To obtain expected rapid-release and sustained-release of ketoprofen gel beads, this paper adopted biopolymer alginate to prepare alginate beads and chitosan-alginate gel beads. Formulation factors were investigated a...To obtain expected rapid-release and sustained-release of ketoprofen gel beads, this paper adopted biopolymer alginate to prepare alginate beads and chitosan-alginate gel beads. Formulation factors were investigated and optimized by the single factor test. The release of ketoprofen from calcium alginate gel beads in pH 1.0 hydrochloric acid solution was less than 10% during 2 h, then in pH6.8 was about 95% during 45 min, which met the requirements of rapid-release preparations. However, the drug release of chitosan-alginate gel beads in pH1.0 was less than 5% during 2 h, then in pH6.8 was about 50% during 6 h and reached more than 95% during 12 h, which had a good sustained-release behavior. In addition, the release kinetics of keteprofen from the calcium alginate gel beads fitted well with the Korsmeyer–Peppas model and followed a case-II transport mechanism. However, the release of keteprofen from the chitosan-alginate gel beads exhibited a non-Fickian mechanism and based on the mixed mechanisms of diffusion and polymer relaxation from chitosanalginate beads. In a word, alginate gel beads of ketoprofen were instant analgesic, while chitosan-alginate gel beads could control the release of ketoprofen during gastrointestinal tract and prolong the drug's action time.展开更多
Three-dimensional printing is a technology that prints the products layer-by-layer,in which materials are deposited according to the digital model designed by computer aided design(CAD)software.This technology has com...Three-dimensional printing is a technology that prints the products layer-by-layer,in which materials are deposited according to the digital model designed by computer aided design(CAD)software.This technology has competitive advantages regarding product design complexity,product personalization,and on-demand manufacturing.The emergence of 3 D technology provides innovative strategies and new ways to develop novel drug delivery systems.This review summarizes the application of 3 D printing technologies in the pharmaceutical field,with an emphasis on the advantages of 3 D printing technologies for achieving rapid drug delivery,personalized drug delivery,compound drug delivery and customized drug delivery.In addition,this article illustrates the limitations and challenges of 3 D printing technologies in the field of pharmaceutical formulation development.展开更多
基金supported by the program of supporting career development of young and middle-aged teachers from Shenyang Pharmaceutical University (ZQN2015011)the Open fund of Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine(zyzx1608)
文摘To obtain expected rapid-release and sustained-release of ketoprofen gel beads, this paper adopted biopolymer alginate to prepare alginate beads and chitosan-alginate gel beads. Formulation factors were investigated and optimized by the single factor test. The release of ketoprofen from calcium alginate gel beads in pH 1.0 hydrochloric acid solution was less than 10% during 2 h, then in pH6.8 was about 95% during 45 min, which met the requirements of rapid-release preparations. However, the drug release of chitosan-alginate gel beads in pH1.0 was less than 5% during 2 h, then in pH6.8 was about 50% during 6 h and reached more than 95% during 12 h, which had a good sustained-release behavior. In addition, the release kinetics of keteprofen from the calcium alginate gel beads fitted well with the Korsmeyer–Peppas model and followed a case-II transport mechanism. However, the release of keteprofen from the chitosan-alginate gel beads exhibited a non-Fickian mechanism and based on the mixed mechanisms of diffusion and polymer relaxation from chitosanalginate beads. In a word, alginate gel beads of ketoprofen were instant analgesic, while chitosan-alginate gel beads could control the release of ketoprofen during gastrointestinal tract and prolong the drug's action time.
基金supported by the National Science and Technology Major Project which belongs to“The research on the key technology of 3D printing techniques in the field of pharmaceutical preparation”(No.2017ZX09201-003-011,China)supported by the China Pharmaceutical Association-Yiling Biomedical Innovation Project(China)financial and instrumental support from Jingxin Pharmaceutical Co.,Ltd.(Zhejiang,China)
文摘Three-dimensional printing is a technology that prints the products layer-by-layer,in which materials are deposited according to the digital model designed by computer aided design(CAD)software.This technology has competitive advantages regarding product design complexity,product personalization,and on-demand manufacturing.The emergence of 3 D technology provides innovative strategies and new ways to develop novel drug delivery systems.This review summarizes the application of 3 D printing technologies in the pharmaceutical field,with an emphasis on the advantages of 3 D printing technologies for achieving rapid drug delivery,personalized drug delivery,compound drug delivery and customized drug delivery.In addition,this article illustrates the limitations and challenges of 3 D printing technologies in the field of pharmaceutical formulation development.
