micro-trauma and rapid recovery.However,the incidence of postoperative abdominal distension can reach 15–30%.This common complication seriously affects the quality of life of patients after surgery,prolongs the length of hospital stay,and may even be complicated by perforation and other problems.This article systematically reviews the latest research progress on the mechanism,related influencing factors and targeted nursing interventions of abdominal distension after EP,so as to explore effective interventions for postoperative comprehensive nursing,which has core value for improving the postoperative experience and prognosis of EP patients.展开更多
In-depth knowledge of the microbes responsible for biogenic amine(BA)production during soy sauce fermentation remains limited.Herein,the variations in the BA profiles,microbial communities,and microbes involved in BA ...In-depth knowledge of the microbes responsible for biogenic amine(BA)production during soy sauce fermentation remains limited.Herein,the variations in the BA profiles,microbial communities,and microbes involved in BA production during the fermentation of soy sauce through Japanese-type(JP)and Cantonese-type(CP)processes were compared.BA analysis revealed that the most abundant BA species were putrescine,tyramine,and histamine in the later three stages(1187.68,785.16,and 193.20 mg/kg on average,respectively).The BA profiles differed significantly,with CP samples containing higher contents of putrescine,tyramine,and histamine(P<0.05)at the end of fermentation.Metagenomic analysis indicated that BA-producing genes exhibited different abundance profiles,with most genes,including spe A,spe B,arg,spe E,and tyr DC,having higher abundances in microbial communities during the CP process.In total,15 high-quality metagenome-assembled genomes(MAGs)were retrieved,of which 10 encoded at BA production-related genes.Enterococcus faecium(MAG10)and Weissella paramesenteroides(MAG5)might be the major tyramine producers.The high putrescine content in CP might be associated with the high abundance of Staphylococcus gallinarum(MAG8).This study provides a comprehensive understanding of the diversity and abundance of genes involved in BA synthesis,especially at the species level,during food fermentation.展开更多
Themulti-skill resource-constrained project scheduling problem(MS-RCPSP)is a significantmanagement science problem that extends from the resource-constrained project scheduling problem(RCPSP)and is integrated with a r...Themulti-skill resource-constrained project scheduling problem(MS-RCPSP)is a significantmanagement science problem that extends from the resource-constrained project scheduling problem(RCPSP)and is integrated with a real project and production environment.To solve MS-RCPSP,it is an efficient method to use dispatching rules combined with a parallel scheduling mechanism to generate a scheduling scheme.This paper proposes an improved gene expression programming(IGEP)approach to explore newly dispatching rules that can broadly solve MS-RCPSP.A new backward traversal decoding mechanism,and several neighborhood operators are applied in IGEP.The backward traversal decoding mechanism dramatically reduces the space complexity in the decoding process,and improves the algorithm’s performance.Several neighborhood operators improve the exploration of the potential search space.The experiment takes the intelligent multi-objective project scheduling environment(iMOPSE)benchmark dataset as the training set and testing set of IGEP.Ten newly dispatching rules are discovered and extracted by IGEP,and eight out of ten are superior to other typical dispatching rules.展开更多
Clear aligner treatment is a novel technique in current orthodontic practice.Distinct from traditional fixed orthodontic appliances,clear aligners have different material features and biomechanical characteristics and...Clear aligner treatment is a novel technique in current orthodontic practice.Distinct from traditional fixed orthodontic appliances,clear aligners have different material features and biomechanical characteristics and treatment efficiencies,presenting new clinical challenges.Therefore,a comprehensive and systematic description of the key clinical aspects of clear aligner treatment is essential to enhance treatment efficacy and facilitate the advancement and wide adoption of this new technique.This expert consensus discusses case selection and grading of treatment difficulty,principle of clear aligner therapy,clinical procedures and potential complications,which are crucial to the clinical success of clear aligner treatment.展开更多
Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination...Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.展开更多
The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can serio...The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.展开更多
