In this study,in view of the corrosion resistance and bio functionality limitations of medical magnesium alloys,a PCL/MAO@TiO_(2)NPS composite coating was fabricated to enhance biodegradable magnesium alloy orthopedic...In this study,in view of the corrosion resistance and bio functionality limitations of medical magnesium alloys,a PCL/MAO@TiO_(2)NPS composite coating was fabricated to enhance biodegradable magnesium alloy orthopedic implants.This composite coating effectively inhibited pitting corrosion and decreased the degradation rate of the magnesium alloy substrate.Specifically,the corrosion current density of the overall specimen decreased by five orders of magnitude compared to that of the substrate.In vitro cell experiments demonstrated that the composite coating significantly decelerated the degradation of the magnesium alloy.The degradation products and appropriate magnesium ion concentration promoted cell growth and proliferation.After 72-h co-culturing of specimen extracts with cells,cell viability remained at 100%.Antimicrobial test results showed that due to the synergistic effect of ultraviolet treated TiO_(2)nanoparticles and other components,the specimens exhibited excellent antimicrobial properties.Moreover,in vivo animal implantation tests revealed that the PCL/MAO@TiO_(2)NPS composite coated specimens had remarkable bone enhancing capabilities,which were conducive to the healing and functional restoration of bone tissue.Overall,the numerous advantages suggest that the PCL/MAO@TiO_(2)NPS composite coatings hold great promise for improving magnesium alloy implants in clinical applications.展开更多
The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body.The skeletal system serves as the fundamental s...The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body.The skeletal system serves as the fundamental supportive and protective framework of the human body and is extensively innervated by nerves.Currently,a large body of epidemiological and experimental evidence confirms the close interplay between bones and the brain,but the underlying mechanisms remain unclear.This review is anchored on the concept of the brain-bone axis,aiming to gain a deeper understanding of the physiological and pathological interactions between these two organs.A comprehensive analysis of the potential foundations and mechanisms underlying the intricate association between the brain and the skeleton is offered.In summary,the brain can influence skeletal homeostasis through modulation of the neuromolecules,extracellular vesicles,and brain-marrow neural circuit;conversely,the skeleton can influence the brain in its development,function,and pathology by physical exercise,massage therapy,and skeletal trauma.Simultaneously,the strategies for the treatment of skeletal and neurological disorders were organized,in which Traditional Chinese Medicine appears to offer new perspectives for the prevention and disease management,ultimately aiming to furnish patients with more effective therapeutic methods.展开更多
Brassica napus,one of the most important oil crops cultivated globally,is severely impacted by prolonged soil contamination with cadmium(Cd),resulting in decreased yields and poor seed quality.This crop exhibits a hig...Brassica napus,one of the most important oil crops cultivated globally,is severely impacted by prolonged soil contamination with cadmium(Cd),resulting in decreased yields and poor seed quality.This crop exhibits a high adsorption capacity for Cd,making creating seed resources with low Cd accumulation an essential strategy to alleviate this challenge.To address this issue,we genetically edited BnaNRAMP1 in B.napus by targeting three different exon regions,resulting in new germplasm resources with significant differences in Cd accumulation capacity and unaffected yield.Among these,the mutant K140-22,specifically targeting the 7th exon,is distinguished by its substantially reduced Cd accumulation.Further,enzyme assays of the antioxidant defense system in both roots and shoots of K140-22 revealed its enhanced antioxidant activity,which contributes to elucidating the molecular mechanisms of plant tolerance to heavy metal stress.Remarkably,this mutant also maintained equivalent agronomic traits and seed quality,which highlights its potential as a germplasm resource for rapeseed breeding for low Cd accumulation and elevating rapeseed economic value in Cd-contaminated soil.展开更多
AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) w...AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.展开更多
