The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine healthcare.Meticulously building bionic-sensitive moieties is vital f...The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine healthcare.Meticulously building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external stimuli.However,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic circuits.Herein,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s epidermis.The bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message communication.Ultimately,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed circuits.This system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning algorithm.Our work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.展开更多
The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory...The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory therapy.The current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and indomethacin.Confocal-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is overexpressed.The TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory cells.Moreover,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse models.In vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise diagnosis.Theranostic behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.展开更多
Photodynamic therapy(PDT)has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues.In recent years,a variety of protocols have been proposed ...Photodynamic therapy(PDT)has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues.In recent years,a variety of protocols have been proposed to improve the PDT efficacy,of which organelle-targeted PDT strategy is supposed to be quite promising.Particularly,lipid droplets(LDs)-localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis.This review provides a comprehensive summary of the advancements of LDs-localized photosensitizers(PSs)according to their chemical structures and functions.Especially,these PSs are featured with fluorescence emission,thereby facilitating an imaging-guided phototherapy.The review highlights the cytocidal actions of these PSs,such as the cell death pathway and their cytotoxicity.Finally,some unresolved issues and challenges in this domain will be discussed.展开更多
Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therap...Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therapies.VEGF and its receptor(VEGFR)play a crucial role in angiogenesis progression;precisely,upregulated VEGF signaling ismainly associated with angiogenesis progression in many types of cancers.Herein,we report a sunitinib-conjugated sonosensitizer(TK-RB:tyrosine kinase-rose bengal)to enhance the anticancer efficacy through VEGF inhibitionmediated antiangiogenesis in conjunction with cellular/tumor damage by ROS generated under ultrasound irradiation.TK-RB reveals good selectivity and cytotoxicity toward VEGFR-positive cells(U87MG)over VEGFR-negative cells(MCF-7).The fluorescent imaging analysis in vivo/ex vivo and the tumor growth investigation in nude mice with U87MG glioblastoma tumor xenografts demonstrate that rose bengal having tyrosine kinase inhibitor(TK-RB)provides an enhanced antitumor effect.The current strategy will make a great contribution to optimizing anticancer performance by utilizing sonodynamic therapy together with antiangiogenics in several different malignancies.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20184,52250077,and 52272080)the Jilin Province Natural Science Foundation of China(No.20220201093GX)+2 种基金the Fundamental Research Funds for the Central Universitiessupported by the National Research Foundation of Korea(2018R1A3B1052702 to JSK)the Starting growth Technological R&D Program(TIPS Program,No.S3201803,2021,MW)funded by the Ministry of SMEs and Startups(MSS,Korea).
文摘The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine healthcare.Meticulously building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external stimuli.However,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic circuits.Herein,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s epidermis.The bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message communication.Ultimately,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed circuits.This system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning algorithm.Our work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.
基金supported by the National Research Foundation of Korea(CRI project no.2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.)Basic Science Research Program(2020R1A6A3A01100551,M.W.and 2020R1A6A3A01100558,S.K.)funded by the Ministry of EducationKorea University Grant。
文摘The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory therapy.The current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and indomethacin.Confocal-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is overexpressed.The TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory cells.Moreover,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse models.In vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise diagnosis.Theranostic behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.
基金supported by the National Natural Science Foundation of China(22207087 to SW)the Medical and Health Research Project of Zhejiang Province(2024KY407 to QW)+2 种基金the National Research Foundation of Korea(2018R1A3B1052702 to JSK,RS-2024-00335130 to MW)supported by the Starting Growth Technological R&D Program(RS-2024-00422852 to JSK,S3201803-TIPS Program 2021 to MW)funded by the Ministry of SMEs and Startups(MSS,Korea).Figures were partially created with Biorender.com.
文摘Photodynamic therapy(PDT)has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues.In recent years,a variety of protocols have been proposed to improve the PDT efficacy,of which organelle-targeted PDT strategy is supposed to be quite promising.Particularly,lipid droplets(LDs)-localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis.This review provides a comprehensive summary of the advancements of LDs-localized photosensitizers(PSs)according to their chemical structures and functions.Especially,these PSs are featured with fluorescence emission,thereby facilitating an imaging-guided phototherapy.The review highlights the cytocidal actions of these PSs,such as the cell death pathway and their cytotoxicity.Finally,some unresolved issues and challenges in this domain will be discussed.
基金National Research Foundation ofKorea,Grant/Award Numbers:2018R1A3B1052702,2019M3E5D1A01068998Basic Science Research Program,Grant/Award Number:2020R1A6A3A01100551Ministry ofEducation,andNationalNatural Science Foundation of China,Grant/Award Number:21673265。
文摘Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therapies.VEGF and its receptor(VEGFR)play a crucial role in angiogenesis progression;precisely,upregulated VEGF signaling ismainly associated with angiogenesis progression in many types of cancers.Herein,we report a sunitinib-conjugated sonosensitizer(TK-RB:tyrosine kinase-rose bengal)to enhance the anticancer efficacy through VEGF inhibitionmediated antiangiogenesis in conjunction with cellular/tumor damage by ROS generated under ultrasound irradiation.TK-RB reveals good selectivity and cytotoxicity toward VEGFR-positive cells(U87MG)over VEGFR-negative cells(MCF-7).The fluorescent imaging analysis in vivo/ex vivo and the tumor growth investigation in nude mice with U87MG glioblastoma tumor xenografts demonstrate that rose bengal having tyrosine kinase inhibitor(TK-RB)provides an enhanced antitumor effect.The current strategy will make a great contribution to optimizing anticancer performance by utilizing sonodynamic therapy together with antiangiogenics in several different malignancies.
