First principles calculations and scanning Kelvin probe force microscopy(SKPFM)were used to investigate the effect of elements migration ofα-AlFeMnSi phase on micro-galvanic corrosion behavior of Al-Zn-Mg alloy.The s...First principles calculations and scanning Kelvin probe force microscopy(SKPFM)were used to investigate the effect of elements migration ofα-AlFeMnSi phase on micro-galvanic corrosion behavior of Al-Zn-Mg alloy.The simulation results showed that the average work function difference between theα-AlFeMnSi phase and Al matrix decreased from 0.232 to 0.065 eV due to the synchronous migration of elements Fe-Mn-Si.Specifically,as the elements Fe-Si migration during the extrusion process,the average Volta potential difference detected by SKPFM between theα-AlFeMnSi phase and Al matrix dropped down to 432.383 mV from 648.370 mV.Thus,the elements migration reduced the micro-galvanic corrosion sensitivity of Al-Zn-Mg alloy.To reach the calculated low micro-galvanic tendency betweenα-AlFeMnSi phase and Al matrix,the diffusion of Mn should be promoted during extruding process.展开更多
Despite recent advances in crop metabolomics,the genetic control and molecular basis of the wheat kernel metabolome at different developmental stages remain largely unknown.Here,we performed widely tar-geted metabolit...Despite recent advances in crop metabolomics,the genetic control and molecular basis of the wheat kernel metabolome at different developmental stages remain largely unknown.Here,we performed widely tar-geted metabolite profiling of kernels from three developmental stages(grain-filling kernels[FKs],mature kernels[MKs],and germinating kernels[GKs])using a population of 159 recombinant inbred lines.We de-tected 625 annotated metabolites and mapped 3173,3143,and 2644 metabolite quantitative trait loci(mQTLs)in FKs,MKs,and GKs,respectively.Only 52 mQTLs were mapped at all three stages,indicating the high stage specificity of the wheat kernel metabolome.Four candidate genes were functionally vali-dated by in vitro enzymatic reactions and/or transgenic approaches in wheat,three of which mediated the tricin metabolic pathway.Metaboliteflux efficiencies within the tricin pathway were evaluated,and su-perior candidate haplotypes were identified,comprehensively delineating the tricin metabolism pathway in wheat.Finally,additional wheat metabolic pathways were re-constructed by updating them to incorporate the 177 candidate genes identified in this study.Our work provides new information on variations in the wheat kernel metabolome and important molecular resources for improvement of wheat nutritional quality.展开更多
A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography.But pure solid T1 lung cancer with≤3...A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography.But pure solid T1 lung cancer with≤3 cm in the greatest dimension is not always at an early stage,despite its small size.This type of cancer can be highiy aggressive and is associated with pathological involvement,metastasis,postoperative relapse,and even death.However,it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health.The percentage of nodal or extrathoracic metastases has been reported to be>20%in T1 lung cancer.As such,understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention,diagnosis,and therapeutic strategies,and beneficial to improving the prognosis.With the widespread of lung cancer screening,these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future.However,there is limited information regarding precision medicine on how to identify these“early-stage”aggressive lung cancers.To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer,this review summarizes its clinical characteristics,imaging,pathology,gene alterations,immune microenvironment,multi-omics,and current techniques for diagnosis and prediction.展开更多
A serials of Lal_xCexMnO3 （x = 0, 0.2, 0.4, 0.6 and 0.8） catalysts have been prepared via a sol-gel process using citric acid as a chelating agent. The phase composition and morphology of the catalysts are character...A serials of Lal_xCexMnO3 （x = 0, 0.2, 0.4, 0.6 and 0.8） catalysts have been prepared via a sol-gel process using citric acid as a chelating agent. The phase composition and morphology of the catalysts are characterized by XRD, SEM and TEM. La1_xCexMnO3/y-AI203/cordierite catalyst has also been prepared by immersion process using cordierite honeycomb ceramic as carrier and Y-AI203 as support agents. The effect of Ce-doping on the structure of perovskite and catalytic property of methane combustion is explored. The results show that with the increase of Ce substitution, the crystal structure of perovskite changes from the tetragonal system to the orthorhombic system and when the x is equal to 0.2, the catalytic property in methane combustion is the best.展开更多
基金National Natural Science Foundation of China(Grant No.81603386)Montr&D subject of the open fund,Engineering Laboratory of Inner Mongolia Autonomous Region(Grant No.MDK2018064)2019 Double First in Class Special Project of Inner Mongolia Autonomous Region-innovative Team Construction of Mongolian Medicine Processing(Grant No.MY20190004)。
基金supported by the National Natural Science Foundation of China(No.52125102)the Fundamental Research Funds for the Central Universities(No.FRF-TP-20-01B)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515120093)the Special Fund Support for Taishan Industrial Leading Talents Project。
文摘First principles calculations and scanning Kelvin probe force microscopy(SKPFM)were used to investigate the effect of elements migration ofα-AlFeMnSi phase on micro-galvanic corrosion behavior of Al-Zn-Mg alloy.The simulation results showed that the average work function difference between theα-AlFeMnSi phase and Al matrix decreased from 0.232 to 0.065 eV due to the synchronous migration of elements Fe-Mn-Si.Specifically,as the elements Fe-Si migration during the extrusion process,the average Volta potential difference detected by SKPFM between theα-AlFeMnSi phase and Al matrix dropped down to 432.383 mV from 648.370 mV.Thus,the elements migration reduced the micro-galvanic corrosion sensitivity of Al-Zn-Mg alloy.To reach the calculated low micro-galvanic tendency betweenα-AlFeMnSi phase and Al matrix,the diffusion of Mn should be promoted during extruding process.
