Metal-organic frameworks(MOFs)as promising electrodes for supercapacitors are attracting increasing research interest.Herein,we report an effective strategy to improve the electrochemical performance of Ni-MOF for sup...Metal-organic frameworks(MOFs)as promising electrodes for supercapacitors are attracting increasing research interest.Herein,we report an effective strategy to improve the electrochemical performance of Ni-MOF for supercapacitor by introducing a secondary Co ion.The Co substitution of Ni in Ni-MOF can improve the intrinsic reactivity and stability.As a result,the bimetallic Co/Ni-MOF-1:15 with an optimal Co/Ni ratio delivers high specific capacitance(359 F/g at 0.5 A/g),good rate performance(81.5%retention at 5 A/g)and cycling stability(81%retention after 5000 cycles).These results demonstrate that the bimetallic synergistic strategy is an effective way to improve the pseudocapacitive performance of MOFs.展开更多
Face recognition is a kind of biometric technology that recognizes identities through human faces. At first, the speed of machine recognition of human faces was slow and the accuracy was lower than manual recognition....Face recognition is a kind of biometric technology that recognizes identities through human faces. At first, the speed of machine recognition of human faces was slow and the accuracy was lower than manual recognition. With the rapid development of deep learning and the application of Convolutional Neural Network (CNN) in the field of face recognition, the accuracy of face recognition has greatly improved. FaceNet is a deep learning framework commo</span><span><span style="font-family:Verdana;">nly used in face recognition in recent years. FaceNet uses the deep learning model GoogLeNet, which has </span><span style="font-family:Verdana;">a high</span><span style="font-family:Verdana;"> accuracy in face recognition. However, its network structure is too large, which causes the </span><span style="font-family:Verdana;">FaceNet</span><span style="font-family:Verdana;"> to run at a low speed. Therefore, to improve the running speed without affecting the recognition accuracy of FaceNet, this paper proposes a lightweight FaceNet model based on MobileNet. This article mainly does the following works:</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">Based on the analysis of the low running speed of FaceNet and the principle of MobileNet, a lightweight FaceNet model based on MobileNet is proposed. The model would reduce the overall calculation of the network by using deep separable convolutio</span><span style="font-family:""><span style="font-family:Verdana;">ns. In this paper, the model is trained on the CASIA-WebFace and VGGFace2 </span><span style="font-family:Verdana;">datasets,</span><span style="font-family:Verdana;"> and tested on the LFW dataset. Experimental results show that the model reduces the network parameters to a large extent while ensuring </span><span style="font-family:Verdana;">the accuracy</span><span style="font-family:Verdana;"> and hence an increase in system computing speed. The model can also perform face recognition on a specific person in the video.展开更多
Refractory high entropy alloys have superior mechanical properties at high temperatures, and the oxidation behavior of these alloys is very important. The present work investigated the high temperature oxidation behav...Refractory high entropy alloys have superior mechanical properties at high temperatures, and the oxidation behavior of these alloys is very important. The present work investigated the high temperature oxidation behavior of three alloys with compositions of TiNbTa0.5Zr, TiNbTa0.5ZrAl and TiNbTa0.5ZrAlMo0.5, and the effects of alloying elements were discussed. Results indicated that the oxidation rates of the TiNbTa0.5Zr and TiNbTa0.5ZrAl alloys are controlled by diffusion, and obey the exponential rule. However, the oxidation rate of the TiNbTa0.5ZrAlMo0.5 alloy is controlled by interface reaction, and obeys the linear rule. The addition of Al leads to a better oxidation resistance by forming a protective oxide scale. However, the protection of Al-rich scale is weakened by the addition of Mo. Extensive pores and cracks occur in the oxide scale of the TiNbTa0.5ZrAlMo0.5 alloy, resulting in a significant decrease in oxidation resistance.展开更多
