In-situ polymerized solid-state lithium metal batteries have garnered significant attention due to their conformal interface contact and continuous pathways for lithium ion(Li^(+))conduction.However,their electrochemi...In-situ polymerized solid-state lithium metal batteries have garnered significant attention due to their conformal interface contact and continuous pathways for lithium ion(Li^(+))conduction.However,their electrochemical performance is often hindered by slow Li^(+)transport within high-area-loading cathodes.This study presents an in-situ poly(ε-caprolactone)electrolyte with gradient molar mass(iGPCE)through lithium metal anode(LMA)-induced anionic ring-opening polymerization.Our electrochemical and kinetic analyses reveal that the iGPCE,characterized by low molar mass(M),significantly enhances Li~+diffusion within high-area-loading cathodes and bulk electrolytes,thereby reducing concentration polarization and promoting uniform electrochemical reactions.Moreover,the high M region on LMA side acts as artificial solid electrolyte interphases,stabilizing the stripping and plating of lithium.Consequently,Li//LFP(20 mg cm^(-2))and Li//NCM622(7.4 mg cm^(-2))utilizing iGPCE exhibit stable charge/discharge behaviors.This study offers a fresh approach to accelerate Li~+diffusion kinetics of high-area-loading batteries and suggests broad applicability in other systems.展开更多
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease.In the current study,we showed that experimental periodontitis,which was established ...Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease.In the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in mice.Mechanistically,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary hypertension.In addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing antibodies.Our study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.展开更多
Zinc-based batteries(ZBs)have been deemed as a potential substitute for lithium-ion batteries due to its unique advantages of abundant resources,low cost and acceptable energy density.Despite great progress in designi...Zinc-based batteries(ZBs)have been deemed as a potential substitute for lithium-ion batteries due to its unique advantages of abundant resources,low cost and acceptable energy density.Despite great progress in designing electrode materials has been made,the development of high-performance ZBs still remain challenges,such as the dendrite growth of zinc anode,hydrogen evolution reaction,limited electrochemical stability window,water evaporation and liquid leakage.Gel polymer electrolytes(GPEs),including hydrous GPEs with low content of active water and anhydrous GPEs without the presence of water,are proposed to avoid these problems.Furthermore,employing GPEs is conductive to fabricate flexible devices owing to the good mechanical strength.To date,most of researches focus on discovering new GPEs and exploring its application on flexible or wearable devices.Recent reviews also have outlined the polymer matrixes and advances of GPEs in various battery systems.Given this,herein,we seek to summarize the gelation mechanisms of GPEs,involving physical gel of polymer,chemical crosslinking of polymer and chemical polymerization of monomers.Peculiarly,the preparation methods are also classified.In addition,not only the features and central conundrum of GPEs are analyzed but also the corresponding strategies are discussed,contributing to design GPEs with ideal properties for high-performance ZBs.展开更多
The persistently high incidence of breast cancer emphasizes the need for precise detection in its diagnosis.Computer-aided medical systems are designed to provide accurate information and reduce human errors,in which ...The persistently high incidence of breast cancer emphasizes the need for precise detection in its diagnosis.Computer-aided medical systems are designed to provide accurate information and reduce human errors,in which accurate and effective segmentation of medical images plays a pivotal role in improving clinical outcomes.Multilevel Threshold Image Segmentation(MTIS)is widely favored due to its stability and straightforward implementation.Especially when dealing with sophisticated anatomical structures,high-level thresholding is a crucial technique in identifying fine details.To enhance the accuracy of complex breast cancer image segmentation,this paper proposes an improved version of RIME optimizer EECRIME,denoted as the double Enhanced solution quality Crisscross RIME algorithm.The original RIME initially conducts an efficient optimization to target promising solutions.The double-enhanced solution quality(EESQ)mechanism is proposed for thorough exploitation without falling into local optimum.In contrast,the crisscross operations perform a further local exploration of the generated feasible solutions.The performance of EECRIME is verified with basic and advanced algorithms on IEEE CEC2017 benchmark functions.Furthermore,an EECRIME-based MTIS method in combination with Kapur’s entropy is applied to segment breast Infiltrating Ductal Carcinoma(IDC)histology images.The results demonstrate that the developed model significantly surpasses its competitors,establishing it as a practical approach for complex medical image processing.展开更多