Protrusive facial deformities,characterized by the forward displacement of the teeth and/or jaws beyond the normal range,affect a considerable portion of the population.The manifestations and morphological mechanisms ...Protrusive facial deformities,characterized by the forward displacement of the teeth and/or jaws beyond the normal range,affect a considerable portion of the population.The manifestations and morphological mechanisms of protrusive facial deformities are complex and diverse,requiring orthodontists to possess a high level of theoretical knowledge and practical experience in the relevant orthodontic field.To further optimize the correction of protrusive facial deformities,this consensus proposes that the morphological mechanisms and diagnosis of protrusive facial deformities should be analyzed and judged from multiple dimensions and factors to accurately formulate treatment plans.It emphasizes the use of orthodontic strategies,including jaw growth modification,tooth extraction or non-extraction for anterior teeth retraction,and maxillofacial vertical control.These strategies aim to reduce anterior teeth and lip protrusion,increase chin prominence,harmonize nasolabial and chin-lip relationships,and improve the facial profile of patients with protrusive facial deformities.For severe skeletal protrusive facial deformities,orthodonticorthognathic combined treatment may be suggested.This consensus summarizes the theoretical knowledge and clinical experience of numerous renowned oral experts nationwide,offering reference strategies for the correction of protrusive facial deformities.展开更多
Lake Taihu,the largest shallow freshwater lake in eastern China,is a vital ecological and economic resource in the Yangtze River Delta.However,the region faces substantial environmental challenges from emerging contam...Lake Taihu,the largest shallow freshwater lake in eastern China,is a vital ecological and economic resource in the Yangtze River Delta.However,the region faces substantial environmental challenges from emerging contaminants(ECs),such as per-and polyfluoroalkyl substances(PFAS)and neonicotinoid insecticides(NEOs),driven by its dense industrial activities and aquaculture and agriculture sectors.A comprehensive literature analysis of the two ECs revealed that PFAS and NEOs have become recent hotspots both globally and in the Taihu Basin.The occurrence and distribution of PFAS and NEOs were summarized to show their high detection frequency and concentrations in the Taihu Basin.Risk assessment indicated that PFAS,NEOs,and other ECs posed considerable ecological risks within the Taihu Basin.Treatment techniques for PFAS and NEOs were systematically reviewed.However,many of these techniques face difficulties in scaling up in the Taihu Basin because of their strict conditions and high energy consumption.Ecological engineering treatment technologies are applied in the Taihu Basin to address emerging agricultural contaminants.Ecological engineering treatment technologies have limitations such as low removal efficiency and toxicity inhibition.Thus,it is necessary to develop more effective technologies for treating ECs in the Taihu Basin.A flowchart for identifying priority controlled ECs is presented and a future for the priority controlled emerging contaminants in the Taihu Basin is discussed.This study provides scientific insights for the sustainable control of ECs.展开更多
To overcome the deficiencies of single-modal emotion recognition based on facial expression or bodily posture in natural scenes,a spatial guidance and temporal enhancement(SG-TE)network is proposed for facial-bodily e...To overcome the deficiencies of single-modal emotion recognition based on facial expression or bodily posture in natural scenes,a spatial guidance and temporal enhancement(SG-TE)network is proposed for facial-bodily emotion recognition.First,ResNet50,DNN and spatial ransformer models are used to capture facial texture vectors,bodily skeleton vectors and wholebody geometric vectors,and an intraframe correlation attention guidance(S-CAG)mechanism,which guides the facial texture vector and the bodily skeleton vector by the whole-body geometric vector,is designed to exploit the spatial potential emotional correlation between face and posture.Second,an interframe significant segment enhancement(T-SSE)structure is embedded into a temporal transformer to enhance high emotional intensity frame information and avoid emotional asynchrony.Finally,an adaptive weight assignment(M-AWA)strategy is constructed to realise facial-bodily fusion.The experimental results on the BabyRobot Emotion Dataset(BRED)and Context-Aware Emotion Recognition(CAER)dataset indicate that the proposed network reaches accuracies of 81.61%and 89.39%,which are 9.61%and 9.46%higher than those of the baseline network,respectively.Compared with the state-of-the-art methods,the proposed method achieves 7.73%and 20.57%higher accuracy than single-modal methods based on facial expression or bodily posture,respectively,and 2.16%higher accuracy than the dual-modal methods based on facial-bodily fusion.Therefore,the proposed method,which adaptively fuses the complementary information of face and posture,improves the quality of emotion recognition in real-world scenarios.展开更多
Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic lo...Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic low carrier density of P3 HT and poor contact between the P3HT/perovskite interface always lead to a low performance of the solar cell,while conventional chemical doping always makes the films unstable and limits the scalability.In this work,for the first time,we simultaneously enhanced the hole transporting properties of P3HT film and the interface of perovskite by doping it with a judiciously designed oxidized small molecule organic semiconductor.The organic salt not only can promote the lamellar crystallinity of P3HT to obtain better charge transport properties,but also reduce the defects of perovskite.As a result,we achieved champion efficiencies of 23.0%for small-area solar cells and 18.8%for larger-area modules(48.0 cm^(2)).This efficiency is the highest value for P3HT-based perovskite modules.Moreover,the solar cells show excellent operational stability,retaining over 95%of their initial efficiencies after1200 h of continuous operation.展开更多
BACKGROUND The current study was to assess the application effects of conventional surgical techniques and ultrasound-guided precise localization technology for early gastric cancer(EGC),with an emphasis on long-term ...BACKGROUND The current study was to assess the application effects of conventional surgical techniques and ultrasound-guided precise localization technology for early gastric cancer(EGC),with an emphasis on long-term survival,postoperative complications,and surgical results.AIM To evaluate perioperative results,postoperative complications,and long-term survival in order to conduct a thorough comparison between conventional surgical techniques and ultrasound-guided precise localization technology for the treatment of EGC.METHODS Of 100 EGC patients were gathered,and they were subsequently divided into two groups based on the surgical technique used:The observation group(n=52)received surgery assisted by ultrasound-guided precise localization technology,whereas the control group(n=48)received traditional surgical treatment.The baseline characteristics were similar between the groups.Operation time,intraoperative hemorrhage,the number of lymph nodes removed,postoperative problems,survival rate,and other surgical and postoperative parameters were compared.RESULTS Compared with the control group,the observation group had significantly less intraoperative blood loss(80 mL vs 120 mL,P<0.05)and more dissected lymph nodes(28 vs 22,P<0.05).There were fewer postoperative complications in the observation group than in the routine group(8%vs 16%,P<0.05),hospitalization after surgery was shorter,and gastrointestinal function returned sooner.The long-term survival rates at 5 years and 3 years were significantly greater in the observation group than in the control group:82%and 88%vs 70%and 78%,respectively(P<0.05).CONCLUSION It is possible that ultrasound-guided accurate localization technology might be utilized more widely in clinical practice because it could significantly enhance the results of surgery for EGC,including reduced blood loss,better lymphadenectomy,lower complication rates,and improved survival rates.Further studies should aim to refine this technology and consider its utility in other types of oncologic surgery.展开更多
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors globally,with its incidence particularly high in East Asia.AIM To analyze the expression of the stem cell marker musashi-1 ...BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors globally,with its incidence particularly high in East Asia.AIM To analyze the expression of the stem cell marker musashi-1 in patients with resectable ESCC undergoing neoadjuvant chemotherapy and its relationship with patient survival prognosis.METHODS A retrospective analysis was conducted on the clinical data of 74 ESCC patients treated at our hospital from June 2020 to January 2022.All patients received neoadjuvant chemotherapy and surgical resection.Immunohistochemistry(IHC)was used to detect musashi-1 expression in tumor tissues.Based on the expression intensity,patients were divided into group A(n=30,IHC total score>2 indicating high expression)and group B(n=44,IHC total score 0-2 indicating low expression).The clinical pathological differences between groups A and B were compared.The treatment outcomes of both groups were compared.Univariate and multivariate Cox