Polylactic acid(PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondary pollution to the environment after application.However,t...Polylactic acid(PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondary pollution to the environment after application.However,there is still a lack of a green and facile way to prepare PLA oil-water separation materials.In this work,a water-assisted thermally induced phase separation method for the preparation of superhydrophobic PLA oil-water separation material with honeycomb-like structures is reported.The PLA material shows great ability in application and could adsorb 27.3 times oil to its own weight.In addition,it could also be applicated as a filter with excellent efficiency(50.9 m^3 m^(-2) h^(-1)).展开更多
Block copolymer(BCP) nanolithography offers potential beyond traditional photolithographic limits, yet reliably producing low-defect, perpendicular domains remains challenging. We introduce a microenvironmentdriven is...Block copolymer(BCP) nanolithography offers potential beyond traditional photolithographic limits, yet reliably producing low-defect, perpendicular domains remains challenging. We introduce a microenvironmentdriven isothermal annealing method for directed self-assembly of BCP thin films. By annealing films at stable temperature in a quasi-sealed, inert-gas chamber, our approach promotes highly uniform perpendicular lamellar nanopatterns over large areas, effectively mitigating environmental fluctuations and emulating solvent-vapor annealing without solvent exposure. Resulting BCP structures demonstrate enhanced spatial coherence and notably low defect density. Furthermore, we successfully transfer these nanopatterns into precise metal nano-line arrays,confirming the method's capability for high-fidelity pattern replication. This scalable, solvent-free technique provides a robust, reliable route for high-resolution nanopatterning in advanced semiconductor manufacturing.展开更多
BACKGROUND Several studies have suggested a close link between depression,overweight,and new-onset diabetes,particularly among middle-aged and older populations;however,the causal associations remain poorly understood...BACKGROUND Several studies have suggested a close link between depression,overweight,and new-onset diabetes,particularly among middle-aged and older populations;however,the causal associations remain poorly understood.AIM To investigate the role of overweight in mediating the association between depression and new-onset diabetes in middle-aged and older populations.METHODS Data of 9426 individuals aged≥50 years from the 1998-2016 Health and Retirement Study database were analyzed.Weighted logistic regression was employed to obtain odds ratios(ORs)and 95%confidence intervals(95%CIs)for depression and new-onset diabetes in the middle-aged and older populations.Mediation analysis and the Sobel test were used to test the mediating effects of overweight between depression and the risk of new-onset diabetes.RESULTS New-onset diabetes was identified in 23.6%of the study population.Depression was significantly associated with new-onset diabetes(OR:1.18,95%CI:1.03-1.35,P value:0.014).Further adjustment for overweight attenuated the effect of depression on new-onset diabetes to 1.14(95%CI:1.00-1.30,P=0.053),with a significant mediating effect(P of Sobel test=0.003).The mediation analysis demonstrated that overweight accounted for 61%in depression for the risk of new-onset diabetes,with overweight having a partially mediating role in the depression-to-diabetes pathway.CONCLUSION New-onset diabetes was not necessarily a direct complication of depression;rather,depression led to behaviors that increase the risk of overweight and,consequently,new-onset diabetes.展开更多
根据国际温度咨询委员会辐射测温工作组(CCT-WG5)对世界各国计量机构开展Co-C共晶点研制工作的相关要求,设计并搭建了Co-C共晶点灌注系统,采用直接共晶法成功灌注了满足复现实验要求的Co-C共晶点坩埚。针对直接共晶灌注法效率低、坩埚...根据国际温度咨询委员会辐射测温工作组(CCT-WG5)对世界各国计量机构开展Co-C共晶点研制工作的相关要求,设计并搭建了Co-C共晶点灌注系统,采用直接共晶法成功灌注了满足复现实验要求的Co-C共晶点坩埚。针对直接共晶灌注法效率低、坩埚破裂风险大的缺陷,提出了对灌注方法的改进方案,并依据该方案成功灌注了2个Co-C共晶点坩埚。对灌注的Co-C-2#共晶点进行了复现试验,结果显示:拐点温度的不确定度为5. 3 m K,满足小于10 m K的CCT要求;短期重复性为9. 6 m K,满足小于20 m K的CCT要求。展开更多
Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are importa...Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality.展开更多
Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response ...Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response functions for DAMPE(DmpIRFs) including the effective area, point-spread function and energy dispersion, which are crucial for gamma-ray data analysis based on statistics from simulation data. A dedicated software named DmpST is developed to facilitate the scientific analyses of DAMPE gamma-ray data. Considering the limited number of photons and angular resolution of DAMPE, the maximum likelihood method is adopted in DmpST to better disentangle different source components. The basic mathematics and framework regarding this software are also introduced in this paper.展开更多
The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals o...The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals of DAMPE is to observe Ge V-Te V high energy γ-rays with accurate energy,angular and time resolution,to indirectly search for dark matter particles and for the study of high energy astrophysics. Due to the comparatively higher fluxes of charged cosmic rays with respect to γ-rays,it is challenging to identify γ-rays with sufficiently high efficiency,minimizing the amount of charged cosmic ray contamination. In this work we present a method to identify γ-rays in DAMPE data based on Monte Carlo simulations,using the powerful electromagnetic/hadronic shower discrimination provided by the calorimeter and the veto detection of charged particles provided by the plastic scintillation detector. Monte Carlo simulations show that after this selection the number of electrons and protons that contaminate the selected γ-ray events at～10 Ge V amounts to less than 1% of the selected sample.Finally,we use flight data to verify the effectiveness of the method by highlighting known γ-ray sources in the sky and by reconstructing preliminary light curves of the Geminga pulsar.展开更多
