Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia origin...Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia originating from plasma cells,which is the most common disease that can lead to CA.The median age of patients with MM at diagnosis is about 65 years old.In this age group,cardiovascular diseases often co-exist,increasing the risk of adverse events related to MM treatment.By convention,the prognosis of AL-CA with MM is extremely poor,with a median survival time of five months.[5]The degree of cardiac involvement has a decisive impact on the prognosis of AL-CA pati-ents.展开更多
Probing the nature of dark matter(DM)remains an outstanding problem in modern cosmology.The 21 cm signal,a sensitive tracer of neutral hydrogen during the cosmic dawn,provides a unique means to investigate DM nature d...Probing the nature of dark matter(DM)remains an outstanding problem in modern cosmology.The 21 cm signal,a sensitive tracer of neutral hydrogen during the cosmic dawn,provides a unique means to investigate DM nature during this critical epoch.The annihilation and decay of DM particles,as well as Hawking radiation of primordial black holes(PBHs),can modify the thermal and ionization histories of the early universe,leaving distinctive imprints on the 21 cm power spectrum.Therefore,the redshifted 21 cm power spectrum serves as an effective tool for investigating such DM processes.In this work,we systematically assess the potential of the upcoming Square Kilometre Array(SKA)to constrain DM and PBH parameters using the 21 cm power spectrum.Assuming 10,000 h of integration time,the SKA is projected to reach sensitivities of <σv>≤10-28 cm^(3)s^(−1) and τ≥10^(28) s for 10 GeV DM particles.It can also probe PBHs with masses of 1016 g and abundances of f_(PBH)≤10^(-6).These results indicate that the SKA can place constraints on DM annihilation,decay,and PBH Hawking radiation that are up to two to three orders of magnitude stronger than current limits.Furthermore,the SKA is expected to exceed existing bounds on sub-GeV DM and probe Hawking radiation from PBHs with masses above 10^(17) g,which are otherwise inaccessible using conventional cosmological probes.Overall,the SKA holds significant promise for advancing our understanding of both DM particles and PBHs,potentially offering new insights into the fundamental nature of DM.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China(grant No.81972149,81871850)Beijing Natural Science Foundation(grant No.7212125).
文摘Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia originating from plasma cells,which is the most common disease that can lead to CA.The median age of patients with MM at diagnosis is about 65 years old.In this age group,cardiovascular diseases often co-exist,increasing the risk of adverse events related to MM treatment.By convention,the prognosis of AL-CA with MM is extremely poor,with a median survival time of five months.[5]The degree of cardiac involvement has a decisive impact on the prognosis of AL-CA pati-ents.
基金Supported by the National SKA Program of China(2022SKA0110200,2022SKA0110203)the National Key R&D Program of China(2023YFC2206403)+2 种基金the National Natural Science Foundation of China(12175243,12473001,12533001)the China Manned Space Program(CMS-CSST-2025-A02)the National 111 Project(B16009)。
文摘Probing the nature of dark matter(DM)remains an outstanding problem in modern cosmology.The 21 cm signal,a sensitive tracer of neutral hydrogen during the cosmic dawn,provides a unique means to investigate DM nature during this critical epoch.The annihilation and decay of DM particles,as well as Hawking radiation of primordial black holes(PBHs),can modify the thermal and ionization histories of the early universe,leaving distinctive imprints on the 21 cm power spectrum.Therefore,the redshifted 21 cm power spectrum serves as an effective tool for investigating such DM processes.In this work,we systematically assess the potential of the upcoming Square Kilometre Array(SKA)to constrain DM and PBH parameters using the 21 cm power spectrum.Assuming 10,000 h of integration time,the SKA is projected to reach sensitivities of <σv>≤10-28 cm^(3)s^(−1) and τ≥10^(28) s for 10 GeV DM particles.It can also probe PBHs with masses of 1016 g and abundances of f_(PBH)≤10^(-6).These results indicate that the SKA can place constraints on DM annihilation,decay,and PBH Hawking radiation that are up to two to three orders of magnitude stronger than current limits.Furthermore,the SKA is expected to exceed existing bounds on sub-GeV DM and probe Hawking radiation from PBHs with masses above 10^(17) g,which are otherwise inaccessible using conventional cosmological probes.Overall,the SKA holds significant promise for advancing our understanding of both DM particles and PBHs,potentially offering new insights into the fundamental nature of DM.
