The refractory metal rhenium(Re),with content of 0−2 at.%,was introduced into a typicalγ-TiAl alloy of Ti−48Al−2Cr−2Nb(at.%)through vacuum arc melting.The effect of Re content on the microstructure and mechanical pro...The refractory metal rhenium(Re),with content of 0−2 at.%,was introduced into a typicalγ-TiAl alloy of Ti−48Al−2Cr−2Nb(at.%)through vacuum arc melting.The effect of Re content on the microstructure and mechanical properties of theγ-TiAl alloy was investigated.The results show that theγ-TiAl−xRe alloy is composed ofγ,α2,andβphases.As the Re content increases,the proportion ofβphase increases,while the content and size ofα2+γlamellar structure decrease gradually.Furthermore,the compressive strength increases with increasing Re content.A maximum compressive strength of 2282 MPa is achieved for theγ-TiAl−2Re alloy.Theγ-TiAl−2Re alloy exhibits a fracture strain of 36.7%,considerably higher than that of theγ-TiAl alloy(31.0%).Moreover,compared with theγ-TiAl alloy,the hardness and compressive strength of theγ-TiAl−2Re alloy considerably increase by 17.5%and 34.2%,respectively.展开更多
Laparoscopic sleeve gastrectomy(LSG),as an effective treatment for morbid obesity and its metabolic complications,exerts its therapeutic effects by significantly reducing body weight and improving metabolic disorders....Laparoscopic sleeve gastrectomy(LSG),as an effective treatment for morbid obesity and its metabolic complications,exerts its therapeutic effects by significantly reducing body weight and improving metabolic disorders.Its core mechanisms involve multi-level regulation of free fatty acid(FFA)metabolism and chronic low-grade inflammatory states(represented by tumor necrosis factor-alpha,TNF-α).This paper systematically reviews the direct impact of LSG on FFA dynamics including lipolysis,tissue uptake,and oxidation,as well as the molecular pathways through which it indirectly regulates TNF-αby reducing adipose tissue inflammation,improving intestinal barrier function,and modulating epigenetic modifications such as SCD gene methylation.Postoperatively,FFA and TNF-αform a bidirectional promoting feedback loop.LSG effectively breaks this vicious cycle of mutual promotion between the two under obese conditions by reducing FFA levels and inhibiting TNF-αexpression.Lower FFA levels alleviate inflammatory signal activation,while reduced TNF-αinhibits lipolysis,collectively promoting the restoration of insulin sensitivity.A thorough understanding of these mechanisms provides a theoretical basis for optimizing surgical strategies and developing targeted therapies.展开更多
人工智能(artificial intelligence,AI)的快速发展,正在重塑工程结构设计的研究图景.在力学长期奠定的理论框架之上,大语言模型(large language model,LLM)等新一代AI技术,为结构设计提供了新的认知工具与方法视角.随着结构形态空间的...人工智能(artificial intelligence,AI)的快速发展,正在重塑工程结构设计的研究图景.在力学长期奠定的理论框架之上,大语言模型(large language model,LLM)等新一代AI技术,为结构设计提供了新的认知工具与方法视角.随着结构形态空间的持续拓展,以及多尺度与多物理场耦合问题的不断涌现,依赖经验积累与局部试探的传统设计路径正逐渐逼近复杂性边界.在这样的背景下,AI不仅为高维设计空间探索、知识表达与跨学科融合提供了新的可能,也在拓展人类理解复杂系统与开展决策分析的方式.面向未来,结构设计有望在AI推动下形成“设计-制造-测试”闭环体系、多物理场统一设计范式和智能结构系统等新的发展路径,从而为结构科学在新的时代背景下持续拓展认知边界提供重要契机.展开更多
Reducing aerobic spoilage and rumen greenhouse gas emissions from anaerobically fermented feeds remains critical challenges in energy saving and environmental protection of animal husbandry.This study investigated the...Reducing aerobic spoilage and rumen greenhouse gas emissions from anaerobically fermented feeds remains critical challenges in energy saving and environmental protection of animal husbandry.This study investigated the effects of dandelions,both alone and combined with Lactobacillus plantarum and Lactobacillus buchneri(LAB)on fermentation quality,bacteriome and mycobiome after 180 d of anaerobic and 4 d of aerobic fermentation of whole-plant corn.In vitro dry matter digestion(IVDMD)and gas production from anaerobically fermented whole-plant corn were also assessed.The results demonstrated that dandelions,either alone or combined with LAB,effectively improved fermentation quality by reducing NH_(3)-N concentrations(22.72–25.99%)after anaerobic fermentation,decreasing the proliferation of yeast and molds to enhance the aerobic stability.Notably,the changes in the bacteriome were more pronounced than those in the mycobiome after aerobic exposure.The addition of dandelions or the combination reduced Acetobacter fabarum abundance,a member of the Acetobacter that was spoilage-induced microbe indicated by correlation analysis.Besides,these treatments facilitated competition relations of microbiome which contributed to the enhanced aerobic stability.Furthermore,dandelions reduced CH_(4)and CO_(2)emissions by 14.88 and 13.73%,respectively,and also positively influencing IVDMD by 4.46%.Collectively,dandelion alone or combined with LAB are promising strategies to improve the aerobic stability of anaerobically fermented whole-plant corn,a process linked to the interactions between the bacteriome and mycobiome,and to contribute to clean production by reducing rumen CH_(4)and CO_(2)emissions.展开更多
基金Natural Science Foundation of Zhejiang Province,China(No.LQ21E040004)National Natural Science Foundation of China(No.52271040)+1 种基金State Key Lab of Advanced Metals and Materials,China(No.2021-Z03)State Key Laboratory of Powder Metallurgy,Central South University,China。
文摘The refractory metal rhenium(Re),with content of 0−2 at.%,was introduced into a typicalγ-TiAl alloy of Ti−48Al−2Cr−2Nb(at.%)through vacuum arc melting.The effect of Re content on the microstructure and mechanical properties of theγ-TiAl alloy was investigated.The results show that theγ-TiAl−xRe alloy is composed ofγ,α2,andβphases.As the Re content increases,the proportion ofβphase increases,while the content and size ofα2+γlamellar structure decrease gradually.Furthermore,the compressive strength increases with increasing Re content.A maximum compressive strength of 2282 MPa is achieved for theγ-TiAl−2Re alloy.Theγ-TiAl−2Re alloy exhibits a fracture strain of 36.7%,considerably higher than that of theγ-TiAl alloy(31.0%).Moreover,compared with theγ-TiAl alloy,the hardness and compressive strength of theγ-TiAl−2Re alloy considerably increase by 17.5%and 34.2%,respectively.
