Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field face...Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.展开更多
Phytoplankton community structure,abundance,and species'spatial and temporal distributions were examined for the Backshore Wetland of Expo Garden in Shanghai from September 2009 to August 2010.A total of 371 phyto...Phytoplankton community structure,abundance,and species'spatial and temporal distributions were examined for the Backshore Wetland of Expo Garden in Shanghai from September 2009 to August 2010.A total of 371 phytoplankton species were identified from 109 genera 8 phyla.There were 18 dominant species in total,and Phormidium tenue was dominant during four seasons.The mean annual abundance and biomass were 711.11×10^(4) cells/L and 5.70 mg/L,respectively.The seasonal changing trend of existing stocks was bimodal,with main peaks of density and biomass occurring in the winter and a secondary peaks occurring in the summer.The Shannon–Wiener diversity index(H′),the Margalef species richness index(D),and Pielou's species evenness index(J)showed a clear seasonal trend.All of the indices showed a changing pattern,with the highest recorded values from the summer to autumn and the lowest recorded values from the winter to spring.The canonical correspondence analysis(CCA)showed that environmental factors,including water temperature,nitrate nitrogen,and pH were the main influencing factors to the change of phytoplankton community structure in the Backshore Wetland of Expo Garden in Shanghai.展开更多
基金supported by Nanjing Science and Technology Bureau International,Hong Kong,Macao,and Taiwan Science and Technology Cooperation Program(No.202401042)。
文摘Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.
文摘Phytoplankton community structure,abundance,and species'spatial and temporal distributions were examined for the Backshore Wetland of Expo Garden in Shanghai from September 2009 to August 2010.A total of 371 phytoplankton species were identified from 109 genera 8 phyla.There were 18 dominant species in total,and Phormidium tenue was dominant during four seasons.The mean annual abundance and biomass were 711.11×10^(4) cells/L and 5.70 mg/L,respectively.The seasonal changing trend of existing stocks was bimodal,with main peaks of density and biomass occurring in the winter and a secondary peaks occurring in the summer.The Shannon–Wiener diversity index(H′),the Margalef species richness index(D),and Pielou's species evenness index(J)showed a clear seasonal trend.All of the indices showed a changing pattern,with the highest recorded values from the summer to autumn and the lowest recorded values from the winter to spring.The canonical correspondence analysis(CCA)showed that environmental factors,including water temperature,nitrate nitrogen,and pH were the main influencing factors to the change of phytoplankton community structure in the Backshore Wetland of Expo Garden in Shanghai.
