目的探讨成年人群中单核细胞与高密度脂蛋白胆固醇比值(monocyte-to-high-density lipoprotein cholesterol ratio,MHR)与肌肉减少症之间的关联。方法从2011~2018年4个周期的国家健康与营养调查(National Health and Nutrition Examinat...目的探讨成年人群中单核细胞与高密度脂蛋白胆固醇比值(monocyte-to-high-density lipoprotein cholesterol ratio,MHR)与肌肉减少症之间的关联。方法从2011~2018年4个周期的国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)中选取了8085例20岁及以上的参与者进行横断面研究。采用多元Logistic回归模型来评估MHR与肌肉减少症之间的关联。方差膨胀因子(variance inflation factors,VIF)检查变量间的多重共线性。通过限制性立方样条探究非线性关系,同时进行了交互作用检验和亚组分析。结果在完全调整的模型中发现,MHR与肌肉减少症呈正相关(OR=2.56,95%CI:1.73~3.79,P<0.001)。这种关联在吸烟和心血管疾病参与者中更加突出。此外,限制性立方样条分析显示,MHR与肌肉减少症之间的关系是线性的。结论MHR与肌肉减少症发病风险呈正相关,可能是早期识别肌肉减少症的潜在指标。展开更多
The degradation and nonlinear interactions of a two-breather solution of the Mel’nikov equation are analyzed.By modulating the phase shift and limit method,we prove that in different regions near the non-singular bou...The degradation and nonlinear interactions of a two-breather solution of the Mel’nikov equation are analyzed.By modulating the phase shift and limit method,we prove that in different regions near the non-singular boundaries,there are four kinds of solutions with repulsive interaction or attractive interaction in addition to the two-breather solution.They are the interaction solution between soliton and breather,the two-soliton solution,and the two-breather solution with small amplitude,which all exhibit repulsive interactions;and the two-breather solution with small amplitude,which exhibits attractive interaction.Interestingly,a new breather acts as a messenger to transfer energy during the interaction between two breather solutions with small amplitude.展开更多
Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villa...Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villages, but also arouse people’s awareness of the protection of traditional villages. This paper took Xingtai County, Hebei Province, China as an example to practice greenway route selection in the county territory. Eight factors were selected for greenway route planning, namely elevation, water body, mountain, ecological protection redline, cultural relics protection units, population density, road traffic network, and important transportation hub. These eight factors were assigned in the GIS platform, and the suitability evaluation system of each factor was constructed. The analytic hierarchy process (AHP) and entropy weight method were combined to calculate the weight of these eight factors. The raster calculator was used to weight and overlay the suitability evaluation system of each factor, and the comprehensive suitability evaluation map of greenway route selection was obtained. Based on an important transport hub, along with the water body and the road traffic, the final selection greenway route of traditional villages in Xingtai county was formed. The results of the research can provide a certain reference for the greenway route selection at the county scale.展开更多
Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic dist...Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.展开更多
A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transfor...A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transformation(DT)which is derived by Taylor expansion and determinants.We obtained a series of higher-order rational solutions by one spectral parameter and we could get the periodic wave solution and three kinds of interaction solutions,singular breather and periodic wave interaction solution,singular breather and traveling wave interaction solution,bimodal breather and periodic wave interaction solution by two spectral parameters.We found a general formula for these solutions in the form of determinants.We also analyzed the complex wave structures of the dynamic behaviors and the effects of special parameters and presented exact solutions for the(2+1)-dimensional reverse space–time nonlocal NLS equation.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52171251 and U21062251)Program of Science and Technology Innovation of Dalian(Grant No.2022JJ12GX036).
文摘The degradation and nonlinear interactions of a two-breather solution of the Mel’nikov equation are analyzed.By modulating the phase shift and limit method,we prove that in different regions near the non-singular boundaries,there are four kinds of solutions with repulsive interaction or attractive interaction in addition to the two-breather solution.They are the interaction solution between soliton and breather,the two-soliton solution,and the two-breather solution with small amplitude,which all exhibit repulsive interactions;and the two-breather solution with small amplitude,which exhibits attractive interaction.Interestingly,a new breather acts as a messenger to transfer energy during the interaction between two breather solutions with small amplitude.
文摘Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villages, but also arouse people’s awareness of the protection of traditional villages. This paper took Xingtai County, Hebei Province, China as an example to practice greenway route selection in the county territory. Eight factors were selected for greenway route planning, namely elevation, water body, mountain, ecological protection redline, cultural relics protection units, population density, road traffic network, and important transportation hub. These eight factors were assigned in the GIS platform, and the suitability evaluation system of each factor was constructed. The analytic hierarchy process (AHP) and entropy weight method were combined to calculate the weight of these eight factors. The raster calculator was used to weight and overlay the suitability evaluation system of each factor, and the comprehensive suitability evaluation map of greenway route selection was obtained. Based on an important transport hub, along with the water body and the road traffic, the final selection greenway route of traditional villages in Xingtai county was formed. The results of the research can provide a certain reference for the greenway route selection at the county scale.
基金supported by the National Natural Science Foundation of China(Nos.21577117 and 22076160)the Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20210521).
文摘Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.
基金the National Natural Science Foundation of China(Nos.52174372,51974224)the Natural Science Foundation of Shaanxi Province,China(No.2020JM-047)the Fundamental Research Funds for Central Universities,China(No.xtr0118008)for their support。
文摘A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transformation(DT)which is derived by Taylor expansion and determinants.We obtained a series of higher-order rational solutions by one spectral parameter and we could get the periodic wave solution and three kinds of interaction solutions,singular breather and periodic wave interaction solution,singular breather and traveling wave interaction solution,bimodal breather and periodic wave interaction solution by two spectral parameters.We found a general formula for these solutions in the form of determinants.We also analyzed the complex wave structures of the dynamic behaviors and the effects of special parameters and presented exact solutions for the(2+1)-dimensional reverse space–time nonlocal NLS equation.
