目的了解阿德福韦酯相关低磷血症的研究现状。方法利用Web of Science数据库检索阿德福韦酯相关低磷血症文献,检索日期截至2018年7月31日,分别从文献发表的年份、引用率、地域及国家、刊载期刊等方面进行统计与分析。结果2004年至2012...目的了解阿德福韦酯相关低磷血症的研究现状。方法利用Web of Science数据库检索阿德福韦酯相关低磷血症文献,检索日期截至2018年7月31日,分别从文献发表的年份、引用率、地域及国家、刊载期刊等方面进行统计与分析。结果2004年至2012年为稳定期(每年发表的文献不超过5篇),2013年至2015年为上升期,2016年至2018年发表量逐年下降;亚洲发表最多(48篇),其中发表最多的国家为中国(33篇);《中国骨质疏松杂志》刊载最多(4篇)。结论阿德福韦酯会引起低磷血症,应采取有效措施进行防治。展开更多
OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to expl...OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.展开更多
OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sec...OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection.展开更多
文摘目的了解阿德福韦酯相关低磷血症的研究现状。方法利用Web of Science数据库检索阿德福韦酯相关低磷血症文献,检索日期截至2018年7月31日,分别从文献发表的年份、引用率、地域及国家、刊载期刊等方面进行统计与分析。结果2004年至2012年为稳定期(每年发表的文献不超过5篇),2013年至2015年为上升期,2016年至2018年发表量逐年下降;亚洲发表最多(48篇),其中发表最多的国家为中国(33篇);《中国骨质疏松杂志》刊载最多(4篇)。结论阿德福韦酯会引起低磷血症,应采取有效措施进行防治。
基金Supported by National Natural Science Foundation of China(No.81803953,81873289,81873187)China Postdoctoral Science Foundation(No.2015M582190,2017M612406)Special Scientific Research of Traditional Chinese Medicine of Henan Province in China(No.2015ZY02097,2016ZY2036,2018ZY2080)
文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.
基金the National Natural Science Foundation of China(No.81803953,81873289,81873187)National Natural Science Foundation of He Nan(No.182300410386)+1 种基金Program for Science and Technology Innovation Talents in Universities of Henan Province(No.16HASTIT031)Special Scientific Research of Traditional Chinese Medicine of Henan Province in China(No.2015ZY02097,2016ZY2036)
文摘OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection.
