Growing evidences showed that heavy metals exposure may be associated with metabolic diseases.Nevertheless,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully elucidated.So ...Growing evidences showed that heavy metals exposure may be associated with metabolic diseases.Nevertheless,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully elucidated.So we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was analyzed.We determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly Cohort.MetS events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident MetS.To investigate the role of SUA in the association between As andMetS,amediation analysiswas conducted.In the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased 1.25-fold.Compared with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS risk.Further mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults population.Mediation analysis indicated that SUA might be a mediator in the association between As exposure and MetS.展开更多
中国人群早发性癌症(诊断年龄<50岁)的疾病负担尚不清楚.为了分析中国人群早发性癌症的疾病负担、危险因素和未来发展趋势,本研究提取了华盛顿大学健康测量及评价研究院发布的全球疾病负担(global burden of disease,GBD)数据库1990~...中国人群早发性癌症(诊断年龄<50岁)的疾病负担尚不清楚.为了分析中国人群早发性癌症的疾病负担、危险因素和未来发展趋势,本研究提取了华盛顿大学健康测量及评价研究院发布的全球疾病负担(global burden of disease,GBD)数据库1990~2019年中国15~49岁人群29种早发性癌症的数据,包括发病数、粗发病率、死亡数、粗死亡率、伤残调整寿命年(disability adjusted life year,DALY)、粗DALY率和危险因素.同时,对2020~2034年早发性癌症的发病和死亡情况进行预测.结果发现,在2019年,中国早发性癌症的标化发病率、标化死亡率和标化DALY率分别为95.02/10万、30.45/10万和1536.61/10万,其中,早发性乳腺癌的标化发病率最高,早发性气管、支气管和肺癌的标化死亡率和标化DALY率最高;1990~2019年,早发性癌症标化发病率出现上升,标化死亡率和标化DALY率出现下降,其中,早发性睾丸癌的标化发病率增长最快,而早发性肾癌的标化死亡率和标化DALY率增长最快.早发性肝癌的标化发病率、标化死亡率和标化DALY率均下降最快;在2019年,早发性乳腺癌和结直肠癌的DALY可归因于饮食风险的比例最高,分别为5.2%和35.9%;而早发性肺癌和肝癌的DALY可归因于吸烟的比例最高,分别为45.2%和13.6%;预测结果显示,2020~2034年,男性和女性早发性癌症的标化发病率均呈上升趋势,而标化死亡率缓慢下降.综上所述,中国早发性癌症的发病率持续上升,死亡率和DALY率则略有下降.不同性别、癌症类型之间的疾病负担存在差异,健康的生活方式可降低早发性癌症疾病负担.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(Nos.2021FZZX001-39 and 2020QNA7018)the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20220204)the Medical Science and Technology Project of Zhejiang Province(No.2023RC037).
文摘Growing evidences showed that heavy metals exposure may be associated with metabolic diseases.Nevertheless,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully elucidated.So we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was analyzed.We determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly Cohort.MetS events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident MetS.To investigate the role of SUA in the association between As andMetS,amediation analysiswas conducted.In the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased 1.25-fold.Compared with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS risk.Further mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults population.Mediation analysis indicated that SUA might be a mediator in the association between As exposure and MetS.
文摘中国人群早发性癌症(诊断年龄<50岁)的疾病负担尚不清楚.为了分析中国人群早发性癌症的疾病负担、危险因素和未来发展趋势,本研究提取了华盛顿大学健康测量及评价研究院发布的全球疾病负担(global burden of disease,GBD)数据库1990~2019年中国15~49岁人群29种早发性癌症的数据,包括发病数、粗发病率、死亡数、粗死亡率、伤残调整寿命年(disability adjusted life year,DALY)、粗DALY率和危险因素.同时,对2020~2034年早发性癌症的发病和死亡情况进行预测.结果发现,在2019年,中国早发性癌症的标化发病率、标化死亡率和标化DALY率分别为95.02/10万、30.45/10万和1536.61/10万,其中,早发性乳腺癌的标化发病率最高,早发性气管、支气管和肺癌的标化死亡率和标化DALY率最高;1990~2019年,早发性癌症标化发病率出现上升,标化死亡率和标化DALY率出现下降,其中,早发性睾丸癌的标化发病率增长最快,而早发性肾癌的标化死亡率和标化DALY率增长最快.早发性肝癌的标化发病率、标化死亡率和标化DALY率均下降最快;在2019年,早发性乳腺癌和结直肠癌的DALY可归因于饮食风险的比例最高,分别为5.2%和35.9%;而早发性肺癌和肝癌的DALY可归因于吸烟的比例最高,分别为45.2%和13.6%;预测结果显示,2020~2034年,男性和女性早发性癌症的标化发病率均呈上升趋势,而标化死亡率缓慢下降.综上所述,中国早发性癌症的发病率持续上升,死亡率和DALY率则略有下降.不同性别、癌症类型之间的疾病负担存在差异,健康的生活方式可降低早发性癌症疾病负担.