The mass fraction of electrolytes is the crucial factor affecting the energy density of lithium-sulfur(Li-S)batteries. Due to the high porosity within the C/S cathode, high concentration of polysulfides, and side reac...The mass fraction of electrolytes is the crucial factor affecting the energy density of lithium-sulfur(Li-S)batteries. Due to the high porosity within the C/S cathode, high concentration of polysulfides, and side reaction in lithiun metal anode under lean electrolyte, it is extremely challenging to improve performance while reducing the electrolyte volume. Here, we report a novel electrolyte with relatively low density(1.16 g cm^(-2)), low viscosity(1.84 m Pa s), and high ionic conductivity, which significantly promotes energy density and cyclability of Li-S batteries under practical conditions. Moreover, such electrolyte enables a hybrid cathode electrolyte interphase(CEI) and solid electrolyte interface(SEI) layer with plentiful Li F, which leads to fast kinetics of ions transport and stable cyclability even under low temperatures.Compared to Li-S batteries in electrolyte employing 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether(TTE) diluent, the ultra-thick cathode(20 mg cm^(-2)) shows a high capacity of 9.48 m Ah cm^(-2)and excellent capacity retention of 80.3% over 191 cycles at a low electrolyte-to-sulfur ratio(E/S = 2) and negative-to-positive capacity ratio(N/P = 2.5), realizing a 19.2% improvement in energy density in coin cells(from 370 to 441 Wh kg^(-1)) and a high energy density up to 467 Wh kg^(-1) in pouch cells. This study not only provides guidance for the electrolyte design but also paves the way for the development of high performance Li-S batteries under practical conditions.展开更多
Solid/solid interface is the major challenge for high-performance solid-state batteries.Solid electrolytes(SEs)play a crucial role in the fabrication of effective interfaces in solid-state batteries.Herein,the electro...Solid/solid interface is the major challenge for high-performance solid-state batteries.Solid electrolytes(SEs)play a crucial role in the fabrication of effective interfaces in solid-state batteries.Herein,the electrolyte distribution with varied particle sizes is tuned to construct solid-state batteries with excellent performance at different operating temperatures.Solid-state batteries with the configuration S/L(small-sized SE in composite cathode and large-sized SE in electrolyte layer)show the best performance at room temperature(168 mA h g^(−1) at 0.2 C,retention of 99%,100 cycles)and−20°C(89 mA h g^(−1) at 0.05 C),while the configuration S/S displays better performance at elevated temperature.The superior performance of S/L battery is associated with faster lithium-ion dynamics due to the better solid/solid interface between active materials and electrolytes.Moreover,the inferior performance at 60℃is caused by the formation of voids and cracks in the electrolyte layer during cycling.In contrast,the S/S battery delivers superior performance at elevated operating temperature because of the integrated structure.This work confirms that tailoring electrolyte size has significant effect on fabricating all-climate solid-state batteries.展开更多
基金supported by the Key Scientific Research Project of Colleges and Universities in Henan(24A480006 and 24A530005)the Natural Science Foundation of Henan Province(242300420337)。
文摘In-situ polymerized solid-state lithium metal batteries have garnered significant attention due to their conformal interface contact and continuous pathways for lithium ion(Li^(+))conduction.However,their electrochemical performance is often hindered by slow Li^(+)transport within high-area-loading cathodes.This study presents an in-situ poly(ε-caprolactone)electrolyte with gradient molar mass(iGPCE)through lithium metal anode(LMA)-induced anionic ring-opening polymerization.Our electrochemical and kinetic analyses reveal that the iGPCE,characterized by low molar mass(M),significantly enhances Li~+diffusion within high-area-loading cathodes and bulk electrolytes,thereby reducing concentration polarization and promoting uniform electrochemical reactions.Moreover,the high M region on LMA side acts as artificial solid electrolyte interphases,stabilizing the stripping and plating of lithium.Consequently,Li//LFP(20 mg cm^(-2))and Li//NCM622(7.4 mg cm^(-2))utilizing iGPCE exhibit stable charge/discharge behaviors.This study offers a fresh approach to accelerate Li~+diffusion kinetics of high-area-loading batteries and suggests broad applicability in other systems.
基金fundings from the National Natural Science Foundation of China(82330015,81991503,81921002,and 82303275)Science and Technology Commission of Shanghai Municipality(23ZR1438300).
文摘Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease.In the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in mice.Mechanistically,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary hypertension.In addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing antibodies.Our study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.
基金supported by the Natural Science Foundation of Henan Province(No.222300420511)Science and Technology Research Project of Henan Province(No.212102210462).
文摘Zinc-based batteries(ZBs)have been deemed as a potential substitute for lithium-ion batteries due to its unique advantages of abundant resources,low cost and acceptable energy density.Despite great progress in designing electrode materials has been made,the development of high-performance ZBs still remain challenges,such as the dendrite growth of zinc anode,hydrogen evolution reaction,limited electrochemical stability window,water evaporation and liquid leakage.Gel polymer electrolytes(GPEs),including hydrous GPEs with low content of active water and anhydrous GPEs without the presence of water,are proposed to avoid these problems.Furthermore,employing GPEs is conductive to fabricate flexible devices owing to the good mechanical strength.To date,most of researches focus on discovering new GPEs and exploring its application on flexible or wearable devices.Recent reviews also have outlined the polymer matrixes and advances of GPEs in various battery systems.Given this,herein,we seek to summarize the gelation mechanisms of GPEs,involving physical gel of polymer,chemical crosslinking of polymer and chemical polymerization of monomers.Peculiarly,the preparation methods are also classified.In addition,not only the features and central conundrum of GPEs are analyzed but also the corresponding strategies are discussed,contributing to design GPEs with ideal properties for high-performance ZBs.
