In recent years,using network pharmacology and molecular docking technology to reveal the therapeutic targets of irritable bowel syndrome(IBS)has become a research hotspot.This paper summarizes 31 studies of tradition...In recent years,using network pharmacology and molecular docking technology to reveal the therapeutic targets of irritable bowel syndrome(IBS)has become a research hotspot.This paper summarizes 31 studies of traditional Chinese medicine for IBS by domestic and foreign scholars,and expounds the action mechanism of single drug,drug pair and compound prescription in the treatment of IBS from the aspects of drug activity,action target,biological process and pathway analysis.It also discusses the shortcomings and prospects of network pharmacology and molecular docking technology in the field of traditional Chinese medicine research,and provides reference for expanding the research ideas of traditional Chinese medicine in treating IBS.展开更多
Phosphorus-modified biochar has been proven to enhance the precipitation and complexation of heavy metal ions from wastewater.However,the current modification methods require large amounts of exogenous P and have high...Phosphorus-modified biochar has been proven to enhance the precipitation and complexation of heavy metal ions from wastewater.However,the current modification methods require large amounts of exogenous P and have high energy consumption.Hence,this study proposes and analyzes a strategy integrating biochar production,phosphorus wastewater treatment,dephosphorization waste recovery,and heavy metal removal.“BC-Ca-P”was derived from Ca-modified biochar after phosphorus wastewater treatment.The adsorption of Pb(II)by BC-Ca-P followed the Langmuir isotherm and pseudo-second-order kinetic models.The maximum adsorption capability of 361.20 mg·g^(−1)at pH 5.0 for 2 h was markedly greater than that of external phosphorous-modified biochar.The adsorption mechanisms were dominated by chemical precipitation and complexation.Furthermore,density functional theory calculations indicated that oxygen-containing functional groups(P-O and C-O)contributed the most to the efficient adsorption of Pb(II)onto BC-Ca-P.To explore its practical feasibility,the adsorption performance of BC-Ca-P recovered from an actual environment was evaluated.The continuous-flow adsorption behavior was investigated and well-fitted utilizing the Thomas and Yoon-Nelson models.There was a negligible P leakage risk of BC-Ca-P during heavy metal treatment.This study describes a novel and sustainable method to utilize dephosphorization waste for heavy metal removal.展开更多
文摘In recent years,using network pharmacology and molecular docking technology to reveal the therapeutic targets of irritable bowel syndrome(IBS)has become a research hotspot.This paper summarizes 31 studies of traditional Chinese medicine for IBS by domestic and foreign scholars,and expounds the action mechanism of single drug,drug pair and compound prescription in the treatment of IBS from the aspects of drug activity,action target,biological process and pathway analysis.It also discusses the shortcomings and prospects of network pharmacology and molecular docking technology in the field of traditional Chinese medicine research,and provides reference for expanding the research ideas of traditional Chinese medicine in treating IBS.
基金supported by the National Natural Science Foundation of China(42107081)the Fundamental Research Funds for the Central Public Research Institutes(2023-jbkyywf-dzl).
文摘Phosphorus-modified biochar has been proven to enhance the precipitation and complexation of heavy metal ions from wastewater.However,the current modification methods require large amounts of exogenous P and have high energy consumption.Hence,this study proposes and analyzes a strategy integrating biochar production,phosphorus wastewater treatment,dephosphorization waste recovery,and heavy metal removal.“BC-Ca-P”was derived from Ca-modified biochar after phosphorus wastewater treatment.The adsorption of Pb(II)by BC-Ca-P followed the Langmuir isotherm and pseudo-second-order kinetic models.The maximum adsorption capability of 361.20 mg·g^(−1)at pH 5.0 for 2 h was markedly greater than that of external phosphorous-modified biochar.The adsorption mechanisms were dominated by chemical precipitation and complexation.Furthermore,density functional theory calculations indicated that oxygen-containing functional groups(P-O and C-O)contributed the most to the efficient adsorption of Pb(II)onto BC-Ca-P.To explore its practical feasibility,the adsorption performance of BC-Ca-P recovered from an actual environment was evaluated.The continuous-flow adsorption behavior was investigated and well-fitted utilizing the Thomas and Yoon-Nelson models.There was a negligible P leakage risk of BC-Ca-P during heavy metal treatment.This study describes a novel and sustainable method to utilize dephosphorization waste for heavy metal removal.
