Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ...Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.展开更多
The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are ...The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are shown,along with a quantum-dot mode-locked laser 20-channel comb source with free space wall plug efficiencies up to 17%,advanced packaging techniques for 3D silicon photonic-electronic integration,and schematics for integrated electronics that control the photonic integrated circuits.Techniques for operating such a system in the presence of changing ambient temperature are addressed.Experiments on a 1 Tbps design are conducted with an optical link experiment indicating sub-picojoule/bit energy consumption at scale.展开更多
The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are ...The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are shown,along with a quantum-dot mode-locked laser 20-channel comb source with free space wall plug efficiencies up to 17%,advanced packaging techniques for 3D silicon photonic-electronic integration,and schematics for integrated electronics that control the photonic integrated circuits.Techniques for operating such a system in the presence of changing ambient temperature are addressed.Experiments on a 1 Tbps design are conducted with an optical link experiment indicating sub-picojoule/bit energy consumption at scale.展开更多
文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.
基金Defense Advanced Research Projects Agency(HR0011-19-C-0083)Semiconductor Research Corporation(2023-JU-3132)。
文摘The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are shown,along with a quantum-dot mode-locked laser 20-channel comb source with free space wall plug efficiencies up to 17%,advanced packaging techniques for 3D silicon photonic-electronic integration,and schematics for integrated electronics that control the photonic integrated circuits.Techniques for operating such a system in the presence of changing ambient temperature are addressed.Experiments on a 1 Tbps design are conducted with an optical link experiment indicating sub-picojoule/bit energy consumption at scale.
基金Defense Advanced Research Projects Agency(HR0011-19-C-0083)Semiconductor Research Corporation(2023-JU-3132).
文摘The architecture and component technology of a low power,high capacity,short reach optical interconnect are detailed.Measurements from high-performance 300 mm silicon photonics components that comprise the system are shown,along with a quantum-dot mode-locked laser 20-channel comb source with free space wall plug efficiencies up to 17%,advanced packaging techniques for 3D silicon photonic-electronic integration,and schematics for integrated electronics that control the photonic integrated circuits.Techniques for operating such a system in the presence of changing ambient temperature are addressed.Experiments on a 1 Tbps design are conducted with an optical link experiment indicating sub-picojoule/bit energy consumption at scale.
