Objective:To investigate the possible molecular mechanism of panax notoginseng in the treatment of vitreous hemorrhage(VH).Methods:The active components of Panax notoginseng were screened by TCMSP database and the cor...Objective:To investigate the possible molecular mechanism of panax notoginseng in the treatment of vitreous hemorrhage(VH).Methods:The active components of Panax notoginseng were screened by TCMSP database and the corresponding targets were collected.Vh-related gene targets were derived from GeneCards and OMIM database,and the target of Panax notoginseng was mapped to disease target genes.STRING database and Cytoscape 3.7.2 software were used to construct the protein-protein interaction(PPI)network diagram and the interaction network of"Pantoginseng-active ingredient-VH-target protein",and the core action target genes were screened out.Finally,gene body(GO)biological process and metabolic pathway enrichment analysis of KEGG were performed on the potential therapeutic targets.Results:We identified 8 active components,162 active component targets,1387 VHrelated genes and 75 candidate targets for VH.In the"Panax notoginseng-active ingredient-VH-target protein"interaction network,there are 82 nodes in total.The core target genes include AKT1,CASP3,VEGF-A,IL-6 and MMP-9.143 major enrichment pathways were identified by GO and KEGG enrichment analysis.The key signal pathways include age-RAGE signaling pathway,fluid shear stress and atherosclerosis,etc.,and the significant molecular functions include cytokine activity,receptor ligand activity,cytokine receptor binding,etc.Conclusion:The potential molecular mechanism of panax notoquinone in the treatment of VH is closely related to the biological processes of anti-angiogenesis,anti-inflammation,regulation of apoptosis and oxidative stress,and AKT1,CASP3,VEGF-A,IL-6 and MMP-9 may be the core target genes.展开更多
Objective:To explore the clinical effect of acupuncture combined with traditional Chinese medicine on optic nerve atrophy caused by neuromyelitis optic(NMO).Methods:the patients with optic atrophy caused by NMO with o...Objective:To explore the clinical effect of acupuncture combined with traditional Chinese medicine on optic nerve atrophy caused by neuromyelitis optic(NMO).Methods:the patients with optic atrophy caused by NMO with optic neuritis who visited the ophthalmology or neuro-ophthalmology clinic of our hospital from March 2016 to December 2019 were collected.The patients were treated with acupuncture and traditional Chinese medicine for 8 weeks before and after treatment.The best corrected visual acuity and dynamic visual field were tested before treatment,4 weeks and 8 weeks after treatment,respectively,to evaluate the effect of acupuncture combined with traditional Chinese medicine on the visual function of patients;Results:after 4 weeks of treatment,the visual acuity of 8 eyes improved more than 2 lines,the total effective rate was 91.67%.after 8 weeks of treatment,the visual acuity of 12 eyes improved more than 2 lines,the total effective rate was 100%;after 4 weeks of treatment,the mean defect(MD)and mean sensitivity(MS)of dynamic visual field were improved,but the difference was not statistically significant(MD:t=1.579,P=0.121;MS:t=-1.500,P=0.140);after 8 weeks of treatment,the MD was significantly decreased(t=2.65,P<0.05),and the MS was significantly improved and statistically significant(t=-2.58,P<0.05).Conclusion:the combination of acupuncture and Chinese medicine can significantly improve the visual function of patients with optic atrophy caused by NMO,improve the best corrected visual acuity and dynamic visual field sensitivity,and reduce the visual field defect.展开更多
Objective:TMeta-analysis was performed to evaluate the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating patients with retinal vein occlusion(RVO)complicated by macu...Objective:TMeta-analysis was performed to evaluate the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating patients with retinal vein occlusion(RVO)complicated by macular edema(ME).Methods:We searched The CNKI,Wanfang Data,PubMed and Cochrane Library from database.All of randomized controlled trials(RCTs)of the combination of traditional Chinese medicine and western medicine in treating patients with RVO complicated by ME were searched.The Revman5.3 software were used for meta-analysis.Results:A total of 30 trials involving 1943 patients and 1976 eyes were included.Meta-analysis showed that compared with western medicine,the combination of traditional Chinese medicine and western medicine can significantly improve the best corrected visual acuity[(MD=0.08,95%CI=0.07~0.10,P<0.00001)(MD=-0.16,95%CI=-0.24^-0.08,P=0.0002)(MD=5.78,95%CI=1.30~10.25,P=0.01)],reduce the central macular thickness(MD=-54.6,95%CI=-73.76^-35.43,P<0.00001),and improve the clinical effective rate(RR=1.32,95%CI=1.22~1.43,P<0.00001).Conclusion:The combination of traditional Chinese and western medicine in treating patients with RVO complicated by ME was superior to western medicine in improving the best corrected visual acuity,reducing the thickness of macular fovea and improving the clinical efficacy.展开更多
