Since the discovery of the extraordinary optical transmission phenomenon,nanohole arrays have attracted much attention and been widely applied in sensing.However,their typical fabrication process,utilizing photolithog...Since the discovery of the extraordinary optical transmission phenomenon,nanohole arrays have attracted much attention and been widely applied in sensing.However,their typical fabrication process,utilizing photolithographic top-down manufacturing technologies,has intrinsic drawbacks including the high costs,time consumption,small footprint,and low throughput.This study presented a low-cost,high-throughput,and scalable method for fabricating centimeter-scale(1×2 cm2)nanohole arrays using the improved nanosphere lithography.The large-scale close-packed polystyrene monolayers obtained by the hemispherical-depression-assisted self-assembly method were employed as colloidal masks for the nanosphere lithography,and the nanohole diameter was tuned from 233 nm to 346 nm with a fixed period of 420 nm via plasma etching.The optical properties and sensing performance of the nanohole arrays were investigated,and two transmission dips were observed due to the resonant coupling of plasmonic modes.Both dips were found to be sensitive to the surrounding environment,and the maximum bulk refractive index sensitivity was up to 162.1 nm/RIU with a 233 nm hole diameter.This study offered a promising approach for fabricating large-scale highly ordered nanohole arrays with various periods and nanohole diameters that could be used for the development of low-cost and high-throughput on-chip plasmonic sensors.展开更多
In this paper,we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit,high selectivity,and strong practicability based on the small molecule of the 4-mercaptopyridine(4-MPY)modifie...In this paper,we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit,high selectivity,and strong practicability based on the small molecule of the 4-mercaptopyridine(4-MPY)modified tilted fiber Bragg grating surface plasmon resonance(TFBG-SPR)sensing platform.The TFBG-SPR sensor has a rich mode field distribution and a narrow bandw idth,which can detect the microscopic physical and chemical reactions on the sensor surface with high sensitivity without being disturbed by the external temperature.For the environmental compatibility and highly efficient capture of the toxic mercury ion,4-MPY is modified on the sensor surface forming a stable(4-MPY)-Hg-(4-MPY)structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg+via multidentate N-bonding.Moreover,gold nanoparticles(AuNPs)are connected to the sensor surface through the(4-MPY)-Hg-(4-MPY)structure,which could play an important role for signal amplification.Under the optimized conditions,the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10^(-10)M(0.1643 nM),and the detection range is 1×10^(-9)M-1×10^(-5)M.At the same time,the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples.We develop a valuable sensing technology for on-time environmental Hg t detection and in-vivo point of care testing in clinic applications.展开更多
Localized surface plasmon resonance(LSPR)biosensors,which enable nanoscale confinement and manipulation of light,offer the enhanced sensitivity and electromagnetic energy localization.The integration of LSPR with the ...Localized surface plasmon resonance(LSPR)biosensors,which enable nanoscale confinement and manipulation of light,offer the enhanced sensitivity and electromagnetic energy localization.The integration of LSPR with the fiber-optic technology has led to the development of compact and versatile sensors for miniaturization and remote sensing.This comprehensive review explores various sensor configurations,fiber types,and geometric shapes,highlighting their benefits in terms of sensitivity,integration,and performance improvement.Fabrication techniques such as focused non-chemical bonding strategies and self-assembly of nanoparticles are discussed,providing control over nanostructure morphology and enhancing sensor performance.Bio-applications of fiber-optic LSPR(FOLSPR)sensors are detailed,specifically in biomolecular interactions and analysis of proteins,pathogens and cells,nucleic acids(DNA and RNA),and other small molecules(organic compounds and heavy metal ions).Surface modification and detection schemes are emphasized for their potential for label-free and real-time biosensing.The challenges and prospects of FOLSPR sensors are addressed,including the developments in sensitivity,fabrication techniques,and measurement reliability.Integration with emerging technologies such as nanomaterials is highlighted as a promising direction for future research.Overall,this review provides insights into the advancements and potential applications of FOLSPR sensors,paving the way for sensitive and versatile optical biosensing platforms in various fields.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.62375036,62005034,62171076,and 61727816)Liaoning Cancer Hospital&Institute“Oncology+”Funds(Grant No.2024-ZLKF-34)Fundamental Research Funds for the Central Universities(Grant No.DUT21RC(3)080).
