BACKGROUND The prevalence and clinical characteristics of chronic kidney disease(CKD)among patients with ketosis-onset diabetes(also known as ketosis-prone diabetes)remain unclear.Furthermore,the classification of ket...BACKGROUND The prevalence and clinical characteristics of chronic kidney disease(CKD)among patients with ketosis-onset diabetes(also known as ketosis-prone diabetes)remain unclear.Furthermore,the classification of ketosis-onset diabetes remains controversial and requires further investigation.AIM To investigate the prevalence and clinical features of CKD in patients with newly diagnosed ketosis-onset diabetes.METHODS This real-world study included 217 patients with type 1 diabetes mellitus(T1DM),698 with ketosis-onset diabetes,and 993 with non-ketotic T2DM.The prevalence and clinical characteristics of CKD were compared among the three groups.Risk factors associated with CKD were evaluated using binary logistic regression for each group.RESULTS After adjusting for age and sex,the prevalence of CKD among patients with ketosis-onset diabetes(17.8%)was significantly higher than that in those with T1DM(8.3%,P=0.007),but was not statistically different compared to those with non-ketotic T2DM(21.7%,P=0.214).Furthermore,some risk factors for CKD,including age,and serum uric acid and C-reactive protein levels,in patients with ketosis-onset diabetes were similar to those with T2DM,but significantly different from those with T1DM.CONCLUSION The prevalence,clinical characteristics,and risk factors for CKD among patients with ketosis-onset diabetes were more similar to those with non-ketotic T2DM but considerably different from those with T1DM.These findings further support the classification of ketosis-onset diabetes as a subtype of T2DM rather than idiopathic T1DM.展开更多
BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal cancer.Metformin,a widely prescribed biguanidine drug for type 2 DM,has been ...BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal cancer.Metformin,a widely prescribed biguanidine drug for type 2 DM,has been suggested to have potential chemoprophylactic effects against various cancers.AIM To explore the correlation between colorectal polyps and metformin use in type 2 DM patients.METHODS Type 2 DM patients were categorized into polyp and non-polyp groups.Following this,all patients were categorized into the type 2 DM-metformin,type 2 DM-non-metformin,and non-type 2 DM groups.Based on the baseline colonoscopy results,we performed pairwise comparisons of the incidence of colorectal polyps among the three groups.Additionally,we analyzed the relationship between colorectal polyps and the duration of metformin use and between the size and number of polyps and metformin use.Simultaneously,we focused on the specific pathological types of polyps and analyzed their relationship with metformin use.Finally,we compared the incidence of polyps between metformin and non-metformin groups according to the interval colonoscopy results.RESULTS The rate of metformin use in patients with colorectal polyps was 0.502 times that of patients without colorectal polyps[odds ratio(OR)=0.502,95%confidence interval(CI):0.365-0.689;P<0.001].The incidence of colorectal polyps did not differ significantly between the type 2 DM-metformin and non-type 2 DM groups(P>0.05).Furthermore,the correlations between the duration of metformin use and the incidence of colorectal polyps and between the size and number of polyps and metformin use were not statistically significant(P>0.05).Metformin use did not affect the incidence of colorectal polyps during interval colonoscopy(P>0.05).CONCLUSION Metformin use and colorectal polyp incidence in type 2 DM patients showed a negative correlation,independent of the hypoglycemic effect of metformin.展开更多
The TRacing Etiology of Non-communicable Diseases(TREND)cohort is a prospective longitudinal cohort and biobank that is mainly based in Ma’anshan,Anhui Province,China.The primary aim of the study is to decipher compr...The TRacing Etiology of Non-communicable Diseases(TREND)cohort is a prospective longitudinal cohort and biobank that is mainly based in Ma’anshan,Anhui Province,China.The primary aim of the study is to decipher comprehensive molecular characterization and deep phenotyping for a broad spectrum of chronic non-communicable diseases(NCDs),which focuses on providing mechanistic insights with diagnostic,prognostic and therapeutic implications.The recruitment was initiated in 2023 and is expected to complete in 2025 with 20,000 participants originated from urban and rural area.In the first phase,3360 participants were recruited.Follow-up visits are scheduled annually and intervally for a total of 30 years.The cohort includes individuals aged over 18 years.Two participants with first-degree linkage were recruited from a household.The age distribution of recruited participants was stratified into four categories:18-45,45-55,55-65,and≥65 years,aligning with the population proportions of Ma’anshan.Meanwhile,the gender distribution was controlled by pairing men and women from the same household.Data collected at baseline includes socio-economic information,medical history,lifestyle and nutritional habits,anthropometrics,blood oxygen,electrocardiogram(ECG),heart sound,as well as blood,urine and feces tests results.Molecular profiling includes genome,proteome,metabolome,microbiome and extracellular vesicles-omics.Blood,urine and fecal samples are collected and stored at−80°C in a storage facility for future research.展开更多
文摘BACKGROUND The prevalence and clinical characteristics of chronic kidney disease(CKD)among patients with ketosis-onset diabetes(also known as ketosis-prone diabetes)remain unclear.Furthermore,the classification of ketosis-onset diabetes remains controversial and requires further investigation.AIM To investigate the prevalence and clinical features of CKD in patients with newly diagnosed ketosis-onset diabetes.METHODS This real-world study included 217 patients with type 1 diabetes mellitus(T1DM),698 with ketosis-onset diabetes,and 993 with non-ketotic T2DM.The prevalence and clinical characteristics of CKD were compared among the three groups.Risk factors associated with CKD were evaluated using binary logistic regression for each group.RESULTS After adjusting for age and sex,the prevalence of CKD among patients with ketosis-onset diabetes(17.8%)was significantly higher than that in those with T1DM(8.3%,P=0.007),but was not statistically different compared to those with non-ketotic T2DM(21.7%,P=0.214).Furthermore,some risk factors for CKD,including age,and serum uric acid and C-reactive protein levels,in patients with ketosis-onset diabetes were similar to those with T2DM,but significantly different from those with T1DM.CONCLUSION The prevalence,clinical characteristics,and risk factors for CKD among patients with ketosis-onset diabetes were more similar to those with non-ketotic T2DM but considerably different from those with T1DM.These findings further support the classification of ketosis-onset diabetes as a subtype of T2DM rather than idiopathic T1DM.
