In this paper, aiming to provide accurate protocols for management of sustainable ecosystems, a design methodology of H<sub>∞</sub>-controller for hunter-prey model under exposure to exogenous di...In this paper, aiming to provide accurate protocols for management of sustainable ecosystems, a design methodology of H<sub>∞</sub>-controller for hunter-prey model under exposure to exogenous disturbance and stochastic noise is presented. Along the development, solution procedure of the stochastic Hamilton-Jacobi-Isaacs equation via Successive Galerkin’s Approximation is described. Utilizing the proposed solution methodology of Hamilton-Jacobi-Isaacs equation, H<sub>∞</sub>-controller of hunter-prey model was successfully designed. Robustness and performance against exogenous disturbance of the designed H<sub>∞</sub>-controller is validated and confirmed by numerical simulations including Monte-Carlo simulation by Simulink software on MATLAB.展开更多
随着行业信息化领域应用的不断深入，客户对信息化也有了更高的需求。满足行业自身特点、满足流程再造的产品方案成为当今客户新的需求。不仅如此，越来越多的客户需要厂商为自己开发出个性化需求的产品，越来越多的厂商需要具备这种随...随着行业信息化领域应用的不断深入，客户对信息化也有了更高的需求。满足行业自身特点、满足流程再造的产品方案成为当今客户新的需求。不仅如此，越来越多的客户需要厂商为自己开发出个性化需求的产品，越来越多的厂商需要具备这种随需应变的能力和可移植的平台架构技术。近几年来，MBS（Microsoft Business Solution，微软企业解决方案）作为业内专注于面向成长型企业的管理软件供应商，一直致力于打造出更加适合国内企业的商务解决方案。展开更多
Intrinsically disordered proteins （IDPs）/intrinsicaUy unstructured proteins are characterized by the lack of fixed or stable tertiary structure, and are increasingly recognized as an important class of proteins with...Intrinsically disordered proteins （IDPs）/intrinsicaUy unstructured proteins are characterized by the lack of fixed or stable tertiary structure, and are increasingly recognized as an important class of proteins with major roles in signal transduction and transcriptional regulation. In this study, we report the identification and functional characterization of a previously uncharacterized protein （UPFO258/KIAA1024）, major intrinsically disordered Notch2-associated receptor 1 （MINAR1）. While MINAR1 carries a single transmembrane domain and a short cytoplasmic domain, it has a large extraceUular domain that shares no similarity with known protein sequences. Uncharacteristically, MINAR1 is a highly IDP with nearly 70% of its amino acids sequences unstructured. We demonstrate that MINAR1 physically interacts with Notch2 and its binding to Notch2 increases its stability and function. MINAR1 is widely expressed in various tissues including the epithelial cells of the breast and endothelial cells of blood vessels. MINAR1 plays a negative role in angioganesis as it inhibits angioganesis in cell culture and in mouse matrigal plug and zebraflsh anglo- genesis models. Furthermore, while MINAR1 is highly expressed in the normal human breast, its expression is significantly down- regulated in advanced human breast cancer and its re-expression in breast cancer cells inhibited tumor growth. Our study demonstrates that MINAR1 is an IDP that negatively regulates angioganesis and growth of breast cancer cells.展开更多
文摘In this paper, aiming to provide accurate protocols for management of sustainable ecosystems, a design methodology of H<sub>∞</sub>-controller for hunter-prey model under exposure to exogenous disturbance and stochastic noise is presented. Along the development, solution procedure of the stochastic Hamilton-Jacobi-Isaacs equation via Successive Galerkin’s Approximation is described. Utilizing the proposed solution methodology of Hamilton-Jacobi-Isaacs equation, H<sub>∞</sub>-controller of hunter-prey model was successfully designed. Robustness and performance against exogenous disturbance of the designed H<sub>∞</sub>-controller is validated and confirmed by numerical simulations including Monte-Carlo simulation by Simulink software on MATLAB.
文摘随着行业信息化领域应用的不断深入，客户对信息化也有了更高的需求。满足行业自身特点、满足流程再造的产品方案成为当今客户新的需求。不仅如此，越来越多的客户需要厂商为自己开发出个性化需求的产品，越来越多的厂商需要具备这种随需应变的能力和可移植的平台架构技术。近几年来，MBS（Microsoft Business Solution，微软企业解决方案）作为业内专注于面向成长型企业的管理软件供应商，一直致力于打造出更加适合国内企业的商务解决方案。
文摘Intrinsically disordered proteins （IDPs）/intrinsicaUy unstructured proteins are characterized by the lack of fixed or stable tertiary structure, and are increasingly recognized as an important class of proteins with major roles in signal transduction and transcriptional regulation. In this study, we report the identification and functional characterization of a previously uncharacterized protein （UPFO258/KIAA1024）, major intrinsically disordered Notch2-associated receptor 1 （MINAR1）. While MINAR1 carries a single transmembrane domain and a short cytoplasmic domain, it has a large extraceUular domain that shares no similarity with known protein sequences. Uncharacteristically, MINAR1 is a highly IDP with nearly 70% of its amino acids sequences unstructured. We demonstrate that MINAR1 physically interacts with Notch2 and its binding to Notch2 increases its stability and function. MINAR1 is widely expressed in various tissues including the epithelial cells of the breast and endothelial cells of blood vessels. MINAR1 plays a negative role in angioganesis as it inhibits angioganesis in cell culture and in mouse matrigal plug and zebraflsh anglo- genesis models. Furthermore, while MINAR1 is highly expressed in the normal human breast, its expression is significantly down- regulated in advanced human breast cancer and its re-expression in breast cancer cells inhibited tumor growth. Our study demonstrates that MINAR1 is an IDP that negatively regulates angioganesis and growth of breast cancer cells.
