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Global burden of benign prostatic hyperplasia,urinary tract infections,urolithiasis,bladder cancer,kidney cancer,and prostate cancer from 1990 to 2021
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作者 Hao Zi meng-yang liu +13 位作者 Li-Sha Luo Qiao Huang Peng-Cheng Luo Hang-Hang Luan Jiao Huang Dan-Qi Wang Yong-Bo Wang Yuan-Yuan Zhang Ren-Peng Yu Yi-Tong Li Hang Zheng Tong-Zu liu Yu Fan Xian-Tao Zeng 《Military Medical Research》 2025年第7期1007-1022,共16页
Background:The burden of common urologic diseases,including benign prostatic hyperplasia(BPH),urinary tract infections(UTI),urolithiasis,bladder cancer,kidney cancer,and prostate cancer,varies both geographically and ... Background:The burden of common urologic diseases,including benign prostatic hyperplasia(BPH),urinary tract infections(UTI),urolithiasis,bladder cancer,kidney cancer,and prostate cancer,varies both geographically and within specific regions.It is essential to conduct a comprehensive and precise assessment of the global burden of urologic diseases.Methods:We obtained data on incidence,prevalence,mortality,and disability-adjusted life-years(DALYs)for the aforementioned urologic diseases by age,sex,location,and year from the Global Burden of Disease(GBD)2021.We analyzed the burden associated with urologic diseases based on socio-demographic index(SDI)and attributable risk factors.The trends in burden over time were assessed using estimated annual percentage changes(EAPC)along with a 95%confidence interval(CI).Results:In 2021,BPH and UTI were the leading causes of age-standardized incidence rate(ASIR)and age-standardized prevalence rate(ASPR),with rates of 5531.88 and 2782.59 per 100,000 persons,respectively.Prostate cancer was the leading cause of both age-standardized mortality rate(ASMR)and age-standardized DALYs rate(ASDR),with rates of 12.63 and 217.83 per 100,000 persons,respectively.From 1990 to 2021,there was an upward trend in ASIR,ASPR,ASMR,and ASDR for UTI,while urolithiasis showed a downward trend.The middle and low-middle SDI quintile levels exhibited higher incidence,prevalence,mortality,and DALYs related to UTI,urolithiasis,and BPH,while the high and high-middle SDI quintile levels showed higher rates for the three cancers.The burden of these 6 urologic diseases displayed diverse age and sex distribution patterns.In 2021,a high body mass index(BMI)contributed to 20.07%of kidney cancer deaths worldwide,while smoking accounted for 26.48%of bladder cancer deaths and 3.00%of prostate cancer deaths.Conclusions:The global burden of 6 urologic diseases presents a significant public health challenge.Urgent international collaboration is essential to advance the improvement of urologic disease management,encompassing the development of effective diagnostic screening tools and the implementation of high-quality prevention and treatment strategies. 展开更多
关键词 Benign prostatic hyperplasia(BPH) Urinary tract infections(UTI) UROLITHIASIS Bladder cancer Kidney cancer Prostate cancer Disability-adjusted life-years(DALYs) Burden of disease
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肺癌上皮间质转化对铁死亡药物的敏感性研究 被引量:2
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作者 习舒 刘梦洋 +5 位作者 郭梦梦 张晋辉 明道靖 戚子昊 袁帅 张祎捷 《药物流行病学杂志》 CAS 2023年第5期513-521,共9页
目的研究肺癌上皮间质转化(EMT)对铁死亡药物敏感性的影响。方法利用生物信息学分析EMT相关基因与多种药物治疗敏感性的相关性;利用流式细胞分选出E-钙黏蛋白低表达且N-钙黏蛋白高表达、E-钙黏蛋白高表达且N-钙黏蛋白低表达的细胞,进而... 目的研究肺癌上皮间质转化(EMT)对铁死亡药物敏感性的影响。方法利用生物信息学分析EMT相关基因与多种药物治疗敏感性的相关性;利用流式细胞分选出E-钙黏蛋白低表达且N-钙黏蛋白高表达、E-钙黏蛋白高表达且N-钙黏蛋白低表达的细胞,进而模拟肺癌间质细胞和上皮细胞;通过铁死亡诱导剂(谷胱甘肽过氧化物酶4抑制剂)和内源性铁死亡诱导剂(干扰素γ联合花生四烯酸)处理肺癌细胞,检测比较不同类型肺癌细胞对铁死亡的敏感性。结果细胞对铁死亡的耐受程度与E-钙黏蛋白的表达呈正相关,与波形蛋白、锌指结构E-box-结合同源框1、锌指结构E-box-结合同源框2的表达呈负相关。铁死亡药物处理结果显示E-钙黏蛋白低表达且N-钙黏蛋白高表达的细胞对铁死亡药物具有更高的敏感性,并且可以通过铁死亡抑制剂铁抑素-1挽救干扰素γ联合花生四烯酸对细胞铁死亡的诱导作用。结论发生EMT的肺癌细胞对铁死亡更加敏感,铁死亡有望成为应对转移和治疗抵抗性肺癌的新策略。 展开更多
关键词 肺癌 上皮间质转化 铁死亡
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Recent Progress on Flexible Room-Temperature Gas Sensors Based on Metal Oxide Semiconductor 被引量:14