The Contra-Rotating Open Rotor(CROR)design confronts significant noise challenges despite being one of the possible options for future green aeroengines.To efficiently estimate the noise emitted from a CROR,a three-di...The Contra-Rotating Open Rotor(CROR)design confronts significant noise challenges despite being one of the possible options for future green aeroengines.To efficiently estimate the noise emitted from a CROR,a three-dimensional unsteady prediction model based on the meshless method is presented.The unsteady wake flow and the aerodynamic load fluctuations on the blade are solved through the viscous vortex particle method,the blade element momentum theory and vortex lattice method.Then,the acoustic field is obtained through the Farassat’s formulation 1A.Validation of this method is conducted on a CROR,and a mesh-based method,e.g.,Nonlinear Harmonic(NLH)method,is also employed for comparison.It is found that the presented method is three times faster than NLH method while maintaining a comparable precision.A thorough parametric analysis is also carried out to illustrate the effects of rotational speed,rotor-rotor spacing and rear rotor diameter on the noise level.The rotor speed is found to be the most influencing factor,and by optimizing the speed difference between the front and rear rotors,a notable noise reduction can be expected.The current findings not only contribute to a deeper comprehension of the CROR’s aeroacoustic properties but also offer an effective tool for engineering applications.展开更多
基金National Natural Science Foundation of China(Nos.51803190,11432003,11572290)National Key Research and Development Program of China(No.2016YFB0101602)+2 种基金China Postdoctoral Science Foundation(Nos.2018M642779,2019M652573,2019T120643)International Postdoctoral Exchange Fellowship Program,University Key Research Project of Henan Province(No.18A430031)Guangdong Province Pearl River Scholar Funded Scheme(2016)for financial support。
文摘Polylactic acid(PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondary pollution to the environment after application.However,there is still a lack of a green and facile way to prepare PLA oil-water separation materials.In this work,a water-assisted thermally induced phase separation method for the preparation of superhydrophobic PLA oil-water separation material with honeycomb-like structures is reported.The PLA material shows great ability in application and could adsorb 27.3 times oil to its own weight.In addition,it could also be applicated as a filter with excellent efficiency(50.9 m^3 m^(-2) h^(-1)).
基金supported by the National Natural Science Foundation of China (Grant Nos.U20A20168 and 62404120)the National Key R&D Program (Grant No.2022YFB3204100)+2 种基金the Postdoctoral Fellowship Program of CPSF (Grant Nos.GZB20240335 and GZC20231216)the China Postdoctoral Science Foundation (Grant No.2025T180151)the Initiative Scientific Research Program of the School of Integrated Circuits,Tsinghua University。
文摘Block copolymer(BCP) nanolithography offers potential beyond traditional photolithographic limits, yet reliably producing low-defect, perpendicular domains remains challenging. We introduce a microenvironmentdriven isothermal annealing method for directed self-assembly of BCP thin films. By annealing films at stable temperature in a quasi-sealed, inert-gas chamber, our approach promotes highly uniform perpendicular lamellar nanopatterns over large areas, effectively mitigating environmental fluctuations and emulating solvent-vapor annealing without solvent exposure. Resulting BCP structures demonstrate enhanced spatial coherence and notably low defect density. Furthermore, we successfully transfer these nanopatterns into precise metal nano-line arrays,confirming the method's capability for high-fidelity pattern replication. This scalable, solvent-free technique provides a robust, reliable route for high-resolution nanopatterning in advanced semiconductor manufacturing.
基金Supported by the Scientific Research Program of the Tianjin Education Commission(Natural Science),No.2023KJ033.
文摘BACKGROUND Several studies have suggested a close link between depression,overweight,and new-onset diabetes,particularly among middle-aged and older populations;however,the causal associations remain poorly understood.AIM To investigate the role of overweight in mediating the association between depression and new-onset diabetes in middle-aged and older populations.METHODS Data of 9426 individuals aged≥50 years from the 1998-2016 Health and Retirement Study database were analyzed.Weighted logistic regression was employed to obtain odds ratios(ORs)and 95%confidence intervals(95%CIs)for depression and new-onset diabetes in the middle-aged and older populations.Mediation analysis and the Sobel test were used to test the mediating effects of overweight between depression and the risk of new-onset diabetes.RESULTS New-onset diabetes was identified in 23.6%of the study population.Depression was significantly associated with new-onset diabetes(OR:1.18,95%CI:1.03-1.35,P value:0.014).Further adjustment for overweight attenuated the effect of depression on new-onset diabetes to 1.14(95%CI:1.00-1.30,P=0.053),with a significant mediating effect(P of Sobel test=0.003).The mediation analysis demonstrated that overweight accounted for 61%in depression for the risk of new-onset diabetes,with overweight having a partially mediating role in the depression-to-diabetes pathway.CONCLUSION New-onset diabetes was not necessarily a direct complication of depression;rather,depression led to behaviors that increase the risk of overweight and,consequently,new-onset diabetes.