文摘Since the discovery of the extraordinary optical transmission phenomenon,nanohole arrays have attracted much attention and been widely applied in sensing.However,their typical fabrication process,utilizing photolithographic top-down manufacturing technologies,has intrinsic drawbacks including the high costs,time consumption,small footprint,and low throughput.This study presented a low-cost,high-throughput,and scalable method for fabricating centimeter-scale(1×2 cm2)nanohole arrays using the improved nanosphere lithography.The large-scale close-packed polystyrene monolayers obtained by the hemispherical-depression-assisted self-assembly method were employed as colloidal masks for the nanosphere lithography,and the nanohole diameter was tuned from 233 nm to 346 nm with a fixed period of 420 nm via plasma etching.The optical properties and sensing performance of the nanohole arrays were investigated,and two transmission dips were observed due to the resonant coupling of plasmonic modes.Both dips were found to be sensitive to the surrounding environment,and the maximum bulk refractive index sensitivity was up to 162.1 nm/RIU with a 233 nm hole diameter.This study offered a promising approach for fabricating large-scale highly ordered nanohole arrays with various periods and nanohole diameters that could be used for the development of low-cost and high-throughput on-chip plasmonic sensors.
基金This work was supported by the National Nature Science Foundation of China(Grant Nos.61520106013 and 61727816)Exchange Fund from Key Laboratory of Optical Fiber Sensing and Communications(Ministry of Education of China)(Grant No.ZYGX2019K006)+1 种基金the Fundamental Research Funds for Central Universities(Grant No.DUT19LAB32)the Local Science and Technology Development Fund Projects guided by the central government(Grant No.206Z4801G).
文摘In this paper,we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit,high selectivity,and strong practicability based on the small molecule of the 4-mercaptopyridine(4-MPY)modified tilted fiber Bragg grating surface plasmon resonance(TFBG-SPR)sensing platform.The TFBG-SPR sensor has a rich mode field distribution and a narrow bandw idth,which can detect the microscopic physical and chemical reactions on the sensor surface with high sensitivity without being disturbed by the external temperature.For the environmental compatibility and highly efficient capture of the toxic mercury ion,4-MPY is modified on the sensor surface forming a stable(4-MPY)-Hg-(4-MPY)structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg+via multidentate N-bonding.Moreover,gold nanoparticles(AuNPs)are connected to the sensor surface through the(4-MPY)-Hg-(4-MPY)structure,which could play an important role for signal amplification.Under the optimized conditions,the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10^(-10)M(0.1643 nM),and the detection range is 1×10^(-9)M-1×10^(-5)M.At the same time,the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples.We develop a valuable sensing technology for on-time environmental Hg t detection and in-vivo point of care testing in clinic applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.62375036,62005034,62171076,and 61727816)Liaoning Cancer Hospital Oncology+Funds(Grant No.2024-ZLKF-34)Fundamental Research Funds for the Central Universities(Grant No.DUT21RC(3)080).
文摘Localized surface plasmon resonance(LSPR)biosensors,which enable nanoscale confinement and manipulation of light,offer the enhanced sensitivity and electromagnetic energy localization.The integration of LSPR with the fiber-optic technology has led to the development of compact and versatile sensors for miniaturization and remote sensing.This comprehensive review explores various sensor configurations,fiber types,and geometric shapes,highlighting their benefits in terms of sensitivity,integration,and performance improvement.Fabrication techniques such as focused non-chemical bonding strategies and self-assembly of nanoparticles are discussed,providing control over nanostructure morphology and enhancing sensor performance.Bio-applications of fiber-optic LSPR(FOLSPR)sensors are detailed,specifically in biomolecular interactions and analysis of proteins,pathogens and cells,nucleic acids(DNA and RNA),and other small molecules(organic compounds and heavy metal ions).Surface modification and detection schemes are emphasized for their potential for label-free and real-time biosensing.The challenges and prospects of FOLSPR sensors are addressed,including the developments in sensitivity,fabrication techniques,and measurement reliability.Integration with emerging technologies such as nanomaterials is highlighted as a promising direction for future research.Overall,this review provides insights into the advancements and potential applications of FOLSPR sensors,paving the way for sensitive and versatile optical biosensing platforms in various fields.
