The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important i...The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions.The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging(MRI),and thus is not ideal for mapping children’s cognitive and affective brain development.By integrating task-dependent functional MRI data from a large sample of 250 children(aged 7 to 12)across multiple domains and the latest easy-to-use and transparent preprocessing workflow,we here created a set of age-specific brain functional activity maps across four domains:attention,executive function,emotion,and risky decision-making.Moreover,we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain-and age-specific brain activity maps for various needs.This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website(http://www.nitrc.org/projects/dbfa).Our study provides domain-and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations.展开更多
Infrared spectroscopy has wide applications in the medical field,industry,agriculture,and other areas.Although the traditional infrared spectrometers are well developed,they face the challenge of miniaturization and c...Infrared spectroscopy has wide applications in the medical field,industry,agriculture,and other areas.Although the traditional infrared spectrometers are well developed,they face the challenge of miniaturization and cost reduction.Advances in nanomaterials and nanotechnology offer new methods for miniaturizing spectrometers.However,most research on nanomaterial-based spectrometers is limited to the visible wavelength or near infrared region.展开更多
Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultrav...Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultraviolet(UV)exposure.The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R(version 4.0.3)software.The epigenetic landscape of the skin,including histone modifications,genetic imprinting and m^(6)A modification,which are mainly involved in collagen formation,extracellular matrix organization,immune function and keratinization,underwent significant changes during neonatal to adult development.Epigenetic effectors such as IGF2BP2,GATA2,GATA3,CPA4 and CDK1 were significantly correlated with extracellular matrix organization,and VEGFA,CDK1 and PRKCB with skin immune function.The m^(6)A readers such as IGF2BP2,IGF2BP3,HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization,metabolism,or antigen processing and presentation.Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors,without any significant effect on the overall epigenetic landscape.However,the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization,cell-matrix adhesion,innate immune response,mitochondrial function and mRNA processing.In addition,epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin.In conclusion,histone modifications,genetic imprinting and m^(6)A modification play critical roles during skin development,and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors.展开更多
Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared wavelengths.Peop...Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared wavelengths.People may question about the upper limit on the CQD wavelength region.To date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave infrared.To figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these nanomaterials.What’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor bulk.In this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe CQD.At liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,respectively.This work is a step toward answering the general question on the CQD photodetection wavelength limitation.展开更多
Prosthetic eye is indispensable as filler after enucleation in patients with anophthalmia,whereas there are still many complications including postoperative infection and eye socket depression or extrusion during the ...Prosthetic eye is indispensable as filler after enucleation in patients with anophthalmia,whereas there are still many complications including postoperative infection and eye socket depression or extrusion during the conventional artificial eye material applications.Some Ca-silicate biomaterials showed superior bioactivity but their biological stability in vivo limit the biomedical application as long-term or permanent implants.Herein we aimed to understand the physicochemical and potential biological responses of zinc doping in wollastonite bioceramic used for orbital implants.The wollastonite powders with different zinc dopant contents(CSi-Znx)could be fabricated as porous implants with strut or curve surface pore geometries(cubic,IWP)via ceramic stereolithography.The experimental results indicated that,by increasing zinc-substituting-Ca ratio(up to 9%),the sintering and mechanical properties could be significantly enhanced,and meanwhile the bio-dissolution in vitro and biodegradability in vivo were thoroughly inhibited.In particular,an appreciable angiogenic activity and expected antibacterial efficacy(over 90%)were synergistically achieved at 9 mol%Zn dopant.In the back-embedding and enucleation and implantation model experiments in rabbits,the superior continuous angiogenesis was corroborated from the 2D/3D fibrovascular reconstruction in the IWP-pore CSi-Zn9 and CSi-Zn13.5 groups within very short time stages.Totally,the present silicate-based bioceramic via selective Zn doping could produce outstanding structural stability and bifunctional biological responses which is especially valuable for developing the next-generation implants with vascular insertion and fixation in orbital reconstruction prothesis.展开更多
Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how...Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.展开更多