regression analysis was performed to identify factors affecting patient prognosis.Kaplan-Meier survival analysis was used,and logrank tests were conducted to compare differences between groups.RESULTS There were statistically significant differences in tumor maximum diameter,T stage,N stage,clinical stage,pathological grade,lymphovascular invasion,and intraoperative blood loss between groups A and B(P<0.05).The disease control rate in group A(86.67%)was lower than that in group B(100.00%)(χ^(2)=3.868,P=0.049);the objective response rate in group A(33.33%)was lower than that in group B(70.45%)(χ^(2)=9.948,P=0.001).The proportion of tumor regression grade 3+4+5 grades in group A(80.00%)was higher than in group B(43.18%)(χ^(2)=9.933,P=0.001).Univariate analysis showed that tumor maximum diameter,T stage,N stage,clinical stage,pathological grade,and musashi-1 expression were associated with patient prognosis(P<0.05).Cox regression analysis model.The results indicated that T stage[hazard ratio(HR)=1.82,95%confidence interval(CI):2.14-7.37],N stage(HR=1.70,95%CI:1.12-2.36),clinical stage(HR=2.08,95%CI:1.36-3.85),pathological grade(HR=1.54,95%CI:1.07-2.41),and musashi-1 expression(HR=2.72,95%CI:2.03-4.11)were independent risk factors affecting patient prognosis(P<0.05).Kaplan-Meier survival curves showed that the median overall survival in group A was 17 months,while in group B it was 28 months.Log-rank analysis revealed that the overall survival rate in group A was worse than in group B(χ^(2)=2.635,P=0.033).CONCLUSION The expression of musashi-1 is closely related to the treatment efficacy,prognosis,and survival of ESCC patients.It is expected to be a potential biomarker for evaluating the efficacy and survival prognosis of ESCC patients.展开更多
Size-fractionated particulate matter(PM_(2.5)and PM>_(2.5))was collected at a traffic site in Kanazawa,Japan in a seasonal sampling work in 2020.Nine polycyclic aromatic hydrocarbons(4-to 6-ring PAHs)were determine...Size-fractionated particulate matter(PM_(2.5)and PM>_(2.5))was collected at a traffic site in Kanazawa,Japan in a seasonal sampling work in 2020.Nine polycyclic aromatic hydrocarbons(4-to 6-ring PAHs)were determined in fine and coarse particles.The gas/particle partitioning coefficients(K_(p))of the PAHs were calculated from the supercooled liquid vapour pressure and octanol-air partitioning coefficient based on the relationships obtained in previous traffic pollution-related studies.Gaseous PAHs were estimated by K_(p) and the concentrations of PM and particulate PAHs.The concentrations of total PAHs were 32.5,320.1 and 5646.2 pg/m^(3) in the PM>_(2.5),PM_(2.5) and gas phases,respectively.Significant seasonal trends in PAHs were observed(particle phase:lowest in summer,gas phase:lowest in spring,particle and gas phase:lowest in spring).Compared to 2019,the total PAH concentrations(in particles)decreased in 2020,especially in spring and summer,which might be due to reduced traffic trips during the COVID-19 outbreak.The incremental lifetime cancer risk(ILCR)calculated from the toxic equivalent concentrations relative to benzo[a]pyrene(BaP_(eq))was lower than the acceptable limit issued by the US Environmental Protection Agency,indicating a low cancer risk in long-term exposure to current PAH levels.It is notable that gaseous PAHs considerably contributed to BaP_(eq) and ILCR(over 50%),which highlighted the significance of gaseous PAH monitoring for public health protection.This low-cost estimation method for gaseous PAHs can be expected to reliably and conveniently obtain PAH concentrations as a surrogate for traditional sampling in the future work.展开更多
基金financially supported by the National Natural Science Foundation of China(30960530)
文摘Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four flavonoids containing one glucose unit with similar molecular weight isolated from the Tibetan medicinal herb Pyrethrum tatsienense,namely.apigenin-7-O-β-D-glucoside（1）,luteolin-7-O-β-D-glucoside（2）.quercetin-7-O-β-D-glucoside（3）.quercetin-3-O-β-D-glycoside（4）.and human serum albumin（HSA）,were investigated by fluorescence.UV-vis absorbance,circular dichroism,and molecular modeling.The effects of biological metal ions Mg2＋,Zn2＋,and Cu2＋ on the binding affinity between flavonoids and HSA were further examined.Structure-activity relationships of four flavonoids binding to HSA were discussed in depth and some meaningful conclusions have been drawn by the experiment data and theoretical simulation.In addition,an interesting phenomenon was observed that the microenvironment of the binding site I in HSA has hardly changed in the presence of 4 differentiating from the other three flavonoids on the basis of conformation investigations.
基金funded with National Key R&D Program of China(2022YFC2405904)National Natural Science Foundation of China(11932012,and 32171348).