Hard carbon material is one of the most promising anode materials for potassium ion batteries(PIBs)due to its distinct disordered and non-expandable framework.However,the intrinsically disordered microarchitecture of ...Hard carbon material is one of the most promising anode materials for potassium ion batteries(PIBs)due to its distinct disordered and non-expandable framework.However,the intrinsically disordered microarchitecture of hard carbon results in low electric conductivity and poor rate capability.Herein,nitrogendoped and partially graphitized hard carbons(NGHCs)derived from commercial coordination compound precursor-ethylenediaminetetraacetic acid(EDTA)disodium cobalt salt hydrate are designed and prepared as high-performance PIBs anode materials.By means of a facile annealing method,nitrogen elements and graphitic domains can be controllably introduced to NGHCs.The resulting NGHCs show structural merits of mesoporous construction,nitrogen doping and homogeneous graphitic domains,which ensures fast kinetics and electron transportation.Applying in anode for PIBs,NGHCs exhibit robust rate capability with high reversible capacity of 298.8 m Ah g^-1 at 50 m A g^-1,and stable cycle stability of 137.6 mAh g^-1 at 500 m A g^-1 after 1000 cycles.Moreover,the ex situ Raman spectra reveal a mixture"adsorption-intercalation mechanism"for potassium storage of NGHCs.More importantly,full PIBs by pairing with perylenetetracarboxylic dianhydride(PTCDA)cathode demonstrate the promising potential of practical application.In terms of commercial precursor,facile synthesis and long cycle lifespan,NGHCs represent a brilliant prospect for practical large-scale applications.展开更多
The length of fexible manipulators with a telescopic arm alters during movement.The dynamic parameters of telescopic fexible manipulators exhibit signifcant time-varying characteristics owing to variations in length.W...The length of fexible manipulators with a telescopic arm alters during movement.The dynamic parameters of telescopic fexible manipulators exhibit signifcant time-varying characteristics owing to variations in length.With an increase in the manipulators’length,the nonlinear terms caused by fexibility in the manipulators’dynamic equations cannot be ignored.The time-varying characteristics and nonlinear terms of telescopic fexible manipulators cause fuctuations in rotation angles,which afect the operation accuracy of end-efectors.In this study,a control strategy based on a combination of fuzzy adjustment and an RBF neural network is utilized to improve the control accuracy of fexible telescopic manipulators.First,the dynamic equation of the manipulators is established using the assumed mode method and Lagrange’s principle,and the infuence of nonlinear terms is analyzed.Subsequently,a combined control strategy is proposed to suppress the fuctuation of the rotation angle in telescopic fexible manipulators.The variation ranges of the feedforward PD controller parameters are determined by the pole placement strategy and length of the manipulators.Fuzzy rules are utilized to adjust the controller parameters in real-time.The RBF neural network is utilized to identify and compensate the uncertain part of the dynamic model of the fexible manipulators.The uncertain part comprises time-varying parameters and nonlinear terms.Finally,numerical simulations and prototype experiments prove the efectiveness of the combined control strategy.The results prove that the proposed control strategy has a smaller standard deviation of errors.Therefore,the combined control strategy is more suitable for telescopic fexible manipulators,which can efectively improve the control accuracy of rotation angles.展开更多
In space operation,flexible manipulators and gripper mechanisms have been widely used because of light weight and flexibility.However,the vibration caused by slender structures in manipulators and the parameter pertur...In space operation,flexible manipulators and gripper mechanisms have been widely used because of light weight and flexibility.However,the vibration caused by slender structures in manipulators and the parameter perturbation caused by the uncertainty derived from grasping mass variation cannot be ignored.The existence of vibration and parameter perturbation makes the rotation control of flexible manipulators difficult,which seriously affects the operation accuracy of manipulators.What’s more,the complex dynamic coupling brings great challenges to the dynamics modeling and vibration analysis.To solve this problem,this paper takes the space flexible manipulator with an underactuated hand(SFMUH)as the research object.The dynamics model considering flexibility,multiple nonlinear elements and disturbance torque is established by the assumed modal method(AMM)and Hamilton’s principle.A dynamic modeling simplification method is proposed by analyzing the nonlinear terms.What’s more,a sliding mode control(SMC)method combined with the radial basis function(RBF)neural network compensation is proposed.Besides,the control law is designed using a saturation function in the control method to weaken the chatter phenomenon.With the help of neural networks to identify the uncertainty composition in the SFMUH,the tracking accuracy is improved.The results of ground control experiments verify the advantages of the control method for vibration suppression of the SFMUH.展开更多