The practical application of Li-S batteries is largely impeded by the“shuttle effect”generated at the cathode which results in a short life cycle of the battery.To address this issue,this work discloses a bimetallic...The practical application of Li-S batteries is largely impeded by the“shuttle effect”generated at the cathode which results in a short life cycle of the battery.To address this issue,this work discloses a bimetallic metal-organic framework(MOF)as a sulfur host material based on Al-MOF,commonly called(Al)MIL-53.To obtain a high-adsorption capacity to lithium polysulfides(Li_(2)S_(x),4≤x≤8),we present an effective strategy to incorporate sulfiphilic metal ion(Cu^(2+))with high-binding energy to Li_(2)S_(x)into the framework.Through a one-step hydrothermal method,Cu^(2+)is homogeneously dispersed in Al-MOF,producing a bimetallic Al/Cu-MOF as advanced cathode material.The macroscopic Li2S4 solution permeation test indicates that the Al/Cu-MOF has better adsorption capacity to lithium polysulfides than monometallic Al-MOF.The sulfur-transfusing process is executed via a melt-diffusion method to obtain the sulfur-containing Al/CuMOF(Al/Cu-MOF-S).The assembled Li-S batteries with Al/Cu-MOF-S yield improved cyclic performance,much better than that of monometallic AlMOF as sulfur host.It is shown that chemical immobilization is an effective method for polysulfide adsorption than physical confinement and the bimetallic Al/Cu-MOF,formed by incorporation of sulfiphilic Cu^(2+)into porous MOF,will provide a novel and powerful approach for efficient sulfur host materials.展开更多
The mechanical properties of refractory high entropy alloys(RHEAs) strongly depend on their phase structures. In this work, the phase stability of a BCC TiNbTa0.5ZrAl0.5 refractory high entropy alloy subjected to ther...The mechanical properties of refractory high entropy alloys(RHEAs) strongly depend on their phase structures. In this work, the phase stability of a BCC TiNbTa0.5ZrAl0.5 refractory high entropy alloy subjected to thermomechanical processing was evaluated, and the effects of phase decomposition on room/high temperature mechanical properties were quantitatively studied. It was found that, the thermomechanical processing at 800℃and 1200℃ leads to phase decomposition in the TiNbTa0.5ZrAl0.5 alloy. The phase decomposition is caused by the rapid rising of free energy of the primary BCC phase. The effect of the precipitates on room temperature strength is determined by the competition between the increasing in precipitation strengthening and the decreasing in solid solution strengthening. But at high temperatures(800-1200℃), the phase decomposition causes significant reduction in strength, mainly due to the grain boundary sliding and the decreasing in solid solution strengthening.展开更多
Mercury（Hg） exists in different chemical forms presenting varied toxic potentials. It is necessary to explore an ecological risk assessment method for different mercury species in aquatic environment. The predicted ...Mercury（Hg） exists in different chemical forms presenting varied toxic potentials. It is necessary to explore an ecological risk assessment method for different mercury species in aquatic environment. The predicted no-effect concentrations（PNECs） for Hg（Ⅱ） and methyl mercury（Me Hg） in the aqueous phase, calculated using the species sensitivity distribution method and the assessment factor method, were 0.39 and 6.5 × 10-3μg/L, respectively. The partition theory of Hg between sediment and aqueous phases was considered, along with PNECs for the aqueous phase to conduct an ecological risk assessment for Hg in the sediment phase. Two case studies, one in China and one in the Western Black Sea, were conducted using these PNECs. The toxicity of mercury is heavily dependent on their forms,and their potential ecological risk should be respectively evaluated on the basis of mercury species.展开更多
Poly(ADP-ribose) polymerase 1 (PARP1) plays important roles in the regulation of transcription factors. Mounting evidence has shown that inhibition of PARP1 influences the expression of genes associated with inflammat...Poly(ADP-ribose) polymerase 1 (PARP1) plays important roles in the regulation of transcription factors. Mounting evidence has shown that inhibition of PARP1 influences the expression of genes associated with inflammatory response. Interferon regulatory factor 1 (IRF1) is a critical transcription factor for the development of both the innate and adaptive immune responses against infections. However, the molecular mechanism through which PARP1 mediates the effects has not been clearly demonstrated. Jurkat cells were exposed to dexamethasone (Dex) or PARP1 inhibitor PJ34. The expression levels of IL-12, LMP2, OAS1 and PKR were detected using real-time RT-PCR. The interactions between PARP1 and IRF1 were examined by coimmunoprecipitation (co-IP) assays. We further explored the mechanism of PARP1 suppressing IRF1 by assessing the activities of interferon stimulated response element (ISRE). The mRNA expression of IL-12, LMP2, OAS1 and PKR was obviously suppressed by Dex in Jurkat cells, which could be rescued by PJ34 treatment. Luciferase study revealed that poly(ADP-ribosyl)- ation suppressed IRF1-mediated transcription through preventing the binding of IRF1 to ISREs. PARP1 inhibited IRF1-mediated transcription in Jurkat cells by preventing IRF1 binding to ISREs in the promoters of target genes. It is suggested that PARP1 is a crucial regulator of IRF1-mediated immune response. This study provides experimental evidence for the possible application of PARP1 inhibitors in the treatment of IRF1-related immune anergy.展开更多