Due to thermal carriers generated by a narrow mid-infrared energy gap,cooling is always necessary to achieve ideal photodetection.In quantum dot(QD),the electron thermal generation should be reduced with quantum confi...Due to thermal carriers generated by a narrow mid-infrared energy gap,cooling is always necessary to achieve ideal photodetection.In quantum dot(QD),the electron thermal generation should be reduced with quantum confinement in all three dimensions.As a result,there would be a great potential to realize high-operating-temperature(HOT)QD mid-IR photodetectors,though not yet achieved.Taking the advantages of colloidal nanocrystals’solution processability and precise doping control by surface dipoles,this work demonstrates a HOT mid-infrared photodetector with a QD gradient homojunction.The detector achieves background-limited performance with D^(*)=2.7×1011 Jones on 4.2μm at 80 K,above 10^(11) Jones until 200 K,above 10^(10 )Jones until 280 K,and 7.6×10^(9) Jones on 3.5μm at 300 K.The external quantum efficiency also achieves more than 77%with responsivity 2.7 A/W at zero bias.The applications such as spectrometers,chemical sensors,and thermal cameras,are also approved,which motivate interest in low-cost,solution-processed and high-performance mid-infrared photodetection beyond epitaxial growth bulk photodetectors.展开更多
Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and mole...Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing.展开更多
Eyeball loss due to severe ocular trauma,intraocular malignancy or infection often requires surgical treatment called orbital implant reconstruction to rehabilitate the orbital volume and restore the aesthetic appeara...Eyeball loss due to severe ocular trauma,intraocular malignancy or infection often requires surgical treatment called orbital implant reconstruction to rehabilitate the orbital volume and restore the aesthetic appearance.However,it remains a challenge to minimize the postoperative exposure and infection complications due to the inert nature of conventional orbital implants.Herein,we developed a novel Ca-Zn-silicate bioceramic implant with multi-functions to achieve the expected outcomes.The porous hardystonite(Ca2ZnSi2O7)scaffolds with triply periodic minimal surfaces(TPMS)-based pore architecture and graded pore size distribution from center to periphery(from 500 to 800μm or vice versa)were fabricated through the digital light processing(DLP)technique,and the scaffolds with homogeneous pores(500 or 800μm)were fabricated as control.The graded porous scaffolds exhibited a controlled bio-dissolving behavior and intermediate mechanical strength in comparison with the homogeneous counterparts,although all of porous implants presented significant antibacterial potential against S.aureus and E.coli.Meanwhile,the pore size-increasing scaffolds indicated more substantial cell adhesion,cell viability and angiogenesis-related gene expression in vitro.Furthermore,the gradually increasing pore feature exhibited a stronger blood vessel infiltrating potential in the dorsal muscle embedding model,and the spherical implants with such pore structure could achieve complete vascularization within 4 weeks in the eyeball enucleation rabbit models.Overall,our results suggested that the novel antibacterial hardystonite bioceramic with graded pore design has excellent potential as a next-generation orbital implant,and the pore topological features offer an opportunity for the improvement of biological performances in orbital reconstruction.展开更多
Although the performance of quantum-dot-based light emitting diodes(QLEDs)has been significantly enhanced over the past years,conventional full-color QLED displays still rely on the side-by-side pattern techniques of ...Although the performance of quantum-dot-based light emitting diodes(QLEDs)has been significantly enhanced over the past years,conventional full-color QLED displays still rely on the side-by-side pattern techniques of red(R)/green(G)/blue(B)quantum dots(QDs).Such lateral integration of multi-color pixels imposes technological difficulty in the development of high-resolution displays due to limited pixel density and fill factors.Herein,we demonstrate the development of full-color QLEDs with bias-tunable emission spectra by engineering mixed R/G/B QDs as light emitting layers.In Commission Internationale de l'Eclairage(CIE)chromaticity coordinates,QLEDs with bias-tunable color exhibit wide color variation ranging from red(0.649,0.330)to green(0.283,0.305)to blue(0.255,0.264)upon increasing voltages and can be tuned to emit white light(0.316,0.325).More importantly,the fabricated multi-color QLEDs show high luminance approaching 103cd m^(-2)and superior external quantum efficiency of 13.3%.Benefitting from the wide spectral tunability and light emitting efficiency,we believe the proposed multi-color QLEDs have great application prospects for both displays and lighting.展开更多
基金This work was supported by the National Natural Science Foundation of China(31522028,71834002,31530031,81571056,31521063,and 61775139)the Youth Science and Technology Innovation Program,Beijing Brain Initiative of Beijing Municipal Science and Technology Commission(Z181100001518003)+1 种基金the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLZD1503 and CNLZD1703)the Fundamental Research Funds for the Central Universities.
文摘The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions.The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging(MRI),and thus is not ideal for mapping children’s cognitive and affective brain development.By integrating task-dependent functional MRI data from a large sample of 250 children(aged 7 to 12)across multiple domains and the latest easy-to-use and transparent preprocessing workflow,we here created a set of age-specific brain functional activity maps across four domains:attention,executive function,emotion,and risky decision-making.Moreover,we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain-and age-specific brain activity maps for various needs.This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website(http://www.nitrc.org/projects/dbfa).Our study provides domain-and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations.