文摘根据国际温度咨询委员会辐射测温工作组(CCT-WG5)对世界各国计量机构开展Co-C共晶点研制工作的相关要求,设计并搭建了Co-C共晶点灌注系统,采用直接共晶法成功灌注了满足复现实验要求的Co-C共晶点坩埚。针对直接共晶灌注法效率低、坩埚破裂风险大的缺陷,提出了对灌注方法的改进方案,并依据该方案成功灌注了2个Co-C共晶点坩埚。对灌注的Co-C-2#共晶点进行了复现试验,结果显示:拐点温度的不确定度为5. 3 m K,满足小于10 m K的CCT要求;短期重复性为9. 6 m K,满足小于20 m K的CCT要求。
基金supported by the National Key Research and Development Program of China(2016YFD0100502)
文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality.
基金supported in part by the National Key Program for Research and Development (2016YFA0400200)the Strategic Priority Research Program of Chinese Academy of Sciences (XDB23040000)+3 种基金the 13th Five-year Informatization Plan of Chinese Academy of Sciences (XXH13506)the National Natural Science Foundation of China (Nos. U1631111, U1738123, U1738136 and U1738210)Youth Innovation Promotion Association of Chinese Academy of Sciencesthe Young Elite Scientists Sponsorship Program
文摘Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response functions for DAMPE(DmpIRFs) including the effective area, point-spread function and energy dispersion, which are crucial for gamma-ray data analysis based on statistics from simulation data. A dedicated software named DmpST is developed to facilitate the scientific analyses of DAMPE gamma-ray data. Considering the limited number of photons and angular resolution of DAMPE, the maximum likelihood method is adopted in DmpST to better disentangle different source components. The basic mathematics and framework regarding this software are also introduced in this paper.
基金founded by the strategic priority science and technology projects in space science of the Chinese Academy of Sciences (Nos.XDA04040000 and XDA04040400)supported in part by the National Key Research and Development Program of China (2016YFA0400200)+7 种基金the National Basic Research Program of China (No.2013CB837000)the Strategic Priority Research Program of the Chinese Academy of Sciences “Multi-Waveband Gravitational Wave Universe” (No.XDB23040000)Youth Innovation Promotion Association of CASthe National Natural Science Foundation of China (Nos.11525313,11673075,11773086,11303107,11303105,11773085,U1738123,U1738136,U1738207 and U1738210)the Young Elite Scientists Sponsorship program by CAST (No.YESS20160196)the 100 Talents Program of Chinese Academy of Sciencessupport by the Swiss National Science Foundation (SNSF)Switzerland and the National Institute for Nuclear Physics (INFN),Italy
文摘The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals of DAMPE is to observe Ge V-Te V high energy γ-rays with accurate energy,angular and time resolution,to indirectly search for dark matter particles and for the study of high energy astrophysics. Due to the comparatively higher fluxes of charged cosmic rays with respect to γ-rays,it is challenging to identify γ-rays with sufficiently high efficiency,minimizing the amount of charged cosmic ray contamination. In this work we present a method to identify γ-rays in DAMPE data based on Monte Carlo simulations,using the powerful electromagnetic/hadronic shower discrimination provided by the calorimeter and the veto detection of charged particles provided by the plastic scintillation detector. Monte Carlo simulations show that after this selection the number of electrons and protons that contaminate the selected γ-ray events at～10 Ge V amounts to less than 1% of the selected sample.Finally,we use flight data to verify the effectiveness of the method by highlighting known γ-ray sources in the sky and by reconstructing preliminary light curves of the Geminga pulsar.
基金the financial support from the National Natural Science Foundation of China(Nos.52276045 and 52206062)the Fundamental Research Funds for the Central Universities,China(Nos.3122019171,3122021087 and 3122022QD06).
文摘The Contra-Rotating Open Rotor(CROR)design confronts significant noise challenges despite being one of the possible options for future green aeroengines.To efficiently estimate the noise emitted from a CROR,a three-dimensional unsteady prediction model based on the meshless method is presented.The unsteady wake flow and the aerodynamic load fluctuations on the blade are solved through the viscous vortex particle method,the blade element momentum theory and vortex lattice method.Then,the acoustic field is obtained through the Farassat’s formulation 1A.Validation of this method is conducted on a CROR,and a mesh-based method,e.g.,Nonlinear Harmonic(NLH)method,is also employed for comparison.It is found that the presented method is three times faster than NLH method while maintaining a comparable precision.A thorough parametric analysis is also carried out to illustrate the effects of rotational speed,rotor-rotor spacing and rear rotor diameter on the noise level.The rotor speed is found to be the most influencing factor,and by optimizing the speed difference between the front and rear rotors,a notable noise reduction can be expected.The current findings not only contribute to a deeper comprehension of the CROR’s aeroacoustic properties but also offer an effective tool for engineering applications.