Lithium-sulfur batteries(LSBs)are considered promising new energy storage systems given their outstanding theoretical energy densities.Nevertheless,issues such as low electrical conductivity and severe volume expansio...Lithium-sulfur batteries(LSBs)are considered promising new energy storage systems given their outstanding theoretical energy densities.Nevertheless,issues such as low electrical conductivity and severe volume expansion,along with the formation of polysulfides during cycling,restrict their practical applications.To overcome these issues,it is necessary to find suitable and effective sulfur host materials.Metal-organic frameworks(MOFs),which are porous crystalline materials in the bourgeoning developmental stages,have demonstrated enormous potential in LSBs owing to their high porosity and tunable porous structure.Herein,we provide a comprehensive overview of MOF-based sulfur-loaded materials and discuss the charge/discharge mechanisms,strategies of enhancing battery performance,sulfur loading methods,and applications in LSBs.An outlook on future directions,prospects,and possible obstacles for the development of these materials is also provided.展开更多
The different toxicity characteristics of arsenic species result in discrepant ecological risk.The predicted no-effect concentrations（PNECs） 43.65, 250.18, and 2.00 × 10^3μg/L were calculated for As（III）, As...The different toxicity characteristics of arsenic species result in discrepant ecological risk.The predicted no-effect concentrations（PNECs） 43.65, 250.18, and 2.00 × 10^3μg/L were calculated for As（III）, As（V）, and dimethylarsinic acid in aqueous phase, respectively. With these PNECs, the ecological risk from arsenic species in Pearl River Delta in China and Kwabrafo stream in Ghana was evaluated. It was found that the risk from As（III） and As（V）in the samples from Pearl River Delta was low, while much high in Kwabrafo stream. This study implies that ecological risk of arsenic should be evaluated basing on its species.展开更多
Due to their inherent tunable spectrum,high brightness,excellent biostability and biocompatibility,and functionalization of surfaces,semiconducting polymer dots(Pdots)are now playing an essential role in fluorescent(F...Due to their inherent tunable spectrum,high brightness,excellent biostability and biocompatibility,and functionalization of surfaces,semiconducting polymer dots(Pdots)are now playing an essential role in fluorescent(FL)imaging and disease treatment through bioconjugation with peptides or biomimetic materials.In particular,biomimetic Pdots exhibit their capability in targeted imaging of lesion and increased efficacy for targeting disease treatment.This review will inspect the recent advances in the design and functionalization strategies of biomodified and biomimetic Pdots for enhanced disease detection and therapy.More importantly,the application of these two modifications in targeted FL imaging and cancer treatment is to be addressed in detail.Meanwhile,the main challenges and prospects of biomimetic and biomodified Pdots are to be discussed,which will pave a new avenue for improved disease detection and imaging-guided treatment.展开更多
Cationic polymers,also known as polycations,are considered to be the most potential non-viral gene carriers due to their unique advantages such as the ability to bind the negative charge of nucleic acid molecules.Mult...Cationic polymers,also known as polycations,are considered to be the most potential non-viral gene carriers due to their unique advantages such as the ability to bind the negative charge of nucleic acid molecules.Multicomponent polymerization(MCP)is a one-step,tandem strategy to construct complex structures based on multicomponent reactions.Herein,we developed a metal-free MCP method based on three monomers of p-dinitrovinylbenzene(p-DNVB),1,1-dimethylethyl N,N-dibromocarbamate(BocNBr_(2)),and bis-secondary-amines with a ratio of 1:2:1,to access a library of Boc-substituted polyamidines with well-defined structures and suitable molecular weights(M w ranging from 4400Da to 11,000Da)in high yields(up to 85%)under mild conditions.Upon the removal of Boc groups,a series of water-soluble polymers with cationic property were prepared and their gene binding capability was further evaluated.展开更多