基金National Natural Science Foundation of China(62475012)Natural Science Foundation of Zhejiang Province(LD25F040001)+2 种基金State Key Laboratory for Mechanical Behavior of Materials(SKLJC-K2024-07)Beijing National Laboratory forCondensedMatterPhysics(2023BNLCMPKF012)Westlake Institute for Optoelectronics(2024GD003).
文摘Infrared spectroscopy has wide applications in the medical field,industry,agriculture,and other areas.Although the traditional infrared spectrometers are well developed,they face the challenge of miniaturization and cost reduction.Advances in nanomaterials and nanotechnology offer new methods for miniaturizing spectrometers.However,most research on nanomaterial-based spectrometers is limited to the visible wavelength or near infrared region.
基金supported by the National Natural Science Foundation of China(82073421 and 82003326)the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(YX202007)+1 种基金the science and technology innovation Program of Hunan Province(2021RC3035)Natural Science Foundation of Hunan Province(2021JJ40924 and 2021JJ20089).
文摘Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultraviolet(UV)exposure.The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R(version 4.0.3)software.The epigenetic landscape of the skin,including histone modifications,genetic imprinting and m^(6)A modification,which are mainly involved in collagen formation,extracellular matrix organization,immune function and keratinization,underwent significant changes during neonatal to adult development.Epigenetic effectors such as IGF2BP2,GATA2,GATA3,CPA4 and CDK1 were significantly correlated with extracellular matrix organization,and VEGFA,CDK1 and PRKCB with skin immune function.The m^(6)A readers such as IGF2BP2,IGF2BP3,HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization,metabolism,or antigen processing and presentation.Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors,without any significant effect on the overall epigenetic landscape.However,the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization,cell-matrix adhesion,innate immune response,mitochondrial function and mRNA processing.In addition,epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin.In conclusion,histone modifications,genetic imprinting and m^(6)A modification play critical roles during skin development,and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors.
基金Westlake Institute for Optoelectronics(No.2024GD003)National Natural Science Foundation of China(No.62105022,No.U22A2081)Beijing National Laboratory for Condensed Matter Physics(No.2023BNLCMPKF012).
文摘Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared wavelengths.People may question about the upper limit on the CQD wavelength region.To date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave infrared.To figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these nanomaterials.What’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor bulk.In this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe CQD.At liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,respectively.This work is a step toward answering the general question on the CQD photodetection wavelength limitation.
基金the National Natural Science Foundation Regional Innovation and Development Joint Fund(U20A20386)the Zhejiang Provincial Basic Research for Public Welfare Funds(LGF22E030002)+1 种基金National Natural Science Foundation of China(82330032,82201236)Zhejiang Provincial Natural Science Foundation of China(LZ22E020002).
文摘Prosthetic eye is indispensable as filler after enucleation in patients with anophthalmia,whereas there are still many complications including postoperative infection and eye socket depression or extrusion during the conventional artificial eye material applications.Some Ca-silicate biomaterials showed superior bioactivity but their biological stability in vivo limit the biomedical application as long-term or permanent implants.Herein we aimed to understand the physicochemical and potential biological responses of zinc doping in wollastonite bioceramic used for orbital implants.The wollastonite powders with different zinc dopant contents(CSi-Znx)could be fabricated as porous implants with strut or curve surface pore geometries(cubic,IWP)via ceramic stereolithography.The experimental results indicated that,by increasing zinc-substituting-Ca ratio(up to 9%),the sintering and mechanical properties could be significantly enhanced,and meanwhile the bio-dissolution in vitro and biodegradability in vivo were thoroughly inhibited.In particular,an appreciable angiogenic activity and expected antibacterial efficacy(over 90%)were synergistically achieved at 9 mol%Zn dopant.In the back-embedding and enucleation and implantation model experiments in rabbits,the superior continuous angiogenesis was corroborated from the 2D/3D fibrovascular reconstruction in the IWP-pore CSi-Zn9 and CSi-Zn13.5 groups within very short time stages.Totally,the present silicate-based bioceramic via selective Zn doping could produce outstanding structural stability and bifunctional biological responses which is especially valuable for developing the next-generation implants with vascular insertion and fixation in orbital reconstruction prothesis.
基金supported by the National Natural Science Foundation of China(31830034,82021004,81620108016,31221003,31521063,81671767,82071998,81971690,32130045,and 61761166004)Changjiang Scholar Professorship Award(T2015027)+3 种基金the National Key Research and Development Project of China(2018YFA0701402)Beijing Nova Program(Z191100001119023)the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518003)the Fundamental Research Funds for the Central Universities(2020NTST29)。
文摘Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.