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作者 Lang-Xi Ou meng-yang liu +2 位作者 Li-Yuan Zhu David Wei Zhang Hong-Liang Lu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第12期310-351,共42页
With the rapid development of the Internet of Things,there is a great demand for portable gas sensors.Metal oxide semiconductors(MOS)are one of the most traditional and well-studied gas sensing materials and have been... With the rapid development of the Internet of Things,there is a great demand for portable gas sensors.Metal oxide semiconductors(MOS)are one of the most traditional and well-studied gas sensing materials and have been widely used to prepare various commercial gas sensors.However,it is limited by high operating temperature.The current research works are directed towards fabricating high-performance flexible room-temperature(FRT)gas sensors,which are effective in simplifying the structure of MOS-based sensors,reducing power consumption,and expanding the application of portable devices.This article presents the recent research progress of MOS-based FRT gas sensors in terms of sensing mechanism,performance,flexibility characteristics,and applications.This review comprehensively summarizes and discusses five types of MOS-based FRT gas sensors,including pristine MOS,noble metal nanoparticles modified MOS,organic polymers modified MOS,carbon-based materials(carbon nanotubes and graphene derivatives)modified MOS,and two-dimensional transition metal dichalcogenides materials modified MOS.The effect of light-illuminated to improve gas sensing performance is further discussed.Furthermore,the applications and future perspectives of FRT gas sensors are also discussed. 展开更多
关键词 Metal oxide semiconductor Flexible gas sensor Room temperature NANOMATERIALS
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Simulating stochastic transport:An efficient random displacement model for multi-domain applications in ecology,hydraulics,and environmental systems
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作者 liu Yang Zhong-hua Yang +2 位作者 meng-yang liu Yi-dan Ai Wen-xin Huai 《Journal of Hydrodynamics》 2025年第3期421-436,共16页
The random displacement model(RDM)can efficiently simulate particle transport processes,which are difficult to observe,incorporating stochastic and hydraulic parameters.In recent decades,it has been used in many domai... The random displacement model(RDM)can efficiently simulate particle transport processes,which are difficult to observe,incorporating stochastic and hydraulic parameters.In recent decades,it has been used in many domains,including environments,hydraulics,and ecology.However,the results exhibit significant uncertainties arising from the model resolution,hydrodynamic accuracy,intrinsic characteristics of particles,and boundary conditions.The objective of the present study is to comprehensively interpret the RDM from theory to application,and emphasize essential considerations for users in different domains.The study also provides several application strategies for the model,based on several practical RDM cases.Determining the turbulent diffusivity and velocity profiles in complex flow field is a critical step to precisely simulate particle movement.Furthermore,the physical and biological properties of passive and active particles require fundamental investigation to extend the applicability of the model.Existing studies suggest that flexibly coupling the RDM with other numerical models customized to the characteristics of distinct problems will substantially expand the utility of the RDM and could yield innovative approaches for addressing previously intractable issues. 展开更多
关键词 Random displacement model(RDM) multi-domain applications stochastic transport particle trajectories numerical simulation
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Flow dynamics and sediment transport in vegetated rivers:A review 被引量:44
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作者 Wen-xin Huai Shuolin Li +2 位作者 Gabriel G.Katul meng-yang liu Zhong-hua Yang 《Journal of Hydrodynamics》 SCIE EI CSCD 2021年第3期400-420,共21页