Introduction: Hepatic magnetic resonance elastography (MRE) allows for noninvasive assessment of liver fibrosis. The purpose of this study was to evaluate the usefulness of MRE in detecting and quantifying liver fibro...Introduction: Hepatic magnetic resonance elastography (MRE) allows for noninvasive assessment of liver fibrosis. The purpose of this study was to evaluate the usefulness of MRE in detecting and quantifying liver fibrosis in patients with rheumatoid arthritis (RA) who have received methotrexate (MTX). Methods: The association between mean liver stiffness value as determined by MRE and variables of interest was determined. The decision for a liver biopsy in participants with an abnormal liver stiffness was made based on clinical judgment. Results: Sixty-five RA patients were enrolled. Mean liver stiffness value by MRE was abnormal in 7 patients, suggestive of hepatic injury. As a result of findings from the MRE, biopsies were performed in 5 patients and all correlated with elevated liver stiffness values. Elevated mean liver stiffness values were associated with body mass index (BMI) (OR = 1.18 per 1 kg/m2;95% CI: 1.03, 1.36;p = 0.017). Neither the total MTX dose nor the duration of MTX treatment was associated with mean liver stiffness value (p = 0.51 and P = 0.20, respectively). Conclusion: MRE provides a reliable, non-invasive assessment of liver fibrosis in patients with RA receiving MTX. Patients with RA receiving MTX who have an elevated BMI may be at increased risk for chronic hepatic injury, regardless of MTX cumulative dose or duration of treatment.展开更多
基金supported by National Natural Science Foundation of China(Grant no 52371070 and 52271249)Key Research and Development Program of Shaanxi(2023-YBGY-488)+1 种基金State Key Laboratory of Solidification Processing in NPU(Grant no SKLSP202415)Xi’an Talent Plan(XAYC240016).
文摘In this study,in view of the corrosion resistance and bio functionality limitations of medical magnesium alloys,a PCL/MAO@TiO_(2)NPS composite coating was fabricated to enhance biodegradable magnesium alloy orthopedic implants.This composite coating effectively inhibited pitting corrosion and decreased the degradation rate of the magnesium alloy substrate.Specifically,the corrosion current density of the overall specimen decreased by five orders of magnitude compared to that of the substrate.In vitro cell experiments demonstrated that the composite coating significantly decelerated the degradation of the magnesium alloy.The degradation products and appropriate magnesium ion concentration promoted cell growth and proliferation.After 72-h co-culturing of specimen extracts with cells,cell viability remained at 100%.Antimicrobial test results showed that due to the synergistic effect of ultraviolet treated TiO_(2)nanoparticles and other components,the specimens exhibited excellent antimicrobial properties.Moreover,in vivo animal implantation tests revealed that the PCL/MAO@TiO_(2)NPS composite coated specimens had remarkable bone enhancing capabilities,which were conducive to the healing and functional restoration of bone tissue.Overall,the numerous advantages suggest that the PCL/MAO@TiO_(2)NPS composite coatings hold great promise for improving magnesium alloy implants in clinical applications.
基金supported by the National Natural Science Foundation of China(82374615)the Major Science and Technology Innovation Project of Shandong Province(2022CXGC020510 and 2024CXGC010609)+4 种基金the Natural Science Foundation of Shandong Province(ZR2024MH189)the University Youth Innovation Team of Shandong Province(2023KJ176)Shandong Province Traditional Chinese Medicine Science and Technology project(M-2022253)Shandong Provincial Medical and Health Science and Technology Project(202412040294)the clinical-basic joint innovation team project of Shandong First Medical University(CX202408)。
文摘The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body.The skeletal system serves as the fundamental supportive and protective framework of the human body and is extensively innervated by nerves.Currently,a large body of epidemiological and experimental evidence confirms the close interplay between bones and the brain,but the underlying mechanisms remain unclear.This review is anchored on the concept of the brain-bone axis,aiming to gain a deeper understanding of the physiological and pathological interactions between these two organs.A comprehensive analysis of the potential foundations and mechanisms underlying the intricate association between the brain and the skeleton is offered.In summary,the brain can influence skeletal homeostasis through modulation of the neuromolecules,extracellular vesicles,and brain-marrow neural circuit;conversely,the skeleton can influence the brain in its development,function,and pathology by physical exercise,massage therapy,and skeletal trauma.Simultaneously,the strategies for the treatment of skeletal and neurological disorders were organized,in which Traditional Chinese Medicine appears to offer new perspectives for the prevention and disease management,ultimately aiming to furnish patients with more effective therapeutic methods.