Protein-protein interactions are vital for a wide range of biological processes.The interactions between the hypoxia-inducible factor and von Hippel Lindau(VHL)are attractive drug targets for ischemic heart disease.In...Protein-protein interactions are vital for a wide range of biological processes.The interactions between the hypoxia-inducible factor and von Hippel Lindau(VHL)are attractive drug targets for ischemic heart disease.In order to disrupt this interaction,the strategy to target VHL binding site using a hydroxyproline-like(pro-like)small molecule has been reported.In this study,we focused on the inhibition mechanism between the pro-like inhibitors and the VHL protein,which were investigated via molecular dynamics simulations and binding free energy calculations.It was found that pro-like inhibitors showed a strong binding affinity toward VHL.Binding free energy calculations and free energy decompositions suggested that the modification of various regions of pro-like inhibitors may provide useful information for future drug design.展开更多
The comfort satisfaction of basic facilities of the rail transit transfer station will influence pedestrian choice of vehicle. Aiming at the problem of traffic jams in Changchun in China, we designed a satisfaction qu...The comfort satisfaction of basic facilities of the rail transit transfer station will influence pedestrian choice of vehicle. Aiming at the problem of traffic jams in Changchun in China, we designed a satisfaction questionnaire to investigate the factors which might affect the pedestrian satisfaction in rail transit transfer station in Changchun. By using the statistical methods, including correlation analysis, factor analysis and comparative analysis of satisfaction and importance, we analyzed the survey data, and get the results of analysis. Some suggestions for rail transit transfer station based on the results are given.展开更多
基金supported by the National Natural Science Foundation of China (NSFC, Nos. 21901222, U1904215 and 21671170)Lvyangjinfeng Talent Program of Yangzhou+2 种基金Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)Program for Young Chang Jiang Scholars of the Ministry of Education, China (No. Q2018270)Natural Science Foundation of Jiangsu Province (No. BK20200044)。
文摘Metal-organic frameworks(MOFs)as promising electrodes for supercapacitors are attracting increasing research interest.Herein,we report an effective strategy to improve the electrochemical performance of Ni-MOF for supercapacitor by introducing a secondary Co ion.The Co substitution of Ni in Ni-MOF can improve the intrinsic reactivity and stability.As a result,the bimetallic Co/Ni-MOF-1:15 with an optimal Co/Ni ratio delivers high specific capacitance(359 F/g at 0.5 A/g),good rate performance(81.5%retention at 5 A/g)and cycling stability(81%retention after 5000 cycles).These results demonstrate that the bimetallic synergistic strategy is an effective way to improve the pseudocapacitive performance of MOFs.
文摘Face recognition is a kind of biometric technology that recognizes identities through human faces. At first, the speed of machine recognition of human faces was slow and the accuracy was lower than manual recognition. With the rapid development of deep learning and the application of Convolutional Neural Network (CNN) in the field of face recognition, the accuracy of face recognition has greatly improved. FaceNet is a deep learning framework commo</span><span><span style="font-family:Verdana;">nly used in face recognition in recent years. FaceNet uses the deep learning model GoogLeNet, which has </span><span style="font-family:Verdana;">a high</span><span style="font-family:Verdana;"> accuracy in face recognition. However, its network structure is too large, which causes the </span><span style="font-family:Verdana;">FaceNet</span><span style="font-family:Verdana;"> to run at a low speed. Therefore, to improve the running speed without affecting the recognition accuracy of FaceNet, this paper proposes a lightweight FaceNet model based on MobileNet. This article mainly does the following works:</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">Based on the analysis of the low running speed of FaceNet and the principle of MobileNet, a lightweight FaceNet model based on MobileNet is proposed. The model would reduce the overall calculation of the network by using deep separable convolutio</span><span style="font-family:""><span style="font-family:Verdana;">ns. In this paper, the model is trained on the CASIA-WebFace and VGGFace2 </span><span style="font-family:Verdana;">datasets,</span><span style="font-family:Verdana;"> and tested on the LFW dataset. Experimental results show that the model reduces the network parameters to a large extent while ensuring </span><span style="font-family:Verdana;">the accuracy</span><span style="font-family:Verdana;"> and hence an increase in system computing speed. The model can also perform face recognition on a specific person in the video.