The significance of riparian vegetation on river flow and material transport is not in dispute.Conveyance laws,sediment erosion and deposition,and element cycling must all be adjusted from their canonical rough-wall b... The significance of riparian vegetation on river flow and material transport is not in dispute.Conveyance laws,sediment erosion and deposition,and element cycling must all be adjusted from their canonical rough-wall boundary layer to accommodate the presence of aquatic plants.In turn,the growth and colonization of riparian vegetation are affected by fluvial processes and river morphology on longer time scales.These interactions and feedbacks at multiple time scales are now drawing significant attention within the research community given their relevance to river restoration.For this reason,a review summarizing methods,general laws,qualitative cognition,and quantitative models regarding the interplay between aquatic plants,flow dynamics,and sediment transport in vegetated rivers is in order.Shortcomings,pitfalls,knowledge gaps,and daunting challenges to the current state of knowledge are also covered.As a multidisciplinary research topic,a future research agenda and opportunities pertinent to river management and enhancement of ecosystem services are also highlighted. 展开更多
关键词 Canopy flow river morphology riparian vegetation sediment transport
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Spatial and temporal clustering analysis of tuberculosis in the mainland of China at the prefecture level,2005-2015 被引量:15
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作者 meng-yang liu Qi-Huan Li +9 位作者 Ying-Jie Zhang Yuan Ma Yue liu Wei Feng Cheng-Bei Hou Endawoke Amsalu Xia Li Wei Wang Wei-Min Li Xiu-Hua Guo 《Infectious Diseases of Poverty》 SCIE 2018年第1期1121-1130,共10页
Background:Tuberculosis(TB)is still one of the most serious infectious diseases in the mainland of China.So it was urgent for the formulation of more effective measures to prevent and control it.Methods:The data of re... Background:Tuberculosis(TB)is still one of the most serious infectious diseases in the mainland of China.So it was urgent for the formulation of more effective measures to prevent and control it.Methods:The data of reported TB cases in 340 prefectures from the mainland of China were extracted from the China Information System for Disease Control and Prevention(CISDCP)during January 2005 to December 2015.The Kulldorff’s retrospective space-time scan statistics was used to identify the temporal,spatial and spatio-temporal clusters of reported TB in the mainland of China by using the discrete Poisson probability model.Spatio-temporal clusters of sputum smear-positive(SS+)reported TB and sputum smearnegative(SS-)reported TB were also detected at the prefecture level.Results:A total of 10200528 reported TB cases were collected from 2005 to 2015 in 340 prefectures,including 5283983 SS-TB cases and 4631734 SS+TB cases with specific sputum smear results,284811 cases without sputum smear test.Significantly TB clustering patterns in spatial,temporal and spatiotemporal were observed in this research.Results of the Kulldorff’s scan found twelve significant space-time clusters of reported TB.The most likely spatio-temporal cluster(RR=3.27,P<0.001)was mainly located in Xinjiang Uygur Autonomous Region of western China,covering five prefectures and clustering in the time frame from September 2012 to November 2015.The spatio-temporal clustering results of SS+TB and SS-TB also showed the most likely clusters distributed in the western China.However,the clustering time of SS+TB was concentrated before 2010 while SS-TB was mainly concentrated after 2010.Conclusions:This study identified the time and region of TB,SS+TB and SS-TB clustered easily in 340 prefectures in the mainland of China,which is helpful in prioritizing resource assignment in high-risk periods and high-risk areas,and to formulate powerful strategy to prevention and control TB. 展开更多
关键词 TUBERCULOSIS Space-time cluster SaTscan Prefecture China
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Numerical investigation of flow with floating vegetation island 被引量:7