基金Qihuang scholars of the talent project of inheriting and innovating"hundreds of millions"of traditional Chinese medicine(Qihuang project)。
文摘Objective:To investigate the possible molecular mechanism of panax notoginseng in the treatment of vitreous hemorrhage(VH).Methods:The active components of Panax notoginseng were screened by TCMSP database and the corresponding targets were collected.Vh-related gene targets were derived from GeneCards and OMIM database,and the target of Panax notoginseng was mapped to disease target genes.STRING database and Cytoscape 3.7.2 software were used to construct the protein-protein interaction(PPI)network diagram and the interaction network of"Pantoginseng-active ingredient-VH-target protein",and the core action target genes were screened out.Finally,gene body(GO)biological process and metabolic pathway enrichment analysis of KEGG were performed on the potential therapeutic targets.Results:We identified 8 active components,162 active component targets,1387 VHrelated genes and 75 candidate targets for VH.In the"Panax notoginseng-active ingredient-VH-target protein"interaction network,there are 82 nodes in total.The core target genes include AKT1,CASP3,VEGF-A,IL-6 and MMP-9.143 major enrichment pathways were identified by GO and KEGG enrichment analysis.The key signal pathways include age-RAGE signaling pathway,fluid shear stress and atherosclerosis,etc.,and the significant molecular functions include cytokine activity,receptor ligand activity,cytokine receptor binding,etc.Conclusion:The potential molecular mechanism of panax notoquinone in the treatment of VH is closely related to the biological processes of anti-angiogenesis,anti-inflammation,regulation of apoptosis and oxidative stress,and AKT1,CASP3,VEGF-A,IL-6 and MMP-9 may be the core target genes.
基金General Project of National Natural Science Foundation of China(No.81574029)。
文摘Objective:To explore the clinical effect of acupuncture combined with traditional Chinese medicine on optic nerve atrophy caused by neuromyelitis optic(NMO).Methods:the patients with optic atrophy caused by NMO with optic neuritis who visited the ophthalmology or neuro-ophthalmology clinic of our hospital from March 2016 to December 2019 were collected.The patients were treated with acupuncture and traditional Chinese medicine for 8 weeks before and after treatment.The best corrected visual acuity and dynamic visual field were tested before treatment,4 weeks and 8 weeks after treatment,respectively,to evaluate the effect of acupuncture combined with traditional Chinese medicine on the visual function of patients;Results:after 4 weeks of treatment,the visual acuity of 8 eyes improved more than 2 lines,the total effective rate was 91.67%.after 8 weeks of treatment,the visual acuity of 12 eyes improved more than 2 lines,the total effective rate was 100%;after 4 weeks of treatment,the mean defect(MD)and mean sensitivity(MS)of dynamic visual field were improved,but the difference was not statistically significant(MD:t=1.579,P=0.121;MS:t=-1.500,P=0.140);after 8 weeks of treatment,the MD was significantly decreased(t=2.65,P<0.05),and the MS was significantly improved and statistically significant(t=-2.58,P<0.05).Conclusion:the combination of acupuncture and Chinese medicine can significantly improve the visual function of patients with optic atrophy caused by NMO,improve the best corrected visual acuity and dynamic visual field sensitivity,and reduce the visual field defect.
基金Traditional Chinese medicine inheritance and innovation“hundreds of millions”talent project(Qihuang project)Qihuang scholars.
文摘Objective:TMeta-analysis was performed to evaluate the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating patients with retinal vein occlusion(RVO)complicated by macular edema(ME).Methods:We searched The CNKI,Wanfang Data,PubMed and Cochrane Library from database.All of randomized controlled trials(RCTs)of the combination of traditional Chinese medicine and western medicine in treating patients with RVO complicated by ME were searched.The Revman5.3 software were used for meta-analysis.Results:A total of 30 trials involving 1943 patients and 1976 eyes were included.Meta-analysis showed that compared with western medicine,the combination of traditional Chinese medicine and western medicine can significantly improve the best corrected visual acuity[(MD=0.08,95%CI=0.07~0.10,P<0.00001)(MD=-0.16,95%CI=-0.24^-0.08,P=0.0002)(MD=5.78,95%CI=1.30~10.25,P=0.01)],reduce the central macular thickness(MD=-54.6,95%CI=-73.76^-35.43,P<0.00001),and improve the clinical effective rate(RR=1.32,95%CI=1.22~1.43,P<0.00001).Conclusion:The combination of traditional Chinese and western medicine in treating patients with RVO complicated by ME was superior to western medicine in improving the best corrected visual acuity,reducing the thickness of macular fovea and improving the clinical efficacy.