基金Project(51671217)supported by the National Natural Science Foundation of ChinaProject(CX2017B047)supported by the Program of Innovation for Postgraduate of Hunan Province,China
文摘Refractory high entropy alloys have superior mechanical properties at high temperatures, and the oxidation behavior of these alloys is very important. The present work investigated the high temperature oxidation behavior of three alloys with compositions of TiNbTa0.5Zr, TiNbTa0.5ZrAl and TiNbTa0.5ZrAlMo0.5, and the effects of alloying elements were discussed. Results indicated that the oxidation rates of the TiNbTa0.5Zr and TiNbTa0.5ZrAl alloys are controlled by diffusion, and obey the exponential rule. However, the oxidation rate of the TiNbTa0.5ZrAlMo0.5 alloy is controlled by interface reaction, and obeys the linear rule. The addition of Al leads to a better oxidation resistance by forming a protective oxide scale. However, the protection of Al-rich scale is weakened by the addition of Mo. Extensive pores and cracks occur in the oxide scale of the TiNbTa0.5ZrAlMo0.5 alloy, resulting in a significant decrease in oxidation resistance.
基金supported by the National Natural Science Foundation of China(U1904215)Natural Science Foundation of Jiangsu Province(BK20200044)+1 种基金Changjiang scholars program of the Ministry of Education(Q2018270)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_2805).
文摘The practical application of Li-S batteries is largely impeded by the“shuttle effect”generated at the cathode which results in a short life cycle of the battery.To address this issue,this work discloses a bimetallic metal-organic framework(MOF)as a sulfur host material based on Al-MOF,commonly called(Al)MIL-53.To obtain a high-adsorption capacity to lithium polysulfides(Li_(2)S_(x),4≤x≤8),we present an effective strategy to incorporate sulfiphilic metal ion(Cu^(2+))with high-binding energy to Li_(2)S_(x)into the framework.Through a one-step hydrothermal method,Cu^(2+)is homogeneously dispersed in Al-MOF,producing a bimetallic Al/Cu-MOF as advanced cathode material.The macroscopic Li2S4 solution permeation test indicates that the Al/Cu-MOF has better adsorption capacity to lithium polysulfides than monometallic Al-MOF.The sulfur-transfusing process is executed via a melt-diffusion method to obtain the sulfur-containing Al/CuMOF(Al/Cu-MOF-S).The assembled Li-S batteries with Al/Cu-MOF-S yield improved cyclic performance,much better than that of monometallic AlMOF as sulfur host.It is shown that chemical immobilization is an effective method for polysulfide adsorption than physical confinement and the bimetallic Al/Cu-MOF,formed by incorporation of sulfiphilic Cu^(2+)into porous MOF,will provide a novel and powerful approach for efficient sulfur host materials.
基金financially supported by the National Natural Science Funds for Distinguished Young Scholar of China (No. 51625404)the National Natural Science Foundation of China (No. 51671217)。
文摘The mechanical properties of refractory high entropy alloys(RHEAs) strongly depend on their phase structures. In this work, the phase stability of a BCC TiNbTa0.5ZrAl0.5 refractory high entropy alloy subjected to thermomechanical processing was evaluated, and the effects of phase decomposition on room/high temperature mechanical properties were quantitatively studied. It was found that, the thermomechanical processing at 800℃and 1200℃ leads to phase decomposition in the TiNbTa0.5ZrAl0.5 alloy. The phase decomposition is caused by the rapid rising of free energy of the primary BCC phase. The effect of the precipitates on room temperature strength is determined by the competition between the increasing in precipitation strengthening and the decreasing in solid solution strengthening. But at high temperatures(800-1200℃), the phase decomposition causes significant reduction in strength, mainly due to the grain boundary sliding and the decreasing in solid solution strengthening.
