In recent years,the biological functions of human milk oligosaccharides and the potential toxic efects of red meat on human health have attracted considerable attention.Sialic acid is an important carbohydrate in milk...In recent years,the biological functions of human milk oligosaccharides and the potential toxic efects of red meat on human health have attracted considerable attention.Sialic acid is an important carbohydrate in milk and red meat,corresponding to sialylated oligosaccharides and N-glycolylneuraminic acid(NeuGc,one type of sialic acid).Herein,we reviewed the metabolic fate of dietary sialic acid in the body and their efects on gut and oral microbes.In summary,dietary NeuAc monomer is directly excreted through urine after being assimilated through the intestines and is not utilized by the human body;in contrast,dietary NeuGc from red meat is easily utilized by the human body and can be incorporated into the brain and other organs.Sialoglycans can be partially utilized by the human body,but they do not afect the cognitive development and growth of children.Dietary sialic acid may mainly regulate the growth and metabolism of gastrointestinal microbiota and human health and development through the gut–brain axis.展开更多
基金This work was supported by the National Science and Technology Major Project(No.2018YFC1604105-5)the Program of Introducing Talents of Discipline to Universities(111-2-06)the National First-Class Discipline Program of Light Industry Technology and Engineering(LITE2018-17).
文摘In recent years,the biological functions of human milk oligosaccharides and the potential toxic efects of red meat on human health have attracted considerable attention.Sialic acid is an important carbohydrate in milk and red meat,corresponding to sialylated oligosaccharides and N-glycolylneuraminic acid(NeuGc,one type of sialic acid).Herein,we reviewed the metabolic fate of dietary sialic acid in the body and their efects on gut and oral microbes.In summary,dietary NeuAc monomer is directly excreted through urine after being assimilated through the intestines and is not utilized by the human body;in contrast,dietary NeuGc from red meat is easily utilized by the human body and can be incorporated into the brain and other organs.Sialoglycans can be partially utilized by the human body,but they do not afect the cognitive development and growth of children.Dietary sialic acid may mainly regulate the growth and metabolism of gastrointestinal microbiota and human health and development through the gut–brain axis.
