Objective:Lung cancer is the leading cause of cancer-related deaths worldwide.Chemotherapy is associated with side effects,such as damage to myeloid cells and a reduction in the number of immune cells in patients.In a...Objective:Lung cancer is the leading cause of cancer-related deaths worldwide.Chemotherapy is associated with side effects,such as damage to myeloid cells and a reduction in the number of immune cells in patients.In addition,tumor cells hijack the mitochondria of immune cells through tunnel nanotubes,thereby weakening immune ability.Methods:In this study the effects of direct mitochondria transplantation on cancer cell proliferation and chemotherapeutic sensitivity were determined,as well as anti-tumor immunity in in vitro and in vivo lung cancer models.Results:A combination of mitochondrial transplantation and cisplatin chemotherapy was shown for the first time to significantly improve immune infiltration of advanced non-small cell lung cancer(NSCLC)and overcome the shortcomings of cisplatin chemotherapy,including damage to myeloid cells and a reduction in the number of immune cells.Conclusions:The findings of the current study provide valuable recommendations for enhancing immune infiltration and augmenting anti-tumor efficacy during chemotherapy in advanced NSCLC.In addition,the findings support“mitochondrial transfer”as a novel paradigm in tumor treatment.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81922030)the International Cooperation Project of the Belt and Road(Grant No.20400750600)+1 种基金the Construction Project of Shanghai TCMintegrated Innovative Flagship Hospital[Grant No.ZY(2021-2023)-0205-05,ZXXT-202203]the Shanghai Municipal Commission of Health and Family Plan(Grant No.201840056).
文摘Objective:Lung cancer is the leading cause of cancer-related deaths worldwide.Chemotherapy is associated with side effects,such as damage to myeloid cells and a reduction in the number of immune cells in patients.In addition,tumor cells hijack the mitochondria of immune cells through tunnel nanotubes,thereby weakening immune ability.Methods:In this study the effects of direct mitochondria transplantation on cancer cell proliferation and chemotherapeutic sensitivity were determined,as well as anti-tumor immunity in in vitro and in vivo lung cancer models.Results:A combination of mitochondrial transplantation and cisplatin chemotherapy was shown for the first time to significantly improve immune infiltration of advanced non-small cell lung cancer(NSCLC)and overcome the shortcomings of cisplatin chemotherapy,including damage to myeloid cells and a reduction in the number of immune cells.Conclusions:The findings of the current study provide valuable recommendations for enhancing immune infiltration and augmenting anti-tumor efficacy during chemotherapy in advanced NSCLC.In addition,the findings support“mitochondrial transfer”as a novel paradigm in tumor treatment.