基金Medical Science and Technology Disciplinary Reserve Talent Program under the Kunming Municipal Health Science and Technology Talent Cultivation Project(Project No.:2024-SW(Reserve)-45)Health Research Project of the Kunming Municipal Health Commission(Project No.:2023-03-06-012)。
文摘Laparoscopic sleeve gastrectomy(LSG),as an effective treatment for morbid obesity and its metabolic complications,exerts its therapeutic effects by significantly reducing body weight and improving metabolic disorders.Its core mechanisms involve multi-level regulation of free fatty acid(FFA)metabolism and chronic low-grade inflammatory states(represented by tumor necrosis factor-alpha,TNF-α).This paper systematically reviews the direct impact of LSG on FFA dynamics including lipolysis,tissue uptake,and oxidation,as well as the molecular pathways through which it indirectly regulates TNF-αby reducing adipose tissue inflammation,improving intestinal barrier function,and modulating epigenetic modifications such as SCD gene methylation.Postoperatively,FFA and TNF-αform a bidirectional promoting feedback loop.LSG effectively breaks this vicious cycle of mutual promotion between the two under obese conditions by reducing FFA levels and inhibiting TNF-αexpression.Lower FFA levels alleviate inflammatory signal activation,while reduced TNF-αinhibits lipolysis,collectively promoting the restoration of insulin sensitivity.A thorough understanding of these mechanisms provides a theoretical basis for optimizing surgical strategies and developing targeted therapies.
文摘人工智能(artificial intelligence,AI)的快速发展,正在重塑工程结构设计的研究图景.在力学长期奠定的理论框架之上,大语言模型(large language model,LLM)等新一代AI技术,为结构设计提供了新的认知工具与方法视角.随着结构形态空间的持续拓展,以及多尺度与多物理场耦合问题的不断涌现,依赖经验积累与局部试探的传统设计路径正逐渐逼近复杂性边界.在这样的背景下,AI不仅为高维设计空间探索、知识表达与跨学科融合提供了新的可能,也在拓展人类理解复杂系统与开展决策分析的方式.面向未来,结构设计有望在AI推动下形成“设计-制造-测试”闭环体系、多物理场统一设计范式和智能结构系统等新的发展路径,从而为结构科学在新的时代背景下持续拓展认知边界提供重要契机.
基金supported by the Henan Provincial Science and Technology Research Project,China(242102111014)the Key Scientific Research Project of Colleges and Universities in Henan Province,China(23A230003)the Cultivation Program for Young Key Teachers and the Scientific Research Foundation for High-level Talents in Henan University of Technology,China(31401489)。
文摘Reducing aerobic spoilage and rumen greenhouse gas emissions from anaerobically fermented feeds remains critical challenges in energy saving and environmental protection of animal husbandry.This study investigated the effects of dandelions,both alone and combined with Lactobacillus plantarum and Lactobacillus buchneri(LAB)on fermentation quality,bacteriome and mycobiome after 180 d of anaerobic and 4 d of aerobic fermentation of whole-plant corn.In vitro dry matter digestion(IVDMD)and gas production from anaerobically fermented whole-plant corn were also assessed.The results demonstrated that dandelions,either alone or combined with LAB,effectively improved fermentation quality by reducing NH_(3)-N concentrations(22.72–25.99%)after anaerobic fermentation,decreasing the proliferation of yeast and molds to enhance the aerobic stability.Notably,the changes in the bacteriome were more pronounced than those in the mycobiome after aerobic exposure.The addition of dandelions or the combination reduced Acetobacter fabarum abundance,a member of the Acetobacter that was spoilage-induced microbe indicated by correlation analysis.Besides,these treatments facilitated competition relations of microbiome which contributed to the enhanced aerobic stability.Furthermore,dandelions reduced CH_(4)and CO_(2)emissions by 14.88 and 13.73%,respectively,and also positively influencing IVDMD by 4.46%.Collectively,dandelion alone or combined with LAB are promising strategies to improve the aerobic stability of anaerobically fermented whole-plant corn,a process linked to the interactions between the bacteriome and mycobiome,and to contribute to clean production by reducing rumen CH_(4)and CO_(2)emissions.
