Hypertrophic cardiomyopathy(HCM)is a prevalent inherited cardiac condition,affecting approximately 1 in 500 in-dividuals.^(1)Recent research highlights immune cell involve-ment in HCM,with altered levels of various im...Hypertrophic cardiomyopathy(HCM)is a prevalent inherited cardiac condition,affecting approximately 1 in 500 in-dividuals.^(1)Recent research highlights immune cell involve-ment in HCM,with altered levels of various immune populations associated with the disease.^(2)However,whether these changes are causative or merely correlational is still uncertain.This study aims to investigate the causal effects of 731 immune cell types on HCM using comprehensive bidi-rectional Mendelian randomization(MR).展开更多
基金supported by the Program for Youth Innovation in Future Medicine,Chongqing Medical University,Chongqing,China(No.W0168)the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX0075)+1 种基金the Joint Project of Chongqing Health Commission and Science and Technology Bureau(China)(No.2025GDRC006)Chongqing Education Committee Grant(China)(No.KJQN202300480).
文摘Hypertrophic cardiomyopathy(HCM)is a prevalent inherited cardiac condition,affecting approximately 1 in 500 in-dividuals.^(1)Recent research highlights immune cell involve-ment in HCM,with altered levels of various immune populations associated with the disease.^(2)However,whether these changes are causative or merely correlational is still uncertain.This study aims to investigate the causal effects of 731 immune cell types on HCM using comprehensive bidi-rectional Mendelian randomization(MR).
