In this paper,the Multi-Temporal Interferometric Synthetic Aperture Radar(MT-InSAR)technology is adopted to monitor the Line of Sight(LOS)displacement of Fushun West Opencast Coal Mine(FWOCM)and its surrounding areas ...In this paper,the Multi-Temporal Interferometric Synthetic Aperture Radar(MT-InSAR)technology is adopted to monitor the Line of Sight(LOS)displacement of Fushun West Opencast Coal Mine(FWOCM)and its surrounding areas in northeast China using Sentinel-1 Synthetic Aperture Radar(SAR)images acquired from 2018 to 2022.The spatial-temporal evolution of urban subsidence and the south-slope landslide are both analyzed in detail.Comparison with ground measurements and cross-correlation analysis via cross wavelet transform with monthly precipitation data are also conducted,to analyze the influence factors of displacements in FWOCM.The monitoring results show that a subsidence basin appeared in the urban area near the eastern part of the north slope in 2018,with settlement center located at the intersection of E3000 and fault F1.The Qian Tai Shan(QTS)landslide on the south slope,which experienced rapid sliding during 2014 to 2016,presents seasonal deceleration and acceleration with precipitation,with the maximum displacement in vicinity of the Liushan paleochannel.The results of this paper have fully taken in account for the complications of large topographic relief,geological conditions,spatial distribution and temporal evolution characteristics of surface displacements in opencast mining area.The wide range and long time series dynamic monitoring of opencast mine are of great significance to ensure mine safety production and geological disaster prevention in the investigated mining area.展开更多
Kelch-like family member 17(KLHL17)is predominantly expressed in the brain and plays a crucial role in neuronal development and function,deletions and/or mutations in KLHL17 have been linked to neurodevelopmental diso...Kelch-like family member 17(KLHL17)is predominantly expressed in the brain and plays a crucial role in neuronal development and function,deletions and/or mutations in KLHL17 have been linked to neurodevelopmental disorders in humans,e.g.,intellectual disability,autism spectrum disorder,and infantile spasms,but the etiology and pathogenesis remain largely enigmatic.1,2 As a member of the family of the Kelch proteins,KLHL17 contains an N-terminal BTB/POZ domain followed by a BACK domain and four to six tandem Kelch motifs at the C-terminal region(Fig.S1A).1,3 Previously,we identified a novel de novo variant in KLHL17(c.701C>T;p.P234L)in a cohort of 225 Chinese children with developmental delay/intellectual disability based on whole-exome sequencing(1/225),the mutation located in the BACK domain,a very high conversed region(Fig.S1B),and the affected boy presented with developmental delay,intellectual disability,hypotonia,and abnormal brainstem auditory evoked potential signal.4 The finding may offer a new clue to investigate the molecular pathogenesis of KLHL17 gene in neurodevelopmental disorders.展开更多
基金supported by the Natural Science Foundation of China[grant number 42071453]the geological hazard investigation project of Liaoning Province[grant number 2022020700179]the Fund of National Key Laboratory of Science and Technology on Remote Sensing Information and imagery Analysis,Beijing Research Institute of Uranium Geology[grant number 6142A01210407].
文摘In this paper,the Multi-Temporal Interferometric Synthetic Aperture Radar(MT-InSAR)technology is adopted to monitor the Line of Sight(LOS)displacement of Fushun West Opencast Coal Mine(FWOCM)and its surrounding areas in northeast China using Sentinel-1 Synthetic Aperture Radar(SAR)images acquired from 2018 to 2022.The spatial-temporal evolution of urban subsidence and the south-slope landslide are both analyzed in detail.Comparison with ground measurements and cross-correlation analysis via cross wavelet transform with monthly precipitation data are also conducted,to analyze the influence factors of displacements in FWOCM.The monitoring results show that a subsidence basin appeared in the urban area near the eastern part of the north slope in 2018,with settlement center located at the intersection of E3000 and fault F1.The Qian Tai Shan(QTS)landslide on the south slope,which experienced rapid sliding during 2014 to 2016,presents seasonal deceleration and acceleration with precipitation,with the maximum displacement in vicinity of the Liushan paleochannel.The results of this paper have fully taken in account for the complications of large topographic relief,geological conditions,spatial distribution and temporal evolution characteristics of surface displacements in opencast mining area.The wide range and long time series dynamic monitoring of opencast mine are of great significance to ensure mine safety production and geological disaster prevention in the investigated mining area.
基金funded by the National Natural Science Foundation of China(No.82160620)the Natural Science Foundation of Guangxi Province,China(No.2023GXNSFAA026036)the Guangxi College Students Innovation and Entrepreneurship Training Program(China)(No.S202310601164).
文摘Kelch-like family member 17(KLHL17)is predominantly expressed in the brain and plays a crucial role in neuronal development and function,deletions and/or mutations in KLHL17 have been linked to neurodevelopmental disorders in humans,e.g.,intellectual disability,autism spectrum disorder,and infantile spasms,but the etiology and pathogenesis remain largely enigmatic.1,2 As a member of the family of the Kelch proteins,KLHL17 contains an N-terminal BTB/POZ domain followed by a BACK domain and four to six tandem Kelch motifs at the C-terminal region(Fig.S1A).1,3 Previously,we identified a novel de novo variant in KLHL17(c.701C>T;p.P234L)in a cohort of 225 Chinese children with developmental delay/intellectual disability based on whole-exome sequencing(1/225),the mutation located in the BACK domain,a very high conversed region(Fig.S1B),and the affected boy presented with developmental delay,intellectual disability,hypotonia,and abnormal brainstem auditory evoked potential signal.4 The finding may offer a new clue to investigate the molecular pathogenesis of KLHL17 gene in neurodevelopmental disorders.