文摘Enamel demineralization,the formation of white spot lesions,is a common issue in clinical orthodontic treatment.The appearance of white spot lesions not only affects the texture and health of dental hard tissues but also impacts the health and aesthetics of teeth after orthodontic treatment.The prevention,diagnosis,and treatment of white spot lesions that occur throughout the orthodontic treatment process involve multiple dental specialties.This expert consensus will focus on providing guiding opinions on the management and prevention of white spot lesions during orthodontic treatment,advocating for proactive prevention,early detection,timely treatment,scientific follow-up,and multidisciplinary management of white spot lesions throughout the orthodontic process,thereby maintaining the dental health of patients during orthodontic treatment.
文摘Endoscopic polypectomy(EP)is the preferred method for the treatment of rectal polyps because of its micro-trauma and rapid recovery.However,the incidence of postoperative abdominal distension can reach 15–30%.This common complication seriously affects the quality of life of patients after surgery,prolongs the length of hospital stay,and may even be complicated by perforation and other problems.This article systematically reviews the latest research progress on the mechanism,related influencing factors and targeted nursing interventions of abdominal distension after EP,so as to explore effective interventions for postoperative comprehensive nursing,which has core value for improving the postoperative experience and prognosis of EP patients.
基金supported by the Natural Science Foundation of Guangdong Province(2022A1515012158)the National Science Foundation of China(41977138)+3 种基金the Construction Project of Teaching Quality and Teaching Reform in Guangdong Province(SJD202001)the General University Project of Guangdong Provincial Department of Education(2021KCXTD070 and 2021ZDZX4072)the Key Project of Social Welfare and Basic Research of Zhongshan City(2020B2010)the Start-up Fund from the Zhongshan Institute at the University of Electronic Science and Technology in China(419YKQN12)。
文摘In-depth knowledge of the microbes responsible for biogenic amine(BA)production during soy sauce fermentation remains limited.Herein,the variations in the BA profiles,microbial communities,and microbes involved in BA production during the fermentation of soy sauce through Japanese-type(JP)and Cantonese-type(CP)processes were compared.BA analysis revealed that the most abundant BA species were putrescine,tyramine,and histamine in the later three stages(1187.68,785.16,and 193.20 mg/kg on average,respectively).The BA profiles differed significantly,with CP samples containing higher contents of putrescine,tyramine,and histamine(P<0.05)at the end of fermentation.Metagenomic analysis indicated that BA-producing genes exhibited different abundance profiles,with most genes,including spe A,spe B,arg,spe E,and tyr DC,having higher abundances in microbial communities during the CP process.In total,15 high-quality metagenome-assembled genomes(MAGs)were retrieved,of which 10 encoded at BA production-related genes.Enterococcus faecium(MAG10)and Weissella paramesenteroides(MAG5)might be the major tyramine producers.The high putrescine content in CP might be associated with the high abundance of Staphylococcus gallinarum(MAG8).This study provides a comprehensive understanding of the diversity and abundance of genes involved in BA synthesis,especially at the species level,during food fermentation.
基金funded by the National Natural Science Foundation of China(Nos.51875420,51875421,52275504).
文摘Themulti-skill resource-constrained project scheduling problem(MS-RCPSP)is a significantmanagement science problem that extends from the resource-constrained project scheduling problem(RCPSP)and is integrated with a real project and production environment.To solve MS-RCPSP,it is an efficient method to use dispatching rules combined with a parallel scheduling mechanism to generate a scheduling scheme.This paper proposes an improved gene expression programming(IGEP)approach to explore newly dispatching rules that can broadly solve MS-RCPSP.A new backward traversal decoding mechanism,and several neighborhood operators are applied in IGEP.The backward traversal decoding mechanism dramatically reduces the space complexity in the decoding process,and improves the algorithm’s performance.Several neighborhood operators improve the exploration of the potential search space.The experiment takes the intelligent multi-objective project scheduling environment(iMOPSE)benchmark dataset as the training set and testing set of IGEP.Ten newly dispatching rules are discovered and extracted by IGEP,and eight out of ten are superior to other typical dispatching rules.