基金financially supported in partial by National Key Technologies R&D Program of China (Research & Development on Suitable Key Technologies of the Village Environmental Monitoring, No. 2012BAJ24B01)
文摘Mercury（Hg） exists in different chemical forms presenting varied toxic potentials. It is necessary to explore an ecological risk assessment method for different mercury species in aquatic environment. The predicted no-effect concentrations（PNECs） for Hg（Ⅱ） and methyl mercury（Me Hg） in the aqueous phase, calculated using the species sensitivity distribution method and the assessment factor method, were 0.39 and 6.5 × 10-3μg/L, respectively. The partition theory of Hg between sediment and aqueous phases was considered, along with PNECs for the aqueous phase to conduct an ecological risk assessment for Hg in the sediment phase. Two case studies, one in China and one in the Western Black Sea, were conducted using these PNECs. The toxicity of mercury is heavily dependent on their forms,and their potential ecological risk should be respectively evaluated on the basis of mercury species.
基金This work was supported by the National Natural Science Foundation of China (No.81370263 and No.81500348).
文摘Poly(ADP-ribose) polymerase 1 (PARP1) plays important roles in the regulation of transcription factors. Mounting evidence has shown that inhibition of PARP1 influences the expression of genes associated with inflammatory response. Interferon regulatory factor 1 (IRF1) is a critical transcription factor for the development of both the innate and adaptive immune responses against infections. However, the molecular mechanism through which PARP1 mediates the effects has not been clearly demonstrated. Jurkat cells were exposed to dexamethasone (Dex) or PARP1 inhibitor PJ34. The expression levels of IL-12, LMP2, OAS1 and PKR were detected using real-time RT-PCR. The interactions between PARP1 and IRF1 were examined by coimmunoprecipitation (co-IP) assays. We further explored the mechanism of PARP1 suppressing IRF1 by assessing the activities of interferon stimulated response element (ISRE). The mRNA expression of IL-12, LMP2, OAS1 and PKR was obviously suppressed by Dex in Jurkat cells, which could be rescued by PJ34 treatment. Luciferase study revealed that poly(ADP-ribosyl)- ation suppressed IRF1-mediated transcription through preventing the binding of IRF1 to ISREs. PARP1 inhibited IRF1-mediated transcription in Jurkat cells by preventing IRF1 binding to ISREs in the promoters of target genes. It is suggested that PARP1 is a crucial regulator of IRF1-mediated immune response. This study provides experimental evidence for the possible application of PARP1 inhibitors in the treatment of IRF1-related immune anergy.
基金supported by the National Natural Science Foundation of China (NSFC-U1904215, and 21671170)Changjiang scholars program of the Ministry of Education (Q2018270)+3 种基金the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)Program for New Century Excel ent Talents of the University in China (NCET-13-0645)the Six Talent Plan (2015-XCL-030)Qinglan Project of Jiangsu and Program for Colleges Natural Science Research in Jiangsu Province (18KJB150036)
文摘Lithium-sulfur batteries(LSBs)are considered promising new energy storage systems given their outstanding theoretical energy densities.Nevertheless,issues such as low electrical conductivity and severe volume expansion,along with the formation of polysulfides during cycling,restrict their practical applications.To overcome these issues,it is necessary to find suitable and effective sulfur host materials.Metal-organic frameworks(MOFs),which are porous crystalline materials in the bourgeoning developmental stages,have demonstrated enormous potential in LSBs owing to their high porosity and tunable porous structure.Herein,we provide a comprehensive overview of MOF-based sulfur-loaded materials and discuss the charge/discharge mechanisms,strategies of enhancing battery performance,sulfur loading methods,and applications in LSBs.An outlook on future directions,prospects,and possible obstacles for the development of these materials is also provided.
基金supported by the National Key Technologies R&D Program of China (Research & Development on Suitable Key Technologies of the Village Environmental Monitoring, No. 2012BAJ24B01)
文摘The different toxicity characteristics of arsenic species result in discrepant ecological risk.The predicted no-effect concentrations（PNECs） 43.65, 250.18, and 2.00 × 10^3μg/L were calculated for As（III）, As（V）, and dimethylarsinic acid in aqueous phase, respectively. With these PNECs, the ecological risk from arsenic species in Pearl River Delta in China and Kwabrafo stream in Ghana was evaluated. It was found that the risk from As（III） and As（V）in the samples from Pearl River Delta was low, while much high in Kwabrafo stream. This study implies that ecological risk of arsenic should be evaluated basing on its species.