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作者 Yi-dan Ai meng-yang liu Wen-xin Huai 《Journal of Hydrodynamics》 SCIE EI CSCD 2020年第1期31-43,共13页
Floating vegetation island(FVI)provides an effective way to remove excessive nutrition and pollutants in rivers.The Reynolds stress model(RSM)is employed to investigate the hydrodynamic characteristics induced by vari... Floating vegetation island(FVI)provides an effective way to remove excessive nutrition and pollutants in rivers.The Reynolds stress model(RSM)is employed to investigate the hydrodynamic characteristics induced by varied canopy densities of FVI in an open channel.In longitudinal direction,four regions are subdivided according to the flow development process:upstream adjustment region(LUD),diverging flow region(LDF),shear layer growth region(LSD),and flilly developed region.The increasing canopy density accelerates the flow adjustment in the diverging flow region and shear layer growth region,signaling a shorter distance to reach an equilibrium stage,while LUD keeps a constant.The vertical profiles of the normalized velocity are found to be self-similar downstream of the diverging flow region.In the vertical direction,the streamwise velocity profiles in the mixing layer collapse for all densities and obey the hyperbolic tangent law.Normalized penetration depth into the canopy was fitted as a function of dimensionless canopy density given by δc/hc=0.404(CDahc)^-0.316.This finding indicates a large space for rapid water renewal between the canopy region and the underlying water driven by the shear-scale vortices.In the lateral direction,the intensification of secondary current and the increasing number of secondary current cells with increasing canopy density reveal that dense floating canopies contribute to strong momentum exchange.The centers of vortices move as canopy density increases,while the vortices in canopy region do not merge with those in the gap region,as limited by the height and width of the canopy region.The distribution of longitudinal velocity in the transects is significantly influenced by secondary current. 展开更多
关键词 Reynolds stress model floating vegetation island flow adjustment mixing layer secondary current
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Highly sensitive and stable β-Ga_(2)O_(3) DUV phototransistor with local back-gate structure and its neuromorphic application 被引量:2
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作者 Xiao-Xi Li Guang Zeng +7 位作者 Yu-Chun Li Qiu-Jun Yu meng-yang liu Li-Yuan Zhu Wenjun liu Ying-Guo Yang David Wei Zhang Hong-Liang Lu 《Nano Research》 SCIE EI CSCD 2022年第10期9359-9367,共9页
Deep ultraviolet(DUV)phototransistors are key integral of optoelectronics bearing a wide spectrum of applications in flame sensor,military detector,oil spill detection,biological sensor,and artificial intelligence fie... Deep ultraviolet(DUV)phototransistors are key integral of optoelectronics bearing a wide spectrum of applications in flame sensor,military detector,oil spill detection,biological sensor,and artificial intelligence fields.In order to further improve the responsivity of UV photodetectors based onβ-Ga_(2)O_(3),in present work,high-performanceβ-Ga_(2)O_(3) phototransistors with local back-gate structure were experimentally demonstrated.The phototransistor shows excellent DUV photoelectrical performance with a high responsivity of 1.01×107 A/W,a high external quantum efficiency of 5.02×109%,a sensitive detectivity of 2.98×1015 Jones,and a fast rise time of 0.2 s under 250 nm illumination.Besides,first-principles calculations reveal the decent stability ofβGa_(2)O_(3) nanosheet against oxidation and humidity without significant performance degradations.Additionally,the hexagonal boron nitride(h-BN)/β-Ga_(2)O_(3) phototransistor can behave as a photonic synapse with ultralow power consumption of~9.6 fJ per spike,which shows its potential for neuromorphic computing tasks such as facial recognition.Thisβ-Ga_(2)O_(3) phototransistor will provide a perspective for the next generation optoelectrical systems. 展开更多