基金supported by the National Key Research and Development Program of China(2022YFD1601502 and 2023YFD1200202)the National Natural Science Foundation of China(32272167 and 32341028)+1 种基金the Sichuan Science and Technology Program,China(2022ZDZX0015)the Fundamental Research Funds for the Central Universities,China(SCU2019D013)。
文摘Brassica napus,one of the most important oil crops cultivated globally,is severely impacted by prolonged soil contamination with cadmium(Cd),resulting in decreased yields and poor seed quality.This crop exhibits a high adsorption capacity for Cd,making creating seed resources with low Cd accumulation an essential strategy to alleviate this challenge.To address this issue,we genetically edited BnaNRAMP1 in B.napus by targeting three different exon regions,resulting in new germplasm resources with significant differences in Cd accumulation capacity and unaffected yield.Among these,the mutant K140-22,specifically targeting the 7th exon,is distinguished by its substantially reduced Cd accumulation.Further,enzyme assays of the antioxidant defense system in both roots and shoots of K140-22 revealed its enhanced antioxidant activity,which contributes to elucidating the molecular mechanisms of plant tolerance to heavy metal stress.Remarkably,this mutant also maintained equivalent agronomic traits and seed quality,which highlights its potential as a germplasm resource for rapeseed breeding for low Cd accumulation and elevating rapeseed economic value in Cd-contaminated soil.
基金Supported by National Institutes of Health,No.EB001981 to Ehman RL and No.EB017197 to Yin Mthe National Natural Science Foundation of China,No.81271562 to Wang J
文摘AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.
基金support of the Innovation Program of Central South University(No.2018zzts139)。
文摘Hard carbon material is one of the most promising anode materials for potassium ion batteries(PIBs)due to its distinct disordered and non-expandable framework.However,the intrinsically disordered microarchitecture of hard carbon results in low electric conductivity and poor rate capability.Herein,nitrogendoped and partially graphitized hard carbons(NGHCs)derived from commercial coordination compound precursor-ethylenediaminetetraacetic acid(EDTA)disodium cobalt salt hydrate are designed and prepared as high-performance PIBs anode materials.By means of a facile annealing method,nitrogen elements and graphitic domains can be controllably introduced to NGHCs.The resulting NGHCs show structural merits of mesoporous construction,nitrogen doping and homogeneous graphitic domains,which ensures fast kinetics and electron transportation.Applying in anode for PIBs,NGHCs exhibit robust rate capability with high reversible capacity of 298.8 m Ah g^-1 at 50 m A g^-1,and stable cycle stability of 137.6 mAh g^-1 at 500 m A g^-1 after 1000 cycles.Moreover,the ex situ Raman spectra reveal a mixture"adsorption-intercalation mechanism"for potassium storage of NGHCs.More importantly,full PIBs by pairing with perylenetetracarboxylic dianhydride(PTCDA)cathode demonstrate the promising potential of practical application.In terms of commercial precursor,facile synthesis and long cycle lifespan,NGHCs represent a brilliant prospect for practical large-scale applications.
基金Supported by National Natural Science Foundation of China(Grant No.51875092)National Key Research and Development Project of China(Grant No.2020YFB2007802)+1 种基金Natural Science Foundation of Ningxia Province(Grant No.2020AAC03279)Fundamental Research Funds for the Central Universities(Grant No.N2103025).