文摘Clear aligner treatment is a novel technique in current orthodontic practice.Distinct from traditional fixed orthodontic appliances,clear aligners have different material features and biomechanical characteristics and treatment efficiencies,presenting new clinical challenges.Therefore,a comprehensive and systematic description of the key clinical aspects of clear aligner treatment is essential to enhance treatment efficacy and facilitate the advancement and wide adoption of this new technique.This expert consensus discusses case selection and grading of treatment difficulty,principle of clear aligner therapy,clinical procedures and potential complications,which are crucial to the clinical success of clear aligner treatment.
基金supports by the National Natural Science Foundation of China(Nos.82201135)"2015"Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School,Medical School of Nanjing University(No.0223A204).
文摘Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.
文摘The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.
基金supported by the National Clinical Key Specialty Project of China nos.GJLCZDZK-2023-01Shanghai Top Priority Research Center Project nos.2023ZZ02009+2 种基金National Natural Science Foundations of China Nos.82230030Clinical Innovation Project of Shanghai Shenkang Hospital Development Center nos.SHDC12021108Angelalign Scientific Research Fund no.EARD20220725046。
文摘Protrusive facial deformities,characterized by the forward displacement of the teeth and/or jaws beyond the normal range,affect a considerable portion of the population.The manifestations and morphological mechanisms of protrusive facial deformities are complex and diverse,requiring orthodontists to possess a high level of theoretical knowledge and practical experience in the relevant orthodontic field.To further optimize the correction of protrusive facial deformities,this consensus proposes that the morphological mechanisms and diagnosis of protrusive facial deformities should be analyzed and judged from multiple dimensions and factors to accurately formulate treatment plans.It emphasizes the use of orthodontic strategies,including jaw growth modification,tooth extraction or non-extraction for anterior teeth retraction,and maxillofacial vertical control.These strategies aim to reduce anterior teeth and lip protrusion,increase chin prominence,harmonize nasolabial and chin-lip relationships,and improve the facial profile of patients with protrusive facial deformities.For severe skeletal protrusive facial deformities,orthodonticorthognathic combined treatment may be suggested.This consensus summarizes the theoretical knowledge and clinical experience of numerous renowned oral experts nationwide,offering reference strategies for the correction of protrusive facial deformities.
基金supported by the National Key Research and Development Program of China(No.2023YFE0100900)the National Natural Science Foundation of China(No.42227806).
文摘Lake Taihu,the largest shallow freshwater lake in eastern China,is a vital ecological and economic resource in the Yangtze River Delta.However,the region faces substantial environmental challenges from emerging contaminants(ECs),such as per-and polyfluoroalkyl substances(PFAS)and neonicotinoid insecticides(NEOs),driven by its dense industrial activities and aquaculture and agriculture sectors.A comprehensive literature analysis of the two ECs revealed that PFAS and NEOs have become recent hotspots both globally and in the Taihu Basin.The occurrence and distribution of PFAS and NEOs were summarized to show their high detection frequency and concentrations in the Taihu Basin.Risk assessment indicated that PFAS,NEOs,and other ECs posed considerable ecological risks within the Taihu Basin.Treatment techniques for PFAS and NEOs were systematically reviewed.However,many of these techniques face difficulties in scaling up in the Taihu Basin because of their strict conditions and high energy consumption.Ecological engineering treatment technologies are applied in the Taihu Basin to address emerging agricultural contaminants.Ecological engineering treatment technologies have limitations such as low removal efficiency and toxicity inhibition.Thus,it is necessary to develop more effective technologies for treating ECs in the Taihu Basin.A flowchart for identifying priority controlled ECs is presented and a future for the priority controlled emerging contaminants in the Taihu Basin is discussed.This study provides scientific insights for the sustainable control of ECs.
基金National Natural Science Foundation of China,Grant/Award Number:62176084,Natural Science Foundation of Anhui Province of China,Grant/Award Number:1908085MF195,Natural Science Research Project of the Education Department of Anhui Province of China Grant/Award Numbers:2022AH051038,2023AH050474 and 2023AH050490.