基金supported by the National Major Program of China (2023ZD0406903)the Natural Science Foundation for Distinguished Young Scientists of Hubei Province (2021CFA058)+2 种基金the Young Topnotch Talent Cultivation Program of Hubei Provincethe National Natural Science Foundation of China (32001541)the China Postdoctoral Science Foundation (2021T140246).
文摘Despite recent advances in crop metabolomics,the genetic control and molecular basis of the wheat kernel metabolome at different developmental stages remain largely unknown.Here,we performed widely tar-geted metabolite profiling of kernels from three developmental stages(grain-filling kernels[FKs],mature kernels[MKs],and germinating kernels[GKs])using a population of 159 recombinant inbred lines.We de-tected 625 annotated metabolites and mapped 3173,3143,and 2644 metabolite quantitative trait loci(mQTLs)in FKs,MKs,and GKs,respectively.Only 52 mQTLs were mapped at all three stages,indicating the high stage specificity of the wheat kernel metabolome.Four candidate genes were functionally vali-dated by in vitro enzymatic reactions and/or transgenic approaches in wheat,three of which mediated the tricin metabolic pathway.Metaboliteflux efficiencies within the tricin pathway were evaluated,and su-perior candidate haplotypes were identified,comprehensively delineating the tricin metabolism pathway in wheat.Finally,additional wheat metabolic pathways were re-constructed by updating them to incorporate the 177 candidate genes identified in this study.Our work provides new information on variations in the wheat kernel metabolome and important molecular resources for improvement of wheat nutritional quality.
基金supported in part by grants from the National Natural Science Foundation of China(Grant No.82203181)the National Cancer Center(Grant No.DSS-YSF2022-10)+2 种基金the Program for Youth Innovation in Future Medicine,Chongqing Medical University(Grant No.W0102)the Key Research and Development Program of Sichuan-Chongqing of the Chongqing Science and Technology Commission(Grant No.CSTB2022TIAD-CUX0001)Chongqing Science and Technology Commission,Chongqing People's Municipal Govermment(Grant No.CSTC2021jscx-gksb-NO023).
文摘A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography.But pure solid T1 lung cancer with≤3 cm in the greatest dimension is not always at an early stage,despite its small size.This type of cancer can be highiy aggressive and is associated with pathological involvement,metastasis,postoperative relapse,and even death.However,it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health.The percentage of nodal or extrathoracic metastases has been reported to be>20%in T1 lung cancer.As such,understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention,diagnosis,and therapeutic strategies,and beneficial to improving the prognosis.With the widespread of lung cancer screening,these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future.However,there is limited information regarding precision medicine on how to identify these“early-stage”aggressive lung cancers.To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer,this review summarizes its clinical characteristics,imaging,pathology,gene alterations,immune microenvironment,multi-omics,and current techniques for diagnosis and prediction.
文摘A serials of Lal_xCexMnO3 （x = 0, 0.2, 0.4, 0.6 and 0.8） catalysts have been prepared via a sol-gel process using citric acid as a chelating agent. The phase composition and morphology of the catalysts are characterized by XRD, SEM and TEM. La1_xCexMnO3/y-AI203/cordierite catalyst has also been prepared by immersion process using cordierite honeycomb ceramic as carrier and Y-AI203 as support agents. The effect of Ce-doping on the structure of perovskite and catalytic property of methane combustion is explored. The results show that with the increase of Ce substitution, the crystal structure of perovskite changes from the tetragonal system to the orthorhombic system and when the x is equal to 0.2, the catalytic property in methane combustion is the best.
