Selenium-enriched polysaccharides refer to polysaccharides that contain selenium,which have emerged as a significant area of research in recent years due to the bioactivities associated with both polysaccharides and s...Selenium-enriched polysaccharides refer to polysaccharides that contain selenium,which have emerged as a significant area of research in recent years due to the bioactivities associated with both polysaccharides and selenium.In this study,we prepared Spirulina platensis polysaccharides(SPP)and selenium-enriched SPP(SeSPP),and assessed their structural properties and hypoglycaemic functions both in vitro and in vivo.The re-sults of the structural characterization indicated that SPP was successfully selenized.The interaction between SPP and selenium primarily occurred in the forms of Se-O-C and O-Se-O through covalent interactions.The molecular weight of SeSPP was found to be more concentrated compared to SPP,and its microscopic morphology exhibited greater complexity,including both rod-shaped and spherical particles.It was determined that SPP and SeSPP were mainly composed of glucose,rhamnose,and fucose.In vitro assays demonstrated that SeSPP exhibited significantly enhanced hypoglycaemic and antioxidant properties compared to SPP.In an in vivo model of streptozotocin-and high-fat diet-induced type 2 diabetes mice,SeSPP improved hypoglycaemic activity by reversing body weight,blood glucose levels,glucose tolerance,insulin resistance,lipid levels,hepatic oxidative stress levels,as well as liver and pancreatic morphology and function.Consequently,SeSPP may serve as a se-lenium supplement that could enhance hypoglycaemic effects.展开更多
In recent years,an increasing number of studies have demonstrated a significant association between gut microbiota dysbiosis and type 2 diabetes mellitus(T2DM).As evidenced by the variations in the composition and fun...In recent years,an increasing number of studies have demonstrated a significant association between gut microbiota dysbiosis and type 2 diabetes mellitus(T2DM).As evidenced by the variations in the composition and functionality of the gut microbiota,levels of gut metabolites,and the extent of gut barrier damage observed in individuals with diabetes compared to their healthy counterparts.The gut microbiota was once considered a novel target for T2DM treatment.Recently,strategies involving functional foods aimed at reducing the incidence of diabetes through modulation of the regulatory effects on gut microbiota have shown promise.Certain selenium compounds have also exhibited potential in managing T2DM.However,a comprehensive systematization and conclusion regarding how selenium and its compounds influence T2DM through impacts on gut health remain to be established.This study investigated how selenium and several common selenium compounds affect T2DM management.The primary objective of this manuscript is to explore the role that selenium plays in controlling T2DM from the perspective of gut microecology.It is crucial to emphasize that adequate levels of selenium supplementation can interact with host gut bacteria,thereby regulating functions within the gut microecology.Consequently,we conduct a thorough review in this area to explore and identify innovative approaches for T2DM treatment.展开更多
基金supported by the National Natural Science Foundation of China(32172259,32472381)the Key Research and Development Project of Henan Province(231111111800)the Food Engineering Technology Research Center/Key Laboratory of Henan Province(GO202318).
文摘Selenium-enriched polysaccharides refer to polysaccharides that contain selenium,which have emerged as a significant area of research in recent years due to the bioactivities associated with both polysaccharides and selenium.In this study,we prepared Spirulina platensis polysaccharides(SPP)and selenium-enriched SPP(SeSPP),and assessed their structural properties and hypoglycaemic functions both in vitro and in vivo.The re-sults of the structural characterization indicated that SPP was successfully selenized.The interaction between SPP and selenium primarily occurred in the forms of Se-O-C and O-Se-O through covalent interactions.The molecular weight of SeSPP was found to be more concentrated compared to SPP,and its microscopic morphology exhibited greater complexity,including both rod-shaped and spherical particles.It was determined that SPP and SeSPP were mainly composed of glucose,rhamnose,and fucose.In vitro assays demonstrated that SeSPP exhibited significantly enhanced hypoglycaemic and antioxidant properties compared to SPP.In an in vivo model of streptozotocin-and high-fat diet-induced type 2 diabetes mice,SeSPP improved hypoglycaemic activity by reversing body weight,blood glucose levels,glucose tolerance,insulin resistance,lipid levels,hepatic oxidative stress levels,as well as liver and pancreatic morphology and function.Consequently,SeSPP may serve as a se-lenium supplement that could enhance hypoglycaemic effects.
基金supported by the National Natural Science Foundation of China(32172259,32472381)the Key Research and Development Project of Henan Province(231111111800).
文摘In recent years,an increasing number of studies have demonstrated a significant association between gut microbiota dysbiosis and type 2 diabetes mellitus(T2DM).As evidenced by the variations in the composition and functionality of the gut microbiota,levels of gut metabolites,and the extent of gut barrier damage observed in individuals with diabetes compared to their healthy counterparts.The gut microbiota was once considered a novel target for T2DM treatment.Recently,strategies involving functional foods aimed at reducing the incidence of diabetes through modulation of the regulatory effects on gut microbiota have shown promise.Certain selenium compounds have also exhibited potential in managing T2DM.However,a comprehensive systematization and conclusion regarding how selenium and its compounds influence T2DM through impacts on gut health remain to be established.This study investigated how selenium and several common selenium compounds affect T2DM management.The primary objective of this manuscript is to explore the role that selenium plays in controlling T2DM from the perspective of gut microecology.It is crucial to emphasize that adequate levels of selenium supplementation can interact with host gut bacteria,thereby regulating functions within the gut microecology.Consequently,we conduct a thorough review in this area to explore and identify innovative approaches for T2DM treatment.