文摘To overcome the deficiencies of single-modal emotion recognition based on facial expression or bodily posture in natural scenes,a spatial guidance and temporal enhancement(SG-TE)network is proposed for facial-bodily emotion recognition.First,ResNet50,DNN and spatial ransformer models are used to capture facial texture vectors,bodily skeleton vectors and wholebody geometric vectors,and an intraframe correlation attention guidance(S-CAG)mechanism,which guides the facial texture vector and the bodily skeleton vector by the whole-body geometric vector,is designed to exploit the spatial potential emotional correlation between face and posture.Second,an interframe significant segment enhancement(T-SSE)structure is embedded into a temporal transformer to enhance high emotional intensity frame information and avoid emotional asynchrony.Finally,an adaptive weight assignment(M-AWA)strategy is constructed to realise facial-bodily fusion.The experimental results on the BabyRobot Emotion Dataset(BRED)and Context-Aware Emotion Recognition(CAER)dataset indicate that the proposed network reaches accuracies of 81.61%and 89.39%,which are 9.61%and 9.46%higher than those of the baseline network,respectively.Compared with the state-of-the-art methods,the proposed method achieves 7.73%and 20.57%higher accuracy than single-modal methods based on facial expression or bodily posture,respectively,and 2.16%higher accuracy than the dual-modal methods based on facial-bodily fusion.Therefore,the proposed method,which adaptively fuses the complementary information of face and posture,improves the quality of emotion recognition in real-world scenarios.
基金financially supported by the National Natural Science Foundation of China(52472248 and 22075221)the Key Research and Development Project of Shanxi Province(202202060301003 and 202202060301015)the Innovation Program of Wuhan-Shuguang Project(2023010201020367)。
文摘Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic low carrier density of P3 HT and poor contact between the P3HT/perovskite interface always lead to a low performance of the solar cell,while conventional chemical doping always makes the films unstable and limits the scalability.In this work,for the first time,we simultaneously enhanced the hole transporting properties of P3HT film and the interface of perovskite by doping it with a judiciously designed oxidized small molecule organic semiconductor.The organic salt not only can promote the lamellar crystallinity of P3HT to obtain better charge transport properties,but also reduce the defects of perovskite.As a result,we achieved champion efficiencies of 23.0%for small-area solar cells and 18.8%for larger-area modules(48.0 cm^(2)).This efficiency is the highest value for P3HT-based perovskite modules.Moreover,the solar cells show excellent operational stability,retaining over 95%of their initial efficiencies after1200 h of continuous operation.
基金Supported by Wenzhou Science and Technology Bureau,No.Y20240363.
文摘BACKGROUND The current study was to assess the application effects of conventional surgical techniques and ultrasound-guided precise localization technology for early gastric cancer(EGC),with an emphasis on long-term survival,postoperative complications,and surgical results.AIM To evaluate perioperative results,postoperative complications,and long-term survival in order to conduct a thorough comparison between conventional surgical techniques and ultrasound-guided precise localization technology for the treatment of EGC.METHODS Of 100 EGC patients were gathered,and they were subsequently divided into two groups based on the surgical technique used:The observation group(n=52)received surgery assisted by ultrasound-guided precise localization technology,whereas the control group(n=48)received traditional surgical treatment.The baseline characteristics were similar between the groups.Operation time,intraoperative hemorrhage,the number of lymph nodes removed,postoperative problems,survival rate,and other surgical and postoperative parameters were compared.RESULTS Compared with the control group,the observation group had significantly less intraoperative blood loss(80 mL vs 120 mL,P<0.05)and more dissected lymph nodes(28 vs 22,P<0.05).There were fewer postoperative complications in the observation group than in the routine group(8%vs 16%,P<0.05),hospitalization after surgery was shorter,and gastrointestinal function returned sooner.The long-term survival rates at 5 years and 3 years were significantly greater in the observation group than in the control group:82%and 88%vs 70%and 78%,respectively(P<0.05).CONCLUSION It is possible that ultrasound-guided accurate localization technology might be utilized more widely in clinical practice because it could significantly enhance the results of surgery for EGC,including reduced blood loss,better lymphadenectomy,lower complication rates,and improved survival rates.Further studies should aim to refine this technology and consider its utility in other types of oncologic surgery.
