A cloud of gas collapsing under gravity will fragment. We present a new theory for this process, in which layers of shocked gas fragment due to their gravitational instability. Our model explains why angular momentum ...A cloud of gas collapsing under gravity will fragment. We present a new theory for this process, in which layers of shocked gas fragment due to their gravitational instability. Our model explains why angular momentum does not inhibit the collapse process. The theory predicts that the fragmentation process produces objects which are significantly smaller than most stars, implying that accretion onto the fragments plays an essential role in determining the initial masses of stars. This prediction is also consistent with the hypothesis that planets can be produced by gravitational collapse.展开更多
A recent study published in Cell by the Kim lab represents a great advance towards expanding DNA editing possibilities to mitochondrial DNA(mtDNA)as they show reasonable targeted A-to-G conversions in human mtDNA usin...A recent study published in Cell by the Kim lab represents a great advance towards expanding DNA editing possibilities to mitochondrial DNA(mtDNA)as they show reasonable targeted A-to-G conversions in human mtDNA using base editors to broaden the arsenal of available tools.1 Mutations in mitochondrial DNA(mtDNA)are linked to several diseases(Fig.1),thus,development of gene therapy and editing approaches could lead to curative options for patients suffering from these illnesses.In this direction,gene editing tools such as zinc-finger nucleases(mitoZFN),transcription activator-like effector nucleases(mitoTALENs)and meganucleases(mitoARCUS)were shown to eliminate mutant mtDNA and shift heteroplasmy.展开更多
Tumor metastases present an often difficult to treat therapeutic challenge for cancer patients and their caregivers.The recent paper by the Kaplan group(Kaczanowska et al.)exploited the natural capacity of monocytes o...Tumor metastases present an often difficult to treat therapeutic challenge for cancer patients and their caregivers.The recent paper by the Kaplan group(Kaczanowska et al.)exploited the natural capacity of monocytes or a subset of monocytes to migrate to tumor sites and pre-metastatic niches to deliver IL-12 in a novel anticancer approach designed to stimulate local immune responses.1 This raises the possibility to simultaneously fight cancer on at least two critical fronts,(1)elimination of the primary tumor and(2)inhibition of newly developing pre-metastatic lesions.展开更多
文摘A cloud of gas collapsing under gravity will fragment. We present a new theory for this process, in which layers of shocked gas fragment due to their gravitational instability. Our model explains why angular momentum does not inhibit the collapse process. The theory predicts that the fragmentation process produces objects which are significantly smaller than most stars, implying that accretion onto the fragments plays an essential role in determining the initial masses of stars. This prediction is also consistent with the hypothesis that planets can be produced by gravitational collapse.
基金Open Access funding enabled and organized by Projekt DEAL.
文摘A recent study published in Cell by the Kim lab represents a great advance towards expanding DNA editing possibilities to mitochondrial DNA(mtDNA)as they show reasonable targeted A-to-G conversions in human mtDNA using base editors to broaden the arsenal of available tools.1 Mutations in mitochondrial DNA(mtDNA)are linked to several diseases(Fig.1),thus,development of gene therapy and editing approaches could lead to curative options for patients suffering from these illnesses.In this direction,gene editing tools such as zinc-finger nucleases(mitoZFN),transcription activator-like effector nucleases(mitoTALENs)and meganucleases(mitoARCUS)were shown to eliminate mutant mtDNA and shift heteroplasmy.
文摘Tumor metastases present an often difficult to treat therapeutic challenge for cancer patients and their caregivers.The recent paper by the Kaplan group(Kaczanowska et al.)exploited the natural capacity of monocytes or a subset of monocytes to migrate to tumor sites and pre-metastatic niches to deliver IL-12 in a novel anticancer approach designed to stimulate local immune responses.1 This raises the possibility to simultaneously fight cancer on at least two critical fronts,(1)elimination of the primary tumor and(2)inhibition of newly developing pre-metastatic lesions.