基金supported in part by the Natural Science Foundation of Zhejiang Province(LZ22F020005)National Natural Science Foundation of China(62076185,62301367).
文摘The persistently high incidence of breast cancer emphasizes the need for precise detection in its diagnosis.Computer-aided medical systems are designed to provide accurate information and reduce human errors,in which accurate and effective segmentation of medical images plays a pivotal role in improving clinical outcomes.Multilevel Threshold Image Segmentation(MTIS)is widely favored due to its stability and straightforward implementation.Especially when dealing with sophisticated anatomical structures,high-level thresholding is a crucial technique in identifying fine details.To enhance the accuracy of complex breast cancer image segmentation,this paper proposes an improved version of RIME optimizer EECRIME,denoted as the double Enhanced solution quality Crisscross RIME algorithm.The original RIME initially conducts an efficient optimization to target promising solutions.The double-enhanced solution quality(EESQ)mechanism is proposed for thorough exploitation without falling into local optimum.In contrast,the crisscross operations perform a further local exploration of the generated feasible solutions.The performance of EECRIME is verified with basic and advanced algorithms on IEEE CEC2017 benchmark functions.Furthermore,an EECRIME-based MTIS method in combination with Kapur’s entropy is applied to segment breast Infiltrating Ductal Carcinoma(IDC)histology images.The results demonstrate that the developed model significantly surpasses its competitors,establishing it as a practical approach for complex medical image processing.
基金supported by the National Natural Science Foundation of China (21975087, U1966214, 22008082)the Certificate of China Postdoctoral Science Foundation Grant (2019M652634,2020M672337)。
文摘The mass fraction of electrolytes is the crucial factor affecting the energy density of lithium-sulfur(Li-S)batteries. Due to the high porosity within the C/S cathode, high concentration of polysulfides, and side reaction in lithiun metal anode under lean electrolyte, it is extremely challenging to improve performance while reducing the electrolyte volume. Here, we report a novel electrolyte with relatively low density(1.16 g cm^(-2)), low viscosity(1.84 m Pa s), and high ionic conductivity, which significantly promotes energy density and cyclability of Li-S batteries under practical conditions. Moreover, such electrolyte enables a hybrid cathode electrolyte interphase(CEI) and solid electrolyte interface(SEI) layer with plentiful Li F, which leads to fast kinetics of ions transport and stable cyclability even under low temperatures.Compared to Li-S batteries in electrolyte employing 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether(TTE) diluent, the ultra-thick cathode(20 mg cm^(-2)) shows a high capacity of 9.48 m Ah cm^(-2)and excellent capacity retention of 80.3% over 191 cycles at a low electrolyte-to-sulfur ratio(E/S = 2) and negative-to-positive capacity ratio(N/P = 2.5), realizing a 19.2% improvement in energy density in coin cells(from 370 to 441 Wh kg^(-1)) and a high energy density up to 467 Wh kg^(-1) in pouch cells. This study not only provides guidance for the electrolyte design but also paves the way for the development of high performance Li-S batteries under practical conditions.
基金supported by the National Natural Science Foundation of China(No.51821005)。
文摘Solid/solid interface is the major challenge for high-performance solid-state batteries.Solid electrolytes(SEs)play a crucial role in the fabrication of effective interfaces in solid-state batteries.Herein,the electrolyte distribution with varied particle sizes is tuned to construct solid-state batteries with excellent performance at different operating temperatures.Solid-state batteries with the configuration S/L(small-sized SE in composite cathode and large-sized SE in electrolyte layer)show the best performance at room temperature(168 mA h g^(−1) at 0.2 C,retention of 99%,100 cycles)and−20°C(89 mA h g^(−1) at 0.05 C),while the configuration S/S displays better performance at elevated temperature.The superior performance of S/L battery is associated with faster lithium-ion dynamics due to the better solid/solid interface between active materials and electrolytes.Moreover,the inferior performance at 60℃is caused by the formation of voids and cracks in the electrolyte layer during cycling.In contrast,the S/S battery delivers superior performance at elevated operating temperature because of the integrated structure.This work confirms that tailoring electrolyte size has significant effect on fabricating all-climate solid-state batteries.