文摘BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors globally,with its incidence particularly high in East Asia.AIM To analyze the expression of the stem cell marker musashi-1 in patients with resectable ESCC undergoing neoadjuvant chemotherapy and its relationship with patient survival prognosis.METHODS A retrospective analysis was conducted on the clinical data of 74 ESCC patients treated at our hospital from June 2020 to January 2022.All patients received neoadjuvant chemotherapy and surgical resection.Immunohistochemistry(IHC)was used to detect musashi-1 expression in tumor tissues.Based on the expression intensity,patients were divided into group A(n=30,IHC total score>2 indicating high expression)and group B(n=44,IHC total score 0-2 indicating low expression).The clinical pathological differences between groups A and B were compared.The treatment outcomes of both groups were compared.Univariate and multivariate Cox regression analysis was performed to identify factors affecting patient prognosis.Kaplan-Meier survival analysis was used,and logrank tests were conducted to compare differences between groups.RESULTS There were statistically significant differences in tumor maximum diameter,T stage,N stage,clinical stage,pathological grade,lymphovascular invasion,and intraoperative blood loss between groups A and B(P<0.05).The disease control rate in group A(86.67%)was lower than that in group B(100.00%)(χ^(2)=3.868,P=0.049);the objective response rate in group A(33.33%)was lower than that in group B(70.45%)(χ^(2)=9.948,P=0.001).The proportion of tumor regression grade 3+4+5 grades in group A(80.00%)was higher than in group B(43.18%)(χ^(2)=9.933,P=0.001).Univariate analysis showed that tumor maximum diameter,T stage,N stage,clinical stage,pathological grade,and musashi-1 expression were associated with patient prognosis(P<0.05).Cox regression analysis model.The results indicated that T stage[hazard ratio(HR)=1.82,95%confidence interval(CI):2.14-7.37],N stage(HR=1.70,95%CI:1.12-2.36),clinical stage(HR=2.08,95%CI:1.36-3.85),pathological grade(HR=1.54,95%CI:1.07-2.41),and musashi-1 expression(HR=2.72,95%CI:2.03-4.11)were independent risk factors affecting patient prognosis(P<0.05).Kaplan-Meier survival curves showed that the median overall survival in group A was 17 months,while in group B it was 28 months.Log-rank analysis revealed that the overall survival rate in group A was worse than in group B(χ^(2)=2.635,P=0.033).CONCLUSION The expression of musashi-1 is closely related to the treatment efficacy,prognosis,and survival of ESCC patients.It is expected to be a potential biomarker for evaluating the efficacy and survival prognosis of ESCC patients.
基金supported by the Bilateral Open Partnership Joint Research Projects of the Japan Society for the Promotion of Science,Japan(No.JPJSBP120219914)the CHOZEN Project of Kanazawa University,Japan(2019)the Cooperative Research Programs of Institute of Nature and Environmental Technology,Kanazawa University,Japan(22002,22013,22007)。
文摘Size-fractionated particulate matter(PM_(2.5)and PM>_(2.5))was collected at a traffic site in Kanazawa,Japan in a seasonal sampling work in 2020.Nine polycyclic aromatic hydrocarbons(4-to 6-ring PAHs)were determined in fine and coarse particles.The gas/particle partitioning coefficients(K_(p))of the PAHs were calculated from the supercooled liquid vapour pressure and octanol-air partitioning coefficient based on the relationships obtained in previous traffic pollution-related studies.Gaseous PAHs were estimated by K_(p) and the concentrations of PM and particulate PAHs.The concentrations of total PAHs were 32.5,320.1 and 5646.2 pg/m^(3) in the PM>_(2.5),PM_(2.5) and gas phases,respectively.Significant seasonal trends in PAHs were observed(particle phase:lowest in summer,gas phase:lowest in spring,particle and gas phase:lowest in spring).Compared to 2019,the total PAH concentrations(in particles)decreased in 2020,especially in spring and summer,which might be due to reduced traffic trips during the COVID-19 outbreak.The incremental lifetime cancer risk(ILCR)calculated from the toxic equivalent concentrations relative to benzo[a]pyrene(BaP_(eq))was lower than the acceptable limit issued by the US Environmental Protection Agency,indicating a low cancer risk in long-term exposure to current PAH levels.It is notable that gaseous PAHs considerably contributed to BaP_(eq) and ILCR(over 50%),which highlighted the significance of gaseous PAH monitoring for public health protection.This low-cost estimation method for gaseous PAHs can be expected to reliably and conveniently obtain PAH concentrations as a surrogate for traditional sampling in the future work.