文摘The length of fexible manipulators with a telescopic arm alters during movement.The dynamic parameters of telescopic fexible manipulators exhibit signifcant time-varying characteristics owing to variations in length.With an increase in the manipulators’length,the nonlinear terms caused by fexibility in the manipulators’dynamic equations cannot be ignored.The time-varying characteristics and nonlinear terms of telescopic fexible manipulators cause fuctuations in rotation angles,which afect the operation accuracy of end-efectors.In this study,a control strategy based on a combination of fuzzy adjustment and an RBF neural network is utilized to improve the control accuracy of fexible telescopic manipulators.First,the dynamic equation of the manipulators is established using the assumed mode method and Lagrange’s principle,and the infuence of nonlinear terms is analyzed.Subsequently,a combined control strategy is proposed to suppress the fuctuation of the rotation angle in telescopic fexible manipulators.The variation ranges of the feedforward PD controller parameters are determined by the pole placement strategy and length of the manipulators.Fuzzy rules are utilized to adjust the controller parameters in real-time.The RBF neural network is utilized to identify and compensate the uncertain part of the dynamic model of the fexible manipulators.The uncertain part comprises time-varying parameters and nonlinear terms.Finally,numerical simulations and prototype experiments prove the efectiveness of the combined control strategy.The results prove that the proposed control strategy has a smaller standard deviation of errors.Therefore,the combined control strategy is more suitable for telescopic fexible manipulators,which can efectively improve the control accuracy of rotation angles.
基金supported by the National Natural Science Foundation of China(No.52275090)the Fundamental Research Funds for the Central Universities(No.N2103025)+1 种基金the National Key Research and Development Program of China(No.2020YFB2007802)the Applied Basic Research Program of Liaoning Province(No.2023JH2/101300159)。
文摘In space operation,flexible manipulators and gripper mechanisms have been widely used because of light weight and flexibility.However,the vibration caused by slender structures in manipulators and the parameter perturbation caused by the uncertainty derived from grasping mass variation cannot be ignored.The existence of vibration and parameter perturbation makes the rotation control of flexible manipulators difficult,which seriously affects the operation accuracy of manipulators.What’s more,the complex dynamic coupling brings great challenges to the dynamics modeling and vibration analysis.To solve this problem,this paper takes the space flexible manipulator with an underactuated hand(SFMUH)as the research object.The dynamics model considering flexibility,multiple nonlinear elements and disturbance torque is established by the assumed modal method(AMM)and Hamilton’s principle.A dynamic modeling simplification method is proposed by analyzing the nonlinear terms.What’s more,a sliding mode control(SMC)method combined with the radial basis function(RBF)neural network compensation is proposed.Besides,the control law is designed using a saturation function in the control method to weaken the chatter phenomenon.With the help of neural networks to identify the uncertainty composition in the SFMUH,the tracking accuracy is improved.The results of ground control experiments verify the advantages of the control method for vibration suppression of the SFMUH.
文摘Introduction: Hepatic magnetic resonance elastography (MRE) allows for noninvasive assessment of liver fibrosis. The purpose of this study was to evaluate the usefulness of MRE in detecting and quantifying liver fibrosis in patients with rheumatoid arthritis (RA) who have received methotrexate (MTX). Methods: The association between mean liver stiffness value as determined by MRE and variables of interest was determined. The decision for a liver biopsy in participants with an abnormal liver stiffness was made based on clinical judgment. Results: Sixty-five RA patients were enrolled. Mean liver stiffness value by MRE was abnormal in 7 patients, suggestive of hepatic injury. As a result of findings from the MRE, biopsies were performed in 5 patients and all correlated with elevated liver stiffness values. Elevated mean liver stiffness values were associated with body mass index (BMI) (OR = 1.18 per 1 kg/m2;95% CI: 1.03, 1.36;p = 0.017). Neither the total MTX dose nor the duration of MTX treatment was associated with mean liver stiffness value (p = 0.51 and P = 0.20, respectively). Conclusion: MRE provides a reliable, non-invasive assessment of liver fibrosis in patients with RA receiving MTX. Patients with RA receiving MTX who have an elevated BMI may be at increased risk for chronic hepatic injury, regardless of MTX cumulative dose or duration of treatment.