关键词 β-Ga_(2)O_(3)phototransistors local back-gate RESPONSIVITY stability photonic synapse
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Predicting submerged vegetation drag with a machine learning-based method
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作者 meng-yang liu Hong-wu Tang +1 位作者 Sai-yu Yuan Jing Yan 《Journal of Hydrodynamics》 SCIE EI CSCD 2024年第3期534-545,共12页
Accurate estimation of the drag forces generated by vegetation stems is crucial for the comprehensive assessment of the impact of aquatic vegetation on hydrodynamic processes in aquatic environments.The coupling relat... Accurate estimation of the drag forces generated by vegetation stems is crucial for the comprehensive assessment of the impact of aquatic vegetation on hydrodynamic processes in aquatic environments.The coupling relationship between vegetation layer flow velocity and vegetation drag makes precise prediction of submerged vegetation drag forces particularly challenging.The present study utilized published data on submerged vegetation drag force measurements and employed a genetic programming(GP)algorithm,a machine learning technique,to establish the connection between submerged vegetation drag forces and flow and vegetation parameters.When using the bulk velocity,U,as the reference velocity scale to define the drag coefficient,C_(d),and stem Reynolds number,the GP runs revealed that the drag coefficient of submerged vegetation is related to submergence ratio(H^(*)),aspect ratio(d^(*)),blockage ratio(ψ^(*)),and vegetation density(λ).The relation between vegetation stem drag forces and flow velocity is implicitly embedded in the definition of C_(d).Comparisons with experimental drag force measurements indicate that using the bulk velocity as the reference velocity,as opposed to using the vegetation layer average velocity,U_(v),eliminates the need for complex iterative processes to estimate U_(v)and avoids introducing additional errors associated with U_(v)estimation.This approach significantly enhances the model’s predictive capabilities and results in a simpler and more user-friendly formula expression. 展开更多
关键词 Drag coefficient genetic programming algorithm submerged vegetation flow resistance cylinder array
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The influence of drag parameter on submerged vegetation flow simulation using a porous approach
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作者 meng-yang liu Yi-sen Wang +1 位作者 Yi-qing Gong Shu-xia Wang 《Journal of Hydrodynamics》 SCIE EI CSCD 2024年第4期796-801,共6页
In simulating vegetated flows using the porous approach,the reasonableness of the drag coefficient significantly impacts the calculation results.This study employs large eddy simulation(LES)to quantitatively investiga... In simulating vegetated flows using the porous approach,the reasonableness of the drag coefficient significantly impacts the calculation results.This study employs large eddy simulation(LES)to quantitatively investigate the effect of drag parameters on key flow characteristics in submerged vegetated flows.The results indicate that changes in the drag coefficient significantly alter the velocity in the middle of the vegetation layer and near the water surface in the free-flow layer.Compared with longitudinal velocity,the drag coefficient has a more pronounced effect on the vertical distribution of Reynolds stress,especially its peak at the top of the vegetation layer.The porous approach can accurately reproduce the vertical distribution of longitudinal velocity and Reynolds stress,consistent with experimental measurements,only when shear-scale flow dominates.Due to the high-intensity secondary flow under moderate vegetation density,fluctuations in the drag coefficient have a more significant impact on the numerical results than in very dense vegetation.Therefore,selecting the drag coefficient value should be done cautiously,especially in the absence of experimental measurements for validation. 展开更多
关键词 Drag parameter large eddy simulation(LES) submerged vegetation secondary flow porous approach
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