基金University of Macao,Grant/Award Numbers:MYRG 2020-00067-FHS,MYRG2019-00082-FHS,MYRG2022-00081-FHSMacao Science and Technology Development Fund,Grant/Award Numbers:FDCT 0011/2018/A1,FDCT 0020/2019/AMJ,FDCT 0048/2021/AGJ+2 种基金Natural Science Foundation of Guangdong ProvinceNational Key R&D Program of China,Grant/Award Number:2019YFE0110400Higher Education Fund of Macao SAR Government,Grant/Award Number:CP-UMAC-2020-01。
文摘Due to their inherent tunable spectrum,high brightness,excellent biostability and biocompatibility,and functionalization of surfaces,semiconducting polymer dots(Pdots)are now playing an essential role in fluorescent(FL)imaging and disease treatment through bioconjugation with peptides or biomimetic materials.In particular,biomimetic Pdots exhibit their capability in targeted imaging of lesion and increased efficacy for targeting disease treatment.This review will inspect the recent advances in the design and functionalization strategies of biomodified and biomimetic Pdots for enhanced disease detection and therapy.More importantly,the application of these two modifications in targeted FL imaging and cancer treatment is to be addressed in detail.Meanwhile,the main challenges and prospects of biomimetic and biomodified Pdots are to be discussed,which will pave a new avenue for improved disease detection and imaging-guided treatment.
基金supported by the National Science Founda-tion of China(No.21978039)Special Funds of the Central Gov-ernment Leading Local Government for the Technology Develop-ment(Nos.2021JH6/10500148,2021JH6/10500146)Fundamental Research Funds for the Central Universities(Nos.DUT21YG133,DUT20YG120).
文摘Cationic polymers,also known as polycations,are considered to be the most potential non-viral gene carriers due to their unique advantages such as the ability to bind the negative charge of nucleic acid molecules.Multicomponent polymerization(MCP)is a one-step,tandem strategy to construct complex structures based on multicomponent reactions.Herein,we developed a metal-free MCP method based on three monomers of p-dinitrovinylbenzene(p-DNVB),1,1-dimethylethyl N,N-dibromocarbamate(BocNBr_(2)),and bis-secondary-amines with a ratio of 1:2:1,to access a library of Boc-substituted polyamidines with well-defined structures and suitable molecular weights(M w ranging from 4400Da to 11,000Da)in high yields(up to 85%)under mild conditions.Upon the removal of Boc groups,a series of water-soluble polymers with cationic property were prepared and their gene binding capability was further evaluated.
基金supported by the National Natural Science Foundation of China(No.21973064)the Post-Doctor Research Project,West China Hospital,Sichuan University(No.2021HXBH017)。
文摘Protein-protein interactions are vital for a wide range of biological processes.The interactions between the hypoxia-inducible factor and von Hippel Lindau(VHL)are attractive drug targets for ischemic heart disease.In order to disrupt this interaction,the strategy to target VHL binding site using a hydroxyproline-like(pro-like)small molecule has been reported.In this study,we focused on the inhibition mechanism between the pro-like inhibitors and the VHL protein,which were investigated via molecular dynamics simulations and binding free energy calculations.It was found that pro-like inhibitors showed a strong binding affinity toward VHL.Binding free energy calculations and free energy decompositions suggested that the modification of various regions of pro-like inhibitors may provide useful information for future drug design.
文摘The comfort satisfaction of basic facilities of the rail transit transfer station will influence pedestrian choice of vehicle. Aiming at the problem of traffic jams in Changchun in China, we designed a satisfaction questionnaire to investigate the factors which might affect the pedestrian satisfaction in rail transit transfer station in Changchun. By using the statistical methods, including correlation analysis, factor analysis and comparative analysis of satisfaction and importance, we analyzed the survey data, and get the results of analysis. Some suggestions for rail transit transfer station based on the results are given.