基金National Natural Science Foundation of China(No.62105022)M.C.is also sponsored by Beijing Nova Program(No.Z211100002121069)+1 种基金Young Elite Scientists Sponsorship Program by CAST(No.YESS20210142)National Key R&D Program of China(2021YFA0717600).
文摘Due to thermal carriers generated by a narrow mid-infrared energy gap,cooling is always necessary to achieve ideal photodetection.In quantum dot(QD),the electron thermal generation should be reduced with quantum confinement in all three dimensions.As a result,there would be a great potential to realize high-operating-temperature(HOT)QD mid-IR photodetectors,though not yet achieved.Taking the advantages of colloidal nanocrystals’solution processability and precise doping control by surface dipoles,this work demonstrates a HOT mid-infrared photodetector with a QD gradient homojunction.The detector achieves background-limited performance with D^(*)=2.7×1011 Jones on 4.2μm at 80 K,above 10^(11) Jones until 200 K,above 10^(10 )Jones until 280 K,and 7.6×10^(9) Jones on 3.5μm at 300 K.The external quantum efficiency also achieves more than 77%with responsivity 2.7 A/W at zero bias.The applications such as spectrometers,chemical sensors,and thermal cameras,are also approved,which motivate interest in low-cost,solution-processed and high-performance mid-infrared photodetection beyond epitaxial growth bulk photodetectors.
基金National Key Research and Development Program of China(2021YFA0717600)National Natural Science Foundation of China(62035004,62105022)。
文摘Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing.
基金support from the National Natural Science Foundation of China(81870635,82000948)the National Key Research and Development Program of China(2017YFE0117700)and Natural Science Foundation of Zhejiang Province(LY20H120007).
文摘Eyeball loss due to severe ocular trauma,intraocular malignancy or infection often requires surgical treatment called orbital implant reconstruction to rehabilitate the orbital volume and restore the aesthetic appearance.However,it remains a challenge to minimize the postoperative exposure and infection complications due to the inert nature of conventional orbital implants.Herein,we developed a novel Ca-Zn-silicate bioceramic implant with multi-functions to achieve the expected outcomes.The porous hardystonite(Ca2ZnSi2O7)scaffolds with triply periodic minimal surfaces(TPMS)-based pore architecture and graded pore size distribution from center to periphery(from 500 to 800μm or vice versa)were fabricated through the digital light processing(DLP)technique,and the scaffolds with homogeneous pores(500 or 800μm)were fabricated as control.The graded porous scaffolds exhibited a controlled bio-dissolving behavior and intermediate mechanical strength in comparison with the homogeneous counterparts,although all of porous implants presented significant antibacterial potential against S.aureus and E.coli.Meanwhile,the pore size-increasing scaffolds indicated more substantial cell adhesion,cell viability and angiogenesis-related gene expression in vitro.Furthermore,the gradually increasing pore feature exhibited a stronger blood vessel infiltrating potential in the dorsal muscle embedding model,and the spherical implants with such pore structure could achieve complete vascularization within 4 weeks in the eyeball enucleation rabbit models.Overall,our results suggested that the novel antibacterial hardystonite bioceramic with graded pore design has excellent potential as a next-generation orbital implant,and the pore topological features offer an opportunity for the improvement of biological performances in orbital reconstruction.
基金National Key Research and Development Program of China(2021YFA0717600)National Natural Science Foundation of China(62035004,62105022)。
文摘Although the performance of quantum-dot-based light emitting diodes(QLEDs)has been significantly enhanced over the past years,conventional full-color QLED displays still rely on the side-by-side pattern techniques of red(R)/green(G)/blue(B)quantum dots(QDs).Such lateral integration of multi-color pixels imposes technological difficulty in the development of high-resolution displays due to limited pixel density and fill factors.Herein,we demonstrate the development of full-color QLEDs with bias-tunable emission spectra by engineering mixed R/G/B QDs as light emitting layers.In Commission Internationale de l'Eclairage(CIE)chromaticity coordinates,QLEDs with bias-tunable color exhibit wide color variation ranging from red(0.649,0.330)to green(0.283,0.305)to blue(0.255,0.264)upon increasing voltages and can be tuned to emit white light(0.316,0.325).More importantly,the fabricated multi-color QLEDs show high luminance approaching 103cd m^(-2)and superior external quantum efficiency of 13.3%.Benefitting from the wide spectral tunability and light emitting efficiency,we believe the proposed multi-color QLEDs have great application prospects for both displays and lighting.