基金The International Institute of Population Health,Peking University Health Science Center,No.JKCJ202102The National Key Clinical Specialty Construction Projects,No.2199000764。
文摘BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal cancer.Metformin,a widely prescribed biguanidine drug for type 2 DM,has been suggested to have potential chemoprophylactic effects against various cancers.AIM To explore the correlation between colorectal polyps and metformin use in type 2 DM patients.METHODS Type 2 DM patients were categorized into polyp and non-polyp groups.Following this,all patients were categorized into the type 2 DM-metformin,type 2 DM-non-metformin,and non-type 2 DM groups.Based on the baseline colonoscopy results,we performed pairwise comparisons of the incidence of colorectal polyps among the three groups.Additionally,we analyzed the relationship between colorectal polyps and the duration of metformin use and between the size and number of polyps and metformin use.Simultaneously,we focused on the specific pathological types of polyps and analyzed their relationship with metformin use.Finally,we compared the incidence of polyps between metformin and non-metformin groups according to the interval colonoscopy results.RESULTS The rate of metformin use in patients with colorectal polyps was 0.502 times that of patients without colorectal polyps[odds ratio(OR)=0.502,95%confidence interval(CI):0.365-0.689;P<0.001].The incidence of colorectal polyps did not differ significantly between the type 2 DM-metformin and non-type 2 DM groups(P>0.05).Furthermore,the correlations between the duration of metformin use and the incidence of colorectal polyps and between the size and number of polyps and metformin use were not statistically significant(P>0.05).Metformin use did not affect the incidence of colorectal polyps during interval colonoscopy(P>0.05).CONCLUSION Metformin use and colorectal polyp incidence in type 2 DM patients showed a negative correlation,independent of the hypoglycemic effect of metformin.
基金National 973 Science and Technology Plan Project“Basic Research on Precision Forming and Measurement and Control Technology of Mechanical Equipment Metal Parts”(2012CB724306)~~
基金supported by:Municipal Designated Funds of Ma'anshan for Chronic Non-communicable Diseases Prevention,National Natural Science Foundation of China(NSFC,32394052,82204033,32270077 and Excellent Young Scientists Fund Program Overseas-2022)Jiangsu Shuangchuang Project(Medical Innovation Team,Medical Expert and JSSCBS20221815)+6 种基金Designated Funds for Provincial Demonstration Areas for Comprehensive Prevention and Control of Chronic Non-communicable Diseases,Desiginated Funds for Basic Healthcare and Health Promotion,the Natural Sci-ence Foundation of Jiangsu grant(BK2022020826,BK20220709)Fundamental Research Funds for the Central Universities of China(2242022R10062/3225002202A1)Medical Foundation of Southeast University(4060692202/021)Zhishan Young Scholar Award at the Southeast University(2242023R40031)The Scientific Research Pro-ject for Health Commission of Anhui Province(AHWJ2023A20172,AHWJ2023BAa20055)Nanjing Medical University(CMCM202204,303073572NC21&YNRCZN0301)Development of Jiangsu Higher Education Institutions Priority Academic Program(PAPD).
文摘The TRacing Etiology of Non-communicable Diseases(TREND)cohort is a prospective longitudinal cohort and biobank that is mainly based in Ma’anshan,Anhui Province,China.The primary aim of the study is to decipher comprehensive molecular characterization and deep phenotyping for a broad spectrum of chronic non-communicable diseases(NCDs),which focuses on providing mechanistic insights with diagnostic,prognostic and therapeutic implications.The recruitment was initiated in 2023 and is expected to complete in 2025 with 20,000 participants originated from urban and rural area.In the first phase,3360 participants were recruited.Follow-up visits are scheduled annually and intervally for a total of 30 years.The cohort includes individuals aged over 18 years.Two participants with first-degree linkage were recruited from a household.The age distribution of recruited participants was stratified into four categories:18-45,45-55,55-65,and≥65 years,aligning with the population proportions of Ma’anshan.Meanwhile,the gender distribution was controlled by pairing men and women from the same household.Data collected at baseline includes socio-economic information,medical history,lifestyle and nutritional habits,anthropometrics,blood oxygen,electrocardiogram(ECG),heart sound,as well as blood,urine and feces tests results.Molecular profiling includes genome,proteome,metabolome,microbiome and extracellular vesicles-omics.Blood,urine and fecal samples are collected and stored at−80°C in a storage facility for future research.
